Continuous conventional EEG video is currently gold standard for identifying neonatal seizures and a substantial proportion of neonatal seizures are electrographic. Currently there is no direct evidence that EEG monitoring, seizure identification, or treatment impacts long-term outcomes.

In neonates with hypoxic ischemic encephalopathy, EEG monitoring and treatment of electrographic seizures results in significant reduction in seizure burden. Increasing seizure burden is associated with more severe brain injury and significantly lower performance scores on Bayley Scales of Infant Development III. (Read the full article)

Makeda Brome, Pia Hansen, Linda Gojak, Marian Small, Kenneth Baum and David Krulwich share their thoughts on the biggest challenges facing math teachers.

A student-centered approach to teaching mathematics enables students to develop conceptual understanding and to grow as confident mathematicians.

Better mathematics screening procedures may help schools choose students for 8th grade Algebra 1 classes who will be able to successfully complete the course, according to a study by the Regional Educational Laboratory West.

Though boys typically perform better in mathematics, a new study shows that girls' superior verbal skills tend to make them better at arithmetic.

High school math classes should be broadened to focus on goals beyond college and careers, including teaching the math students will need to be literate participants in civic life.

Helping students to categorize different types of word problems can help elementary-age students tackle a common challenge in math class, according to a new analysis of 21 studies in the journal Review of Educational Research.

A health expert discusses what late joiner penalties are and how to avoid them.

There has been a distinct trend of consolidation among private medical schemes in South Africa, according to an actuarial specialist at Alexander Forbes.

The first hotel will break ground later this year in Phoenix, Arizona. Another is being planned for Las Vegas. They promise to offer Atari-themed lodging, along with lots of video gaming experiences.

Equipping teachers to help transgender students feel safe and included requires special training, advocates say.

The attempt by Congo and Rwanda to end the deadly conflict in eastern Congo by a secret presidential deal and military force is failing and must be changed fundamentally by the Kinshasa government and the international community.

QPX7728 is a new ultra-broad-spectrum inhibitor of serine and metallo beta-lactamases from a class of cyclic boronates that gave rise to vaborbactam. The spectrum and mechanism of beta-lactamase inhibition by QPX7728 were assessed using purified enzymes from all molecular classes. QPX7728 inhibits class A ESBLs (IC₅₀ range 1-3 nM) and carbapenemases such as KPC (IC₅₀ 2.9±0.4 nM) as well as class C P99 (IC₅₀ of 22±8 nM) with a potency that is comparable or higher than recently FDA approved BLIs avibactam, relebactam and vaborbactam. Unlike those other BLIs, QPX7728 is also a potent inhibitor of class D carbapenemases such as OXA-48 from Enterobacteriaceae and OXA enzymes from A. baumannii (OXA-23/24/58, IC₅₀ range 1-2 nM) as well as MBLs such as NDM-1 (IC₅₀ 55±25 nM), VIM-1 (IC₅₀ 14±4 nM) and IMP-1 (IC₅₀ 610±70 nM). Inhibition of serine enzymes by QPX7728 is associated with progressive inactivation with a high efficiency k₂/K ranging from of 6.3 x 10⁴ (for P99) to 9.9 x 10⁵ M^-1 s^-1 (for OXA-23). This inhibition is reversible with variable stability of the QPX7728-beta-lactamase complexes with target residence time ranging from minutes to several hours: 5-20 minutes for OXA carbapenemases from A. baumanii, ~50 minutes for OXA-48 and 2-3 hours for KPC and CTX-M-15. QPX7728 inhibited all tested serine enzymes at 1:1 molar ratio. Metallo-beta-lactamases NDM, VIM, and IMP were inhibited by a competitive mechanism with fast-on-fast-off kinetics, with K_is of 7.5±2.1 nM, 32±14 nM and 240±30 nM for VIM-1, NDM-1 and IMP-1, respectively. QPX7728 ultra-broad-spectrum of BLI inhibition combined with its high potency enables combinations with multiple different beta-lactam antibiotics.

Lipid II is an essential precursor of the bacterial cell wall biosynthesis and thereby an important target for various antibiotics. Several lanthionine-containing peptide antibiotics target lipid II with lanthionine-stabilized lipid II-binding motifs. Here, we used the biosynthesis system of the lantibiotic nisin to synthesize a two lipid II binding motifs-containing lantibiotic, termed TL19, which contains the N-terminal lipid II binding motif of nisin and the distinct C-terminal lipid II binding motif of one peptide of the two-component haloduracin (i.e. HalA1). Further characterization demonstrated that (i) TL19 exerts 64-fold stronger antimicrobial activity against E. faecium than nisin (1-22), which has only one lipid II binding site, and (ii) both the N- and C-terminal domains are essential for the potent antimicrobial activity of TL19, as evidenced by mutagenesis of each single and double domains. These results show the feasibility of a new approach to synthesize potent lantibiotics with two different lipid II binding motifs to treat specific antibiotic-resistant pathogens.

OBJECTIVES:

Infantile hemangiomas (IHs) are common; some cases require timely referral and treatment to prevent complications. We developed and validated a reliable instrument for timely and adequate referral of patients with IH to experts by nonexpert primary physicians.

Many investors do not fully understand the tax incentive and structure of a Section 12J venture capital investment, according to a managing director involved in this sector.

Don’t like to wait for programs to boot up when you’re looking for a specific document? With the right tools, you can preview a variety of files in Windows 10 without opening their applications.

Perhaps there were some who had hoped for a dossier of lurid juiciness.

After recent confidence-eroding breaches, VPN providers are banding together to form a "trust initiative." This is the industry's much-needed chance to prove it's a safe guardian of customers' sensitive information, explains security expert Max Eddy.

Math teachers are more likely to be using highly-rated curricula than English-language arts teachers, according to a new analysis from the RAND Corporation.

More than 9.3 million U.S. students attended a rural school last year. A new report examines factors that affect them like poverty, academic achievement, and diversity.

It's 2020 and time to upgrade your business skill set. Creativity and persuasion are the most desirable soft business skills, while blockchain and cloud computing skills dominate as the most in-demand hard skills as we begin the new decade.

The pharmaceutical retailer says it was forced to increase prices of surgical masks because of suppliers' inflated quotes and to match competitors, while the commission says retailers could have been following Dis-Chem's lead.

If you have lost your income due to the lockdown, your options are limited.

By manipulating the expression of one gene, geneticists can induce a form of “stress memory” in plants that is inherited by some progeny, giving them the potential for more vigorous, hardy and productive growth, according to Penn State researchers, who suggest the discovery has significant implications for plant breeding.

Through propensity score analysis, we examine the effect of living in a segregated area on the development of neonatal IVH, stratified by maternal race.

Sexual assault kit testing initiative generates rape conviction; Child sexual abuse, armed robbery also lead to guilty pleas An employee of the state Division of Motor Vehicles and a man who bribed her have pleaded guilty to issuing drivers’ licenses to people who hadn’t earned them. Danielle Haldeman, 29, of Greenwood, who worked at the […]

Secretary of State Jeffrey Bullock has suspended the Delaware chemical dependency counseling license of Sachin Karnik in light of recent criminal charges filed against him.

The book also conveys an important message that misconceptions often lead to wrong judgment about people, and aims at making us better decision makers.

WeChat also jumped on the bandwagon recently. Its story feature, Time Capsule, allows users to upload short, time-bound videos that appear on a user’s homepage with additional features such as music, location, emojis, etc.

Kesavananda Bharati V. state of Kerala that outlined the basic structure doctrine of the constitution. The judgment was delivered by the largest SC bench so far i.e. 13 judges.

ESIC & EPF relief scheme guidelines 2020 due to COVID19

Delhi: BJP leader Vijay Goel who left his house in an odd numbered car to protest against Odd-Even scheme, issued a challan for violation of the scheme. BJP leader Vijay Goel drove an odd numbered car in protest against Odd-Even scheme, and said, 'This scheme is just a gimmick, they(Delhi

<strong>New Delhi:</strong> Delhi Government's Odd-Even scheme has come into effect from today and will continue till November 15. In a bid to control the deteriorating air quality in the national capital, this is the third Odd-Even car rationing scheme that has kicked off from Monday. A flagship scheme of the

A second instalment of the government-run Sovereign Gold Bond (SGB) scheme will open for subscription from Monday, May 11. The Sovereign Gold Bonds - issued by the Reserve Bank of India (RBI) on...

Ms Sitharaman also said that about three crore farmers with agri loans totaling Rs 4,22,113 crore availed the benefit of the 3-month loan moratorium.

A pharmacist died and his boss was left hospitalised after the pair drank a chemical concoction they had developed in an effort to treat coronavirus, police said Saturday. The men worked for a herbal...

Dover, Del. – The Delaware Department of Agriculture announced today that they have launched the Delaware Hemp Research Pilot Program in partnership with Delaware State University’s College of Agriculture and Related Sciences. “The research component announced today gives producers an opportunity to see if hemp is a worthwhile product for their farming operation,” said Secretary […]

The Delaware Department of Agriculture announced today that the USDA approved the state plan submitted for the Delaware Domestic Hemp Production Program. Delaware is now the second state on the East Coast to receive approval to administer a domestic hemp program.

Following up on the recent announcement of USDA’s approval of Delaware’s Domestic Hemp Production Program, the Delaware Department of Agriculture released their registration materials online Friday, February 7.

Op-ed by Rick Geisenberger, Secretary of the Delaware Department of Finance Over the next several weeks, as we complete another budget debate in Dover, we should not lose sight of Delaware’s long-term challenges and of one issue in particular: the rising cost of health care. The projected growth rate for state spending on health care […]

DOVER (March 1, 2019) — Although the overall number of laboratory-confirmed flu cases in Delaware this flu season remains lower than the total number of cases reported at the same time last year, the number of flu-related deaths has continued to increase during the 2018-2019 flu season. As of February 16, 2019, the most recent […]

The US Air Force and Dover Air Force Base have notified Delaware’s Department of Natural Resources and Environmental Control and Division of Public Health, that four wells near the base sampled by the federal government for perfluoroalkyl substances (PFAS), including perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), have returned elevated levels of PFOS and PFOA above the US Environmental Protection Agency’s health advisory for these substances of 70 parts per trillion (ppt).

Many independent agencies have forecast that Indian economy may grow at less than 1% in FY21 from around 5% (advance estimate) in FY20.

The Indian arm of a South Korean chemical major has apologised after a gas leak at its plant in Andhra Pradesh killed 11 and affected at least a thousand people. A tank used to store chemicals for...

Enforcement actions have been initiated throughout state to handle noncompliance Attorney General Kathy Jennings urges Delawareans to heed Gov. John Carney’s Declarations of a State of Emergency.  The Declaration of a State of Emergency and all its modifications carry criminal punishment and have been enforced throughout Delaware. “This is a tremendously difficult time for everyone, […]

To assist customers during this difficult time, Hyundai India has devised a set of new finance schemes that may help ease their financial burden. We explain what is being offered and exactly what they entail.