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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
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Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3597-3608
DOI: 10.1039/D4MD00378K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. Jenkins
In silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.
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A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00517A, Research Article
Open Access
Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
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Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators

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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00673A, Review Article
Juhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong Jun
Potential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.
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Introduction to the themed collection in honour of Professor Christian Leumann

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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90039A, Editorial
Marcel Hollenstein, Eugen Stulz
Marcel Hollenstein and Eugen Stulz introduce the cross-journal themed collection celebrating Christian Leumann’s retirement.
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
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A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis

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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article
Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
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Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
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A novel approach for the synthesis of the cyclic lipopeptide globomycin

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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00685B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Samantha J. Bann, Stephen A. Cochrane
Lipid swapping: a new approach for the synthesis of globomycin that allows for facile lipid diversification.
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Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism

By pubs.rsc.org
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00670D, Research Article
Yuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen Zhou
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
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Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles

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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article
Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
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meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
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Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates

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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
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Property-based optimisation of PROTACs

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00769G, Opinion
James Scott, Iacovos Michaelides, Markus Schade
PROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...
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A practical guide for the assay-dependent characterisation of irreversible inhibitors

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
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SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00722K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice Mangiatordi
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
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U.S. Presidential polls: Thulasendrapuram residents pray for Kamala Harris ‘victory

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 12:48:36 +0530


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50 new primary health centres to be opened in State soon: Minister

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 19:37:18 +0530


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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 21:04:51 +0530


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Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 18:23:30 +0530


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Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 19:30:58 +0530


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Urban Primary Health Centre stuck in cramped, temporary facility

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 20:31:50 +0530


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Property owners block the entrance to Balasubramanya temple in Karur

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 17:35:45 +0530


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Govt. urged to extend last date to pay crop insurance premium by farmers

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 17:45:02 +0530


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Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 18:48:04 +0530

Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects


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Ernakulam Express to stop at Muthupettai during Kandhoori festival

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 18:51:18 +0530


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HR&CE plans to bring properties around the Vennaimalai Temple under tenants list

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 19:36:32 +0530

The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders


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Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 07:51:25 +0530

Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base


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‘State should retain primary agricultural cooperative societies under its purview’

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 18:23:59 +0530


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Nagapattinam MP presses for new express trains, railway line extensions

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 20:34:19 +0530


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Association holds protest against delay in Anna University’s staff absorption, promotions

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 22:02:50 +0530


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544: Feedback, RSS Talk, Arc Brower, and Product Talk

By shoptalkshow.com
Published On :: Mon, 05 Dec 2022 08:15:42 +0000

Getting feedback for what you're building or writing, RSS feed reminiscing, Arc browser thoughts, products that didn't make that should have.


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547: WordPress and GraphQL with Jason Bahl

By shoptalkshow.com
Published On :: Mon, 09 Jan 2023 09:31:13 +0000

Jason Bahl joins the show to talk about the GraphQL and WordPress connection, his work on WP GraphQL plugin, Faust and Atlas from WP Engine, Jamstack and Wordpress, and more.


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555: React Documentary, Front of the Front End, Fast Fallacy, and Best Practices

By shoptalkshow.com
Published On :: Mon, 06 Mar 2023 09:39:37 +0000

Reacting to the React.js documentary, is there still jobs for front of the front end anymore? The fast fallacy in frameworks, best practices, dealing with too much or too little isolation, and AI test generation.


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558: Esoteric Weird Content Editable Problems with Kristin Valentine

By shoptalkshow.com
Published On :: Mon, 27 Mar 2023 07:34:54 +0000

Kristin Valentine from Vox joins the show to talk about text editor CMS fun across multiple sites, Vox's Chorus, The Verge redesign, sharing Design Systems, theming articles, and a fun new game called "Can Your Text Editor Do This??"


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569: Apple’s Web Apps, Meta Quest and Vision Pro, and Missing Sticky Headers

By shoptalkshow.com
Published On :: Mon, 12 Jun 2023 07:20:15 +0000

How do you point out things in a UI? Are Arc Boosts the end of the web? What do you think of VR and AR / Vision Pro and Meta Quest? And what do you do when the sticky header goes missing?


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572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements

By shoptalkshow.com
Published On :: Mon, 03 Jul 2023 08:24:15 +0000

Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […]


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575: CSS Errors, Proxy and Reverse Proxy, and What’s The Edge?

By shoptalkshow.com
Published On :: Mon, 24 Jul 2023 09:00:16 +0000

Bluesky adds first class support for urls as a username, text-wrap pretty update, sqwunching text update, should CSS spit out errors, anchor functionality, what does the edge mean, eSports and bowling, how to test websites on slower CPUs, and what does proxy or reverse proxy mean?


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578: Customer Support, P3 Color, Dave on Productivity, and Mobile vs Desktop

By shoptalkshow.com
Published On :: Mon, 14 Aug 2023 07:24:25 +0000

Is Apple's Numbers amazing or the worst? Customer support at various levels of software, Figma and P3 color, imagining a colorspace property in CSS, what's Dave doing for productivity, how has offloading CSS Tricks affected Chris, and should we build different websites for mobile vs desktop?


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581: DevRel, Musical Mics, Social Sharing, and 100 Years of WordPress

By shoptalkshow.com
Published On :: Mon, 04 Sep 2023 08:25:38 +0000

Dave calls a quick Luro branding meeting, some thoughts on DevRel, Chris tries to figure out musical instrument mics, follow up on WordPress from a previous episode, Chris' journey through the social graph options, 100 year hosting with WordPress, and the introduction of a new segment: Happy Project Share Time.


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582: Lifetime Plan, Pricing #HotDrama, and CSS Resets

By shoptalkshow.com
Published On :: Mon, 11 Sep 2023 09:33:44 +0000

Getting tripped up on audio at conferences, announcing the ShopTalk Show Lifetime Plan, some Once pricing #hotdrama, remembering Molly Holzschlag, web components, Luro launch day thoughts, and a question about using a normalize or sanitize in 2023 prompts a run through of Andy Bell's Modern CSS Reset.


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608: Can WordPress Kill Your Resume, Fav Parts of Web Dev, Exploring HTMX, and more!

By shoptalkshow.com
Published On :: Mon, 25 Mar 2024 07:55:38 +0000

We're opening up the ShopTalk mailbag and answering your questions, including does WordPress on your resume kill your job chances, what are our fav and least fav parts of web dev, our thoughts on HTMX, and what is it like to use pnpm instead of npm.


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610: TypeScript in 2024, Signals, Productivity Sniped, and Follow Up

By shoptalkshow.com
Published On :: Mon, 08 Apr 2024 08:38:19 +0000

Dave's about to be eclipsed, the state of TypeScript in 2024, signals stage zero proposal, corrections on accessibility in frameworks (thanks!), web apps for better collaborative writing, getting productivity sniped, the problem with email may be you, indieweb follow up, and ultimate guitar tab apps.


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613: Recording Live Music, WebC, Open Source, & WordPress Studio

By shoptalkshow.com
Published On :: Mon, 29 Apr 2024 19:44:02 +0000

Chris bought recording gear off an Instagram ad, our thoughts on WebC, CodePen upgrades Yarn, thoughts on the commercial value of open source, Automattic releases an app to install WordPress locally, IBM buys Hashicorp, income tax software, and a hack for getting Safari to respect background colors used in a pseudo selector.


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620: Cloudflare #HotDrama, Auth, and Prototyping Thoughts

By shoptalkshow.com
Published On :: Mon, 17 Jun 2024 08:27:24 +0000

Show DescriptionWe dive a bit deeper into the Cloudflare drama of the past couple of weeks, Instagram ads vs Cara art, what to do about Auth in your app, pre-negging any sponsorships, prototyping and feedback on projects, and ideas for future topics. Listen on Website →Links Cloudflare took down our website after trying to force […]


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621: Setting Up Prettier and Linting, Comparing Colors, and Accessibility Overlays

By shoptalkshow.com
Published On :: Mon, 24 Jun 2024 08:05:22 +0000

We've got follow up on Cloudflare and Cara from last episode, a question about setting up Prettier and auto linting, a cool tool from a listener on comparing colors, a question about using tooling like Craft or more user friendly apps like Webflow when working with clients, and our takes on accessibility overlays.


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634: Fabian Kägy on WordPress, Blocks, and Enterprise Dev

By shoptalkshow.com
Published On :: Mon, 23 Sep 2024 08:36:23 +0000

Fabian Kägy helps us understand the modern WordPress development process, Gutenberg vs Block editor vs full site editing, building with blocks or pages, what's coming in the Twenty Twenty-Five Theme, and whether the theme authoring process has been made too difficult in 2024?


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