expe Twinning Partnership Network: A Learning and Experience-Sharing Network Among Health Professionals in Rwanda to Improve Health Services By ghspjournal.org Published On :: 2024-10-29T12:28:39-07:00 ABSTRACTWe describe the development, implementation, and evaluation of a novel twinning approach: the Twinning Partnership Network (TPN). Twinning is a well-known approach to peer learning that has been used in a variety of settings to build organizational capacity. Although twinning takes many forms, the heart of the approach is that institutions with shared characteristics collaborate via sharing information and experiences to achieve a specific goal. We adapted a twinning partnership strategy developed by the World Health Organization to create a network of like-minded health institutions. The key innovation of the TPN is the network, which ensures that an institution always has a high-performing peer with whom to partner on a specific topic area of interest. We identified 10 hospitals and 30 districts in Rwanda to participate in the TPN. These districts and hospitals participated in a kickoff workshop in which they identified capacity gaps, clarified goals, and selected twinning partners. After the workshop, districts and hospitals participated in exchange visits, coaching visits, and virtual and in-person learning events. We found that districts and hospitals that selected specific areas and worked on them throughout the duration of the TPN with their peers improved their performance significantly when compared with those that selected and worked on other areas. Accreditation scores improved by 5.6% more in hospitals selecting accreditation than those that did not. Districts that selected improving community-based health insurance coverage improved by 4.8% more than districts that did not select this topic area. We hypothesize that these results are due to senior management’s interest and motivation to improve in these specific areas, the motivation gained by learning from high-performing peers with similar resources, and context-specific knowledge sharing from peer hospitals and districts. Full Article
expe Initial Experience with [177Lu]Lu-PSMA-617 After Regulatory Approval for Metastatic Castration-Resistant Prostate Cancer: Efficacy, Safety, and Outcome Prediction By jnm.snmjournals.org Published On :: 2024-11-01T04:25:31-07:00 [177Lu]Lu-PSMA-617 was approved by the U.S. Food and Drug Administration for patients with prostate-specific membrane antigen (PSMA)–positive metastatic castration-resistant prostate cancer (mCRPC). Since the time of regulatory approval, however, real-world data have been lacking. This study investigated the efficacy, safety, and outcome predictors of [177Lu]Lu-PSMA-617 at a major U.S. academic center. Methods: Patients with mCRPC who received [177Lu]Lu-PSMA-617 at the Johns Hopkins Hospital outside clinical trials were screened for inclusion. Patients who underwent [177Lu]Lu-PSMA-617 and had available outcome data were included in this study. Outcome data included prostate-specific antigen (PSA) response (≥50% decline), PSA progression-free survival (PFS), and overall survival (OS). Toxicity data were evaluated according to the Common Terminology Criteria for Adverse Events version 5.03. The study tested the association of baseline circulating tumor DNA mutational status in homologous recombination repair, PI3K alteration pathway, and aggressive-variant prostate cancer–associated genes with treatment outcome. Baseline PSMA PET/CT images were analyzed using SelectPSMA, an artificial intelligence algorithm, to predict treatment outcome. Associations with the observed treatment outcome were evaluated. Results: All 76 patients with PSMA-positive mCRPC who received [177Lu]Lu-PSMA-617 met the inclusion criteria. A PSA response was achieved in 30 of 74 (41%) patients. The median PSA PFS was 4.1 mo (95% CI, 2.0–6.2 mo), and the median OS was 13.7 mo (95% CI, 11.3–16.1 mo). Anemia of grade 3 or greater, thrombocytopenia, and neutropenia were observed in 9 (12%), 3 (4%), and 1 (1%), respectively, of 76 patients. Transient xerostomia was observed in 23 (28%) patients. The presence of aggressive-variant prostate cancer–associated genes was associated with a shorter PSA PFS (median, 1.3 vs. 6.3 mo; P = 0.040). No other associations were observed between circulating tumor DNA mutational status and treatment outcomes. Eighteen of 71 (25%) patients classified by SelectPSMA as nonresponders had significantly lower rates of PSA response than patients classified as likely responders (6% vs. 51%; P < 0.001), a shorter PSA PFS (median, 1.3 vs. 6.3 mo; P < 0.001), and a shorter OS (median, 6.3 vs. 14.5 mo; P = 0.046). Conclusion: [177Lu]Lu-PSMA-617 offered in a real-world setting after regulatory approval in the United States demonstrated antitumor activity and a favorable toxicity profile. Artificial-intelligence–based analysis of baseline PSMA PET/CT images may improve patient selection. Validation of these findings on larger cohorts is warranted. Full Article
expe Reimagining Biologically Adapted Somatostatin Receptor-Targeted Radionuclide Therapy: Perspectives Based on Personal Experience and Observations on Recent Trials By jnm.snmjournals.org Published On :: 2024-11-01T04:25:31-07:00 Full Article
expe Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities [75th Anniversary Celebration Collection Special Section] By pharmrev.aspetjournals.org Published On :: 2024-10-16T07:40:25-07:00 Both preclinical and clinical studies implicate functional impairments of several neuroactive metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential amino acid tryptophan in mammals, in the pathophysiology of neurologic and psychiatric diseases. A number of KP enzymes, such as tryptophan 2,3-dioxygenase (TDO2), indoleamine 2,3-dioxygenases (IDO1 and IDO2), kynurenine aminotransferases (KATs), kynurenine 3-monooxygenase (KMO), 3-hydroxyanthranilic acid oxygenase (3-HAO), and quinolinic acid phosphoribosyltransferase (QPRT), control brain KP metabolism in health and disease and are therefore increasingly considered to be promising targets for the treatment of disorders of the nervous system. Understanding the distribution, cellular expression, and regulation of KP enzymes and KP metabolites in the brain is therefore critical for the conceptualization and implementation of successful therapeutic strategies. Significance Statement Studies have implicated the kynurenine pathway of tryptophan in the pathophysiology of neurologic and psychiatric diseases. Key enzymes of the kynurenine pathway regulate brain metabolism in both health and disease, making them promising targets for treating these disorders. Therefore, understanding the distribution, cellular expression, and regulation of these enzymes and metabolites in the brain is critical for developing effective therapeutic strategies. This review endeavors to describe these processes in detail.: Full Article
expe Cyclic Aspiration in Mechanical Thrombectomy: Influencing Factors and Experimental Validation [RESEARCH] By www.ajnr.org Published On :: 2024-11-07T15:14:12-08:00 BACKGROUND AND PURPOSE: Mechanical thrombectomy is a fundamental intervention for acute ischemic stroke treatment. While conventional techniques are effective, cyclic aspiration (CyA) shows potential for better recanalization rates. We aim to investigate factors affecting CyA and compare them with static aspiration (StA). MATERIALS AND METHODS: StA setup consisted of an aspiration pump connected to pressure transducer. CyA was tested with 5 subsequent iterations: single solenoid valve with air plus saline (i1) or saline alone (i2) as aspiration medium; 2 solenoid valves with air plus saline (i3) as aspiration medium; complete air removal and saline feeding (i4); and pressurized saline feeding (i5). To assess the efficacy of clot ingestion, the pressure transducer was replaced with a distal aspiration catheter. Moderately stiff clot analogs (15 mm) were used to investigate the ingestion quantified as clot relative weight loss. Additionally, the aspiration flow rate was assessed for each setup. RESULTS: With CyA i1, the amplitude of the achieved negative pressure waves declined with increasing frequencies but progressively increased with each subsequent iteration, achieving a maximum amplitude of 81 kPa for i5 at 1 Hz. Relative clot weight loss was significantly higher with i5 at 5 Hz than with StA (100% versus 37.8%; P = .05). Aspiration flow rate was lower with CyA than with StA (i5 at 5 Hz: 199.8 mL/min versus StA: 311 mL/min; P < .01). CONCLUSIONS: CyA with the appropriate setup may represent an encouraging innovation in mechanical thrombectomy, offering a promising pathway for improving efficacy in clot ingestion and recanalization. The observed benefits warrant confirmation in a clinical setting. Full Article
expe Conversations matter: improving the diagnosis experience for people with type 2 diabetes By bjgp.org Published On :: 2024-10-31T16:05:26-07:00 Full Article
expe Lack of Knowledge of Antibiotic Risks Contributes to Primary Care Patients Expectations of Antibiotics for Common Symptoms [Research Briefs] By www.annfammed.org Published On :: 2024-09-23T14:00:14-07:00 Patient expectations of receiving antibiotics for common symptoms can trigger unnecessary use. We conducted a survey (n = 564) between January 2020 to June 2021 in public and private primary care clinics in Texas to study the prevalence and predictors of patients’ antibiotic expectations for common symptoms/illnesses. We surveyed Black patients (33%) and Hispanic/Latine patients (47%), and over 93% expected to receive an antibiotic for at least 1 of the 5 pre-defined symptoms/illnesses. Public clinic patients were nearly twice as likely to expect antibiotics for sore throat, diarrhea, and cold/flu than private clinic patients. Lack of knowledge of potential risks of antibiotic use was associated with increased antibiotic expectations for diarrhea (odds ratio [OR] = 1.6; 95% CI, 1.1-2.4) and cold/flu symptoms (OR = 2.9; 95% CI, 2.0-4.4). Lower education and inadequate health literacy were predictors of antibiotic expectations for diarrhea. Future antibiotic stewardship interventions should tailor patient education materials to include information on antibiotic risks and guidance on appropriate antibiotic indications. Full Article
expe Challenges in Receiving Care for Long COVID: A Qualitative Interview Study Among Primary Care Patients About Expectations and Experiences [Original Research] By www.annfammed.org Published On :: 2024-09-23T14:00:14-07:00 BACKGROUND For many patients with post–COVID-19 condition (long COVID), primary care is the first point of interaction with the health care system. In principle, primary care is well situated to manage long COVID. Beyond expressions of disempowerment, however, the patient’s perspective regarding the quality of long COVID care is lacking. Therefore, this study aimed to analyze the expectations and experiences of primary care patients seeking treatment for long COVID. METHODS A phenomenological approach guided this analysis. Using purposive sampling, we conducted semistructured interviews with English-speaking, adult primary care patients describing symptoms of long COVID. We deidentified and transcribed the recorded interviews. Transcripts were analyzed using inductive qualitative content analysis. RESULTS This article reports results from 19 interviews (53% female, mean age = 54 years). Patients expected their primary care practitioners (PCPs) to be knowledgeable about long COVID, attentive to their individual condition, and to engage in collaborative processes for treatment. Patients described 2 areas of experiences. First, interactions with clinicians were perceived as positive when clinicians were honest and validating, and negative when patients felt dismissed or discouraged. Second, patients described challenges navigating the fragmented US health care system when coordinating care, treatment and testing, and payment. CONCLUSION Primary care patients’ experiences seeking care for long COVID are incongruent with their expectations. Patients must overcome barriers at each level of the health care system and are frustrated by the constant challenges. PCPs and other health care professionals might increase congruence with expectations and experiences through listening, validating, and advocating for patients with long COVID. Annals Early Access article Full Article
expe The new Nvidia App is out now, justly banishing GeForce Experience to history By www.rockpapershotgun.com Published On :: Tue, 12 Nov 2024 13:56:26 +0000 After nearly a year of public beta honing, the Nvidia App – Team Green’s new one-stop shop for desktop GPU management – is out in full. Not alongside the upcoming RTX 50 series, as rumoured, but right-now-today-this-minute. I’ve been testing out the launch version and while it’s not without some dud features, it does agreeably achieve its stated goal of combining the functions within Nvidia Control Panel and GeForce Experience. And if installing it means never having to use the latter again, well, that’s 149MB well spent. Read more Full Article Graphics Cards Nvidia Nvidia G-Sync Hardware Nvidia DLDSR Overclocking
expe BBC Morning Live expert gives 'double tax' warning on new Labour pensions raid By www.express.co.uk Published On :: Tue, 12 Nov 2024 12:20:00 +0000 Finance guru Laura Pomfret explained how changes to inheritance tax in the budget may hit people in a way they hadn't realised Full Article Personal Finance
expe Five of the most important International Space Station experiments By www.newscientist.com Published On :: Tue, 06 Aug 2024 17:00:33 +0100 From artificial retinas to ageing mice, here are five of the most promising results from research performed on the ISS – and what they might mean for humans on Earth and in space Full Article
expe A new life on Mars? Expect toxic dust, bad vibes and insects for lunch By www.newscientist.com Published On :: Tue, 12 Nov 2024 16:00:00 +0000 You might have heard about plans to establish a self‑sustaining city on Mars. Here’s what life would really be like on the Red Planet Full Article
expe The AI expert who says artificial general intelligence is nonsense By www.newscientist.com Published On :: Mon, 16 Sep 2024 17:00:00 +0100 Artificial intelligence has more in common with ants than humans, says Neil Lawrence. Only by taking a more nuanced view of intelligence can we see how machines will truly transform society Full Article
expe Google says its AI designs chips better than humans – experts disagree By www.newscientist.com Published On :: Wed, 02 Oct 2024 22:30:18 +0100 Google DeepMind claims its AlphaChip AI method can deliver “superhuman” chip designs that are already used in its data centres – but independent experts say public proof is lacking Full Article
expe The Common Experience That Explains Trump's Gains By www.realclearpolitics.com Published On :: Tue, 12 Nov 2024 07:48:31 -0600 The most impressive aspect of Donald Trump's victory over Vice President Kamala Harris last week was the uniformity of his gains across the electoral landscape. Full Article AM Update
expe Trump picks John Ratcliffe for CIA, expected to name Gov. Kristi Noem for Homeland Security By www.washingtontimes.com Published On :: Tue, 12 Nov 2024 18:41:19 -0500 President-elect Donald Trump announced a flurry of appointments Tuesday for key posts in his new administration, including former Director of National Intelligence John Ratcliffe to lead the CIA and the expected nomination of South Dakota Gov. Kristi Noem to head the Department of Homeland Security. Full Article
expe Cilic Expecting First Child In 2020 By www.sport.co.uk Published On :: Wed, 09 Oct 2019 04:50:00 +0000 Marin Cilic has experienced many great moments on court in recent years, but the 18-time tour-level titlist announced that he will enjoy a milestone moment off the court in 2020. Speaking to his 170,000 followers on Twitter, the Croat shared the news that he will become a father next year. The news comes just 18 months after Cilic married Kristina Milkovic in Dubrovnik. Cilic’s announcement was accompanied by a photo of the 31-year-old shopping for a pushchair. New ride ?? ?? Excited to share with you all that #teamCilic will be growing. New member joining us in 2020 ???????? pic.twitter.com/m0Qxn6AdQB — Marin Cilic (@cilic_marin) 7 October 2019 Cilic will compete at next week’s VTB Kremlin Cup in Moscow, where he will be aiming to achieve his 500th tour-level victory. If Cilic achieves the feat, he would become the 10th active player on the ATP Tour to reach that mark.. Full Article
expe Stadium-sized asteroid deemed 'potentially hazardous' by NASA, is expected to move 'relatively close' to Earth By www.foxnews.com Published On :: Tue, 17 Sep 2024 15:27:04 -0400 A stadium-sized asteroid is passing relatively close to Earth on Tuesday, NASA announced. Its distance from Earth and its massive size makes it a "potentially hazardous object." Full Article 5a8fc74a-2407-585e-90c7-d1d9363b06cd fnc Fox News fox-news/science fox-news/science/air-and-space fox-news/odd-news fox-news/science/air-and-space/nasa fox-news/science article
expe Geomagnetic storm expected to hit Earth following autumnal equinox By www.foxnews.com Published On :: Tue, 24 Sep 2024 14:11:23 -0400 A coronal mass ejection could strike the Earth's magnetosphere this week and cause a geomagnetic storm due to conditions caused by the autumnal equinox. Full Article 015d1c3d-4d26-5e20-9f92-591f1125c714 fnc Fox News fox-news/science/air-and-space fox-news/science/planet-earth fox-news/weather fox-news/us fox-news/science article
expe Will an experimental mRNA vaccine help fight the mpox outbreak? By www.newscientist.com Published On :: Wed, 04 Sep 2024 17:00:02 +0100 After an mRNA vaccine for mpox achieved promising results in monkeys, researchers say it could have several advantages over existing vaccines – but cold storage requirements mean it will be hard to roll out in some hard-hit countries Full Article
expe Can we finally reverse balding with these new experimental treatments? By www.newscientist.com Published On :: Tue, 26 Sep 2023 17:00:00 +0100 Male pattern baldness could soon be a thing of the past, with new hair loss treatments beginning to show tantalising results Full Article
expe Slowing growth in life expectancy means few people will live to 100 By www.newscientist.com Published On :: Mon, 07 Oct 2024 17:00:57 +0100 While the 20th century saw rapid rises in average life expectancy at birth, more recent years have seen a slowdown, suggesting we may be reaching the limit of human lifespan Full Article
expe Cancer deaths expected to nearly double worldwide by 2050 By www.newscientist.com Published On :: Tue, 05 Nov 2024 16:00:05 +0000 Experts predict that the number of cancer cases around the world will skyrocket, resulting in millions more fatalities by 2050 Full Article
expe Experts explain approach to estimating foodborne diseases By www.foodsafetynews.com Published On :: Tue, 12 Nov 2024 05:03:00 +0000 Scientists have shared details of how they are going about updating foodborne infection figures that will be published by the World Health Organization (WHO) in 2025. As part of the process to update estimates on the burden of foodborne diseases published in 2015, WHO is conducting a global source attribution... Continue Reading Full Article For Public Health Professionals World Foodborne Disease Burden Epidemiology Reference Group (FERG) foodborne illness estimates source attribution World Health Organization (WHO)
expe Teens Gain Experience at IEEE’s TryEngineering Summer Institute By spectrum.ieee.org Published On :: Tue, 29 Oct 2024 19:00:03 +0000 The future of engineering is bright, and it’s being shaped by the young minds at the TryEngineering Summer Institute (TESI), a program administered by IEEE Educational Activities. This year more than 300 students attended TESI to fuel their passion for engineering and prepare for higher education and careers. Sessions were held from 30 June through 2 August on the campuses of Rice University, the University of Pennsylvania, and the University of San Diego.The program is an immersive experience designed for students ages 13 to 17. It offers hands-on projects, interactive workshops, field trips, and insights into the profession from practicing engineers. Participants get to stay on a college campus, providing them with a preview of university life.Student turned instructorOne future innovator is Natalie Ghannad, who participated in the program as a student in 2022 and was a member of this year’s instructional team in Houston at Rice University. Ghannad is in her second year as an electrical engineering student at the University of San Francisco. University students join forces with science and engineering teachers at each TESI location to serve as instructors.For many years, Ghannad wanted to follow in her mother’s footsteps and become a pediatric neurosurgeon. As a high school junior in Houston in 2022, however, she had a change of heart and decided to pursue engineering after participating in the TESI at Rice. She received a full scholarship from the IEEE Foundation TESI Scholarship Fund, supported by IEEE societies and councils. “I really liked that it was hands-on,” Ghannad says. “From the get-go, we were introduced to 3D printers and laser cutters.” The benefit of participating in the program, she says, was “having the opportunity to not just do the academic side of STEM but also to really get to play around, get your hands dirty, and figure out what you’re doing.” “Looking back,” she adds, “there are so many parallels between what I’ve actually had to do as a college student, and having that knowledge from the Summer Institute has really been great.”She was inspired to volunteer as a teaching assistant because, she says, “I know I definitely want to teach, have the opportunity to interact with kids, and also be part of the future of STEM.”More than 90 students attended the program at Rice. They visited Space Center Houston, where former astronauts talked to them about the history of space exploration.Participants also were treated to presentations by guest speakers including IEEE Senior Member Phil Bautista, the founder of Bull Creek Data, a consulting company that provides technical solutions; IEEE Senior Member Christopher Sanderson, chair of the IEEE Region 5 Houston Section; and James Burroughs, a standards manager for Siemens in Atlanta. Burroughs, who spoke at all three TESI events this year, provided insight on overcoming barriers to do the important work of an engineer.Learning about transit systems and careersThe University of Pennsylvania, in Philadelphia, hosted the East Coast TESI event this year. Students were treated to a field trip to the Southeastern Pennsylvania Transportation Association (SEPTA), one of the largest transit systems in the country. Engineers from AECOM, a global infrastructure consulting firm with offices in Philadelphia that worked closely with SEPTA on its most recent station renovation, collaborated with IEEE to host the trip. The benefit of participating in the program was “having the opportunity to not just do the academic side of STEM but also to really get to play around, get your hands dirty, and figure out what you’re doing.” — Natalie GhannadParticipants also heard from guest speakers including Api Appulingam, chief development officer of the Philadelphia International Airport, who told the students the inspiring story of her career.Guest speakers from Google and MetaStudents who attended the TESI camp at the University of San Diego visited Qualcomm. Hosted by the IEEE Region 6 director, Senior Member Kathy Herring Hayashi, they learned about cutting-edge technology and toured the Qualcomm Museum.Students also heard from guest speakers including IEEE Member Andrew Saad, an engineer at Google; Gautam Deryanni, a silicon validation engineer at Meta; Kathleen Kramer, 2025 IEEE president and a professor of electrical engineering at the University of San Diego; as well as Burroughs.“I enjoyed the opportunity to meet new, like-minded people and enjoy fun activities in the city, as well as get a sense of the dorm and college life,” one participant said.Hands-on projectsIn addition to field trips and guest speakers, participants at each location worked on several hands-on projects highlighting the engineering design process. In the toxic popcorn challenge, the students designed a process to safely remove harmful kernels. Students tackling the bridge challenge designed and built a span out of balsa wood and glue, then tested its strength by gradually adding weight until it failed. The glider challenge gave participants the tools and knowledge to build and test their aircraft designs.One participant applauded the hands-on activities, saying, “All of them gave me a lot of experience and helped me have a better idea of what engineering field I want to go in. I love that we got to participate in challenges and not just listen to lectures—which can be boring.” The students also worked on a weeklong sparking solutions challenge. Small teams identified a societal problem, such as a lack of clean water or limited mobility for senior citizens, then designed a solution to address it. On the last day of camp, they pitched their prototypes to a team of IEEE members that judged the projects based on their originality and feasibility. Each student on the winning teams at each location were awarded the programmable Mech-5 robot.Twenty-nine scholarships were awarded with funding from the IEEE Foundation. IEEE societies that donated to the cause were the IEEE Computational Intelligence Society, the IEEE Computer Society, the IEEE Electronics Packaging Society, the IEEE Industry Applications Society, the IEEE Oceanic Engineering Society, the IEEE Power & Energy Society, the IEEE Power Electronics Society, the IEEE Signal Processing Society, and the IEEE Solid-State Circuits Society. Full Article Ieee member news Type:ti
expe Comment on Keep Your Heart Safe This Chhath Puja: Expert Fasting Tips For A Healthy Celebration by Blue Techker By www.thehealthsite.com Published On :: Thu, 07 Nov 2024 23:49:34 +0000 <a href="https://bluetechker.com/" rel="nofollow ugc">Blue Techker</a> naturally like your web site however you need to take a look at the spelling on several of your posts. A number of them are rife with spelling problems and I find it very bothersome to tell the truth on the other hand I will surely come again again. Full Article
expe Endurance tells story of two expeditions, centuries apart By arstechnica.com Published On :: Tue, 05 Nov 2024 21:27:59 +0000 New NatGeo documentary was directed by the same duo who brought us the Oscar-winning Free Solo. Full Article Science disney plus Endurance shipwreck exploration National Geographic science documentaries Sir Ernest Shackleton streaming television
expe Anthropic’s Haiku 3.5 surprises experts with an “intelligence” price increase By arstechnica.com Published On :: Tue, 05 Nov 2024 22:50:48 +0000 Anthropic’s smallest AI model now beats its older largest LLM, Opus, at some tasks. Full Article AI Biz & IT AI pricing Anthropic Anthropic Claude API chatbots ChatGPT chatgtp Claude Claude 3.5 Claude 3.5 Haiku Claude Haiku large language models machine learning
expe Donald Trump's Administration Takes Shape After 15 Official or Expected Picks By www.breitbart.com Published On :: Wed, 13 Nov 2024 00:34:38 +0000 President-elect Donald Trump has made many selections to lead his administration as his transition gets underway, ranging from chief of staff to head of the Environmental Protection Agency (EPA). At the same time, a number of crucial positions have yet to be filled just one week removed from the landslide election. The post Donald Trump’s Administration Takes Shape After 15 Official or Expected Picks appeared first on Breitbart. Full Article 2024 Election Politics cabinet Donald Trump Trump Administration Trump Transition Team
expe Tesla posts bigger-than-expected loss, bigger-than-expected revenue [Updated] By arstechnica.com Published On :: Wed, 01 Aug 2018 23:52:30 +0000 Company expects to be cash flow positive in the next two quarters. Full Article Biz & IT Cars business Energy financial Tesla
expe Safety experts outline what Toronto Taylor Swift fans should know By www.cbc.ca Published On :: Tue, 12 Nov 2024 11:44:32 EST As Toronto readies for Taylor Swift's arrival this week, some crowd management and planning experts say additional safety precautions should be taken when tens of thousands of fans fill the city's downtown core on show nights. Full Article News/Canada/Toronto
expe Lock-out dans les ports: Ottawa n’aurait pas été assez «proactif», selon un expert By www.journaldemontreal.com Published On :: Tue, 12 Nov 2024 15:15:42 EST Ottawa aurait laissé trop de liberté aux syndicats, en leur donnant «carte blanche» pour déclencher des grèves dans les ports du pays. Full Article
expe Des arnaqueurs ciblent les Swifties: «90% des billets à vendre sur les réseaux sociaux sont de l’arnaque», croit un expert By www.journaldemontreal.com Published On :: Mon, 11 Nov 2024 20:25:46 EST La majorité des billets encore offerts en ligne pour aller voir Taylor Swift à Toronto sont des arnaques, constate un expert en cybersécurité. Full Article
expe DGFT to organize EODC Camp from November 11 to 22 in New Delhi to expedite pending export obligations By www.pharmabiz.com Published On :: Thursday, November 7, 2024 08:00 IST The office of the Additional Director General of Foreign Trade (CLA DGFT) has announced an Export Obligation Discharge Certificate (EODC) Camp scheduled from November 11 to 22, 2024. The camp is Full Article
expe Is Election Anxiety Keeping You Awake? Sleep Experts Share Advice By www.scientificamerican.com Published On :: Thu, 31 Oct 2024 10:30:00 +0000 Scientific American staff and sleep experts share advice on how to get better sleep in the stressful days leading up to the U.S. presidential election—and those that come after Full Article
expe Transparency Shocker: Biosimilars Are Getting Cheaper—But Hospitals and Insurers Can Make Them Expensive By feeds.feedblitz.com Published On :: Mon, 04 Nov 2024 11:00:00 +0000 Here on Drug Channels, we have long highlighted the boom in provider-administered biosimilars. In contrast to the pharmacy market, adoption of these biosimilars is growing, prices are dropping, and formulary barriers continue to fall. Novel transparency information reveals that this good news doesn’t always translate into savings. Below, we rely on a unique data set from Turquoise Health to examine how much four national commercial health plans—Aetna, Anthem, Cigna, and UnitedHealthcare—paid hospitals for Avastin and its two most significant biosimilar competitors. As we demonstrate, health plans pay hospitals far above acquisition costs for biosimilars. What’s more, plans can pay hospitals more for a biosimilar than for the higher-cost reference product. The U.S. drug channel system is warping hospitals’ incentives to adopt biosimilars, while simultaneously raising costs for commercial plans. The namesake of my alma mater once said: “Sunlight is said to be the best of disinfectants.” What would happen if we disinfected the entire channel? Read more » Full Article Average Sales Price (ASP) Biosimilars Buy-and-Bill Costs/Reimbursement Hospitals Specialty Drugs
expe Orphan Drugs at 30: Will Success Become Too Expensive? By www.fdamatters.com Published On :: Mon, 14 Jan 2013 19:09:11 +0000 The Orphan Drug Act (ODA) turned 30 this month, demonstrating that good laws really can have an enduring impact. Amidst the celebrations, a reporter asked me a provocative question: can we afford more orphan drugs costing hundreds of thousands of dollars per year? FDA Matters answered “yes.” However, I added a caveat that should worry everyone eager for orphan drugs to succeed. When genomics and personalized medicine become successful, this will multiply the number of rare diseases and the overall cost of orphan drugs, perhaps beyond what the system can bear. Full Article FDA and Congress FDA and Industry Orphan Drugs
expe Lessons From A Private Funding Round: Science, Relationships, And Experience By lifescivc.com Published On :: Tue, 02 Apr 2024 11:00:46 +0000 By Mike Cloonan, CEO of Sionna Therapeutics, as part of the From The Trenches feature of LifeSciVC An insightful piece on this blog following the JPM healthcare conference noted the “refreshing burst of enthusiasm” in the biotech sector. It’s true The post Lessons From A Private Funding Round: Science, Relationships, And Experience appeared first on LifeSciVC. Full Article Biotech financing From The Trenches Fundraising CFTR Sionna Therapeutics
expe Reflections On My Experience As A Board Member By lifescivc.com Published On :: Wed, 18 Sep 2024 11:00:01 +0000 By Ivana Magovčević-Liebisch, CEO of Vigil Neuroscience, as part of the From The Trenches feature of LifeSciVC In an industry where boom and bust cycles occur regularly and 90 percent of drug candidates fail to reach the market, an outstanding The post Reflections On My Experience As A Board Member appeared first on LifeSciVC. Full Article Boards and governance From The Trenches Leadership
expe AbbVie Drug Expected to Rival Bristol Myers’s New Schizophrenia Med Flunks Phase 2 Test By medcitynews.com Published On :: Mon, 11 Nov 2024 18:25:01 +0000 AbbVie schizophrenia drug candidate emraclidine failed to beat a placebo in two Phase 2 clinical trials. The drug, once projected to compete with Bristol Myers Squibb’s Cobenfy, is from AbbVie’s $8.7 billion acquisition of Cerevel Therapeutics. The post AbbVie Drug Expected to Rival Bristol Myers’s New Schizophrenia Med Flunks Phase 2 Test appeared first on MedCity News. Full Article BioPharma Daily Pharma AbbVie biopharma nl Cerevel Therapeutics Clinical Trials emraclidine schizophrenia
expe Megan Fox expecting her first child with Machine Gun Kelly By www.asiaone.com Published On :: Tue, 12 Nov 2024 10:30:12 +0800 Megan Fox is pregnant. The 38-year-old actress — who has Noah, 12, Bodhi, ten, and Journey, eight, with her ex-husband Brian Austin Green — has confirmed via social media that she's expecting her first child with Machine Gun Kelly. Full Article
expe Legal Experts Discuss Accountability Measures Against Russia at HLS Event By www.belfercenter.org Published On :: Nov 17, 2022 Nov 17, 2022 The speakers included Yale Law School professor Harold H. Koh ’75, and Patrick W. Pearsall, Director of the International Claims and Reparations Project at Columbia Law School. Koh and Pearsall discussed their experiences representing Ukraine in legal proceedings against Russia before the International Court of Justice. Full Article
expe Six disparate expert voices at the Kennedy School on the Israel-Hamas war By www.belfercenter.org Published On :: May 14, 2024 May 14, 2024 Excerpts from remarks of participants in the Middle East Dialogues series led by HKS Professor Tarek Masoud throughout the 2024 spring semester. Full Article
expe EU expected to approve climate, energy commissioners By www.argusmedia.com Published On :: 06 Nov 2024 14:22 GMT Full Article Electricity Emissions Hydrogen Europe Politics Environmental politics Regulation Energy policy Climate change Renewable and alternative energy
expe State Farm� Teams Up with Canine Expert Victoria Stilwell to Take a Bite Out of Dog Attacks - Video OneTitle By multivu.prnewswire.com Published On :: 14 May 2014 15:53:00 EDT National Dog Bite Prevention Week is May 18-24. Any dog can bite, regardless of breed. Be a responsible pet owner. Full Article Banking Financial Services Insurance Contracts Broadcast Feed Announcements Animals Pets MultiVu Video
expe Farmers Insurance Highlights Know-How and Agent Insight Featuring Unique and Real Claims for Customers in New "We Know From Experience" Ad Campaign - Stag Pool Party By www.multivu.com Published On :: 28 Dec 2015 13:00:00 EST Farmers Insurance "We Know From Experience" Ad Campaign Spot Full Article Advertising Banking Financial Services Insurance New Products Services Broadcast Feed Announcements MultiVu Video
expe CREATE A THANKSGIVING FEAST THAT WILL BE SURE TO KEEP THE FAMILY TALKING! - Lifestyle Expert Shares Easy Tricks For Turkey Day! By www.hickoryfarms.com Published On :: 23 Nov 2015 18:10:00 EST Lifestyle Expert Shares Easy Tricks For Turkey Day! Full Article Food Beverages Broadcast Feed Announcements MultiVu Video
expe Oceanwide Expeditions Announces New Departures to the Ross Sea in Antarctica - Video impression Ross Sea Cruise By www.multivu.com Published On :: 06 Jan 2016 13:00:00 EST Video impression Ross Sea Cruise Full Article Leisure Travel Hotels Maritime Shipbuilding Travel New Products Services MultiVu Video
expe Live Free. Couch Hard.: Totino's Pizza Rollsâ„¢ Unveils First-Ever 'Bucking Couch' to Deliver the Ultimate Gaming Experience Before the Big Game - Brad Hiranga Interview By www.multivu.com Published On :: 26 Jan 2016 15:00:00 EST Brad Hiranga, General Mills Business Unit Director, Pizza and Tacos Business Unit discusses the Bucking Couch and Bucking Couch Bowl. Full Article Computer Electronics Consumer Electronics Food Beverages Household Consumer Cosmetics Retail Electronic Gaming Licensing Marketing Agreements New Products Services Broadcast Feed Announcements MultiVu Video
expe XCMG Apprentice Program Introduces Latest Technologies and Chinese Culture to International Apprentices - XCMG Apprentice Experience By www.multivu.com Published On :: 22 Feb 2016 16:45:00 EST XCMG Apprentice Program introduces latest technologies and Chinese culture to international apprentices. Full Article Auto Construction Building Education Mining Metals Transportation Trucking Railroad Workforce Management Human Resources Broadcast Feed Announcements