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'A bit ambitious': Sports Minister waters down NRL's restart hopes

The NRL is leading the charge to get sport restarted, planning games by late next month — but Australia's Federal Sports Minister is urging all codes to have patience amid the coronavirus pandemic.




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NRL warned May 28 return date for season is 'very ambitious'

The league wants its competition back up and running next month after being shut down by coronavirus, but a global sporting group says the NRL cannot focus on financial concerns at the expense of player safety.




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'Keep a bit of match fitness': Origin star calls for young NRL guns to head home

Former Maroon Dallas Johnson says some fledgling NRL players at the Titans, Broncos and Cowboys should consider playing for their junior clubs this season.




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Latrell Mitchell, two other Rabbitohs test negative for COVID-19 after flu symptoms

South Sydney and the NRL breathe a sigh of relief as three Rabbitohs players — including Latrell Mitchell, fresh from being fined for breaching social distancing on a camping trip — return negative results to coronavirus tests.




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'A bit shocked': Melbourne Storm barred by Albury council, but training goes on

Albury City Council's decision to block the NRL's Melbourne Storm from using public facilities for training divides both the council and the community.




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Serkis: ‘Hobbit reading will take you on an adventure’

Gollum actor Andy Serkis is doing a continuous live reading of The Hobbit for charity.




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Google Acquires FameBit for Undisclosed Sum

Largest marketplace that makes YouTube, Twitter, Instagram and Vine influencer marketing easy for advertisers, brands and influencers.




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Pfizer Pays Valneva $130M for a Bite at a Lyme Disease Vaccine

If you’re looking for a Lyme disease vaccine, you can choose from among several—for your dog. A vaccine for humans hasn’t been available for years and few companies have tried to fill that void. Valneva has advanced its Lyme vaccine candidate to mid-stage clinical testing, and the company now has the help of drug giant […]




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Rabbit Virus Could Provide Gene Therapy

Originally published in February 1967

-- Read more on ScientificAmerican.com




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Sir David Barnes obituary

ICI executive who helped turn its bioscience business into the pharmaceuticals giant AstraZeneca

Sir David Barnes, who has died aged 84, was the self-effacing but determined and clear-sighted chief executive who turned the bioscience interests of ICI into one of the world’s major pharmaceutical corporations, AstraZeneca.

Teased at its launch in 1993 that Zeneca sounded like a Czechoslovakian camera, Barnes responded that its performance would define its brand – and was vindicated. The first suggested name had been Zenica, but then Barnes, tracking the Bosnian conflict days before the launch, found to his horror that hostilities were threatening to spread to a previously unremarked town of that name. Alarmed that it “could become as notorious as Guernica”, he changed the spelling and held his breath.

Continue reading...




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Men most likely to exhibit the worst COVID-19 symptoms, according to a new study

Research into coronavirus cases in Shenzhen, China found that men were 2.5 times as likely to exhibit severe symptoms.




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AZ's Farxiga becomes first FDA-approved SGLT2 inhibitor for heart failure with reduced ejection fraction

The FDA has moved to approve an oral tablet formulation of AstraZeneca’s Farxiga (dapagliflozin) to reduce the risk of cardiovascular death and hospitalisation in adult patients with New York Heart Association’s functional class II-IV heart failure with reduced ejection fraction.




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Boeing to Restore Significant Habitat in Washington State Waterway to Resolve Natural Resource Damage Liability

The Boeing Company has agreed to undertake two significant habitat restoration projects in Washington state to resolve its liability for natural resource damages caused by hazardous substances released from Boeing facilities along the Duwamish Waterway.



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Justice Department Reaches Settlement with Texas Hospital Prohibiting Anticompetitive Contracts with Health Insurers

The Department of Justice reached a settlement today with United Regional Health Care System of Wichita Falls, Texas, that prohibits it from entering into contracts that improperly inhibit commercial health insurers from contracting with United Regional’s competitors.



  • OPA Press Releases

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Former Administrative Assistant to U.S. Senator Charged with Making Prohibited Communications to Senate Office

The former administrative assistant to a U.S. senator was charged today by a federal grand jury in the District of Columbia with violating criminal conflict of interest laws.



  • OPA Press Releases

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Two Southern California Men Plead Guilty for Their Roles in a Nationwide Breach of Credit and Debit Card Terminals at Michaels Stores Inc.

Edward Arakelyan, 21, and Arman Vardanyan, 22, were each charged in a criminal information filed on March 5, 2012, in U.S. District Court in Oakland, Calif., with one count of conspiracy to commit bank fraud, one count of bank fraud, and one count of aggravated identity theft.



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Montgomery, Alabama, Woman Indicted for Using Stolen Identities and Debit Cards to Obtain Tax Refunds

A federal grand jury in Montgomery returned an indictment on March 28, 2012, charging Antoinette Djonret for using stolen identities to file false tax returns, the Justice Department, U.S. Attorney George L. Beck Jr. and the Internal Revenue Service (IRS) announced today. The 19-count indictment, which was unsealed today following her arrest, charges Djonret with filing false claims, theft of government funds, access device fraud, aggravated identity theft and possession of unauthorized access devices.



  • OPA Press Releases

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Two Southern California Men Each Sentenced to 60 Months in Prison for Their Roles in a Nationwide Breach of Credit and Debit Card Terminals at Michaels Stores Inc.

Eduard Arakelyan, 21, and Arman Vardanyan, 23, were each sentenced yesterday to serve 36 months in prison on bank fraud and conspiracy charges, and an additional, consecutive 24 months in prison for the identity theft charge.



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Justice Department Files Motion to Dismiss Antitrust Lawsuit Against Blue Cross Blue Shield of Michigan After Michigan Passes Law to Prohibit Health Insurers from Using Most Favored Nation Clauses in Provider Contracts

The Department of Justice today filed a motion to dismiss its antitrust lawsuit against Blue Cross Blue Shield of Michigan after the state of Michigan passed a law that prohibits health insurers from using most favored nation clauses in contracts with health care providers.



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Court Prohibits S.C. Tax Return Preparer from Preparing Returns for Others

A federal district judge in Charleston, S.C., has permanently barred Jessica Geddis, of Summerville, S.C., from preparing federal income tax returns for others, the Justice Department announced today.



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Government Intervenes in Lawsuit Against Medical Equipment Supplier Orbit Medical Inc. and Former Vice President Jake Kilgore

The government has intervened in a False Claims Act lawsuit against Orbit Medical Inc. and Jake Kilgore alleging that Orbit Medical’s sales representatives boosted power wheelchair and accessory sales by altering and forging physician prescriptions and supporting documentation.



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Court Prohibits Mississippi Tax Preparer from Preparing Tax Returns for Others

A federal court has permanently barred Kavivah Branson, aka Kavivah Bradley, of Clinton, Mississippi, and her Jackson, Mississippi, business, Branson Tax Service, from preparing federal tax returns for others, the Justice Department announced today. The civil injunction order, to which Branson consented, was signed by Judge Tom S. Lee of the U.S. District Court for the Southern District of Mississippi



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Curious to know if Bitcoin is here to stay ?

Read the latest developments from the cryptocurrency space, breaking news and analysis on Bitcoin and blockchain on RTTNews. Know more about altcoins, mining, ICOs, warnings and regulation. Find out how to acquire and trade digital currencies.




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Andy Serkis (and maybe Gollum?) will read 'The Hobbit' for coronavirus charities

Andy Serkis, who plays Gollum in the "Lord of the Rings" films, announced that he will livestream a reading of J.R.R. Tolkien's "The Hobbit" on Friday.




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No bitterness: Chinese company raises $500m in US despite Luckin




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Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing




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Compensation between Wnt-driven tumorigenesis and cellular responses to ribosome biogenesis inhibition in the murine intestinal epithelium




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Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein




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Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis




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MdMYB6 regulates anthocyanin formation in apple both through direct inhibition of the biosynthesis pathway and through substrate removal




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Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells




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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment




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Gasdermin D inhibitor protects against sepsis




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Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide




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Effects of chronic type 5 phosphodiesterase inhibition on penile microvascular reactivity in hypertensive patients with erectile dysfunction: a randomized crossover placebo-controlled trial




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Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur




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Author Correction: Metabolic activity analyses demonstrate that Lokiarchaeon exhibits homoacetogenesis in sulfidic marine sediments




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Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors




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Immune-related adverse events of checkpoint inhibitors




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Immune-related adverse events of checkpoint inhibitors




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PARP inhibitors as a new therapeutic option in metastatic prostate cancer: a systematic review




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Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy




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Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells




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Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




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Translational tidbits

Yabao and MRC Technology partner in PD; charities form Neuro-MAP to insource pharma's abandoned compounds; Singapore creates a diagnostic hub; a roundup of public-private partnerships.




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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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High-purity orbital angular momentum states from a visible metasurface laser




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9