For obvious reasons, there has been a lot of attention paid to work going into developing vaccines that could prevent Covid-19 infection, and drugs that could treat it. In particular, there has been some excitement about new animal trial data for remdesivir, a drug developed by Gilead Sciences. Gilead's share price rose nearly 10% on the day the trial data were announced.
It will be some time yet before the safety and efficacy of remdesvir is established, if ever (it's worth noting that it was tried, unsuccessfully, as a treatment for Ebola). And since I started work on this post…

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Job Alert This week we've got job openings from all over the globe to tempt you, your friends or your past colleagues back into work, or indeed into new ventures.…

A pirate is starting his first day aboard his new ship and the captain is giving him the tour. ”There’s the plank for trouble makers, there’s the deck that needs swabbing everyday and there’s the barrel for all you sexual needs.” ”Whatcha mean? my sexual needs?” ”Well, you stick your willy in the hole and […]

The post Those Dirty Pirates appeared first on Funny & Jokes.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial changes in fat and muscle and improve metabolic homeostasis.METHODS Before and after β3-AR agonist treatment, oral glucose tolerance tests and euglycemic clamps were performed, and histochemical analysis and gene expression profiling were performed on fat and muscle biopsies. PET-CT scans quantified brown adipose tissue volume and activity, and we conducted in vitro studies with primary cultures of differentiated human adipocytes and muscle.RESULTS The clinical effects of mirabegron treatment included improved oral glucose tolerance (P < 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. In skeletal muscle, mirabegron reduced triglycerides, increased the expression of PPARγ coactivator 1 α (PGC1A) (P < 0.05), and increased type I fibers (P < 0.01). Conditioned media from adipocytes treated with mirabegron stimulated muscle fiber PGC1A expression in vitro (P < 0.001).CONCLUSION Mirabegron treatment substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans. Since β cells and skeletal muscle do not express β3-ARs, these data suggest that the beiging of SC WAT by mirabegron reduces adipose tissue dysfunction, which enhances muscle oxidative capacity and improves β cell function.TRIAL REGISTRATION Clinicaltrials.gov NCT02919176.FUNDING NIH: DK112282, P30GM127211, DK 71349, and Clinical and Translational science Awards (CTSA) grant UL1TR001998.

The internet was seen as a major catalyst for the furry fandom finding one another during the times before we held conventions. During that earlier period in the 1990s, conventions and meets were rare, and finding one another was done mostly through the chat rooms and message boards of the past. There was no bandwidth for video or sharing major animation projects, therefore most of our intimate conversations were textual.

For many younger furries, it was a time that was lost in the annals of a distant history. Instead they found themselves joining in amongst a wave of growing conventions being held in various places around the world on any given weekend. Ones where those in custom fursuits march out in the streets openly rather than feeling a stifling isolation of being cooped up in hotel spaces, with a handful of home made creations, being wary of a hostile media looking for a freak show.

Coming out of 2019, it seemed that the time where furry was just an internet thing was fully behind it. However a series of unfortunate events were in line for 2020, a year that has led humanity to be forced into their rooms by an irate Mother Nature as an easily spread virus has forced governments around the globe to take drastic measures to slow its spread and put strict limits on social gatherings. A situation which has forced both the furry fandom, and the internet that brought it together, back to their roots.

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December 6, 2015, 10:50 AM|Senator Bernie Sanders, I-Vermont, believes there must be an international coalition led by Arab nations in the fight against ISIS. Continue reading →

lior Banque annonce aujourd’hui avoir choisi l’application IBM MobileFirst sur iOS pour apporter une transformation fondamentale à la façon dont les clients en Pologne interagissent avec leur banque. A l’aide d’un iPad, les professionnels des services bancaires pourront fournir une expérience plus dynamique et personnalisée aux clients en tirant avantage de la puissance de l’analyse prédictive, et ce de façon sécurisée, facile, rapide et disponible 24h/24.

dollypopinspiration:

nanushka

Pull up a chair ???? via

@jaynemckenna

edit by

@veronika.breuer

#nanushkanyc

dollypopinspiration:

nanushka

Open space with natural light in the Lousiana Museum of Modern Art ✨ via

@mariavannguyen

dollypopinspiration:

eberfigueira

Back to the set I designed for

@herculesuniversal

early September in Brazil. Thanks

@francescosourigues

dollypopinspiration:

Diego Delgado-Elias

http://diegodelgadoelias.com/

Viral marketing is different from conventional marketing in that it contains elements that are exceedingly attractive to the audience and compel those exposed to it ...

The post 10 Sure-fire Viral Marketing Tips That Will Get You Noticed appeared first on Saleschase Stories.

NIH clinical trial testing antiviral remdesivir plus anti-inflammatory drug baricitinib for COVID-19 begins  National Institutes of HealthView Full coverage on Google News

Once a month (or so), I share a dozen things that have inspired me to greater personal, professional, and financial success in my life. I hope they bring similar success to your life. Please enjoy the archives of earlier collections of inspirational things. This month’s installment is heavily geared toward things that have inspired me to better writing, being a better parent, being a better husband, and keeping my head on straight during this most challenging of times. 1. Winnie […]

The post Inspiration from Brooke Foss Westcott, Handwritten Letters, Elizabeth Gilbert, and More appeared first on The Simple Dollar.

Every few months, Sarah and I clean out our pantry and cupboards. We pull out absolutely every item in there, sort them into sensible groups, make sure everything in there is still good, and put the good items back in there in a sensible fashion. Usually, at the same time, we make a bunch of meal plans for the next few weeks to use up some of the items that have been there for a while. The thing is, you’ll […]

The post Expiration Dates and What They Really Mean appeared first on The Simple Dollar.

Systematic review produced by the EPPI-Centre in 2015.This systematic review aimed to evaluate the effect of HAART and ARV monotherapy on liver disease progression and liver-related mortality in individuals co-infected with HIV and hepatitis C, including in patients with haemophilia.

Jeffrey Epstein was found dead in his cell on Saturday morning, allegedly by suicide. While the media announced that the sex offender and financier had hung himself, the internet is not as convinced. Most people share the sentiment that he was in fact killed by someone with a whole lot of power. Here are the best conspiracy theory memes that play largely on Epstein's connections with the Clinton and Trump administration, the Clinton body count, and the accusations that many more people were involved in the wealthy man's sex trafficking operation. You don't need to drink the conspiracy theory Kool-Aid to find these funny memes entertaining, so make up your minds for yourselves.

Everyone needs to read this woman's insightful Facebook post amidst the whole college admission's scandal dominating our news feeds. 

One of the greatest teachers around is life. Through life, we experience all kinds of things. But more importantly, these experiences come with very important, inspirational life lessons. The beauty of these life lessons though is that you do not need to experience all of them first hand. Many people have already gone through various [...]Read More...

While the world is consumed with the terrifying coronavirus pandemic, on March 19 the Trump administration will be marking the 17th anniversary of the U.S. invasion of Iraq by ramping up the conflict there. After an Iran-aligned militia allegedly struck a U.S. base near Baghdad on March 11, the U.S. military carried out retaliatory strikes against five […]

About a month ago, we had yet another health worry with Butter Bib (a/k/a Zen). Since then she has bounced back and is in fine form, still going up and down the stairs, and also going up and down the little plastic steps we have by our bed. Now that the weather is colder, I... Continue Reading →

President Donald Trump has twice now advanced the flawed theory that China nefariously continued to allow flights out of Wuhan, the city where the COVID-19 outbreak originated, to Western cities while blocking flights into other cities in China.

The post Trump’s Flawed China Travel Conspiracy appeared first on FactCheck.org.

So, you are here to learn how you can use viral marketing techniques to get free home business leads! Well great stuff I have a few magical tips for you to achieve just that.

Responding to a challenge that tragic necessity has thrown to countless research labs around the world, a team from the Department of Chemistry will deploy its new cell mapping technology to shed light on the molecular interplay between COVID-19 and its host. The team is collaborating with Princeton molecular biologists who study viruses.

Hodeny do seba cokoladovy puding a smer zastavka rodoeste oproti praca do esmeraldo.Rano nieco pred 800 to v uliciach zije ako keby aby nebol ziadny virus. Tetulky zametaju ulice ludia chodia hore dole. Len tie otvorene obchodiky a kaviarnicky chybaju

Co dnes No zas nist.Teda az na jednu vec opat idem do obchodu bo vm mi slubila ze so mnou bude varit zemiakove placky.Kupene ingrediencie mimo smotany tu som nenasiel ale nasiel som kinder cokoladky ktorym som neodolal.Sibacka sa blizi

Este k vcerajsku nabehla mi posledna vyplata z amazonu ale kedze som zabudol heslo na vyplatnu pasku neviem ci to je vratane aj danoveho priznania.Ako si tak zacinam robit ranajky zrazu z pod chladnicky vybehla mys a smerovala dalej do domu.Jedl

Dnes mesiac na ceste a furt prakticky na tom istom mieste ak neratam noc vo viedni a noci v porte.Asi by to chcelo neaky suhrn. Spisem ho zajtra bo ma prsat a tak nebude i tak o com pisat.I ked nevim ci ma aj zmysel este pisat zapisky bo kazdy de

Po budicku sledujem co je nove na leteckom poli. A kuknime let do lisabonu 5.5 za 35 ota s tap. Nevaham ani minutu registrujem sa do tap miles programu a kupujem to na priamo cez aerolinku za 47 5 zlava za mile co mi dali az 200. Tarif je

Ako bolo vcera dohodnute s vm tak sa aj stalo. Spolocne corn flaks ranajky.Po ranajkach nazad do postele a len driemanie.Vonku je dnes pekne slnecno tak spakovanie sa smer mesto.Dnes je tez zakaz nevyhnuteho vychadzania ale v uliciach sok.

Na ranajky spravena omeleta z cukiny a fazule. Po jedle zbalenie rozpadajuceho batuzku voda salam syr eps chleba paprika susene hrusky a smer cca 8km vzdialeny cristo rei v casti garajau.Maps.me a mapu.cz mi ukazali dve odlisne trasy nakoniec s

Po dlhom case na ranajky vajicka.Po jedle trosku surfovania na nete a potom smer mesto a oddych pri mori oproti lanovke co ide na monte.Ludi v meste normalne ruska sa tu furt moc nenosia i ked postupne ich nositelov pribuda. Dnes som videl 5ludi.

Ranajky opat vybavene vajickami tentoraz aj s fazulou.Ono sa ide dnes cvicit von treba energiu resp neake tie podporne vetry ked budem potrebovat podvihnut.Jasne ze rano zas octavia aj s jej prijebanymi problemami co mavaju deti na zakladnej sko

Z ubytka vykopanie okolo 1100 a smer cvicisko.Cestou tri zaujimavosti.Chodim okolo polikliniky. Ludia sa vybavuju medzi dverami. Obsluhuje ich sestricka odena v plasti rukaviciach navlekoch na topankach ruske a ochrannym plexisklom na hlave.

Nuz rano sa poberam klasicky na hradzu oproti cvicisku.Tu este vychutnane slnko.Odtial pokracujem k budke rodoeste pri pekarni na nabreznej ceste. No ta zavreta na budke vycapene ze je otvorene len cez tyzden od 930 do 1900 co mi je hovno platne

Sunka a vajicka z toho moze vzist len hemendex.Plny energie na cvicisko pri lanovke.Dnes ma byt krasny den.No ten mi je pokazeny hned po prichode k predajni listkov horarios company na bus pri lanovke.Chlapik vravi ze tu sa nepredavaju

Silne ranajky vo forme omelety s cukinou a slaninou. Cili papricka nesmela chybat. Cele to posypane syrom tak de luxe ranajky.Rucne preprate ukoristene kratase a zvesenie oprateho pradla.Zimna ciapka neako nezniesla pracku a je taka divna ale poho

Rano si robim cholesterolovu bombu. Hranolky vajicko slanina.Po velmi vydatnych ranajkach teda smer cvicisko treba to dostat z tela von.V meste velke prekvapenie. Strasne moc ludi ma rusky.Na bilbordoch odfoteny rozny ludia rozneho veku s ru

Dnes sa ide po case opat na cvicisko tak vydatne ranajky slanina vajicka cuketa.Vonku nadherne slnecno na cvicisku opat latino chlapci. Inak vymakany.Davam si klasiku zhyby robim vsak len raz vytiahnutie a pomale spustanie.Par ludi sa slni

Vcera som pred spankom este zacal pozerat film mama mia no nedopozeral som ho bo prisli do toho dolezitejsie veci.Cornflakes s mliekom a smer cvicisko.Neviem ci som to spominal ale ako som si dal oprat veci tak sa mi zbehol opasok cul ho ledvaj

Dnes bude velmi kratky zapisok.Po ranajkach smer cvicisko.Vonku je krasne slnecno.Zastavujem sa v papiernictve medzi dvermi vravim co chcem no na moje prekvapenie mi tetula vravi ze zosit format a5 nemaju. Sa pytala este kolegu. No neviem n