By Matt Solomon Published: November 12th, 2024

1. “Wir müssen uns von der Vorstellung lösen, dass Journalismus gleichbedeutend mit Content ist” (journalist.de, Leif Kramp & Stephan Weichert) Bei journalist.de ist ein lesenswertes Interview mit dem US-amerikanischen Journalismus-Experten Jeff Jarvis erschienen, der gleich in der ersten Antwort ziemlich direkt wird: “Während wir die US-Wahlen durchlaufen, frage ich mich, ob es Zeit ist, den […]

Their movies feature lush cinematography (whether in color or black-and-white), passionate romances that are all the more affecting because the characters are so very British.

The festival’s opening-night gala will feature the West Coast Premiere of Tom Nesher’s Come Closer at the Saban Theatre in Beverly Hills.

Touché! .@POTUS45: "If the Democrats could fight wars as well as they execute Election Fraud, we would have obliterated all of our many enemies throughout the World, and would have nothing to worry about!" pic.twitter.com/GpMO46zrNQ — Natalie Harp (@NatalieJHarp) August […]

The post “If the Democrats could fight wars as well as they execute Election Fraud, we would have obliterated all of our many enemies throughout the World, and would have nothing to worry about!” ~ Donald J. Trump appeared first on Powdered Wig Society.

The ARJ21 is now to be known as the C909. The renaming plays into COMAC's ambition to enter the global market.

An important mechanism of resistance to β-lactam antibiotics is via their β-lactamase–catalyzed hydrolysis. Recent work has shown that, in addition to the established hydrolysis products, the reaction of the class D nucleophilic serine β-lactamases (SBLs) with carbapenems also produces β-lactones. We report studies on the factors determining β-lactone formation by class D SBLs. We show that variations in hydrophobic residues at the active site of class D SBLs (i.e. Trp105, Val120, and Leu158, using OXA-48 numbering) impact on the relative levels of β-lactones and hydrolysis products formed. Some variants, i.e. the OXA-48 V120L and OXA-23 V128L variants, catalyze increased β-lactone formation compared with the WT enzymes. The results of kinetic and product studies reveal that variations of residues other than those directly involved in catalysis, including those arising from clinically observed mutations, can alter the reaction outcome of class D SBL catalysis. NMR studies show that some class D SBL variants catalyze formation of β-lactones from all clinically relevant carbapenems regardless of the presence or absence of a 1β-methyl substituent. Analysis of reported crystal structures for carbapenem-derived acyl-enzyme complexes reveals preferred conformations for hydrolysis and β-lactone formation. The observation of increased β-lactone formation by class D SBL variants, including the clinically observed carbapenemase OXA-48 V120L, supports the proposal that class D SBL-catalyzed rearrangement of β-lactams to β-lactones is important as a resistance mechanism.

Lauri Hitruhin and Sauli Lindberg
Proc. Amer. Math. Soc. 152 (), 5265-5278.
Abstract, references and article information

Visual Abstract

Some cases of chylomicronemia are caused by autoantibodies against glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1), an endothelial cell protein that shuttles LPL to the capillary lumen. GPIHBP1 autoantibodies prevent binding and transport of LPL by GPIHBP1, thereby disrupting the lipolytic processing of triglyceride-rich lipoproteins. Here, we review the "GPIHBP1 autoantibody syndrome" and summarize clinical and laboratory findings in 22 patients. All patients had GPIHBP1 autoantibodies and chylomicronemia, but we did not find a correlation between triglyceride levels and autoantibody levels. Many of the patients had a history of pancreatitis, and most had clinical and/or serological evidence of autoimmune disease. IgA autoantibodies were present in all patients, and IgG4 autoantibodies were present in 19 of 22 patients. Patients with GPIHBP1 autoantibodies had low plasma LPL levels, consistent with impaired delivery of LPL into capillaries. Plasma levels of GPIHBP1, measured with a monoclonal antibody–based ELISA, were very low in 17 patients, reflecting the inability of the ELISA to detect GPIHBP1 in the presence of autoantibodies (immunoassay interference). However, GPIHBP1 levels were very high in five patients, indicating little capacity of their autoantibodies to interfere with the ELISA. Recently, several GPIHBP1 autoantibody syndrome patients were treated successfully with rituximab, resulting in the disappearance of GPIHBP1 autoantibodies and normalization of both plasma triglyceride and LPL levels. The GPIHBP1 autoantibody syndrome should be considered in any patient with newly acquired and unexplained chylomicronemia.

The study found that youth in rural New Hampshire have poor perceptions of job opportunities in the area, and are more likely to be depressed or abuse substances than other rural youth.

To save a species from extinction, scientists scour the Panamanian jungle for the few remaining frogs. But will they be too late?

A "staggering array" of markings have been hiding in plain sight carved into the walls of Gainsborough Old Hall, a 500-year-old home in Lincolnshire, England

The OM team in Bar, Montenegro, received an enthusiastic response when they showed the JESUS film in the Roma language for the first time.

Medical industry manufacturer reducing R&D costs, time to market, and scrap by up to 50 percent

During a medical outreach in Guatemala, the OM team members and volunteers witnessed a special moment of forgiveness.

South Africa's unemployment rate fell by more than expected in the third quarter, declining by 1.4 percentage points to 32.1%.

The Delaware Department of Labor Fox Valley location in Wilmington will no longer offer “counter service” for unemployment insurance claims beginning January 22, 2019. All unemployment insurance claims will be filed using the streamlined process available online at https://ui.delawareworks.com. Individuals can file a claim using any computer or smart phone without the inconvenience of travelling […]

In the event of a Federal government shutdown, Federal employees may be eligible for Unemployment Compensation for Federal Employees (UCFE). The UCFE program is administered by state unemployment insurance (UI) agencies acting as agents of the Federal government. The program is operated under the same terms and conditions that apply to regular state UI. In […]

  Wilmington, DE. May 6, 2019–The Delaware Department of Labor Pencader Office will no longer offer “counter service” and process unemployment insurance applications at its location. Beginning May 20, 2019, individuals must apply for unemployment insurance online. To file an unemployment insurance claim, log on to ui.delawareworks.com and click the red/orange button “File An Unemployment […]

Together with the IRS and Delaware’s Department of Labor Unemployment Insurance Division, the Division of Revenue has announced a COVID–19 Relief Discussion this coming Friday, May 22, 2020, at 11:30 a.m. Eastern Standard Time (EST). This free 60-minute conference will be open to the public. Delaware’s Director of Revenue Jennifer Hudson, and Director of Unemployment […]

For Immediate Release Friday, May 29, 2020: Wilmington, DE: The Delaware Department of Labor, in its effort to respond to the COVID-19 pandemic, reached another milestone this week by paying the first Pandemic Unemployment Assistance claims to eligible Delawareans. The Pandemic Unemployment Assistance program provides benefits for independent contractors and self-employed workers in the state […]

  For Immediate Release July 20, 2020 Contact: Kenneth Briscoe Director of Communications Kenneth.Briscoe@delaware.gov   (Wilmington, DE) – The Delaware Department of Labor announced today that Delaware has already begun offering the Federal-State Extended Benefits program for those who have exhausted their previous unemployment benefits.   Delaware’s most recent insured unemployment rate (IUR) exceeded the […]

FOR IMMEDIATE RELEASE- Thursday, July 30, 2020, Wilmington, Delaware. The Delaware Department of Labor releases public notification to inform all Delawareans currently receiving Unemployment Insurance Benefits, that the Federal Pandemic Unemployment Compensation (FPUC) program ended on July 25, 2020.   Due to the rise in unemployment resulting from the COVID-19 global pandemic, Congress authorized a […]

  FOR RELEASE: December 9, 2020 CONTACT: Kenneth Briscoe Kenneth.Briscoe@delaware.gov   Unemployment Benefits Scheduled to Expire on December 26, 2020 for Many Claimants in Delaware   WILMINGTON, DELAWARE – According to federal program guidelines, all unemployment compensation programs created by the CARES Act are currently scheduled to expire on or before December 26, 2020.   Many […]

The U.S. Department of Justice has received reports that fraudsters are creating websites mimicking unemployment benefit websites, including state workforce agency (SWA) websites, and Facebook pages to unlawfully capture consumers’ personal information.   To lure consumers to these fake websites, fraudsters send spam text messages and emails purporting to be from an SWA and containing […]

WILMINGTON, DE – The Delaware Department of Labor (DOL) has issued policy to address questions and concerns about a claimant’s eligibility to collect Unemployment Insurance (UI) benefits after refusing to be vaccinated or tested as required by an employer. Delaware law states that claimants are not allowed to receive UI benefits if they have violated […]

The Division of Unemployment Insurance (UI) recently mailed 2024 UI tax rate letters that contained incorrect information. We apologize for the error. We are working to correct the issue and will mail new letters with the correct rate as quickly as possible. All employers will receive updated letters even if their rate does not change. […]

The Division of Unemployment Insurance has corrected the issue related to the 2024 UI tax rate letters mailed in January. Corrected letters have been mailed to employers the week of February 5, 2024. The corrected letters have a date of February 1, 2024. The Division of Unemployment would like to thank all employers for their […]

A Florida appellate court has upheld AG Kathy Jennings’ authority to continue advocating for funding for Nemours Children’s Hospital. “The consequences of this case could be a game changer for kids in Delaware,” said AG Jennings. “Anyone whose child has received care at Nemours Hospital understands how exceptional they are. That’s the hallmark of A.I. […]

[COSATU] The Congress of South African Trade Unions (COSATU) welcomes the slight drop in the expanded unemployment rate from 42.6% in the second quarter to 41.9% in the third quarter of this year.

Sustainability is gaining traction in the creative industries, with the Italian region of Trentino designing a film production rating protocol that is being considered by the EU.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

At just 11 years old, with a heavy heart, Louis  peered up at his parents and said goodbye. He was leaving his small village in northern Benin to live with his uncle in Parakou, where the schools were better. Ever since, Louis has continued to make sacrifices to pursue a strong education and a better […]

Chloe Fineman named 'SNL' host that made cast cry on the comedy sketch show. Chloe Fineman has recently come out and called the businessman Elon Musk for his time hosting on Saturday Night Live . In a now deleted TikTok video, the American actress claimed that the Tesla CEO made cast...

The small community of Ribeira stands out in the Northeast, the poorest region of Brazil. There is no unemployment here. One in five inhabitants make a living directly or indirectly from the Arteza Cooperative of Tanners and Leather Artisans. “An idea has the power to transform your world,” said in a philosophical tone Ângelo Macio, […]

Rival tribes of bacteria armed with poison darts are fighting it out in your gut, with armies of traitors often winning the day

Friends who blow hot and cold put more strain on your physical and mental health than enemies. Here's how to spot them and handle them

It was the 20-year anniversary of Halo 2 at the weekend, which saw the shooter's modern counterparts celebrating with classic multiplayer maps and long-lost levels. But also emerging from the dust of time are insights to the sequel's development back in 2004. Rolling Stone interviewed two key designers of the game and made a fun discovery. The Flood (the sickly pale alien infestation that briefly turns Halo into sci-fi horror) was partly inspired by a colourful and innocent children's book about a nice elephant.

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“It’s not funny,” he told her while hosting Saturday Night Live.

To restore the rule of law, Trump's Department of Justice must investigate those who subverted our constitutional order.

Eddie reflects on his favourite scene in cinema.

Welcome, film enthusiasts, to a captivating exploration of the diverse world of nudity in global cinema! In an era where cultural nuances shape the way we perceive art, it’s fascinating to dissect how different societies approach the depiction of the human form on the silver screen. Among different diversities like age diversity, political diversity, and […]

The post Unveiling Diversity: Nudity Across Borders in Global Cinema appeared first on Chart Attack.