Macroeconomic risks for grains and oilseeds include China's growth and FX rates.

Company delivers kits that car enthusiasts use to build their own replicas of classics

Episode Showcases Performance of Straitline Components’ Custom Hydraulic Brake Line Detangler in JumpShip Competition

The swirl of attention around Democratic presidential candidate Elizabeth Warren’s story of being forced out of a teaching job when she was pregnant intensifies the spotlight on her background and K-12 credentials.

The recent Chicago Teachers Union strike drew attention from Democratic presidential candidates in Illinois, a state won by Democrats in the last White House contest. For 2020, it's possible we could see a twist on that story: big-city teacher strikes in states with less predictable outcomes.

Keisha Oliver, who is pursuing a dual-title doctoral degree in art education and African American and diaspora studies, was named a fall 2024 artist-in-residence at the Penn State College of Engineering’s Learning Factory.

Churches are alive and thriving in the most surprising places.

The Government Employees' Pension Fund delivered a return of 4.9% on investments for its members in the year to end-March.

Former Australia skipper Ricky Ponting and his longtime teammate Justin Langer could potentially miss out commentating on the opening Test against India at Perth

Liam Payne, who rose to fame as a member of the boy band One Direction has died at the age of 31. The British singer fell to his death from the third-floor balcony of Hotel CasaSur Palermo in Buenos Aires, Argentina.

Title: Neighborhood Factors Could Raise Your Child's Odds for Asthma
Category: Health News
Created: 7/25/2022 12:00:00 AM
Last Editorial Review: 7/25/2022 12:00:00 AM

Title: Brain Scans Show Risk Factor for Alzheimer's
Category: Health News
Created: 8/25/2011 11:01:00 AM
Last Editorial Review: 8/25/2011 12:00:00 AM

Title: Mental Decline a Risk Factor for Stroke, Study Suggests
Category: Health News
Created: 8/25/2014 12:36:00 PM
Last Editorial Review: 8/26/2014 12:00:00 AM

Title: Cheesecake Factory's Breakfast Burrito Tops Latest Xtreme Eating Awards
Category: Health News
Created: 8/28/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM

Title: Can Breast Cancer Be a Risk Factor for Opioid Use Among Older Patients?
Category: Health News
Created: 8/27/2019 12:00:00 AM
Last Editorial Review: 8/28/2019 12:00:00 AM

Title: Obesity in Youth Could Be Big Risk Factor for MS
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/27/2020 12:00:00 AM

Title: Rheumatoid Factor (RF)
Category: Procedures and Tests
Created: 1/28/2002 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Background

Immature lung development and respiratory morbidity place preterm-born children at high risk of long-term pulmonary sequelae. This systematic review and meta-analysis aims to quantify lung function in preterm-born children and identify risk factors for a compromised lung function.

Most studies of genome organization have focused on intrachromosomal (cis) contacts because they harbor key features such as DNA loops and topologically associating domains. Interchromosomal (trans) contacts have received much less attention, and tools for interrogating potential biologically relevant trans structures are lacking. Here, we develop a computational framework that uses Hi-C data to identify sets of loci that jointly interact in trans. This method, trans-C, initiates probabilistic random walks with restarts from a set of seed loci to traverse an input Hi-C contact network, thereby identifying sets of trans-contacting loci. We validate trans-C in three increasingly complex models of established trans contacts: the Plasmodium falciparum var genes, the mouse olfactory receptor "Greek islands," and the human RBM20 cardiac splicing factory. We then apply trans-C to systematically test the hypothesis that genes coregulated by the same trans-acting element (i.e., a transcription or splicing factor) colocalize in three dimensions to form "RNA factories" that maximize the efficiency and accuracy of RNA biogenesis. We find that many loci with multiple binding sites of the same DNA-binding proteins interact with one another in trans, especially those bound by factors with intrinsically disordered domains. Similarly, clustered binding of a subset of RNA-binding proteins correlates with trans interaction of the encoding loci. We observe that these trans-interacting loci are close to nuclear speckles. These findings support the existence of trans-interacting chromatin domains (TIDs) driven by RNA biogenesis. Trans-C provides an efficient computational framework for studying these and other types of trans interactions, empowering studies of a poorly understood aspect of genome architecture.

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

BACKGROUND AND PURPOSE:

Mechanical thrombectomy is a fundamental intervention for acute ischemic stroke treatment. While conventional techniques are effective, cyclic aspiration (CyA) shows potential for better recanalization rates. We aim to investigate factors affecting CyA and compare them with static aspiration (StA).

New research to better understand the biological factors of suicidal behaviour Researchers at the University of Glasgow are embarking on two new PhD projects to better understand the impact that biological factors may have on suicidal behaviour.

It's the RPGCast trio bringing you another week of mild insanity. Kelley struggles because Japanese names are hard. Chris wants to take all the cats camping, but Anna Marie swiftly vetoes the idea. The dad jokes arrive in full force, and everyone's thinking about vacations.

The post RPG Cast – Episode 604: “Press 5 for More Rune Factory” appeared first on RPGamer.

Ryan slip 'n slides his health away. Robert lives on the side of danger and poor choices in video games. Meanwhile, Chris makes his own bathtub Geralt.

The post RPG Cast – Episode 725: “Not Every Idea in the Factory Is a Good One” appeared first on RPGamer.

REVERB features 17 audiovisual installations including new works by Es Devlin and Theaster Gates, plus Devon Turnbull's Listening Room.

The post The Vinyl Factory celebrates art and sound with immersive exhibition at 180 Studios appeared first on Fact Magazine.

Reverb features new works by Es Devlin and Theaster Gates, plus Devon Turnbull's Listening Room.

The post The Vinyl Factory: Reverb exhibition extended until 22 December appeared first on Fact Magazine.

A collective gasp echoed like a thunderclap in a valley in our Daily Beast newsroom late Wednesday afternoon at the news that singer Liam Payne, who became famous as a member of the group One Direction, died at age 31.

TMZ reports that Payne fell from a hotel balcony in Argentina, where he had reunited with bandmates at 1D-er Niall Horan’s concert. He had, according to the site, been behaving “erratically,” earlier in the day, and was spotted smashing a laptop in the hotel lobby and having to be carried back to his room. He had been in headlines on gossip blogs over tension with his ex-fiancée Maya Henry, who, TMZ says, alleged “he'd left her after asking her to get an abortion.”

In the shock of his death, fans couldn’t ignore the eerie nature that Payne had just connected with his One Direction bandmates. Dark questions emerge when a celebrity dies so young: What role did the often horrific toll of fame have on a person like Payne, who has been open about addiction and suicidal ideation? But there’s also an impulse to go back to the roots of a person’s talent, to revisit what it was that we all fell in love with—and was their passion—in the first place.

Read more at The Daily Beast.

To say that Factorio: Space Age throws out the rulebook is an understatement. It'd be more fitting to say it's somehow automated the whole process: an inserter plucked out the rulebook from my brain and deposited it in hot magma, while a new rulebook was churned out in a nearby machine and plopped into my brain from the other side - only for that to be immediately plucked out and incinerated as well. With each new planet and each new phase, Space Age reinvents itself. I'm battling hyperbole here, but ah hell, I admit defeat. Factorio: Space Age is a masterpiece, the final form of perhaps the most well-crafted building game I'll ever play.

Read more

A new battery plant under construction in South Carolina will supply BMW factories.

The deal secured by the Hull facility is for the East Anglia TWO project off the Suffolk coast.

Hospitals have been forced to innovate with new ways of hydrating patients and giving them medications, after a key factory that produces IV fluid bags flooded during Hurricane Helene. (This story first aired on Morning Edition on Nov. 7, 2024.)

Growth Unlocked: Closing the Strategy-to-Execution Gap

Clayton home building group team members share their stories of being part of the Clayton manufacturing family.

SMASHD Labs Season 2 is a 10-week accelerator program based out of Los Angeles talent firm Atom Factory. We are inviting companies at the intersection of entertainment, technology, and culture to work alongside our team to accelerate their growth. Join us and our roster of world-class mentors for a masterclass in hustle.

About 40% of postmenopausal hormone-positive breast cancer cases may be linked to excess body fat, according to Spanish research published online in the

While stress is known to significantly contribute to the onset of various health issues, a new study on Sunday showed how stress can worsen colorectal cancer (CRC) (!--ref1--).

Sepsis is a life-threatening condition that happens when the body's response to infections causes adverse effects on the tissues and organs. Dr. Finn E.

Y chromosome plays a role in increasing the likelihood of autism, providing a potential explanation for the higher rates in males. (!--ref1--) h2What

Tesla CEO Elon Musk on Saturday turned his first European Gigafactory near Berlin into a fairground where visitors could tour the facility. The project faced some delays and local resistance but Musk said the company expects to start production in November. Photo: Patrick Pleul/Associated Press

Safeguarding online accounts is crucial when everything happens online. Two-factor authentication (2FA) offers an extra layer of security beyond passwords. This method ensures that even if your password is compromised, your account remains protected. For tech enthusiasts in India, understanding and

7th Pay Commission : સાતમુ પગાર પંચ લાગુ થવાની સાથે જ સરકારી કર્મચારીઓના પગારમાં મોટો વધારો થવાની શક્યતા છે. DA Hike અને Fitment Factor Hike જેવા આર્થિક લાભ મળશે. પગારમાં નોંધપાત્ર વધારો થવાને કારણે કર્મચારીઓની આવક વધશે. આજે આપણે Pay Commission

Cambridge, United Kingdom ; New York, NY : Cambridge University Press, 2023.

David J Linden investigates what makes us human and what makes us distinctly, immutably ourselves

Why VC firm Good Capital wants to be an early investor in AI-powered businesses