Title: Insulin Resistance
Category: Diseases and Conditions
Created: 2/10/2004 12:00:00 AM
Last Editorial Review: 7/28/2022 12:00:00 AM

Title: Smoking Rates Drop for Americans Battling Depression, Substance Abuse
Category: Health News
Created: 4/27/2022 12:00:00 AM
Last Editorial Review: 4/27/2022 12:00:00 AM

Extract

We read with great interest the review article by Randerath et al. [1] recently published in the European Respiratory Review. We would like to congratulate the authors on this clearly structured review, which emphasises the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

Solid tumors that arise in the body interact with neurons, which influences cancer progression and treatment response. Here, we discuss key questions in the field, including defining the nature of interactions between tumors and neural circuits and defining how neural signals shape the tumor microenvironment. This information will allow us to optimally target neural signaling to improve outcomes for cancer patients.

Solute carrier family 6 member 19 (SLC6A19) inhibitors are being studied as therapeutic agents for phenylketonuria. In this work, a potent SLC6A19 inhibitor (RA836) elevated rat kidney uremic toxin indoxyl sulfate (IDS) levels by intensity (arbitrary unit) of 13.7 ± 7.7 compared with vehicle 0.3 ± 0.1 (P = 0.01) as determined by tissue mass spectrometry imaging analysis. We hypothesized that increased plasma and kidney levels of IDS could be caused by the simultaneous inhibition of both Slc6a19 and a kidney IDS transporter responsible for excretion of IDS into urine. To test this, we first confirmed the formation of IDS through tryptophan metabolism by feeding rats a Trp-free diet. Inhibiting Slc6a19 with RA836 led to increased IDS in these rats. Next, RA836 and its key metabolites were evaluated in vitro for inhibiting kidney transporters such as organic anion transporter (OAT)1, OAT3, and breast cancer resistance protein (BCRP). RA836 inhibits BCRP with an IC₅₀ of 0.045 μM but shows no significant inhibition of OAT1 or OAT3. Finally, RA836 analogs with either potent or no inhibition of SLC6A19 and/or BCRP were synthesized and administered to rats fed a normal diet. Plasma and kidney samples were collected to quantify IDS using liquid chromatography–mass spectrometry. Neither a SLC6A19 inactive but potent BCRP inhibitor nor a SLC6A19 active but weak BCRP inhibitor raised IDS levels, whereas compounds inhibiting both transporters caused IDS accumulation in rat plasma and kidney, supporting the hypothesis that rat Bcrp contributes to the excretion of IDS. In summary, we identified that inhibiting Slc6a19 increases IDS formation, while simultaneously inhibiting Bcrp results in IDS accumulation in the kidney and plasma.

Sterol 12α-hydroxylase (CYP8B1) is the unique P450 enzyme with sterol 12-oxidation activity, playing an exclusive role in 12α-hydroxylating intermediates along the bile acid (BA) synthesis pathway. Despite the long history of BA metabolism studies, it is unclear whether CYP8B1 catalyzes 12α-hydroxylation of C₂₇ BAs, the key intermediates shuttling between mitochondria and peroxisomes. This work provides robust in vitro evidence that both microsomal and recombinant CYP8B1 enzymes catalyze the 12α-hydroxylation of dihydroxycoprostanic acid (DHCA) into trihydroxycoprostanic acid (THCA). On the one hand, DHCA 12α-hydroxylation reactivity is conservatively detected in liver microsomes of both human and preclinical animals. The reactivity of human tissue fractions conforms well with the selectivity of CYP8B1 mRNA expression, while the contribution of P450 enzymes other than CYP8B1 is excluded by reaction phenotyping in commercial recombinant enzymes. On the other hand, we prepared functional recombinant human CYP8B1 proteins according to a recently published protocol. Titration of the purified CYP8B1 proteins with either C4 (7α-hydroxy-4-cholesten-3-one) or DHCA yields expected blue shifts of the heme Soret peak (type I binding). The recombinant CYP8B1 proteins efficiently catalyze 12α-hydroxylation of both DHCA and C4, with substrate concentration occupying half of the binding sites of 3.0 and 1.9 μM and k_cat of 3.2 and 2.6 minutes^–1, respectively. In summary, the confirmed role of CYP8B1 in 12α-hydroxylation of C₂₇ BAs has furnished the forgotten passageway in the BA synthesis pathway. The present finding might have opened a new window to consider the biology of CYP8B1 in glucolipid metabolism and to evaluate CYP8B1 inhibition as a therapeutic approach of crucial interest for metabolic diseases.

The phase 3 VISION trial demonstrated that [¹⁷⁷Lu]Lu-PSMA-617 prolonged progression-free survival and overall survival (OS) in prostate-specific membrane antigen [PSMA]–positive metastatic castration-resistant prostate cancer (mCRPC) patients who progressed on taxane-based chemotherapy and androgen receptor–signaling inhibitors (ARSIs). The U.S. expanded-access program (EAP; NCT04825652) was opened to provide access to [¹⁷⁷Lu]Lu-PSMA-617 for eligible patients until regulatory approval was obtained. This study aimed to evaluate the efficacy and safety profile of [¹⁷⁷Lu]Lu-PSMA-617 within the EAP and compare the results with those from the VISION trial. Methods: Patients enrolled in the EAP at 4 institutions in the United States with available toxicity and outcome data were included. Outcome measures included OS, a prostate-specific antigen (PSA) response rate (RR) of at least 50%, and incidences of toxicity according to Common Terminology Criteria for Adverse Events version 5.0. Differences in baseline characteristics, outcome data, and toxicity between the EAP and VISION were evaluated using t testing of proportions and survival analyses. Results: In total, 117 patients with mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 within the EAP between May 2021 and March 2022 were eligible and included in this analysis. Patients enrolled in the EAP were more heavily pretreated with ARSI (≥2 ARSI regimens: 70% vs. 46%; P < 0.001) and had worse performance status at baseline (Eastern Cooperative Oncology Group score ≥ 2: 19% vs. 7%; P < 0.001) than VISION patients. EAP and VISION patients had similar levels of grade 3 or higher anemia (18% vs. 13%; P = 0.15), thrombocytopenia (13% vs. 8%; P = 0.13), and neutropenia (3% vs. 3%; P = 0.85) and similar PSA RRs (42% vs. 46%; P = 0.50) and OS (median: 15.1 vs. 15.3 mo; P > 0.05). Conclusion: Patients with PSMA-positive mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 within the EAP were later in their disease trajectory than VISION patients. Patients enrolled in the EAP achieved similar PSA RRs and OS and had a safety profile similar to that of the VISION trial patients.

[¹⁷⁷Lu]Lu-PSMA-617 was approved by the U.S. Food and Drug Administration for patients with prostate-specific membrane antigen (PSMA)–positive metastatic castration-resistant prostate cancer (mCRPC). Since the time of regulatory approval, however, real-world data have been lacking. This study investigated the efficacy, safety, and outcome predictors of [¹⁷⁷Lu]Lu-PSMA-617 at a major U.S. academic center. Methods: Patients with mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 at the Johns Hopkins Hospital outside clinical trials were screened for inclusion. Patients who underwent [¹⁷⁷Lu]Lu-PSMA-617 and had available outcome data were included in this study. Outcome data included prostate-specific antigen (PSA) response (≥50% decline), PSA progression-free survival (PFS), and overall survival (OS). Toxicity data were evaluated according to the Common Terminology Criteria for Adverse Events version 5.03. The study tested the association of baseline circulating tumor DNA mutational status in homologous recombination repair, PI3K alteration pathway, and aggressive-variant prostate cancer–associated genes with treatment outcome. Baseline PSMA PET/CT images were analyzed using SelectPSMA, an artificial intelligence algorithm, to predict treatment outcome. Associations with the observed treatment outcome were evaluated. Results: All 76 patients with PSMA-positive mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 met the inclusion criteria. A PSA response was achieved in 30 of 74 (41%) patients. The median PSA PFS was 4.1 mo (95% CI, 2.0–6.2 mo), and the median OS was 13.7 mo (95% CI, 11.3–16.1 mo). Anemia of grade 3 or greater, thrombocytopenia, and neutropenia were observed in 9 (12%), 3 (4%), and 1 (1%), respectively, of 76 patients. Transient xerostomia was observed in 23 (28%) patients. The presence of aggressive-variant prostate cancer–associated genes was associated with a shorter PSA PFS (median, 1.3 vs. 6.3 mo; P = 0.040). No other associations were observed between circulating tumor DNA mutational status and treatment outcomes. Eighteen of 71 (25%) patients classified by SelectPSMA as nonresponders had significantly lower rates of PSA response than patients classified as likely responders (6% vs. 51%; P < 0.001), a shorter PSA PFS (median, 1.3 vs. 6.3 mo; P < 0.001), and a shorter OS (median, 6.3 vs. 14.5 mo; P = 0.046). Conclusion: [¹⁷⁷Lu]Lu-PSMA-617 offered in a real-world setting after regulatory approval in the United States demonstrated antitumor activity and a favorable toxicity profile. Artificial-intelligence–based analysis of baseline PSMA PET/CT images may improve patient selection. Validation of these findings on larger cohorts is warranted.

New research shows that bystander CPR can substantially improve a person's odds of surviving a cardiac arrest while avoiding major brain damage, especially if given immediately.

Watch Video | Listen to the Audio

HARI SREENIVASAN: The desire of the Kurds along Iraq’s northern border to govern themselves is receiving more resistance from Iraq’s central government. Iraqi army forces are demanding Kurdish troops withdraw from oil fields and military bases around Kirkuk, a city in the Kurdistan region that voted for independence last month. Kirkuk also has 10% of Iraq’s known oil reserves. Washington Post’s Loveday Morris is in Baghdad covering this standoff joins me now via Skype. First of all the significance of this. Why is it so important?

LOVEDAY MORRIS: There’s been a longtime conflict between Baghdad and Kurdistan over these disputed territories. Most significant of which is Kirkuk because of the oil reserves. But the referendum last month has really sharpened these disputes because you have Baghdad opposing independence and so it feels like they have to restate its territorial claims these areas. So that’s why we’re seeing a lot of tension right now.

HARI SREENIVASAN: And just to give people a little bit of a brief timeline – Iraqi forces control this area for a while and then in June ISIS took over the area and now it’s kind of back in Kurdish hands?

LOVEDAY MORRIS: Right. So in June 2014 Iraq lost control of a lot of the areas and we have this huge collapse in the face of an ISIS offensive. Over 100,000 soldiers fled and Kurdish forces moved in some of these areas – some of them maybe took from ISIS and others just moved into into the vacuum. And so Iraqi forces have been in these areas since June 2014. And that’s their main demand that they return to the areas.

HARI SREENIVASAN: What’s the likelihood that this standoff right now turns violent? Into some sort of a civil war?

LOVEDAY MORRIS:: I think at this point both sides don’t want violence. Al-Abadi, the prime minister, is really trying to defuse the situation by saying there’s going to be no military attack. But at the same time there is this buildup of forces so that I think they are trying to, in a way, intimidate the Kurds to withdraw from some areas but they don’t want to see a fight per say. But in this really tense situation there can be a small spark and things can turn violent quite easily.

HARI SREENIVASAN: Thank you.

The post Iraqi, Kurdish forces in standoff, weeks after Kurdish vote for independence appeared first on PBS NewsHour.

The Herald understands that former first minister Nicola Sturgeon has made no decisions on whether she will stand for election in 2026.

"I look forward to any contest, where of course it will be for branch members to select those they wish to represent them in Holyrood in the 2026 Scottish Parliament elections.”

"I hear journalists are wondering if I’ve put my name in for the Scottish Parliament. Big news re 2026 coming in the next hour…watch this space."

New research to better understand the biological factors of suicidal behaviour Researchers at the University of Glasgow are embarking on two new PhD projects to better understand the impact that biological factors may have on suicidal behaviour.

NFL Commissioner Roger Goodell held a news conference today after the second day of the annual owners meeting. Watch his remarks in the player above.

NFL players will be encouraged to stand for the national anthem at the start of the football games, the league’s chief told reporters today.

After two days of meeting with owners of each NFL team, representatives for the players’ union and players themselves, the NFL has reiterated its decision to keep its existing policy of not requiring players to stand during the anthem. Goodell said yesterday that the league wouldnot instate a rule that would penalize players who refuse to stand for the anthem.

“We believe everyone should stand for the national anthem,” he told reporters at a news conference today. “That’s an important part of our policy. It’s also an important part of our game that we all take great pride in. And it’s also important for us to honor our flag and our country and I think our fans expect us to do that.”

Goodell’s remarks came after President Donald Trump continued his criticism of the NFL this morning. On Twitter, Trump said: “The NFL has decided that it will not force players to stand for the playing of our National Anthem. Total disrespect for our great country!”

After former San Francisco 49ers quarterback Colin Kaepernick kneeled during the anthem last year to protest police killings of unarmed black men, dozens of other players joined him to draw greater attention to social and racial injustice. Last month, Trump said the NFL ought to fire players who didn’t stand for the anthem.

The players “are not doing this in any way to be disrespectful to the flag,” Goodell said today. “But they also understand how it’s being interpreted.”

Goodell also said the league wanted to stay out of the political arena over the issue.

“We’re not looking to get into politics,” he told reporters. “What we’re looking to do is to continue to get people focused on football.”

The post WATCH: NFL commissioner says players ‘should stand for the national anthem’ appeared first on PBS NewsHour.

A groundbreaking civilian spacewalk saw two astronauts partially exit a SpaceX Crew Dragon capsule wearing a brand new design of spacesuit. Every previous spacewalk completed before this was performed by government-trained astronauts.

Andrew McConnell's otherworldly photograph captures a Russian cosmonaut in front of the just-landed Soyuz MS spacecraft in Kazakhstan's remote grasslands

A small world in the outer solar system appears to have volcanic activity possibly spurred by liquid water

Many people enjoy the experience of using AIs like ChatGPT or voice assistants like Alexa to find out information, but it turns out doing so makes it less likely you will spot inaccurate information

Voice assistants can build profiles of their users’ habits and preferences, but the consistency and accuracy of these profiles vary

Krasinski scores the title of People’s Sexiest Man Alive 2024.

The standard model predicted that the NASA/ESA/CSA James Webb Space Telescope would see dim signals from small, primitive galaxies.

The post New Research Questions Standard Theory of How Galaxies Formed in Early Universe appeared first on Sci.News: Breaking Science News.

Wastewater is a major reservoir for antibiotic resistance genes, but modified bacteria can chop up this DNA before the dangerous microbes reach people

Narratives around addiction often reduce it to a series of poor choices, lack of values and weakness. This has real-world consequences, warns Anna Wolfe

People with cancer may have understandable reasons to follow Australian supermodel Elle Macpherson in declining chemotherapy, but the odds aren’t in their favour, warns Elle Hunt

The number of people worldwide directly killed by antibiotic resistance will rise to 1.9 million a year by 2050, according to the most comprehensive study so far

Video Friday is your weekly selection of awesome robotics videos, collected by your friends at IEEE Spectrum robotics. We also post a weekly calendar of upcoming robotics events for the next few months. Please send us your events for inclusion.

Humanoids 2024: 22–24 November 2024, NANCY, FRANCE

Enjoy today’s videos!

Just when I thought quadrupeds couldn’t impress me anymore...

[ Unitree Robotics ]

Researchers at Meta FAIR are releasing several new research artifacts that advance robotics and support our goal of reaching advanced machine intelligence (AMI). These include Meta Sparsh, the first general-purpose encoder for vision-based tactile sensing that works across many tactile sensors and many tasks; Meta Digit 360, an artificial fingertip-based tactile sensor that delivers detailed touch data with human-level precision and touch-sensing; and Meta Digit Plexus, a standardized platform for robotic sensor connections and interactions that enables seamless data collection, control and analysis over a single cable.

[ Meta ]

The first bimanual Torso created at Clone includes an actuated elbow, cervical spine (neck), and anthropomorphic shoulders with the sternoclavicular, acromioclavicular, scapulothoracic and glenohumeral joints. The valve matrix fits compactly inside the ribcage. Bimanual manipulation training is in progress.

[ Clone Inc. ]

Equipped with a new behavior architecture, Nadia navigates and traverses many types of doors autonomously. Nadia also demonstrates robustness to failed grasps and door opening attempts by automatically retrying and continuing. We present the robot with pull and push doors, four types of opening mechanisms, and even spring-loaded door closers. A deep neural network and door plane estimator allow Nadia to identify and track the doors.

[ Paper preprint by authors from Florida Institute for Human and Machine Cognition ]

Thanks, Duncan!

In this study, we integrate the musculoskeletal humanoid Musashi with the wire-driven robot CubiX, capable of connecting to the environment, to form CubiXMusashi. This combination addresses the shortcomings of traditional musculoskeletal humanoids and enables movements beyond the capabilities of other humanoids. CubiXMusashi connects to the environment with wires and drives by winding them, successfully achieving movements such as pull-up, rising from a lying pose, and mid-air kicking, which are difficult for Musashi alone.

[ CubiXMusashi, JSK Robotics Laboratory, University of Tokyo ]

Thanks, Shintaro!

An old boardwalk seems like a nightmare for any robot with flat feet.

[ Agility Robotics ]

This paper presents a novel learning-based control framework that uses keyframing to incorporate high-level objectives in natural locomotion for legged robots. These high-level objectives are specified as a variable number of partial or complete pose targets that are spaced arbitrarily in time. Our proposed framework utilizes a multi-critic reinforcement learning algorithm to effectively handle the mixture of dense and sparse rewards. In the experiments, the multi-critic method significantly reduces the effort of hyperparameter tuning compared to the standard single-critic alternative. Moreover, the proposed transformer-based architecture enables robots to anticipate future goals, which results in quantitative improvements in their ability to reach their targets.

[ Disney Research paper ]

Human-like walking where that human is the stompiest human to ever human its way through Humanville.

[ Engineai ]

We present the first static-obstacle avoidance method for quadrotors using just an onboard, monocular event camera. Quadrotors are capable of fast and agile flight in cluttered environments when piloted manually, but vision-based autonomous flight in unknown environments is difficult in part due to the sensor limitations of traditional onboard cameras. Event cameras, however, promise nearly zero motion blur and high dynamic range, but produce a large volume of events under significant ego-motion and further lack a continuous-time sensor model in simulation, making direct sim-to-real transfer not possible.

[ Paper University of Pennsylvania and University of Zurich ]

Cross-embodiment imitation learning enables policies trained on specific embodiments to transfer across different robots, unlocking the potential for large-scale imitation learning that is both cost-effective and highly reusable. This paper presents LEGATO, a cross-embodiment imitation learning framework for visuomotor skill transfer across varied kinematic morphologies. We introduce a handheld gripper that unifies action and observation spaces, allowing tasks to be defined consistently across robots.

[ LEGATO ]

The 2024 Xi’an Marathon has kicked off! STAR1, the general-purpose humanoid robot from Robot Era, joins runners in this ancient yet modern city for an exciting start!

[ Robot Era ]

In robotics, there are valuable lessons for students and mentors alike. Watch how the CyberKnights, a FIRST robotics team champion sponsored by RTX, with the encouragement of their RTX mentor, faced challenges after a poor performance and scrapped its robot to build a new one in just nine days.

[ CyberKnights ]

In this special video, PAL Robotics takes you behind the scenes of our 20th-anniversary celebration, a memorable gathering with industry leaders and visionaries from across robotics and technology. From inspiring speeches to milestone highlights, the event was a testament to our journey and the incredible partnerships that have shaped our path.

[ PAL Robotics ]

Thanks, Rugilė!

Last year, FDA advisers unanimously voted that oral phenylephrine is ineffective.

Susan Holt, who repeatedly emphasized her differences with the prime minister leading up to last month’s election, was on more welcoming terms Tuesday after their first official meeting in Fredericton.

The billionaire businessman has spent weeks campaigning relentlessly for Donald Trump. That dedication could lead to major benefits for him and his companies.

1. Have a protein-rich breakfast every day for these 7 benefits  Hindustan Times
2. 6 Protein-Packed Breakfast Without Eggs  HerZindagi
3. 8 High-Protein Indian Breakfast Recipes to Fuel Your Day  Recipes
4. Wholesome Indian breakfasts that boost energy  Business Insider India
5. 5 DIY Protein-Packed Snacks That You Can Replace Breakfast With  WION

1. Mohammed Shami's return date announced as Gautam Gambhir, Rohit Sharma heave huge sigh of relief ahead of BGT  Hindustan Times
2. "360 Days Is A...": Mohammed Shami Posts Picture From Airport. Ex-India Star Says "Brother..."  NDTV Sports
3. Live Cricket Update - GOA vs ARP Plate Group - Ranji Trophy blog: Round 5, day 1: Shami set for return in Indore  ESPNcricinfo
4. Mohammed Shami makes Ranji Trophy comeback, plays first match with brother Kaif for Bengal  The Indian Express
5. Ranji Trophy: Double delight for Mohammed Shami on comeback as brother Kaif named in Bengal playing XI ag  The Times of India

1. Best smartphones under ₹20,000 with good cameras: Redmi Note 13 Pro, Vivo T3 5G and others  Hindustan Times
2. Best smartphones under ₹30,000 with good battery life and cameras  Mint
3. 5 Affordable Camera Phones To Make Instagram Reels  Times Now
4. Best Smartphones Under Rs 20,000 With Excellent Cameras, Redmi Note 13 Pro, Vivo T3 5G & More  NewsX

1. Swiggy’s reclusive CEO Sriharsha Majety makes rare public appearance at IPO listing ceremony  Hindustan Times
2. Zomato gives ‘Jai and Veeru’ vibes with special meme for rival Swiggy on IPO day  Hindustan Times
3. JM Financial gives Swiggy its first 'buy' tag, sees 20% upside from IPO price  Moneycontrol
4. Swiggy IPO: 9 execs who will become richer by Rs 50 crore or more  The Times of India
5. ‘You and I…’: Zomato welcomes Swiggy on Dalal Street post stock market listing  India Today

1. Church of England head Justin Welby who married Prince Harry and Meghan Markle resigns over pedophile scandal  Hindustan Times
2. Archbishop of Canterbury, Trump critic Justin Welby resigns. What is the sex abuse scandal?  The Times of India
3. Video | UK Church Abuse Scandal: Head Of Church Of England Steps Down  NDTV
4. ‘Church in crisis’: what the papers say about the archbishop of Canterbury’s resignation  The Guardian
5. World News Today Live Updates on November 13, 2024 : Archbishop of Canterbury Justin Welby resigns amid sexual abuse case—Who is he? What's the scandal? All you need to know  Mint

1. RG Kar rape case: Bengal governor seeks report from CM after Sanjay Roy made big allegation against ex-Kolkata top cop  Hindustan Times
2. RG Kar rape case: Bengal Guv seeks report from Mamata govt after accused Sanjay Roy claims ‘Vineet Goel is threatening…’  Mint
3. Video | RG Kar Case News | Kolkata Horror: Prime Accused Sanjay Roy's 'Shocking Revelation' On Camera  NDTV
4. RG Kar rape-murder victim’s dad deposes on day 1 of trial  The Times of India
5. RG Kar case: CM Mamata asked to submit report on prime accused's claim  CNBCTV18

1. Jharkhand election 2024 live: Over 13% voter turnout in 43 seats till 9am  Hindustan Times
2. Jharkhand Election 2024 Live Updates: Former CM, BJP candidate Champai Soren casts vote  The Times of India
3. Vote to protect rights, strengthen Constitution: Rahul to Jharkhand voters  The Hindu
4. Jharkhand elections phase 1: NDA vs INDIA bloc face-off with crucial tribal votes in play  India Today
5. Think of forming inclusive government not one that divides: Kharge to voters  Deccan Herald

A quarter-century in, Eiichiro Oda’s sprawling Japanese pirate saga has transformed into an ever-evolving odyssey, spawning a multimedia franchise to rival its Western counterparts 

‘Singham Again’ had an ensemble cast which includes Ajay Devgn, Akshay Kumar, Ranveer Singh, Tiger Shroff, Kareena Kapoor Khan, Deepika Padukone, Arjun Kapoor and Jackie Shroff

Balatro from developer LocalThunk and publisher Playstack is finally coming to mobile later this month on iOS, Android, and also …

Continue reading "‘Balatro’ Is Coming to Apple Arcade and Also iOS as a Standalone Premium Release Beginning September 26th"

All-timer of a game show moment stunned audience into silence

Social distancing, shelter-in-place, lockdown, quarantine:  the global coronavirus outbreak has made these terms part of daily usage. Governments and health organisations across the world are recommending social distancing. It is ...

The post Social distancing need not mean social isolation appeared first on Star Observer.

What will Judge Merchan do this week?

Lahore, Pakistan (AFP) Nov 13, 2024
On the streets of Pakistan's second biggest city, smog stings eyes and burns throats. Inside homes, few people can afford air purifiers to limit the damage of toxic particles that seep through doors and windows. Lahore - a city of 14 million people stuffed with factories on the border with India - regularly ranks among the world's most polluted cities, but it has hit record levels this mon

Manu Prakash spoke with IEEE Spectrum shortly after returning to Stanford University from a month aboard a research vessel off the coast of California, where he was testing tools to monitor oceanic carbon sequestration. The associate professor conducts fieldwork around the world to better understand the problems he’s working on, as well as the communities that will be using his inventions.

Prakash develops imaging instruments and diagnostic tools, often for use in global health and environmental sciences. His devices typically cost radically less than conventional equipment—he aims for reductions of two or more orders of magnitude. Whether he’s working on pocketable microscopes, mosquito or plankton monitors, or an autonomous malaria diagnostic platform, Prakash always includes cost and access as key aspects of his engineering. He calls this philosophy “frugal science.”

Why should we think about science frugally?

Manu Prakash: To me, when we are trying to ask and solve problems and puzzles, it becomes important: In whose hands are we putting these solutions? A frugal approach to solving the problem is the difference between 1 percent of the population or billions of people having access to that solution.

Lack of access creates these kinds of barriers in people’s minds, where they think they can or cannot approach a kind of problem. It’s important that we as scientists or just citizens of this world create an environment that feels that anybody has a chance to make important inventions and discoveries if they put their heart to it. The entrance to all that is dependent on tools, but those tools are just inaccessible.

How did you first encounter the idea of “frugal science”?

Prakash: I grew up in India and lived with very little access to things. And I got my Ph.D. at MIT. I was thinking about this stark difference in worlds that I had seen and lived in, so when I started my lab, it was almost a commitment to [asking]: What does it mean when we make access one of the critical dimensions of exploration? So, I think a lot of the work I do is primarily driven by curiosity, but access brings another layer of intellectual curiosity.

How do you identify a problem that might benefit from frugal science?

Prakash: Frankly, it’s hard to find a problem that would not benefit from access. The question to ask is “Where are the neglected problems that we as a society have failed to tackle?” We do a lot of work in diagnostics. A lot [of our solutions] beat the conventional methods that are neither cost effective nor any good. It’s not about cutting corners; it’s about deeply understanding the problem—better solutions at a fraction of the cost. It does require invention. For that order of magnitude change, you really have to start fresh.

Where does your involvement with an invention end?

Prakash: Inventions are part of our soul. Your involvement never ends. I just designed the 415th version of Foldscope [a low-cost “origami” microscope]. People only know it as version 3. We created Foldscope a long time ago; then I realized that nobody was going to provide access to it. So we went back and invented the manufacturing process for Foldscope to scale it. We made the first 100,000 Foldscopes in the lab, which led to millions of Foldscopes being deployed.

So it’s continuous. If people are scared of this, they should never invent anything [laughs], because once you invent something, it’s a lifelong project. You don’t put it aside; the project doesn’t put you aside. You can try to, but that’s not really possible if your heart is in it. You always see problems. Nothing is ever perfect. That can be ever consuming. It’s hard. I don’t want to minimize this process in any way or form.

The FDA has proposed removing oral phenylephrine from its guidelines for over-the-counter drugs due to inefficacy as a decongestant. Use of this ingredient in cold and allergy medicines grew after a federal law required that pseudoephedrine-containing products be kept behind pharmacy counters.

The post FDA Takes Step Toward Removal of Ineffective Decongestants From the Market appeared first on MedCity News.

Technology has revolutionized the way people live their lives. Individuals can use smartphones to access their bank account, shop from almost any store, and connect with friends and family around the globe. In fact, these personal devices have tethered communities together during the coronavirus pandemic, allowing many people to maintain much of their lives remotely.

This SAS Usage Note illustrates fitting a model containing a spline effect in PROC GLIMMIX. It discusses the spline basis output, the interpretation of the output, how to use the spline model to make predictions, and how to use the LSMEANS and ESTIMATE statements to compute quantities of interest.