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meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
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SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00722K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice Mangiatordi
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
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Adjuvant strategies to tackle mcr-mediated polymyxin resistance

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00654B, Review Article
Madison R. Nuske, Junlang Zhong, Renjie Huang, Vijayalekshmi Sarojini, Jack L. Y. Chen, Christopher J. Squire, Mark A. T. Blaskovich, Ivanhoe K. H. Leung
The emergence of the mobile colistin resistance (mcr) gene is a significant threat contributing to the worldwide antibiotic resistance crisis. This review discusses adjuvant strategies to restore polymyxin sensitivity in these resistant bacteria.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Changes in train services notified due to demolition of old bridge near Tiruchi junction




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Data crucial for building climate resilience, says ISRO scientist




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Plea to include ‘panneer karumbu’ in Pongal gift hamper




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HC directs authorities to maintain park and ensure no encroachment




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Property owners block the entrance to Balasubramanya temple in Karur




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Govt. urged to extend last date to pay crop insurance premium by farmers




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Peravurani farmers’ market starts functioning




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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa




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Advanced baggage handling system introduced in Tiruchi airport




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557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life

When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life.




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570: Haircut Maintenance, Dave’s Bookshelf, Lazy Loading, and APIs

We're talking Dave's new haircut, playing Hondo, what Dave uses for images on his bookshelf page, lazy-loading thoughts, vh vw follow up, eyeball tracking updates, loading website with js, Vue transitions, charging for API access, and do you cross post, one post, or no post on social media in 2023?




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572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements

Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […]




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589: CSS Functions, Read It Later, Making Money in Business, and More

A quick bit of union news follow up, CSS function round up, Read It Later inside Feedbin, fun uses for a Stream Deck+, how to turn up the money dial in your own business, and having the audacity to call yourself a publisher.




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591: Cascade Layers, CSS Functions, and more CSS with Miriam Suzanne

Miriam Suzanne stops by to talk about CSS updates and news on container queries, rolling out cascade layers, !important things to remember, custom properties, exit animations, CSS functions, state queries, and more.




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603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth

Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web.




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607: Astro Launches an Integrated Database

Fred K. Schott stops by to talk about Astro announcement of Astro DB, the pluses and minuses of it, whether you have to always use the database with Astro DB, how to migrate data, seeding your database, upgrading the database, and what about Astro DB pricing?




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619: Svencodes

Sven Neumann aka Sven Codes talks with us about SudokuPad, developing a cross-platform app, integrating new puzzles and features, the benefits of being easy to use, building a community, and monetizing an app while not upsetting your user base.




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The fight against encroachment

No one has the right to use precious road space as their private storage yard.




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Style and substance, from waste

Many architects with green ideologies have converted waste to usable construction material, some of it in the most innovative manner.




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Homes with a ‘conscience’

Around 5,000 homes in the city shun BWSSB water supply and produce enough power of their own. By M.A. Siraj




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Gunning for a slice of billion-dollar defence contracts 

How a college project birthed a bootstrapped manufacturer of components for the armed forces 




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A sporty knock from India Inc

A growing crop of corporates are making serious investments in sports and beginning to reap the rewards, too




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The delicate balance in doctor-patient interaction

How clear communication and accountability in healthcare can significantly improve patient outcomes




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Carbon credits to boost incomes of Jharkhand village farmers 

The Birsa Harit Gram project serves as a potential model for agro-forestry, which is gaining ground because the buyers of carbon credits prefer — pay a premium — for credits based on Nature Based Solution, as opposed to offsetting projects like renewable energy or projects like carbon capture.




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Why banks are branching furiously

From financial inclusion to wooing back savings deposits, lenders have reasons to reject digital-only mode




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New venture Zerofifty from ad veterans wants to simplify the agency model

ZeroFifty Mediaworks, set up by three ad veterans, wants to bring in Bandra vibes into the agency model




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How Ratan Tata pushed for evidence-led ayurveda 

Ratan Tata sought to promote research that could validate ayurveda through contemporary science




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Senior feline resident: Defib stays at his ambulance station 

Online petition halts re-homing of 16-year-old cat in London




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Indo National plans battery of home-care launches

The maker of Nippo batteries plans to innovate in its core business and get into LED bulbs




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Shifting gift preferences

Employees today prefer personalised gifts, and India Inc is taking cognisance




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How Jio is powering Reliance’s media, entertainment biz

Despite a late entry into telecom, digital services, and media, Reliance has raced to the top




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Why more NRIs are buying health insurance in India

The number of NRIs buying health insurance from India has increased steadily over the past three years




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Spotlight on ways to end violence against children




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Concussion: FIFA kicks off ‘suspect and protect’ drive 

Campaign raises awareness that concussion is a traumatic brain injury and a risk to every player on the pitch




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Nvidia: The lynchpin of the AI revolution

The meteoric rise of the Santa Clara-headquartered chipmaker is powered by bold innovation




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Trump presidency casts long shadow over climate summit 

The return of the climate denier as head of the world’s biggest greenhouse gas emitter threatens to throw net-zero negotiations into disarray once again




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ADB increases climate finance after US, Japan give world's first sovereign guarantees




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HC refuses to entertain plea to enhance funds allocated to MCD councillors

The Hight Court expressed surprise that members of the Legislative Assembly (MLAs) and Municipal Corporation of Delhi (MCD) councillors were approaching courts with their grievances and asked them to raise the issue in the House or before the public




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Cannot change rules of the game once recruitment to public services commences: SC

The Constitution Bench says laws, rules and procedure governing recruitments to public services must be governed by the overarching principles of fundamental rights of equality and non-discrimination




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Delhi cop Nidhin Valsan’s inspiring journey from arresting cancer to Ironman finish line

Diagnosed with stage 4 non-Hodgkin’s lymphoma in 2021, IPS officer Nidhin Valsan resurrected himself by competing the Ironman triathlon and writing his memoir because he hopes to be a good influence on other cancer patients




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Kejriwal gives clarion call to sarpanchs in Punjab to wipe out curse of drugs

Opposition says AAP government has ‘mishandled and mismanaged’ every aspect of State administration




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Delhi govt okays proposal, 10000 Civil Defence Volunteers to return for anti-pollution work: Atishi

Within two-three days of the registration, the CDVs will be deployed on duties like management of pollution hotspots, preventing dust pollution and garbage burning, she said in a press briefing




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One dead, one injured in two firing incidents in Delhi within 10 minutes

The two incidents of firing in northeast Delhi leave one dead and one injured; three suspects apprehended by police




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A year after being sacked, 10,000 civil defence volunteers in Delhi set to return to work

The former bus marshals, dismissed last year on grounds of ‘improper recruitment process’, to be deployed for anti-pollution measures for 4 months; will send proposal to L-G to make them permanent employees: CM; our MPs put pressure on Atishi, ‘forced’ her to announce the reinstatement: BJP




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Delhi Transport Minister Kailash Gahlot announces two new bus routes for outer Delhi