We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.

Some trends are worth the hype and organic hair products is one such trend. Switching to natural and organic products seems like a gamble that we are not too crazy about. Don't you think that it is high time that you

The state has been conducting virtual classes using video conferencing platforms such as Skype, Cisco, Google Meet and Microsoft Teams to conduct online classes.

The UK is set to modify its Stay At Home social distancing message to curb the spread of coronavirus to Stay Alert as British Prime Minister Boris Joh

Nintendo Servers look to be down this evening with many users receiving a 2219-2502 Error on Nintendo Switch

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.

Southeast Asia’s over-reliance on natural resources like oil, gas, minerals and wood for economic growth is unsustainable over the long term and is causing environmental damage that will hurt future prosperity if left unchecked, according to a new OECD report.

Southeast Asia’s over-reliance on natural resources like oil, gas, minerals and wood for economic growth is unsustainable over the long term and is causing environmental damage that will hurt future prosperity if left unchecked, according to a new OECD report.

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.

A simple and robust tool for spatio-temporal overlap of THz and XUV pulses in in-vacuum pump–probe experiments is presented. The technique exploits ultrafast changes of the optical properties in semiconductors (i.e. silicon) driven by ultrashort XUV pulses that are probed by THz pulses. This work demonstrates that this tool can be used for a large range of XUV fluences that are significantly lower than when probing by visible and near-infrared pulses. This tool is mainly targeted at emerging X-ray free-electron laser facilities, but can be utilized also at table-top high-harmonics sources.

Tannerella forsythia is an oral dysbiotic periodontopathogen involved in severe human periodontal disease. As part of its virulence factor armamentarium, at the site of colonization it secretes mirolysin, a metallopeptidase of the unicellular pappalysin family, as a zymogen that is proteolytically auto-activated extracellularly at the Ser54–Arg55 bond. Crystal structures of the catalytically impaired promirolysin point mutant E225A at 1.4 and 1.6 Å revealed that latency is exerted by an N-terminal 34-residue pro-segment that shields the front surface of the 274-residue catalytic domain, thus preventing substrate access. The catalytic domain conforms to the metzincin clan of metallopeptidases and contains a double calcium site, which acts as a calcium switch for activity. The pro-segment traverses the active-site cleft in the opposite direction to the substrate, which precludes its cleavage. It is anchored to the mature enzyme through residue Arg21, which intrudes into the specificity pocket in cleft sub-site S1'. Moreover, residue Cys23 within a conserved cysteine–glycine motif blocks the catalytic zinc ion by a cysteine-switch mechanism, first described for mammalian matrix metallopeptidases. In addition, a 1.5 Å structure was obtained for a complex of mature mirolysin and a tetradecapeptide, which filled the cleft from sub-site S1' to S6'. A citrate molecule in S1 completed a product-complex mimic that unveiled the mechanism of substrate binding and cleavage by mirolysin, the catalytic domain of which was already preformed in the zymogen. These results, including a preference for cleavage before basic residues, are likely to be valid for other unicellular pappalysins derived from archaea, bacteria, cyanobacteria, algae and fungi, including archetypal ulilysin from Methanosarcina acetivorans. They may further apply, at least in part, to the multi-domain orthologues of higher organisms.

Transforming growth factor β-1 (TGFβ-1) is a secreted signalling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. The primary endogenous activity regulatory mechanism for TGFβ-1 is sequestration by its pro-peptide, latency-associated peptide (LAP), which sterically prohibits receptor binding by caging TGFβ-1. As such, recombinant LAP is promising as a protein-based therapeutic for modulating TGFβ-1 activity; however, the mechanism of binding is incompletely understood. Comparison of the crystal structure of unbound LAP (solved here to 3.5 Å resolution) with that of the bound complex shows that LAP is in a more open and extended conformation when unbound to TGFβ-1. Analysis suggests a mechanism of binding TGFβ-1 through a large-scale conformational change that includes contraction of the inter-monomer interface and caging by the `straight-jacket' domain that may occur in partnership through a loop-to-helix transition in the core jelly-roll fold. This conformational change does not appear to include a repositioning of the integrin-binding motif as previously proposed. X-ray scattering-based modelling supports this mechanism and reveals possible orientations and ensembles in solution. Although native LAP is heavily glycosylated, solution scattering experiments show that the overall folding and flexibility of unbound LAP are not influenced by glycan modification. The combination of crystallography, solution scattering and biochemical experiments reported here provide insight into the mechanism of LAP sequestration of TGFβ-1 that is of fundamental importance for therapeutic development.

A rising spike in West Nile virus is taking health officials across the country by surprise as this year more than 2,600 people in 45 states and the District of Columbia, have been stricken with severe symptoms of this mosquito-transmitted disease.

The post As robins disperse, West Nile mosquitoes switch diet to humans: Q&A with Smithsonian ornithologist Peter Marra appeared first on Smithsonian Insider.

Many animals change sex at some point in their lives, often after reaching a certain size. Snails called slipper limpets begin life as males, and […]

The post The Power of Touch: Sex-changing snails switch sooner when together appeared first on Smithsonian Insider.

For the first time researchers from the Smithsonian, South Dakota State University and the University of Nebraska described the immature stages of the switchgrass moth, first collected in Denver in 1910.

The post Potential biofuel pest, the switchgrass moth, under renewed scrutiny of entomologists appeared first on Smithsonian Insider.

For many Californians, last year’s wet winter triggered a case of whiplash. After five years of drought, rain from October 2016 to February 2017 broke […]

The post In San Francisco, one wet winter can switch up Bay’s invasive species appeared first on Smithsonian Insider.

One of the essential components of molecular electronic circuits are switching elements that are stable in two different states and can ideally be switched on and off many times. Here, distinct buckminsterfullerenes within a self-assembled monolayer, forming a two-dimensional dodecagonal quasicrystal on a Pt-terminated Pt3Ti(111) surface, are identified to form well separated molecular rotational switching elements. Employing scanning tunneling microscopy, the molecular-orbital appearance of the fullerenes in the quasicrystalline monolayer is resolved. Thus, fullerenes adsorbed on the 36 vertex configuration are identified to exhibit a distinctly increased mobility. In addition, this finding is verified by differential conductance measurements. The rotation of these mobile fullerenes can be triggered frequently by applied voltage pulses, while keeping the neighboring molecules immobile. An extensive analysis reveals that crystallographic and energetic constraints at the molecule/metal interface induce an inequality of the local potentials for the 36 and 32.4.3.4 vertex sites and this accounts for the switching ability of fullerenes on the 36 vertex sites. Consequently, a local area of the 8/3 approximant in the two-dimensional fullerene quasicrystal consists of single rotational switching fullerenes embedded in a matrix of inert molecules. Furthermore, it is deduced that optimization of the intermolecular interactions between neighboring fullerenes hinders the realization of translational periodicity in the fullerene monolayer on the Pt-terminated Pt3Ti(111) surface.

What drives people to behave in more environmentally friendly ways? A new study explores factors that affect Dutch motorists’ intentions to switch to electric vehicles. The authors found that they could reliably predict the intention to switch by applying a theoretical framework—Protection Motivation Theory—based on perceptions of the threat of environmental damage.

Planning future sustainable water management in cities is a challenge. A recent study describes a new computer tool that enables quick comparisons of different water management options in cities, to help develop future strategies for effective integrated urban water management.

The effect on bats of the replacement of mercury lamps with light-emitting diodes (LEDs) in street lighting has been investigated in a recent study. Artificial light affects bat species differently and the activity of species normally more sensitive to light were affected less by the new LED street lamps than by traditional mercury lamps. Use of LEDs may, therefore, help to reduce the impacts of outdoor lighting on light-sensitive bats, if used at an appropriate level.

Plans are also underway for initiatives that expand oil export capacity.

Although a recent renewable energy bill stalled, the hurricane-ravaged territory isn't giving up on its fossil fuel-free aspirations.

Did you know you could be polluting the air in your house by burning candles? Learn more here.

A family ate organically for 2 weeks, reducing pesticides in their bodies big-time. Here's why it matters.

Ethanol from switchgrass, a perennial plant traditionally used for foraging and decoration, promises to be among the next big biofuel breakthroughs marketed as

Scientists have learned out how much energy bees use to fly when carrying heavy and light loads, and they learned about a new ability along the way.

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