α-Synuclein (AS) is a small presynaptic protein that is genetically, biochemically, and neuropathologically linked to Parkinson's disease (PD) and related synucleinopathies. We present here a review of the topic of this relationship, focusing on more recent knowledge. In particular, we review the genetic evidence linking AS to familial and sporadic PD, including a number of recently identified point mutations in the SNCA gene. We briefly go over the relevant neuropathological findings, stressing the evidence indicating a correlation between aberrant AS deposition and nervous system dysfunction. We analyze the structural characteristics of the protein, in relation to both its physiologic and pathological conformations, with particular emphasis on posttranslational modifications, aggregation properties, and secreted forms. We review the interrelationship of AS with various cellular compartments and functions, with particular focus on the synapse and protein degradation systems. We finally go over the recent exciting data indicating that AS can provide the basis for novel robust biomarkers in the field of synucleinopathies, while at the same time results from the first clinical trials specifically targeting AS are being reported.

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New research to better understand the biological factors of suicidal behaviour Researchers at the University of Glasgow are embarking on two new PhD projects to better understand the impact that biological factors may have on suicidal behaviour.

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The post RPGCast – Episode 657 : “Well-Seasoned Blobber” appeared first on RPGamer.

The hunt for missing flight MH370 will end in two weeks, Malaysia’s transport minister said yesterday.

Call Of Duty: Black Ops 6 has been out for a little while already, what with me giving its multiplayer largely a thumbs up. Still, it's an ever-evolving thing and Activision have announced the game's first seasonal drop. It's a hefty one with a lot of additions, so I'll try my best to break down the good stuff. TLDR: there's some new maps for multiplayer and zombies, new modes, and a few extra bits. I'm mildly excited for more. More in this case is good.

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Let’s try and get you up to speed on the fascinating oddity that is simulation game Ecosystem, on the off chance that Nate's coverage of it hasn't stuck with you like an unwelcome brain parasite you’re nonetheless unwilling to get removed for fear of the lingering emptiness it might cause (he once described an eel as “a quaver with erectile dysfunction”). Broadly speaking, this game is Spore’s evolutionary-biology-degree-having cousin. It’s been in early access for about three years now, but with the latest "Crustacean" update, it’s just hit 1.0. Once again, carcinization has come for all things.

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Today, Boston Dynamics and the Toyota Research Institute (TRI) announced a new partnership “to accelerate the development of general-purpose humanoid robots utilizing TRI’s Large Behavior Models and Boston Dynamics’ Atlas robot.” Committing to working towards a general purpose robot may make this partnership sound like a every other commercial humanoid company right now, but that’s not at all that’s going on here: BD and TRI are talking about fundamental robotics research, focusing on hard problems, and (most importantly) sharing the results.

The broader context here is that Boston Dynamics has an exceptionally capable humanoid platform capable of advanced and occasionally painful-looking whole-body motion behaviors along with some relatively basic and brute force-y manipulation. Meanwhile, TRI has been working for quite a while on developing AI-based learning techniques to tackle a variety of complicated manipulation challenges. TRI is working toward what they’re calling large behavior models (LBMs), which you can think of as analogous to large language models (LLMs), except for robots doing useful stuff in the physical world. The appeal of this partnership is pretty clear: Boston Dynamics gets new useful capabilities for Atlas, while TRI gets Atlas to explore new useful capabilities on.

Here’s a bit more from the press release:

The project is designed to leverage the strengths and expertise of each partner equally. The physical capabilities of the new electric Atlas robot, coupled with the ability to programmatically command and teleoperate a broad range of whole-body bimanual manipulation behaviors, will allow research teams to deploy the robot across a range of tasks and collect data on its performance. This data will, in turn, be used to support the training of advanced LBMs, utilizing rigorous hardware and simulation evaluation to demonstrate that large, pre-trained models can enable the rapid acquisition of new robust, dexterous, whole-body skills.

The joint team will also conduct research to answer fundamental training questions for humanoid robots, the ability of research models to leverage whole-body sensing, and understanding human-robot interaction and safety/assurance cases to support these new capabilities.

For more details, we spoke with Scott Kuindersma (Senior Director of Robotics Research at Boston Dynamics) and Russ Tedrake (VP of Robotics Research at TRI).

How did this partnership happen?

Russ Tedrake: We have a ton of respect for the Boston Dynamics team and what they’ve done, not only in terms of the hardware, but also the controller on Atlas. They’ve been growing their machine learning effort as we’ve been working more and more on the machine learning side. On TRI’s side, we’re seeing the limits of what you can do in tabletop manipulation, and we want to explore beyond that.

Scott Kuindersma: The combination skills and tools that TRI brings the table with the existing platform capabilities we have at Boston Dynamics, in addition to the machine learning teams we’ve been building up for the last couple years, put us in a really great position to hit the ground running together and do some pretty amazing stuff with Atlas.

What will your approach be to communicating your work, especially in the context of all the craziness around humanoids right now?

Tedrake: There’s a ton of pressure right now to do something new and incredible every six months or so. In some ways, it’s healthy for the field to have that much energy and enthusiasm and ambition. But I also think that there are people in the field that are coming around to appreciate the slightly longer and deeper view of understanding what works and what doesn’t, so we do have to balance that.

The other thing that I’d say is that there’s so much hype out there. I am incredibly excited about the promise of all this new capability; I just want to make sure that as we’re pushing the science forward, we’re being also honest and transparent about how well it’s working.

Kuindersma: It’s not lost on either of our organizations that this is maybe one of the most exciting points in the history of robotics, but there’s still a tremendous amount of work to do.

What are some of the challenges that your partnership will be uniquely capable of solving?

Kuindersma: One of the things that we’re both really excited about is the scope of behaviors that are possible with humanoids—a humanoid robot is much more than a pair of grippers on a mobile base. I think the opportunity to explore the full behavioral capability space of humanoids is probably something that we’re uniquely positioned to do right now because of the historical work that we’ve done at Boston Dynamics. Atlas is a very physically capable robot—the most capable humanoid we’ve ever built. And the platform software that we have allows for things like data collection for whole body manipulation to be about as easy as it is anywhere in the world.

Tedrake: In my mind, we really have opened up a brand new science—there’s a new set of basic questions that need answering. Robotics has come into this era of big science where it takes a big team and a big budget and strong collaborators to basically build the massive data sets and train the models to be in a position to ask these fundamental questions.

Fundamental questions like what?

Tedrake: Nobody has the beginnings of an idea of what the right training mixture is for humanoids. Like, we want to do pre-training with language, that’s way better, but how early do we introduce vision? How early do we introduce actions? Nobody knows. What’s the right curriculum of tasks? Do we want some easy tasks where we get greater than zero performance right out of the box? Probably. Do we also want some really complicated tasks? Probably. We want to be just in the home? Just in the factory? What’s the right mixture? Do we want backflips? I don’t know. We have to figure it out.

There are more questions too, like whether we have enough data on the Internet to train robots, and how we could mix and transfer capabilities from Internet data sets into robotics. Is robot data fundamentally different than other data? Should we expect the same scaling laws? Should we expect the same long-term capabilities?

The other big one that you’ll hear the experts talk about is evaluation, which is a major bottleneck. If you look at some of these papers that show incredible results, the statistical strength of their results section is very weak and consequently we’re making a lot of claims about things that we don’t really have a lot of basis for. It will take a lot of engineering work to carefully build up empirical strength in our results. I think evaluation doesn’t get enough attention.

What has changed in robotics research in the last year or so that you think has enabled the kind of progress that you’re hoping to achieve?

Kuindersma: From my perspective, there are two high-level things that have changed how I’ve thought about work in this space. One is the convergence of the field around repeatable processes for training manipulation skills through demonstrations. The pioneering work of diffusion policy (which TRI was a big part of) is a really powerful thing—it takes the process of generating manipulation skills that previously were basically unfathomable, and turned it into something where you just collect a bunch of data, you train it on an architecture that’s more or less stable at this point, and you get a result.

The second thing is everything that’s happened in robotics-adjacent areas of AI showing that data scale and diversity are really the keys to generalizable behavior. We expect that to also be true for robotics. And so taking these two things together, it makes the path really clear, but I still think there are a ton of open research challenges and questions that we need to answer.

Do you think that simulation is an effective way of scaling data for robotics?

Tedrake: I think generally people underestimate simulation. The work we’ve been doing has made me very optimistic about the capabilities of simulation as long as you use it wisely. Focusing on a specific robot doing a specific task is asking the wrong question; you need to get the distribution of tasks and performance in simulation to be predictive of the distribution of tasks and performance in the real world. There are some things that are still hard to simulate well, but even when it comes to frictional contact and stuff like that, I think we’re getting pretty good at this point.

Is there a commercial future for this partnership that you’re able to talk about?

Kuindersma: For Boston Dynamics, clearly we think there’s long-term commercial value in this work, and that’s one of the main reasons why we want to invest in it. But the purpose of this collaboration is really about fundamental research—making sure that we do the work, advance the science, and do it in a rigorous enough way so that we actually understand and trust the results and we can communicate that out to the world. So yes, we see tremendous value in this commercially. Yes, we are commercializing Atlas, but this project is really about fundamental research.

What happens next?

Tedrake: There are questions at the intersection of things that BD has done and things that TRI has done that we need to do together to start, and that’ll get things going. And then we have big ambitions—getting a generalist capability that we’re calling LBM (large behavior models) running on Atlas is the goal. In the first year we’re trying to focus on these fundamental questions, push boundaries, and write and publish papers.

I want people to be excited about watching for our results, and I want people to trust our results when they see them. For me, that’s the most important message for the robotics community: Through this partnership we’re trying to take a longer view that balances our extreme optimism with being critical in our approach.

Black Ops 6 is here, and fans have been itching to know what's included in Season 1 - and now we have an answer. Here's what's included, and when you can play

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They must have played. They must ….

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In Canada, your IP address has the right to remain silent. Elon Musk is suing OpenAI for not being Open. Apple faces a class action not allowing competitive access to backup services and the World Server Throwing Competition in March 2024 is accused of being too violent towards servers.   All this and more on the […]

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Azerbaijan next week will garner much of the attention of the climate tech world, and not just because it will host COP29, the United Nation’s giant annual climate change conference. The country is promoting a grand, multi-nation plan to generate renewable electricity in the Caucasus region and send it thousands of kilometers west, under the Black Sea, and into energy–hungry Europe.

The transcontinental connection would start with wind, solar, and hydropower generated in Azerbaijan and Georgia, and off-shore wind power generated in the Caspian Sea. Long-distance lines would carry up to 1.5 gigawatts of clean electricity to Anaklia, Georgia, at the east end of the Black Sea. An undersea cable would move the electricity across the Black Sea and deliver it to Constanta, Romania, where it could be distributed further into Europe.

The scheme’s proponents say this Caspian-Black Sea energy corridor will help decrease global carbon emissions, provide dependable power to Europe, modernize developing economies at Europe’s periphery, and stabilize a region shaken by war. Organizers hope to build the undersea cable within the next six years at an estimated cost of €3.5 billion (US $3.8 billion).

To accomplish this, the governments of the involved countries must quickly circumvent a series of technical, financial, and political obstacles. “It’s a huge project,” says Zviad Gachechiladze, a director at Georgian State Electrosystem, the agency that operates the country’s electrical grid, and one of the architects of the Caucasus green-energy corridor. “To put it in operation [by 2030]—that’s quite ambitious, even optimistic,” he says.

Black Sea Cable to Link Caucasus and Europe

The technical lynchpin of the plan falls on the successful construction of a high voltage direct current (HVDC) submarine cable in the Black Sea. It’s a formidable task, considering that it would stretch across nearly 1,200 kilometers of water, most of which is over 2 km deep, and, since Russia’s invasion of Ukraine, littered with floating mines. By contrast, the longest existing submarine power cable—the North Sea Link—carries 1.4 GW across 720 km between England and Norway, at depths of up to 700 meters.

As ambitious as Azerbaijan’s plans sound, longer undersea connections have been proposed. The Australia-Asia PowerLink project aims to produce 6 GW at a vast solar farm in Northern Australia and send about a third of it to Singapore via a 4,300-km undersea cable. The Morocco-U.K. Power Project would send 3.6 GW over 3,800 km from Morocco to England. A similar attempt by Desertec to send electricity from North Africa to Europe ultimately failed.

Building such cables involves laying and stitching together lengths of heavy submarine power cables from specialized ships—the expertise for which lies with just two companies in the world. In an assessment of the Black Sea project’s feasibility, the Milan-based consulting and engineering firm CESI determined that the undersea cable could indeed be built, and estimated that it could carry up to 1.5 GW—enough to supply over 2 million European households.

But to fill that pipe, countries in the Caucasus region would have to generate much more green electricity. For Georgia, that will mostly come from hydropower, which already generates over 80 percent of the nation’s electricity. “We are a hydro country. We have a lot of untapped hydro potential,” says Gachechiladze.

Azerbaijan and Georgia Plan Green Energy Corridor

Generating hydropower can also generate opposition, because of the way dams alter rivers and landscapes. “There were some cases when investors were not able to construct power plants because of opposition of locals or green parties” in Georgia, says Salome Janelidze, a board member at the Energy Training Center, a Georgian government agency that promotes and educates around the country’s energy sector.

“It was definitely a problem and it has not been totally solved,” says Janelidze. But “to me it seems it is doable,” she says. “You can procure and construct if you work closely with the local population and see them as allies rather than adversaries.”

For Azerbaijan, most of the electricity would be generated by wind and solar farms funded by foreign investment. Masdar, the renewable-energy developer of the United Arab Emirates government, has been investing heavily in wind power in the country. In June, the company broke ground on a trio of wind and solar projects with 1 GW capacity. It intends to develop up to 9 GW more in Azerbaijan by 2030. ACWA Power, a Saudi power-generation company, plans to complete a 240-MW solar plant in the Absheron and Khizi districts of Azerbaijan next year and has struck a deal with the Azerbaijani Ministry of Energy to install up to 2.5 GW of offshore and onshore wind.

CESI is currently running a second study to gauge the practicality of the full breadth of the proposed energy corridor—from the Caspian Sea to Europe—with a transmission capacity of 4 to 6 GW. But that beefier interconnection will likely remain out of reach in the near term. “By 2030, we can’t claim our region will provide 4 GW or 6 GW,” says Gachechiladze. “1.3 is realistic.”

COP29: Azerbaijan’s Renewable Energy Push

Signs of political support have surfaced. In September, Azerbaijan, Georgia, Romania, and Hungary created a joint venture, based in Romania, to shepherd the project. Those four countries in 2022 inked a memorandum of understanding with the European Union to develop the energy corridor.

The involved countries are in the process of applying for the cable to be selected as an EU “project of mutual interest,” making it an infrastructure priority for connecting the union with its neighbors. If selected, “the project could qualify for 50 percent grant financing,” says Gachechiladze. “It’s a huge budget. It will improve drastically the financial condition of the project.” The commissioner responsible for EU enlargement policy projected that the union would pay an estimated €2.3 billion ($2.5 billion) toward building the cable.

Whether next week’s COP29, held in Baku, Azerbaijan, will help move the plan forward remains to be seen. In preparation for the conference, advocates of the energy corridor have been taking international journalists on tours of the country’s energy infrastructure.

Looming over the project are the security issues threaten to thwart it. Shipping routes in the Black Sea have become less dependable and safe since Russia’s invasion of Ukraine. To the south, tensions between Armenia and Azerbaijan remain after the recent war and ethnic violence.

In order to improve relations, many advocates of the energy corridor would like to include Armenia. “The cable project is in the interests of Georgia, it’s in the interests of Armenia, it’s in the interests of Azerbaijan,” says Agha Bayramov, an energy geopolitics researcher at the University of Groningen, in the Netherlands. “It might increase the chance of them living peacefully together. Maybe they’ll say, ‘We’re responsible for European energy. Let’s put our egos aside.’”

Two astronauts relinquished their seats on a four-person spacecraft so that their colleagues could return to Earth from the ISS, where they’ve been stuck since June.

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