Title: Heart Failure
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 6/29/2022 12:00:00 AM

Aurora, CO — Raise your cup, coffee drinkers! Drinking one or more cups of caffeinated coffee a day may reduce your risk of heart failure, according to the results of a recent review conducted by researchers from the University of Colorado.

Alexander Solzhenitsyn, Dostoyevsky of 20th century, dies of heart failureAlexander Solzhenitsyn died in Moscow at age 89. President Dmitry Medvedev presented his condolences to writer’s wife and sons. Stepan Solzhenitsyn told The Associated Press his father died late Sunday of heart failure, but declined further comment. Solzhenitsyn's unflinching accounts of torment and survival in the Soviet Union's labor camps riveted his countrymen, whose secret history he exposed. They earned him 20 years of bitter exile, but international renown. And they inspired millions, perhaps, with the knowledge that one person's courage and integrity could, in the end, defeat the totalitarian machinery of an empire.

Statement Highlights: Previous studies have found that 14-81% of patients with heart failure experience some degree of cognitive impairment affecting language, memory or executive function. Evidence also indicates that people with atrial fibrillation...

Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development  Nature.com

Title: Heart Failure Patients Wind Up in ER Too Often: Study
Category: Health News
Created: 8/25/2014 4:35:00 PM
Last Editorial Review: 8/26/2014 12:00:00 AM

Title: High Salt Intake May Double Heart Failure Risk
Category: Health News
Created: 8/28/2017 12:00:00 AM
Last Editorial Review: 8/29/2017 12:00:00 AM

Title: Stress, Anger May Worsen Heart Failure
Category: Health News
Created: 8/21/2020 12:00:00 AM
Last Editorial Review: 8/24/2020 12:00:00 AM

Title: AHA News: Preeclampsia May Double a Woman's Chances for Later Heart Failure
Category: Health News
Created: 8/24/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM

Title: Flu, Pneumonia Vaccines Save Lives of Heart Failure Patients: Study
Category: Health News
Created: 8/28/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Title: What Are the 4 Stages of Congestive Heart Failure?
Category: Diseases and Conditions
Created: 6/24/2020 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Title: What Causes Congestive Heart Failure?
Category: Diseases and Conditions
Created: 6/12/2020 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Title: Congestive Heart Failure (CHF)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Title: Certain Painkillers Raise Heart Failure Risk in People With Type 2 Diabetes
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM

Extract

We read with great interest the correspondence by T. Bitter and co-workers in the European Respiratory Review, about our recently published review entitled "Central sleep apnoea: not just one phenotype" [1]. We first want to express our gratefulness to the authors for their support and appreciation of our work, particularly regarding the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

Extract

We read with great interest the review article by Randerath et al. [1] recently published in the European Respiratory Review. We would like to congratulate the authors on this clearly structured review, which emphasises the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

It is now a little clearer why a condition that often occurs in older men, showing a large number of hematopoietic cells showing loss of the Y chromosome,

Researchers find metabolic surgery lowers heart failure risk factors, offering promising insights for heart health.

People with type 2 diabetes are at an increased risk for heart failure and many people have both diseases, which requires careful medical management.

Statements Highlights: Adverse social factors, such as insurance status, food insecurity, lack of funds for medication and others, may lead to worse heart failure outcomes. Caregiving by family and friends of people with heart failure is increasingly...

DALLAS, April 23, 2020 — As social distancing keeps families apart, many who care for a parent or loved one with heart failure may be left wondering how to best keep them safe. In the United States, more than 6 million people are living with heart...

Jim Tees should check his facts before jumping in with both feet and looking foolish.

(Wiley) Heart failure and cancer are conditions with a number of shared characteristics. A new study published in the Journal of Internal Medicine found that in patients with heart failure, several known tumor markers can also be indicators of heart failure severity and progression.

Inflammation contributes to ventricular remodeling after myocardial ischemia, but its role in nonischemic heart failure is poorly understood. Local tissue inflammation is difficult to assess serially during pathogenesis. Although ¹⁸F-FDG accumulates in inflammatory leukocytes and thus may identify inflammation in the myocardial microenvironment, it remains unclear whether this imaging technique can isolate diffuse leukocytes in pressure-overload heart failure. We aimed to evaluate whether inflammation with ¹⁸F-FDG can be serially imaged in the early stages of pressure-overload–induced heart failure and to compare the time course with functional impairment assessed by cardiac MRI. Methods: C57Bl6/N mice underwent transverse aortic constriction (TAC) (n = 22), sham surgery (n = 12), or coronary ligation as an inflammation-positive control (n = 5). MRI assessed ventricular geometry and contractile function at 2 and 8 d after TAC. Immunostaining identified the extent of inflammatory leukocyte infiltration early in pressure overload. ¹⁸F-FDG PET scans were acquired at 3 and 7 d after TAC, under ketamine-xylazine anesthesia to suppress cardiomyocyte glucose uptake. Results: Pressure overload evoked rapid left ventricular dilation compared with sham (end-systolic volume, day 2: 40.6 ± 10.2 μL vs. 23.8 ± 1.7 μL, P < 0.001). Contractile function was similarly impaired (ejection fraction, day 2: 40.9% ± 9.7% vs. 59.2% ± 4.4%, P < 0.001). The severity of contractile impairment was proportional to histology-defined myocardial macrophage density on day 8 (r = –0.669, P = 0.010). PET imaging identified significantly higher left ventricular ¹⁸F-FDG accumulation in TAC mice than in sham mice on day 3 (10.5 ± 4.1 percentage injected dose [%ID]/g vs. 3.8 ± 0.9 %ID/g, P < 0.001) and on day 7 (7.8 ± 3.7 %ID/g vs. 3.0 ± 0.8 %ID/g, P = 0.006), though the efficiency of cardiomyocyte suppression was variable among TAC mice. The ¹⁸F-FDG signal correlated with ejection fraction (r = –0.75, P = 0.01) and ventricular volume (r = 0.75, P < 0.01). Western immunoblotting demonstrated a 60% elevation of myocardial glucose transporter 4 expression in the left ventricle at 8 d after TAC, indicating altered glucose metabolism. Conclusion: TAC induces rapid changes in left ventricular geometry and contractile function, with a parallel modest infiltration of inflammatory macrophages. Metabolic remodeling overshadows inflammatory leukocyte signal using ¹⁸F-FDG PET imaging. More selective inflammatory tracers are requisite to identify the diffuse local inflammation in pressure overload.

Poverty and poor or non-existent health insurance coverage might worsen the effects of heart failure, the American Heart Association said Thursday.

OBJECTIVE

To determine the effects of dapagliflozin in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) on left ventricular (LV) remodeling using cardiac MRI.

OBJECTIVE

Although blood pressure variability is increasingly appreciated as a risk factor for cardiovascular disease, its relationship with heart failure (HF) is less clear. We examined the relationship between blood pressure variability and risk of HF in two cohorts of type 2 diabetes participating in trials of glucose and/or other risk factor management.

Title: New Drug Fails to Improve Odds for Heart Failure Patients
Category: Health News
Created: 5/2/2007 2:00:00 AM
Last Editorial Review: 5/2/2007 12:00:00 AM

Title: Aspirin as Effective as Warfarin for Heart Failure: Study
Category: Health News
Created: 5/2/2012 6:05:00 PM
Last Editorial Review: 5/3/2012 12:00:00 AM

Title: Knowledge Is Power for Patients With Heart Failure
Category: Health News
Created: 4/29/2015 12:00:00 AM
Last Editorial Review: 4/30/2015 12:00:00 AM

Title: Heart Failure Implant Tied to Weakening of Thinking, Memory
Category: Health News
Created: 4/30/2015 12:00:00 AM
Last Editorial Review: 5/1/2015 12:00:00 AM

Title: Heart Failure, Job Loss May Be Deadly Combo
Category: Health News
Created: 5/2/2017 12:00:00 AM
Last Editorial Review: 5/3/2017 12:00:00 AM

Title: Have Heart Failure? Take Precautions During Pandemic
Category: Health News
Created: 4/28/2020 12:00:00 AM
Last Editorial Review: 4/28/2020 12:00:00 AM

Title: FDA OKs Farxiga for Heart Failure With Reduced Ejection Fraction
Category: Health News
Created: 5/6/2020 12:00:00 AM
Last Editorial Review: 5/7/2020 12:00:00 AM

The FDA today approved a new use for the diabetes drug, dapagliflozin (Farxiga), to reduce the risk of a hospital stay or death in people who have a type of heart failure.

Combined pre-and post-capillary hypertension (CpcPH) is a relatively common complication of heart failure (HF) associated with a poor prognosis. Currently, there is no specific therapy approved for this entity. Recently, treatment with beta-3 adrenergic receptor (β3AR) agonists was able to improve pulmonary hemodynamics and right ventricular (RV) performance in a translational, large animal model of chronic PH. The authors present the design of a phase II randomized clinical trial that tests the benefits of mirabegron (a clinically available β3AR agonist) in patients with CpcPH due to HF. The effect of β3AR treatment will be evaluated on pulmonary hemodynamics, as well as clinical, biochemical, and advanced cardiac imaging parameters. (Beta3 Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure [SPHERE-HF]; NCT02775539)

Farxiga is the first sodium glucose co-transporter 2 inhibitor cleared by the FDA to treat heart failure with reduced ejection fraction

The FDA has moved to approve an oral tablet formulation of AstraZeneca’s Farxiga (dapagliflozin) to reduce the risk of cardiovascular death and hospitalisation in adult patients with New York Heart Association’s functional class II-IV heart failure with reduced ejection fraction.

Farxiga (dapagliflozin) has been approved in the US to reduce the risk of cardiovascular (CV) death and…

AstraZeneca has watched superstar SGLT2 diabetes med Farxiga nail trial after trial in highly coveted kidney and heart failure indications, with the FDA expediting reviews to back them up. The one thing AstraZeneca was missing? The agency taking Farxiga across the finish line. 

Scios Inc., a subsidiary of pharmaceutical giant Johnson & Johnson, pleaded guilty today to a misdemeanor violation of the Food, Drug and Cosmetic Act for introducing into interstate commerce its heart failure drug, Natrecor, for a use that was not approved by the Food and Drug Administration.

Too busy or lazy to exercise? Men and women take note. Living without physical activity for six years during their middle age could be at an increased risk of suffering heart failure, researchers have warned.

The findings, described in the journal Circulation, suggest that consistently participating in the recommended 150 minutes of moderate to vigorous activity each week, such as brisk walking or biking, in middle age can reduce the heart failure risk by 31 per cent.

While it is known that people who are more physically active have lower risks of heart failure than those who are less active, but little is known about the impact of changes in exercise levels over time on heart failure risk.

"Going from no exercise to recommended activity levels over six years in middle age may reduce heart failure risk by 23 per cent," said Chiadi Ndumele, Assistant Professor at the Johns Hopkins University in Maryland, US.

For the study, the team included 11,351 participants, with an average age 60, monitored annually for an average of 19 years.

According to the American Heart Association, the "recommended" amount is at least 75 minutes per week of vigorous intensity or at least 150 minutes per week of moderate intensity exercise.

Heart failure risk decreased by about 12 per cent in the participants who increased their physical activity category from poor to intermediate or recommended, or from intermediate to recommended, compared with those with consistently poor or intermediate activity ratings.

Conversely, heart failure risk increased by 18 per cent in the participants who reported decreased physical activity from visit one to visit three, compared with those with consistently recommended or intermediate activity levels.

Unlike heart attack, in which heart muscle dies, heart failure is marked by a long-term, chronic inability of the heart to pump enough blood, or pump it hard enough, to bring needed oxygen to the body.

The leading cause of hospitalisations in those over 65, the disorder's risk factors include high blood pressure, high cholesterol, diabetes, smoking and a family history.

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Consuming fish which are high in Omega-3 fatty acids twice a week can help reduce the risk of heart failure, coronary heart disease, cardiac arrest and ischemic stroke, says a new scientific advisory from the American Heart Association.

The Association recommends eating two 3.5-ounce servings of non-fried fish, or about three-fourth cup of flaked fish every week.

Emphasis should be placed on eating oily fish like salmon, mackerel, herring, lake trout, sardines or albacore tuna, which are all high in omega-3 fatty acids.

"Scientific studies have established the beneficial effects of eating seafood rich in Omega-3 fatty acids, especially when it replaces less healthy foods such as meats that are high in artery-clogging saturated fat," said Eric B. Rimm, Professor at the Harvard University's T.H. Chan School of Public Health in Boston, US.

Further, the advisory, published in the journal Circulation, laid emphasis on eating fish such as shark, swordfish, tilefish, king mackerel, bigeye tuna, marlin and orange roughy that are high in mercury.

Even though mercury contamination has been linked with serious neurological problems in newborns, it does not have adverse effects on heart disease risk in adults, the advisory noted.

Moreover, the benefits of eating fish substantially outweighed any risks associated with mercury contamination, especially if a variety of seafood is consumed, it said.

According to a study, published in the journal Molecular Nutrition and Food Research, adding fatty fish to our diet increases the size and lipid composition of high-density lipoprotein (HDL) particles, also known as good cholesterol, in people with impaired glucose metabolism.

Another study, published in the Journal of Nutritional Biochemistry, showed that Omega-3 fatty acids are more beneficial than flaxseed and other oils for preventing cancer.

Catch up on all the latest Mumbai news, crime news, current affairs, and also a complete guide on Mumbai from food to things to do and events across the city here. Also download the new mid-day Android and iOS apps to get latest updates

An investigational drug vericiguat offers new hope for patients with worsening heart failure, reports a new study. Patients with worsening heart failure

Highlights: A sensor based on Artificial Intelligence (AI) has been developed The sensor can inst

Patients with heart failure, several known tumor markers can also be indicators of heart failure severity and progression. In the study, researchers

Patients with heart failure, several known tumor markers can also be indicators of heart failure severity and progression.

Clayton Hague-Winterbottom had an enlarged heart which was picked up on a chest X-ray - a sign of a struggling heart - but Dr Rida Fatima discharged him from Royal Oldham Hospital last year.