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Electrochemical aptasensor based on silver-thiolated graphene for high-sensitive detection of Pb2+

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00322E, Paper
Jie Zhou, Changchun Hu, Shuo Li, Chuanxiang Zhang, Yuan Liu, Zhu Chen, Song Li, Hui Chen, Yan Deng
The presence of lead ions (Pb2+) not only leads to environmental contamination but also poses a significant risk to public health through their migration into food and drinking water. Therefore,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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An efficient electrochemical sensor based on the Ce-MOF/g-C3N5 composite for the detection of nitrofurazone

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02221H, Paper
Jianxia Gu, Yiqiong Jia, Zhanbin Jin, Tingting Wei, Yongxia Li
The Ce-MOF/g-C3N5 composite was first constructed using a simple reflux method in an oil bath, and the electrochemical sensor fabricated based on this composite shows excellent detection performance in nitrofurazone detection in practical samples.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Converging optical and electrochemical detection strategies for multimodal hydrazine sensing: insights into substituent-driven diverse response

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00063C, Paper
Rikitha S. Fernandes, Sahil Deepak Vasistha, Ritesh Kumar Singh, Sanket Goel, Nilanjan Dey
A pair of pyrene-based chalcogen derivatives have been developed, which demonstrate multimodal ratiometric response towards hydrazine.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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LAMP-based hydrogen ion selective electrochemical sensor for highly sensitive detection of Mycoplasma pneumoniae

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00341A, Paper
Huiqing Wang, Yang Li, Lin Tian, Xinyi Li, Qian Gao, Yaru Liu, Cuiping Ma, Qing Wang, Chao Shi
An urgent need for a concise and rapid detection method for Mycoplasma pneumoniae is required due to its severe impact on human’s health. To meet such a need, this study...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Heparin-stabilized gold nanoparticles embedded in graphene for the electrochemical determination of esculetin

Anal. Methods, 2024, 16,2256-2266
DOI: 10.1039/D4AY00229F, Paper
Vinicius José da Silva, Luan Gabriel Baumgarten, Juliana Priscila Dreyer, Edson Roberto Santana, Almir Spinelli, João Paulo Winiarski, Iolanda Cruz Vieira
A conductive nanocomposite consisting of heparin-stabilized gold nanoparticles embedded in graphene was prepared for esculetin determination in tea and jam samples.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Direct solid sample analysis of low-cost jewelry using spectroanalytical techniques: exploratory chemical data evaluation and metal migration with synthetic sweat

Anal. Methods, 2024, 16,2286-2291
DOI: 10.1039/D4AY00325J, Paper
Thaila Lorena de Araújo, Fabiola Manhas Verbi Pereira, Edenir Rodrigues Pereira-Filho
Jewelry samples were directly analyzed using LIBS and XRF.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advancements in the development of fluorescent chemosensors based on CN bond isomerization/modulation mechanistic approaches

Anal. Methods, 2024, 16,2198-2228
DOI: 10.1039/D3AY02321D, Critical Review
Arpna Tamrakar, Manzoor Ahmad Wani, Gargi Mishra, Ankur Srivastava, Rampal Pandey, Mrituanjay D. Pandey
The CN bond isomerization/modulation as a fluorescence signalling mechanism was explored by studying the photophysical properties of conformationally restricted molecules.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A chemiluminescence immunoassay for type IV collagen as a promising marker for liver fibrosis and cirrhosis

Anal. Methods, 2024, 16,2248-2255
DOI: 10.1039/D3AY02240D, Paper
Xiaoling Fu, Fan Zhang, Fangda Zhen, Lian Duan, Jian Zhou, Jianguo Ma
Herein, a magnetic bead-based chemiluminescence assay is reported to detect type IV collagen (col-IV) in serum samples.
The content of this RSS Feed (c) The Royal Society of Chemistry




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An overview of electrochemical biosensors used for COVID-19 detection

Anal. Methods, 2024, 16,2164-2176
DOI: 10.1039/D3AY02042H, Minireview
Tatiana Lima Valerio, Raquel Anastácio, Stella Schuster da Silva, Carolina Camargo de Oliveira, Marcio Vidotti
This short review presents the latest advances in the field of electrochemical biosensors, focusing particularly on impedimetric biosensors for the direct measurement of analytes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00264D, Paper
Mariya Antony John Felix, Santhiyagu Sahayaraj Rex Shanlee, Shen-Ming Chen, Sundaresan Ruspika, Ramachandran Balaji, Narendhar Chandrasekar, Periyanayagam Arockia Doss
Fabrication of potent electrocatalyst, La-based perovskites coupled with functionalized carbon nanofibers (LMO/f-CNF) for ultrasensitive electrochemical detection of roxarsone in edible and water samples.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A chemodosimetric chemosensor for the ratiometric detection of nerve agent-mimic DCP in solution and vapor phases

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00451E, Paper
Shilpita Banerjee, Pintu Ghosh, Anirban Karak, Dipanjan Banik, Ajit Kumar Mahapatra
The probe MNFZ undergoes a hydrolysis reaction in the presence of DCP to exhibit a naked eye color change from blue to cyan. It was successfully applied to sense DCP in the vapor phase.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Good, but not enough: On the extended coverage of the Ayushman Bharat scheme

Extension of free health coverage to all over 70 years is good, but more needs to be done  




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A learning curve: On the PM Internship Scheme

The outcomes of the PM Internship Scheme’s pilot project need monitoring




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​Marina mayhem: On the IAF’s Chennai air show

The deaths at the air show in Chennai could have been prevented with better arrangements 




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Biology transformed: On the Nobel Prize in chemistry

Nobel for determining protein structure recognises a big advance




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Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective

RSC Med. Chem., 2024, 15,3345-3370
DOI: 10.1039/D4MD00317A, Review Article
Meghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep Kumar
Semisynthetic phytochemicals in cancer treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Introduction to the themed collection on ‘AI in Medicinal Chemistry’

RSC Med. Chem., 2024, 15,3284-3285
DOI: 10.1039/D4MD90035A, Editorial
Jian Zhang, Ola Engkvist, Gerhard Hessler
Jian Zhang, Ola Engkvist and Gerhard Hessler introduce the RSC Medicinal Chemistry themed collection on ‘AI in Medicinal Chemistry’.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Introduction to the themed collection in honour of Professor Christian Leumann

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90039A, Editorial
Marcel Hollenstein, Eugen Stulz
Marcel Hollenstein and Eugen Stulz introduce the cross-journal themed collection celebrating Christian Leumann’s retirement.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article
Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
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Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00558A, Research Article
Laura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva Júnior
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Ensure time-bound implementation of development schemes, says Thirumavalavan




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Don’t trash them

Here’s how to give used wrapping paper, scrapbooks and old newspapers new life, says Teja Lele Desai




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₹200-crore decentralised green hydrogen scheme 

Decentralised use of green hydrogen could include cooking, off-grid electricity generation




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Several Delhi govt. schemes to tackle toxic air yet to take off

AAP govt. yet to implement at least 5 programmes it announced over the past two years to curb air pollution; these include using drones to map bad air sources and making PUC mandatory to buy fuel; our plans have been stopped by Centre: AAP




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Issue of infiltration in Santhal Pargana was raised, Hemant did not listen: Champai Soren

The longtime JMM-loyalist, who has now switched to the BJP, adds that decisions he had taken as CM — on tribal language education, PESA implementation, and jump-starting state recruitments — have been put on hold now




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Cabinet clears new scheme to supply virus-free planting material

It will cover all farmers, regardless of their landholding size or socioeconomic status: Ministry




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The chemical treasury in garlic




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Cabinet clears 7 schemes with ₹ 14,235.30 crore for agriculture sector

Digital Agriculture Mission, which has an outlay of ₹2.817 crore and aims to create a consolidated database on crop data, among initiatives to get nod; schemes to boost nutritional security and livestock production also approved




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Observability and mathematics [electronic resource] : Quantum Yang-Mills theory and modelling / Boris Khots.




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Won’t let them wreck our plant: Tata’s Dutch workers

Trade union leaders say returns would have been higher if Tata’s leaders hadn’t diverted investment to Britain




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Tatas extend Rs. 56 cr. to U.K. varsity fellowship scheme




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25 tribal girls to undergo skill development training under Tholkudi scheme




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Chemo-mechanical model of cell polarization initiated by structural polarity

Soft Matter, 2024, 20,8407-8419
DOI: 10.1039/D4SM00800F, Paper
Hexiang Wang, Zhimeng Jia, Yuqiang Fang
We establish a multiscale model of a cell to explore the chemomechanical mechanisms of cell polarization initiated by structural polarity. The two-dimensional vertex model is built by coupling the cytoskeletal reorganization and the Cdc42 activation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Thickness-dependent response of aerosol-jet-printed ultrathin high-aspect-ratio electrochemical microactuators

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00886C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ji Zhang, Jeremy J. Baumberg, Sohini Kar-Narayan
Trilayer electrochemical actuators comprising an electrolyte layer sandwiched between two electrode layers have been shown to exhibit large deformations at low actuation voltages. Here we report aerosol-jet printing (AJP) of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Enhanced chemotaxis efficiency of Escherichia coli in viscoelastic solutions

Soft Matter, 2024, 20,8675-8683
DOI: 10.1039/D4SM01094A, Paper
Shaoying Zhu, Rui He, Caijuan Yue, Rongjing Zhang, Junhua Yuan
E. coli shows enhanced chemotaxis in viscoelastic media, with faster migration and higher accumulation in attractant-rich areas compared to Newtonian conditions.
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Future Accessibility Guidelines—for People Who Can’t Wait to Read Them

Alan Dalton uses this, the International Day of Persons with Disabilities, to look back at where we’ve come from, to evaluate where we are, and to look forward to what’s coming next in the future of accessibility guidelines.


Happy United Nations International Day of Persons with Disabilities! The United Nations have chosen “Promoting the participation of persons with disabilities and their leadership: taking action on the 2030 Development Agenda” for this year’s observance. Let’s see how the World Wide Web Consortium (W3C)’s Web Accessibility Initiative (WAI) guidelines of accessibility past, present, and yet-to-come can help us to follow that goal, and make sure that the websites—and everything else!—that we create can include as many potential users as possible.

Guidelines of Accessibility Past

The W3C published the Web Content Accessibility Guidelines (WCAG) 1.0 on 5th May 1999, when most of us were playing Snake on our Nokia 3210s’ 1.5” monochrome screens…a very long time ago in technology terms. From the start, those guidelines proved enlightening for designers and developers who wanted to avoid excluding users from their websites. For example, we learned how to provide alternatives to audio and images, how to structure information, and how to help users to find the information they needed. However, those guidelines were specific to the web technologies of the time, resulting in limitations such as requiring developers to “use W3C technologies when they are available […]”. Also, those guidelines became outdated; I doubt that you, gentle reader, consult their technical documentation about “directly accessible applets” or “Writing for browsers that do not support FRAME” in your day-to-day work.

Guidelines of Accessibility Present

The W3C published the Web Content Accessibility Guidelines (WCAG) 2.0 on 11th December 2008, when most of us were admiring the iPhone 3G’s innovative “iPhone OS 2.0” software…a long time ago in technology terms. Unlike WCAG 1, these guidelines also applied to non-W3C technologies, such as PDF and Flash. These guidelines used legalese and future-proofed language, with terms such as “time-based media” and “programmatically determined”, and testable success criteria. This made these guidelines more difficult for designers and developers to grasp, but also enabled the guidelines to make their way into international standards (see EN 301 549 — Accessibility requirements suitable for public procurement of ICT products and services in Europe and ISO/IEC 40500:2012 Information technology — W3C Web Content Accessibility Guidelines (WCAG) 2.0) and even international law (see EU Directive 2016/2102 … on the accessibility of the websites and mobile applications of public sector bodies).

More importantly, these guidelines enabled designers and developers to create inclusive websites, at scale. For example, in the past 18 months:

The updated Web Content Accessibility Guidelines (WCAG) 2.1 arrived on 5th June last year—almost a 10-year wait for a “.1” update!—and added 17 new success criteria to help bring the guidelines up to date. Those new criteria focused on people using mobile devices and touchscreens, people with low vision, and people with cognitive and learning disabilities.

(If you need to get up to speed with these guidelines, take 36 minutes to read “Web Content Accessibility Guidelines—for People Who Haven’t Read Them” and Web Content Accessibility Guidelines 2.1—for People Who Haven’t Read the Update.)

Guidelines of Accessibility Yet to Come

So, what’s next? Well, the W3C hope to release another minor update (WCAG 2.2) in November 2020. However, they also have a Task Force working on produce major new guidelines with wider scope (more people, more technologies) and fewer limitations (easier to understand, easier to use) in November 2022. These next guidelines will have a different name, because they will cover more than “Web” and “Content”. Andrew Kirkpatrick (Adobe’s Head of Accessibility) named the Task Force “Silver” (because the initials of “Accessibility Guidelines” form the symbol of the silver element).

The Silver Task Force want the next major accessibility guidelines to:

  • take account of more disabilities;
  • apply to more technologies than just the web, including virtual reality, augmented reality, voice assistants, and more;
  • consider all the technologies that people use, including authoring tools, browsers, media players, assistive technologies (including screen readers and screen magnifiers), application software, and operating systems.

That’s quite a challenge, and so the more people who can help, the better. The Silver Task Force wanted an alternative to W3C’s Working Groups, which are made up of employees of organisations who are members of the W3C, and invited experts. So, they created a Silver Community Group to allow everyone to contribute towards this crucial work. If you want to join right now, for free, just create a W3C account.

Like all good designers, the Silver Task Force and Silver Community Group began by researching. They examined the problems that people have had when using, conforming to, and maintaining the existing accessibility guidelines, and then summarised that research. From there, the Silver Community Group drafted ambitious design principles and requirements. You can read about what the Silver Community Group are currently working on, and decide whether you would like to get involved now, or at a later stage.

Emphasise expertise over empathy

Remember that today’s theme is “Promoting the participation of persons with disabilities and their leadership: taking action on the 2030 Development Agenda”. (The United Nations’ 2030 Development Agenda is outside the scope of this article, but if you’re looking to be inspired, read Alessia Aquaro’s article on Public Digital’s blog about how digital government can contribute to the UN’s Sustainable Development Goals.) In line with this theme, if you don’t have a disability and you want to contribute to the Silver Community Group, resist the temptation to try to empathise with people with disabilities. Instead, take 21 minutes during this festive season to enjoy the brilliant Liz Jackson explaining how empathy reifies disability stigmas, and follow her advice.

Choose the right route

I think we can expect the next Accessibility Guidelines to make their way into international standards and international law, just like their predecessors. We can also expect successful companies to apply them at scale. If you contribute to developing those guidelines, you can help to make sure that as many people as possible will be able to access digital information and services, in an era when that access will be crucial to every aspect of people’s lives. As Cennydd Bowles explained in “Building Better Worlds”, “There is no such thing as the future. There are instead a near-infinity of potential futures. The road as-yet-untravelled stretches before us in abundant directions. We get to choose the route. There is no fate but what we make.”


About the author

Alan Dalton worked for Ireland’s National Disability Authority for 9½ years, mostly as Accessibility Development Advisor. That involved working closely with public sector bodies to make websites, services, and information more accessible to all users, including users with disabilities. Before that, he was a consultant and trainer for Software Paths Ltd. in Dublin. In his spare time, he maintains StrongPasswordGenerator.com to help people stay safe online, tweets, and takes photos.

More articles by Alan




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Onam weaves for 2022 comes alive with blooms and Kerala-themed motifs

Designers dress up the traditional cream-and-gold Kerala cotton with hand-painted motifs, embroidery, cut work and more




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This Chennai-based startup customises your sneakers so you can put your personality on them

Pastels, bling, or bold colours, whatever be your taste, K-kix, a sneaker customisation platform from Chennai can do it for you



  • Life & Style

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Luck, logic, and white lies [electronic resource] : the mathematics of games / Jörg Bewersdorff ; translated by David Kramer.

Boca Raton, FL : CRC Press, 2021.




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Compact Riemann surfaces [electronic resource] : an introduction to contemporary mathematics / by Jürgen Jost

Berlin ; Heidelberg : Springer-Verlag Berlin Heidelberg, 2006




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Growing mathematical minds [electronic resource] : conversations between developmental psychologists and early childhood teachers / edited by Jennifer S. McCray, Jie-Qi Chen, and Janet Eisenband-Sorkin.

New York, NY : Routledge, 2019.




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Illustrating mathematics [electronic resource] / Diana Davis, editor.

Providence, Rhode Island : American Mathematical Society, [2020]




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Fuchsian reduction [electronic resource] : applications to geometry, cosmology and mathematical physics / Satyanad Kichenassamy

Boston : Birkhauser, 2007




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Functional equations and how to solve them [electronic resource] / Christopher G. Small

New York, N.Y. : Springer Science, 2007




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Probability and partial differential equations in modern applied mathematics [electronic resource] / Edward C. Waymire, Jinqiao Duan, editors

New York : Springer, [2005]




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Number theory and combinatorics [electronic resource] : a collection in honor of the mathematics of Ronald Graham / edited by Bruce M. Landman, Florian Luca, Melvyn B. Nathanson, Jaroslav Nešetřil, and Aaron Robertson.

Berlin ; Boston : De Gruyter, [2022]




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The splendors and miseries of martingales [electronic resource] : their history from the casino to mathematics / Laurent Mazliak, Glenn Shafer, editors.

Cham : Birkhäuser, 2022




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Basic gambling mathematics [electronic resource] : the numbers behind the neon / Mark Bollman

Boca Raton : CRC Press, Taylor & Francis Group, 2024