Are the two offensive tackles who will start for the Broncos in 2021 on the current roster? It seems increasingly unlikely.

When FanDuel asked, Will the Broncos Make the Playoffs?, 97% of the weekend action among Colorado bettors was on “Yes.” These days, if you can’t trust your heart, trust your gut.

No sooner had Broncos coach Vic Fangio walked over to the deep end of the pool when NFL Commissioner Roger Goodell ran over, unseen, and shoved him straight into the water.

The rapper has the best sneaker game in the world.

There are thousands of Swarovski crystals involved.

The duo take on Mexican fare on Cooking With Kylie.

Wait 'till you see the newest in their impressive fleet.

Many airports undertake stormwater projects to accommodate facility expansion, address obsolescence, and respond to evolving regulatory requirements. Often, stormwater infrastructure is installed or upgraded on a project-by-project and piecemeal basis, resulting in mismatches of sizes, material types, ages, and conditions. When airports are considering expanding or improving their stormwater facilities, the immediate need for stormwater infrastructure modification may not be clear, and a benefit–cost ana...

TRB’s Airport Cooperative Research Program (ACRP) Research Report 199: Climate Resilience and Benefit–Cost Analysis: A Handbook for Airports provides information on how to apply benefit–cost analysis tools and techniques to improve decision making affecting resilience of airport infrastructure projects in response to potential long-term impacts of climate change and extreme weather events. The handbook is designed to improve the process by which infrastructure investment strategies are evaluated, with an...

Many airports undertake stormwater projects to accommodate facility expansion, address obsolescence, and respond to evolving regulatory requirements. Often, stormwater infrastructure is installed or upgraded on a project-by-project and piecemeal basis, resulting in mismatches of sizes, material types, ages, and conditions. When airports are considering expanding or improving their stormwater facilities, the immediate need for stormwater infrastructure modification may not be clear, and a benefit–cost ana...

TRB’s Airport Cooperative Research Program (ACRP) Synthesis 21: Airport Energy Efficiency and Cost Reduction explores energy efficiency improvements being implemented at airports across the country that are low cost and short payback.

Use of Surface Treatments to Extend Pavement Life: A Case Study on US 301, Sussex County, Virginia , released by the Virginia Department of Transportation

Cosappzsearch.online redirect removal instructions

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Cosappzsearch.online is a useless, fake search engine. As a rule, such search engines are promoted through potentially unwanted applications (PUAs), browser hijackers. Apps of this type promote fake search engines by changing certain browser's settings. It is common that they gather browsing data and/or other information as well. Quite often users download and install potentially unwanted apps unknowingly, accidentally.

Scientists published the first assessment of the impact that invasive hippos imported by drug lord Pablo Escobar are having on Colombian aquatic ecosystems. The hippos are changing the area's water quality by importing large amounts of nutrients and organic material from the surrounding landscape.

This dinner recipe has become my new favorite! It's easy, fast and tastes as great as the local taqueria!

craving more? check out TasteSpotting

BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would have inferior storage quality for transfusion as compared with G6PD-normal RBCs.METHODS Male volunteers were screened for G6PD deficiency; 27 control and 10 G6PD-deficient volunteers each donated 1 RBC unit. After 42 days of refrigerated storage, autologous 51-chromium 24-hour posttransfusion RBC recovery (PTR) studies were performed. Metabolomics analyses of these RBC units were also performed.RESULTS The mean 24-hour PTR for G6PD-deficient subjects was 78.5% ± 8.4% (mean ± SD), which was significantly lower than that for G6PD-normal RBCs (85.3% ± 3.2%; P = 0.0009). None of the G6PD-normal volunteers (0/27) and 3 G6PD-deficient volunteers (3/10) had PTR results below 75%, a key FDA acceptability criterion for stored donor RBCs. As expected, fresh G6PD-deficient RBCs demonstrated defects in the oxidative phase of the pentose phosphate pathway. During refrigerated storage, G6PD-deficient RBCs demonstrated increased glycolysis, impaired glutathione homeostasis, and increased purine oxidation, as compared with G6PD-normal RBCs. In addition, there were significant correlations between PTR and specific metabolites in these pathways.CONCLUSION Based on current FDA criteria, RBCs from G6PD-deficient donors would not meet the requirements for storage quality. Metabolomics assessment identified markers of PTR and G6PD deficiency (e.g., pyruvate/lactate ratios), along with potential compensatory pathways that could be leveraged to ameliorate the metabolic needs of G6PD-deficient RBCs.TRIAL REGISTRATION ClinicalTrials.gov NCT04081272.FUNDING The Harold Amos Medical Faculty Development Program, Robert Wood Johnson Foundation grant 71590, the National Blood Foundation, NIH grant UL1 TR000040, the Webb-Waring Early Career Award 2017 by the Boettcher Foundation, and National Heart, Lung, and Blood Institute grants R01HL14644 and R01HL148151.

Brown and beige adipose tissues contain thermogenic fat cells that can be activated by β3-adrenergic receptor agonists. In rodents, such drugs both diminish obesity and improve glucose homeostasis. In this issue of the JCI, O’Mara et al. and Finlin and Memetimin et al. report that chronic administration of the approved β3 agonist mirabegron to human subjects was without effect on body weight or fat mass, but improved several measures of glucose homeostasis. Though the mechanisms mediating these metabolic effects are uncertain, the data suggest that β3 agonists could have therapeutic utility in disorders of glucose homeostasis.

BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial changes in fat and muscle and improve metabolic homeostasis.METHODS Before and after β3-AR agonist treatment, oral glucose tolerance tests and euglycemic clamps were performed, and histochemical analysis and gene expression profiling were performed on fat and muscle biopsies. PET-CT scans quantified brown adipose tissue volume and activity, and we conducted in vitro studies with primary cultures of differentiated human adipocytes and muscle.RESULTS The clinical effects of mirabegron treatment included improved oral glucose tolerance (P < 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. In skeletal muscle, mirabegron reduced triglycerides, increased the expression of PPARγ coactivator 1 α (PGC1A) (P < 0.05), and increased type I fibers (P < 0.01). Conditioned media from adipocytes treated with mirabegron stimulated muscle fiber PGC1A expression in vitro (P < 0.001).CONCLUSION Mirabegron treatment substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans. Since β cells and skeletal muscle do not express β3-ARs, these data suggest that the beiging of SC WAT by mirabegron reduces adipose tissue dysfunction, which enhances muscle oxidative capacity and improves β cell function.TRIAL REGISTRATION Clinicaltrials.gov NCT02919176.FUNDING NIH: DK112282, P30GM127211, DK 71349, and Clinical and Translational science Awards (CTSA) grant UL1TR001998.

Apple's rumored high-end over-ear headphones may be called "AirPods Studio" and retail for $349, according to Jon Prosser of YouTube channel Front Page Tech.


In keeping with the successful ‌AirPods‌ brand, the rumored "Studio" over-ear headphones would significantly diversify Apple's ‌AirPods‌ lineup, which last added the in-ear AirPods Pro in October 2019. The supposed price of $349 would place "‌AirPods‌ Studio" as a direct competitor to high-end noise-canceling over-ear headphones from Bose and Sony.

William Brighenti, who founded the Berlin Property Owners Association, argued that the town can’t afford a new police headquarters, and police should look to clear space in their current building. He thinks one way to accomplish this is to get rid of tactical gear. Continue reading →

Eyewitness News has learned that the Berlin High School football recruiting scandal may have cost Berlin taxpayers tens of thousands of dollars. Continue reading →

IBM Security today announced the results of a global study exploring the implications and effects of data breaches on today’s businesses. Sponsored by IBM Security and conducted by Ponemon Institute, the study found that the average cost of a data breach is $3.62 million globally , a 10 percent decline from 2016 results. This is the first time since the global study was created that there has been an overall decrease in the cost. According to the study, these data breaches cost companies $141 per lost or stolen record on average

While I usually stick to halloween costumes, I couldn't resist the temptation to hitch onto the Fidget Spinner fad before it flames out. Also, I wanted to make a costume that spins!

IBM announced today two significant quantum processor upgrades for its IBM Q early-access commercial systems. These upgrades represent rapid advances in quantum hardware as IBM continues to drive progress across the entire quantum computing technology stack, with focus on systems, software, applications and enablement.

IBM today announced sweeping advances in its all-flash storage solutions and software to significantly drive down the costs of data and extend its solutions for hybrid and private cloud environments.

IBM Security anunció hoy los resultados de un estudio global que examina el impacto financiero de una violación de datos en los resultados de una empresa. El estudio descubrió que los costos ocultos en las brechas de datos, como la pérdida de negocios, el impacto negativo en la reputación y el tiempo empleado en la recuperación, son difíciles y costosos de administrar. Por ejemplo, encontró que un tercio del costo de las mega infracciones (más de 1 millón de registros perdidos) se derivan del negocio perdido.

IBM (NYSE: IBM) today announced that Queensland Sugar Limited (QSL), a global leader in raw sugar marketing that manages over 90 percent of Australia’s raw sugar exports, has selected IBM advanced storage systems to support rapidly growing data demands.

Today IBM announced the Australian results of the global 2017 Ponemon Cost of Data Breach report.

IBM today announced that Victoria University has selected IBM to design and build the university’s first green data centre.

The solution is not to scold drivers but to make structural solutions.

  I must confess: I was tempted to write a column along the lines of “Yes, it’s a war on the car, and it’s a just war!” But we don’t need a war on the car. What we need is an intervention. We need a serious conversation about our collective, structural addiction to this substance, […]

The post Our addiction to driving is costing lives, and more appeared first on Torontoist.

White males make up the largest sector of the U.S. workforce and have, on average, always made the highest salaries. If we compare their salaries to those of women, ethnic minorities, the differently-abled, and LGBTQ+ persons, we see a large disparity between the wages of similarly-qualified candidates in the same fields. The gap is glaring, […]

The post Race, Gender, and LGBTQ+ wage gaps are real – and they end up costing us all appeared first on DiversityJobs.com.

Explores how the Institute for Research and Innovation in Social Services (IRISS) promotes the delivery of cost effective social services in Scotland that will support the achievement of positive outcomes for people accessing support. It identifies a number of principles that underpin the work of IRISS and suggests how these facilitate innovative evidence-informed practice. The approach to evidence-informed practice comprises four pillars of activity. The first pillar focuses on improving awareness and access to evidence and is exemplified by the Learning Exchange, the IRISS Insights series, and audio and video recording. The second pillar refers to strengthening the evidence base and is discussed in the context of work on self-directed support. Improving skills and confidence to use evidence forms the third pillar and is represented by work on data visualisation and peer support for self-evaluation. The final pillar is embedding evidence in organisations, through co-production, creating spaces to test and challenge evidence, and through the development of evidence-based products. Supporting people to share knowledge, learn from each other and to collectively produce new knowledge and solutions is an innovative approach but also one which should be cost-effective. Pre-print. Published in Evidence and Policy, 2014 (10)4 as Embedding research into practice through innovation and creativity: a case study from social services

I get it:  We all must vote by mail—or we die. 
There is really no other safe choice. But there is much to fear, with a switch to all-mail voting—unless our broken absentee ballot system is fixed. Here’s what the “Go Postal” crowd doesn’t tell you

The post Rush to Vote-by-Mail could cost Dems the Election<div id='sec-title'>Mail-in Voting puts Millions of Minority Ballots at Risk</div> appeared first on Greg Palast.

Costa Rican architectural firm Gussa has unveiled a peaceful eco-lodge located on the country's beautiful Caribbean coastline. Esquina Verde is a cozy rental accommodation made out of locally sourced materials and reclaimed wood salvaged from a 100-year-old home. Surrounded by lush vegetation and native wildlife, the lodge's multiple hammocks that hang from the thatched roofs make it an idyllic place to disconnect.[...]

When Ed and Leigh approached Colorado-based architecture firm F9 Productions to design their custom Rocky Mountain home, the couple wanted a residence that could last well into the future. This meant that the forever home not only had to be engineered with ADA-compliant features, but it also needed to be robust enough to weather the region’s extreme winter conditions for years to come. As a result, the architects crafted the Eastwatch House, a highly durable home that also takes advantage of passive solar conditions to reduce energy demands.[...]

As there have been countless cases of Zoombombing in the recent weeks, the security in the video conferencing platform Zoom has been doubted by its users. In response to this, Zoom finally announced on Thursday that they will be implementing and offering end-to-end encryption.

With the acquisition of Keybase, a New York-based startup specializing in encrypted messaging and cloud services, Zoom will finally be able to make good on its claims of offering end-to-end encryption.

“We are excited to integrate Keybase’s team into the Zoom family to help us build end-to-end encryption that can reach current Zoom scalability,” CEO Eric Yuan said in a Zoom blog post on Thursday.

Unfortunately, not all Zoom users will benefit from the company’s new move, as the end-to-end encryption feature will only be available to users who have paid plans (which start at $14.99/month, by the way) on the video conferencing platform.

If a meeting’s host has enabled this feature, participants will be barred from joining by phone and cloud-based recording will be disabled. In Thursday’s blog post, Yuan emphasized that the feature will not store the encryption key on Zoom’s servers, so the company will not be able to see any part of the call.

What are your thoughts about this one?

(Image Credit: Zoom/ Wikimedia Commons)

Warmed tortillas filled tender carne guisada, tangy onions, cheese, cilantro and a splash of lime juice! Today’s recipe is a quick one using the carne guisada (that I recently shared) in tacos; perfect for Cinco de Mayo! I like to eat the carne guisada as a chili or stew but it’s also great in tacos!...

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The post Carne Guisada Tacos appeared first on Closet Cooking.