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The Effect of gem-Difluorination on the Conformation and Properties of a Model Macrocyclic System

By pubs.rsc.org
Published On ::

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05424E, Edge Article
Open Access
Laurent Knerr, Thomas Cogswell, Marie. Ahlqvist, Richard James Lewis, Anneli Nordqvist, Christian Sköld
Conformational control of drug candidates to engineer improved potency and ADME properties is an ongoing area of research. Macrocyclic rings tend to offer a greater degree of rigidity than non-cyclised...
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Pd/NHC sequentially catalyzed atroposelective synthesis of planar-chiral macrocycles

By pubs.rsc.org
Published On ::

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05482B, Edge Article
Open Access
Gongming Yang, Shangde Liu, Shujie Ji, Xingsen Wu, Jian Wang
The unprecedented non-enzymatically atroposelective synthesis of planar-chiral macrocycles via a Pd/NHC sequential catalytic intermolecular macrocyclization is reported.
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From small changes to big gains: pyridinium-based tetralactam macrocycle for enhanced sugar recognition in water

By pubs.rsc.org
Published On ::

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06190J, Edge Article
Open Access
Canjia Zhai, Ethan Cross Zulueta, Alexander Mariscal, Chengkai Xu, Yunpeng Cui, Xudong Wang, Huang Wu, Carson Doan, Lukasz Wojtas, Haixin Zhang, Jianfeng Cai, Libin Ye, Kun Wang, Wenqi Liu
Incorporating pyridinium into an anthracene-based macrocycle significantly enhances its sugar binding affinity by increasing hydrogen bonding and expanding the contact surface area.
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Dynamic satellite–parent liposome networks for quantitative microreactions

By pubs.rsc.org
Published On ::

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC04925J, Edge Article
Open Access
Jia-Qi Tian, Nan-Nan Deng
A dynamic satellite–parent liposome network was developed to explore molecular transfer and quantitative microreactions through environmental stimuli, offering a platform to mimic multicellular systems in vitro.
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Ligand Cross-Links as a Design Element in Oligo- and PolyMOFs

By pubs.rsc.org
Published On ::

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06109H, Edge Article
Open Access
Debobroto Sensharma, Seth M Cohen
Metal-Organic Frameworks (MOFs) constructed using cross-linked oligomeric or polymeric ligands (OligoMOFs and PolyMOFs respectively) have so far relied on a handful of canonical structural blueprints, in which the cross-links have...
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Understanding the Formation of Nitrate from Nitrogen at the Interface of Gas-Water Microbubbles

By pubs.rsc.org
Published On ::

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06989G, Edge Article
Open Access
Sandeep Bose, Yu Xia, Richard N. Zare
Understanding the Formation of Nitrate from Nitrogen at the Interface of Gas-Water MicrobubblesWater microbubbles containing Fe2+ ion has been found to efficiently transform nitrogen (N2) to nitrate (NO3-) by initiating...
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Synergetic effect of mild hypothermia and antioxidant treatment on ROS-mediated neuron injury under oxygen-glucose deprivation investigated by scanning electrochemical microscopy

By pubs.rsc.org
Published On ::

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05977H, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Junjie Zhang, Yulin Liu, Yuxiang Zhao, Siyu Zhang, Feng Xu, Fei Li
Ischemic stroke and reperfusion injury result in neuronal damage and dysfunction associated with oxidative stress, leading to overproduction of cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS). In...
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At ₹40,608 crore, MFs asset and equity inflows hit a new high in June

By www.thehindubusinessline.com
Published On :: Tue, 09 Jul 2024 18:54:17 +0530

Industry AUM crosses ₹60 lakh-crore on new fund offers, mark-to-market gain


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Prudent crosses ₹1 lakh crore in MF Assets Under Management

By www.thehindubusinessline.com
Published On :: Mon, 29 Jul 2024 15:06:53 +0530

Prudent became the second non-banking mutual fund distributor to achieve this milestone last Friday


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Placental microphysiological systems: new advances on promising platforms that mimic the microenvironment of the human placenta

By pubs.rsc.org
Published On ::

Lab Chip, 2025, Advance Article
DOI: 10.1039/D4LC00500G, Critical Review
Inês M. Gonçalves, Muhammad Afzal, Nithil Kennedy, Ana Moita, Rui Lima, Serge Ostrovidov, Takeshi Hori, Yuji Nashimoto, Hirokazu Kaji
This review presents new advancements in placental MPS models for toxicological screening, preeclampsia assessment, and embryo uterine implantation and an overview of bioprinting technology and current advances in endometrial MPSs.
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Engineered cortical microcircuits for investigations of neuroplasticity

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,4974-4988
DOI: 10.1039/D4LC00546E, Paper
Nicolai Winter-Hjelm, Pawel Sikorski, Axel Sandvig, Ioanna Sandvig
An advanced microfluidic platform integrated with a microelectrode array for the study of structural and functional adaptations of neural networks in response to localized perturbations.
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Rapid miRNA detection in skin interstitial fluid using a hydrogel microneedle patch integrated with DNA probes and graphene oxide

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,4989-4997
DOI: 10.1039/D4LC00715H, Paper
Hanjia Zheng, Fatemeh Keyvani, Sadegh Sadeghzadeh, Dragos F. Mantaila, Fasih A. Rahman, Joe Quadrilatero, Mahla Poudineh
A simple and rapid fluorescence-based sensor sensors using DNA functionalized graphene oxide for miRNA detection from skin interstitial fluid.
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A paper-in-polymer-pond (PiPP) hybrid microfluidic microplate for multiplexed ultrasensitive detection of cancer biomarkers

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,4962-4973
DOI: 10.1039/D4LC00485J, Paper
Sanjay S. Timilsina, XiuJun Li
A reusable and cost-effective paper-in-polymer-pond (PiPP) hybrid microfluidic microplate with unique features for ultrasensitive and high-throughput multiplexed detection of disease biomarkers within an hour without using specialized instruments.
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Reversible bonding in thermoplastic elastomer microfluidic platforms for harvestable 3D microvessel networks

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,4948-4961
DOI: 10.1039/D4LC00530A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Byeong-Ui Moon, Kebin Li, Lidija Malic, Keith Morton, Han Shao, Lauren Banh, Sowmya Viswanathan, Edmond W. K. Young, Teodor Veres
An openable, reversibly bonded microfluidic cell culture platform fabricated in thermoplastic elastomer and polystyrene for the generation, recovery, and extraction of engineered-microvessel networks.
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Artificial intelligence performance in testing microfluidics for point-of-care

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,4998-5008
DOI: 10.1039/D4LC00671B, Paper
Open Access
Mert Tunca Doganay, Purbali Chakraborty, Sri Moukthika Bommakanti, Soujanya Jammalamadaka, Dheerendranath Battalapalli, Anant Madabhushi, Mohamed S. Draz
AI is revolutionizing medicine by enhancing diagnostics and patient care. Our study showed ML and DL AI models excel in microchip testing, underscoring AI's potential to improve precision medicine and POC diagnostics.
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Dynamic sampling from ex vivo adipose tissue using droplet-based microfluidics supports separate mechanisms for glycerol and fatty acid secretion

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,5020-5031
DOI: 10.1039/D4LC00664J, Paper
Md Moniruzzaman, Andresa B. Bezerra, Md Mohibullah, Robert L. Judd, James G. Granneman, Christopher J. Easley
Droplet-based microfluidic sampling of adipose tissue reveals unique information on lipolytic dynamics.
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Inertial co-focusing of heterogeneous particles in hybrid microfluidic channels with constantly variable cross-sections

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,5032-5042
DOI: 10.1039/D4LC00479E, Paper
Tianwei Zhao, Peng Zeng, Yuanting Zhang, Jinxia Li, Hui Sun, Imrich Gablech, Honglong Chang, Xichen Yuan, Pavel Neužil, Jianguo Feng
Inertial focusing chips based on hybrid microfluidic channels were presented for high-efficiency heterogeneous particle co-focusing, offering significant applications in microfluidic flow cytometry and single-cell analysis.
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Microfluidic antisolvent crystallization for chiral symmetry breaking

By pubs.rsc.org
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Lab Chip, 2024, 24,5055-5064
DOI: 10.1039/D4LC00658E, Paper
Jiye Jang, Gerard Coquerel, Tae Seok Seo, Woo-Sik Kim, Bum Jun Park
Microfluidic antisolvent crystallization was used to study the effect of solution volume on chiral symmetry breaking (CSB) in NaClO3 crystals. 100% CSB occurs below a critical emulsion volume due to rapid molecule depletion and suppressed nucleation.
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Surface modification of paper-based microfluidic devices via initiated chemical vapor deposition

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,4940-4947
DOI: 10.1039/D4LC00414K, Tutorial Review
Stacey Bacheller, Malancha Gupta
Paper-based microfluidic devices offer a low-cost platform for biological and environmental detection. This tutorial review shows that initiated chemical vapor deposition can be used to modify these devices with functional polymers.
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Rapid low-cost assembly of modular microvessel-on-a-chip with benchtop xurography

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,5065-5076
DOI: 10.1039/D4LC00565A, Paper
Open Access
Shashwat S. Agarwal, Marcos Cortes-Medina, Jacob C. Holter, Alex Avendano, Joseph W. Tinapple, Joseph M. Barlage, Miles M. Menyhert, Lotanna M. Onua, Jonathan W. Song
Our study is a novel implementation of xurography for multi-layer microfluidic device fabrication. We demonstrate the versatility of this approach by presenting several modular 3D vessel-matrix arrangements.
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A microfluidic hanging droplet as a programmable platform for mammalian egg vitrification

By pubs.rsc.org
Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00428K, Paper
Open Access
Haidong Feng, Georgios Katsikis, India D. Napier, Gong Du, Josh Lim, Joseph O. Doyle, Scott R. Manalis, Linda G. Griffith
Programmable microfluidic hanging drop system for motorized, contactless cryoprotectant loading and egg vitrification.
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Zonal patterning of extracellular matrix and stromal cell populations along a perfusable cellular microchannel

By pubs.rsc.org
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00579A, Paper
Open Access
Brea Chernokal, Bryan J. Ferrick, Jason P. Gleghorn
Developed a system to regionally pattern stromal cell populations and hydrogel properties along the length of a perfused epithelial tube. This enables the dissection of specific microenvironmental factors that govern developmental tissue patterning.
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Self-actuated microfluidic chiplet for two-stage multiplex nucleic acid amplification assay

By pubs.rsc.org
Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00752B, Paper
Open Access
Felix Ansah, Marziyeh Hajialyani, Fatemeh Ahmadi, Yuming Gu, Ergün Alperay Tarım, Michael G. Mauk, Gordon A. Awandare, Haim H. Bau
Self-actuated chiplet for Penn-RAMP assay.
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5-axis CNC micro-milling machine for three-dimensional microfluidics

By pubs.rsc.org
Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00496E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mitchell Modarelli, Devin Kot-Thompson, Kazunori Hoshino
The gold standard of microfluidic fabrication techniques, SU-8 patterning, requires photolithography equipment and facilities and is not suitable for 3D microfluidics. A 3D printer is more convenient and may achieve...
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3D-printed microfluidic–microwave device for droplet network formation and characterisation

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,5101-5112
DOI: 10.1039/D4LC00387J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kai Silver, Jin Li, Adrian Porch, William David Jamieson, Oliver Castell, Pantelitsa Dimitriou, Colin Kallnik, David Barrow
A 3D-printed microwave–microfluidic device using a liquid metal resonator for droplet network formation and characterisation.
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Real-time monitoring of a 3D blood–brain barrier model maturation and integrity with a sensorized microfluidic device

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,5085-5100
DOI: 10.1039/D4LC00633J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Ceccarelli, Marie Celine Lefevre, Attilio Marino, Francesca Pignatelli, Katarzyna Krukiewicz, Matteo Battaglini, Gianni Ciofani
A new in vitro sensorized model of the blood–brain barrier has been developed and characterized.
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Impact of microchannel width on axons for brain-on-chip applications

By pubs.rsc.org
Published On ::

Lab Chip, 2024, 24,5155-5166
DOI: 10.1039/D4LC00440J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katarina Vulić, Giulia Amos, Tobias Ruff, Revan Kasm, Stephan J. Ihle, Joël Küchler, János Vörös, Sean Weaver
Axon growth is influenced by the width and number of microchannels, with growth cone adaptability reaching its limit for constraints smaller than 350 nm. Tradeoffs between axon growth and control need to be made for neurofluidic devices.
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Optical tweezer-assisted cell pairing and fusion for somatic cell nuclear transfer within an open microchannel

By pubs.rsc.org
Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00561A, Paper
Yidi Zhang, Han Zhao, Zhenlin Chen, Zhen Liu, Hanjin Huang, Yun Qu, Yaowei Liu, Mingzhu Sun, Dong Sun, Xin Zhao
We developed a somatic cell nuclear transfer-electrofusion system for pairing and fusing oocytes and somatic cells with a thousand-fold volume difference. The system showed a 90.56% pairing efficiency, potentially boosting batch cloning efficiency.
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Dual-drive acoustic micromixer for rapid nucleation and ultrafast growth of perovskite nanoparticles

By pubs.rsc.org
Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00721B, Paper
Zhifang Liu, Yuwen Lu, Wei Tan, Guorui Zhu
An acoustic micromixer driven by bubbles and sharp edges, controlling the nucleation and growth of perovskite nanoparticles.
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Discretised microfluidics for noninvasive health monitoring using sweat sensing

By pubs.rsc.org
Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00763H, Paper
Open Access
Emma J. M. Moonen, Walther Verberne, Eduard Pelssers, Jason Heikenfeld, Jaap M. J. den Toonder
We present the first wearable device with integrated electrowetting, which collects and transports sweat from single glands and measures sweat rate for extremely low sweat rate. This enables non-invasive biomarker monitoring of hospitalized patients.
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An imaging scheme to study the flow dynamics of co-flow regimes in microfluidics: implications for nanoprecipitation

By pubs.rsc.org
Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00652F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wali Inam, Anton Vladyka, Joanna W. Pylvänäinen, Junel Solis, Dado Tokic, Pasi Kankaanpää, Hongbo Zhang
Herein, by presenting a novel imaging-based scheme for analyzing fluid interactions in co-flow regimes, we identify oscillatory and chaotic flow behaviors to optimize nanoprecipitation through controlled fluid manipulation.
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Microstring-engineered tension tissues: a novel platform for replicating tissue mechanics and advancing mechanobiology

By pubs.rsc.org
Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00753K, Paper
Zixing Zhou, Tingting Li, Wei Cai, Xiaobin Zhu, Zuoqi Zhang, Guoyou Huang
A simple, cost-effective approach for fabricating soft microstring chips that enables precise engineering of tension tissues (METTs), advancing research in mechanobiology and biomedical applications.
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SERS-based pump-free microfluidic chip sensor for highly sensitive competitive immunoassay of cortisol in human sweat

By pubs.rsc.org
Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00858H, Paper
Siyue Xiong, Chushu Zhu, Chengxuan Wang, Peitao Dong, Xuezhong Wu
Cortisol, known as the "stress hormone," is secreted by the adrenal cortex. Measuring cortisol levels in body fluids is essential for evaluating stress levels, adrenal function, hormone imbalances, and psychological...
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Del Aviz, Southern Force, Balmoral, Nyx, Chotipari and Macron excel

By www.thehindu.com
Published On :: Wed, 23 Oct 2024 18:09:59 +0530


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All Stars, Soft Whisper, Crown Drive and Raffinato please

By www.thehindu.com
Published On :: Sun, 03 Nov 2024 20:22:57 +0530


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Cabinet clears ₹2,254 crore for national forensic infra enhancement scheme

By www.thehindubusinessline.com
Published On :: Wed, 19 Jun 2024 20:43:05 +0530

Under this scheme, the MHA will establish campuses of the National Forensic Sciences University and central forensic science laboratories in the country


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Indian government hikes kharif crops support price by 1-13%

By www.thehindubusinessline.com
Published On :: Wed, 19 Jun 2024 20:58:49 +0530

Farmers will receive ₹2-lakh crore from the new minimum support prices


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Union Cabinet announces economic decisions worth over ₹2.88-lakh crore

By www.thehindubusinessline.com
Published On :: Wed, 19 Jun 2024 21:26:11 +0530

These include the MSP hike for 14 Kharif crops, Varanasi airport expansion, and a new major port at Vadhavan


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Budget 2024: ₹5,000 monthly internship allowance announced for 1 crore youth

By www.thehindubusinessline.com
Published On :: Tue, 23 Jul 2024 12:46:40 +0530

Internship scheme aims to create job opportunities in top 500 companies over next five years


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Disaster management Bill tabled in LS; Opposition says Bill encroaches on States’ jurisdiction

By www.thehindubusinessline.com
Published On :: Thu, 01 Aug 2024 18:44:30 +0530

Centre asserts that there is no interference in the rights of the States as disaster management is the first responsibility of the States.


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Entering a decade of financial inclusion: PMJDY reaches 53 crore beneficiaries and ₹2.28 lakh crore in deposits

By www.thehindubusinessline.com
Published On :: Mon, 12 Aug 2024 18:26:17 +0530

The scheme has largely been women-centric with 29.48 crore beneficiaries while 35.27 crore of total accounts are from rural and semi-urban branches


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Government partners with MicroSave to optimise Community Investment Support Fund

By www.thehindubusinessline.com
Published On :: Thu, 22 Aug 2024 20:52:38 +0530

MicroSave has signed MoU with Rural Development Ministry on July 29


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Cabinet approves ₹6,456 crore worth of new rail projects across West Bengal, Jharkhand, Odisha and Chhattisgarh

By www.thehindubusinessline.com
Published On :: Wed, 28 Aug 2024 19:10:22 +0530

Three projects include setting up of two new lines and one multi-tracking project across Indian Railways


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India enforces mandatory CCI approval for M&As over ₹2,000 crore under new regulations

By www.thehindubusinessline.com
Published On :: Tue, 10 Sep 2024 13:07:50 +0530

The updated regulations define ‘India nexus’ criteria, including user metrics and turnover, and introduce a ₹500 crore monetary threshold.  


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Centre releases ₹1.78 lakh crore to States towards tax devolution

By www.thehindubusinessline.com
Published On :: Thu, 10 Oct 2024 19:34:31 +0530

Aimed at enabling States to accelerate capital spending ahead of festive season


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PM E-DRIVE: Government starts disbursal of incentives amounting to ₹320 crore in first month of scheme

By www.thehindubusinessline.com
Published On :: Mon, 04 Nov 2024 20:53:09 +0530

Total 28,81,436 units of EVs to be incentivised with an outlay of ₹10,900 crore in the next 2 years


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Toyota Innova Hycross Hybrid: In the mix

By www.thehindubusinessline.com
Published On :: Sat, 13 Jul 2024 06:00:00 +0530

Can the Toyota Innova Hycross Hybrid live up to the model’s legacy?


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TN Health Dept to launch 25 bike ambulances with Rs 1.60 crore allocation

By www.newkerala.com
Published On :: Fri, 08 Nov 2024 00:30:02 +0530


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Heavy rains predicted across Tamil Nadu for next five days

By www.newkerala.com
Published On :: Sun, 10 Nov 2024 09:15:36 +0530


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Sri Lankan Navy arrests 23 Tamil fishers for crossing IMBL

By www.newkerala.com
Published On :: Sun, 10 Nov 2024 22:42:02 +0530


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