Targeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only now beginning to be mechanistically explored. In this review, we focus on two recently appreciated cannabinoid-based targeting strategies, treatments with cannabidiol (CBD) and α/β-hydrolase domain containing 6 (ABHD6) inhibitors, which have the exciting potential to produce pain relief through distinct mechanisms of action and without intoxication. We review evidence on plant-derived cannabinoids for pain, with an emphasis on CBD and its multiple molecular targets expressed in pain pathways. We also discuss the function of eCB signaling in regulating pain responses and the therapeutic promises of inhibitors targeting ABHD6, a 2-arachidonoylglycerol (2-AG)-hydrolyzing enzyme. Finally, we discuss how the novel cannabinoid biosensor GRAB_eCB2.0 may be leveraged to enable the discovery of targets modulated by cannabinoids at a circuit-specific level.

The National Center for Complementary and Integrative Health (NCCIH), which is part of the US National Institutes of Health (NIH), has a broad interest in studying the biologic activities of natural products, especially those for which compelling evidence from preclinical research suggests biologic activities that may be beneficial to health or have a potential role in disease treatment, as well as products used extensively by the American public. As of 2023, use of cannabis for medical purposes is legal in 38 states and Washington, D.C. Such use continues to climb generally without sufficient knowledge regarding risks and benefits. In keeping with NCCIH’s natural product research priorities and recognizing this gap in knowledge, NCCIH formally launched a research program in 2019 to expand research on the possible benefits for pain management of certain substances found in cannabis: minor cannabinoids and terpenes. This Viewpoint provides additional details and the rationale for this research priority at NCCIH. In addition, NCCIH’s efforts and initiatives to facilitate and coordinate an NIH research agenda focused on cannabis and cannabinoid research are described.

Cannabis and its products have been used for centuries for both medicinal and recreational purposes. The recent widespread legalization of cannabis has vastly expanded its use in the United States across all demographics except for adolescents. Meanwhile, decades of research have advanced our knowledge of cannabis pharmacology and particularly of the endocannabinoid system with which the components of cannabis interact. This research has revealed multiple targets and approaches for manipulating the system for therapeutic use and to ameliorate cannabis toxicity or cannabis use disorder. Research has also led to new questions that underscore the potential risks of its widespread use, particularly the enduring consequences of exposure during critical windows of brain development or for consumption of large daily doses of cannabis with high content ⁹-tetrahydrocannabinol. This article highlights current neuroscience research on cannabis that has shed light on therapeutic opportunities and potential adverse consequences of misuse and points to gaps in knowledge that can guide future research.

gp130 functions as a shared signal-transducing subunit not only for interleukin (IL)-6 but also for eight other human cytokine receptor complexes. The IL-6 signaling pathway mediated through gp130 encompasses classical, trans, or cluster signaling, intricately regulated by a diverse array of modulators affecting IL-6, its receptor, and gp130. Currently, only a limited number of small molecule antagonists and agonists for gp130 are known. This review aims to comprehensively examine the current knowledge of these modulators and provide insights into their pharmacological properties, particularly in the context of cancer and other diseases. Notably, the prominent gp130 modulators SC144, bazedoxifene, and raloxifene are discussed in detail, with a specific focus on the discovery of SC144’s iron-chelating properties. This adds a new dimension to the understanding of its pharmacological effects and therapeutic potential in conditions where iron homeostasis is significant. Our bioinformatic analysis of gp130 and genes related to iron homeostasis reveals insightful correlations, implicating the role of iron in the gp130 signaling pathway. Overall, this review contributes to the evolving understanding of gp130 modulation and its potential therapeutic applications in various disease contexts.

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile acids generates bile flow and facilitates biliary secretion of lipids, endogenous metabolites, and xenobiotics. In intestine, bile acids facilitate the digestion and absorption of dietary lipids and fat-soluble vitamins. Through activation of nuclear receptors and G protein-coupled receptors and interaction with gut microbiome, bile acids critically regulate host metabolism and innate and adaptive immunity and are involved in the pathogenesis of cholestasis, metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, type-2 diabetes, and inflammatory bowel diseases. Bile acids and their derivatives have been developed as potential therapeutic agents for treating chronic metabolic and inflammatory liver diseases and gastrointestinal disorders.

Nitric oxide (NO) from endothelial NO synthase importantly contributes to vascular homeostasis. Reduced NO production or increased scavenging during disease conditions with oxidative stress contribute to endothelial dysfunction and NO deficiency. In addition to the classical enzymatic NO synthases (NOS) system, NO can also be generated via the nitrate-nitrite-NO pathway. Dietary and pharmacological approaches aimed at increasing NO bioactivity, especially in the cardiovascular system, have been the focus of much research since the discovery of this small gaseous signaling molecule. Despite wide appreciation of the biological role of NOS/NO signaling, questions still remain about the chemical nature of NOS-derived bioactivity. Recent studies show that NO-like bioactivity can be efficiently transduced by mobile NO-ferroheme species, which can transfer between proteins, partition into a hydrophobic phase, and directly activate the soluble guanylyl cyclase-cGMP-protein kinase G pathway without intermediacy of free NO. Moreover, interaction between red blood cells and the endothelium in the regulation of vascular NO homeostasis have gained much attention, especially in conditions with cardiometabolic disease. In this review we discuss both classical and nonclassical pathways for NO generation in the cardiovascular system and how these can be modulated for therapeutic purposes.

Vision is initiated by capturing photons in highly specialized sensory cilia known as the photoreceptor outer segment. Because of its lipid and protein composition, the outer segments are prone to photo-oxidation, requiring photoreceptors to have robust antioxidant defenses and high metabolic synthesis rates to regenerate the outer segments every 10 days. Both processes required high levels of glucose uptake and utilization. Retinitis pigmentosa is a prevalent form of inherited retinal degeneration characterized by initial loss of low-light vision caused by the death of rod photoreceptors. In this disease, rods die as a direct effect of an inherited mutation. Following the loss of rods, cones eventually degenerate, resulting in complete blindness. The progression of vision loss in retinitis pigmentosa suggested that rod photoreceptors were necessary to maintain healthy cones. We identified a protein secreted by rods that functions to promote cone survival, and we named it rod-derived cone viability factor (RdCVF). RdCVF is encoded by an alternative splice product of the nucleoredoxin-like 1 (NXNL1) gene, and RdCVF was found to accelerate the uptake of glucose by cones. Without RdCVF, cones eventually die because of compromised glucose uptake and utilization. The NXNL1 gene also encodes for the thioredoxin RdCVFL, which reduces cysteines in photoreceptor proteins that are oxidized, providing a defense against radical oxygen species. We will review here the main steps of discovering this novel intercellular signaling currently under translation as a broad-spectrum treatment for retinitis pigmentosa.

A radio signal detected in 1977, sometimes claimed as evidence for aliens, may have been caused by a laser-like beam of microwave radiation

A computer simulation suggests that some collisions between exotic, hypothetical stars would make space-time ripple with detectable waves

Electromagnetic radiation leaking from the cable between your computer and monitor can be intercepted and decoded by AI to reveal what you are looking at

Like many innovators, Hagit Messer-Yaron had a life-changing idea while doing something mundane: Talking with a colleague over a cup of coffee. The IEEE Life Fellow, who in 2006 was head of Tel Aviv University’s Porter School of Environmental Studies, was at the school’s cafeteria with a meteorological researcher. He shared his struggles with finding high-resolution weather data for his climate models, which are used to forecast and track flash floods.

Predicting floods is crucial for quickly evacuating residents in affected areas and protecting homes and businesses against damage.

Hagit Messer-Yaron

Employer Tel Aviv University

Title Professor emerita

Member grade Life Fellow

Her colleague “said researchers in the field had limited measurements because the equipment meteorologists used to collect weather data—including radar satellites—is expensive to purchase and maintain, especially in developing countries,” Messer-Yaron says.

Because of that, she says, high-resolution data about temperature, air quality, wind speed, and precipitation levels is often inconsistent—which is a problem when trying to produce accurate models and predictions.

An expert in signal processing and cellular communication, Messer-Yaron came up with the idea of using existing wireless communication signals to collect weather data, as communication networks are spread across the globe.

In 2006 she and her research team developed algorithms that process and analyze data collected by communication networks to monitor rainfall. They measure the difference in amplitude of the signals transmitted and received by the systems to extract data needed to predict flash floods.

The method was first demonstrated in Israel. Messer-Yaron is working to integrate it into communication networks worldwide.

For her work, she received this year’s IEEE Medal for Environmental and Safety Technologies for “contributions to sensing of the environment using wireless communication networks.” The award is sponsored by Toyota.

“Receiving an IEEE medal, which is the highest-level award you can get within the organization, was really a surprise, and I was extremely happy to [receive] it,” she says. “I was proud that IEEE was able to evaluate and see the potential in our technology for public good and to reward it.”

A passion for teaching

Growing up in Israel, Messer-Yaron was interested in art, literature, and science. When it came time to choose a career, she found it difficult to decide, she says. Ultimately, she chose electrical engineering, figuring it would be easier to enjoy art and literature as hobbies.

After completing her mandatory service in the Israel Defense Forces in 1973, she began her undergraduate studies at Tel Aviv University, where she found her passion: Signal processing.

“Electrical engineering is a very broad topic,” she says. “As an undergrad, you learn all the parts that make up electrical engineering, including applied physics and applied mathematics. I really enjoyed applied mathematics and soon discovered signal processing. I found it quite amazing how, by using algorithms, you can direct signals to extract information.”

She graduated with a bachelor’s degree in EE in 1977 and continued her education there, earning master’s and doctoral degrees in 1979 and 1984. She moved to the United States for a postdoctoral position at Yale. There she worked with IEEE Life Fellow Peter Schultheiss, who was known for his research in using sensor array systems in underwater acoustics.

Inspired by Schultheiss’s passion for teaching, Messer-Yaron decided to pursue a career in academia. She was hired by Tel Aviv University as an electrical engineering professor in 1986. She was the first woman in Israel to become a full professor in the subject.

“Being a faculty member at a public university is the best job you can do. I didn’t make a lot of money, but at the end of each day, I looked back at what I did [with pride].”

For the next 14 years, she conducted research in statistical signal processing, time-delay estimation, and sensor array processing.

Her passion for teaching took her around the world as a visiting professor at Yale, the New Jersey Institute of Technology, the Institut Polytechnique de Paris, and other schools. She collaborated with colleagues from the universities on research projects.

In 1999 she was promoted to director of Tel Aviv University’s undergraduate electrical engineering program.

A year later, she was offered an opportunity she couldn’t refuse: Serving as chief scientist for the Israeli Ministry of Science, Culture, and Sports. She took a sabbatical from teaching and for the next three years oversaw the country’s science policy.

“I believe [working in the public sector] is part of our duty as faculty members, especially in public universities, because that makes you a public intellectual,” she says. “Working for the government gave me a broad view of many things that you don’t see as a professor, even in a large university.”

When she returned to the university in 2004, Messer-Yaron was appointed as the director of the new school of environmental studies. She oversaw the allocation of research funding and spoke with researchers individually to better understand their needs. After having coffee with one researcher, she realized there was a need to develop better weather-monitoring technology.

Hagit Messer-Yaron proudly displays her IEEE Medal for Environmental and Safety Technologies at this year’s IEEE Honors Ceremony. She is accompanied by IEEE President-Elect Kathleen Kramer and IEEE President Tom Couglin.Robb Cohen

Using signal processing to monitor weather

Because the planet is warming, the risk of flash floods is steadily increasing. Warmer air holds more water—which leads to heavier-than-usual rainfall and results in more flooding, according to the U.S. Environmental Protection Agency.

Data about rainfall is typically collected by satellite radar and ground-based rain gauges. However, radar images don’t provide researchers with precise readings of what’s happening on the ground, according to an Ensia article. Rain gauges are accurate but provide data from small areas only.

So Messer-Yaron set her sights on developing technology that connects to cellular networks close to the ground to provide more accurate measurements, she says. Using existing infrastructure eliminates the need to build new weather radars and weather stations.

Communication systems automatically record the transmitted signal level and the received signal level, but rain can alter otherwise smooth wave patterns. By measuring the difference in the amplitude, meteorologists could extract the data necessary to track rainfall using the signal processing algorithms.

In 2005 Messer-Yaron and her group successfully tested the technology. The following year, their “Environmental Monitoring by Wireless Communication Networks” paper was published in Science.

The algorithm is being used in Israel in partnership with all three of the country’s major cellular service providers. Messer-Yaron acknowledges, however, that negotiating deals with cellular service companies in other countries has been difficult.

To expand the technology’s use worldwide, Messer-Yaron launched a research network through the European Cooperation in Science and Technology (COST), called an opportunistic precipitation sensing network known as OPENSENSE. The group connects researchers, meteorologists, and other experts around the world to collaborate on integrating the technology in members’ communities.

Monitoring the effects of climate change

Since developing the technology, Messer-Yaron has held a number of jobs including president of the Open University of Israel and vice chair of the country’s Council for Higher Education, which accredits academic institutions.

She is maintaining her link with Tel Aviv University today as a professor emerita.

“Being a faculty member at a public university is the best job you can do,” she says. “I didn’t make a lot of money, but at the end of each day, I looked back at what I did [with pride]. Because of the academic freedom and the autonomy I had, I was able to do many things in addition to teaching, including research.”

To continue her work in developing technology to monitor weather events, in 2016, she helped found ClimaCell, now Tomorrow.io, based in Boston. The startup aims to use wireless communication infrastructure and IoT devices to collect real-time weather data. Messer-Yaron served as its chief scientist until 2017.

She continues to update the original algorithms with her students, most recently with machine learning capabilities to extract data from physical measurements of the signal level in communication networks.

A global engineering community

When Messer-Yaron was an undergraduate student, she joined IEEE at the suggestion of one of her professors.

“I didn’t think much about the benefits of being a member until I became a graduate student,” she says. “I started attending conferences and publishing papers in IEEE journals, and the organization became my professional community.”

She is an active volunteer and a member of the IEEE Signal Processing Society. From 1994 to 2010 she served on the society’s Signal Processing Theory and Methods technical committee. She was associate editor of IEEE Signal Processing Letters and IEEE Transactions on Signal Processing. She is a member of the editorial boards of the IEEE Journal of Selected Topics in Signal Processing and IEEE Transactions on Signal Processing.

In the past 10 years, she’s been involved with other IEEE committees including the conduct review, ethics and member conduct, and global public policy bodies.

“I don’t see my career or my professional life without the IEEE,” she says

Signal decoders are vital components in radio broadcasting. Without them, the transmission and reception of clear audio or data would be impossible. They take what is essentially noise and turn it into coherent, useful information. Having worked with radio broadcasting systems for some time, I’ve seen firsthand how essential decoders are to maintaining communication networks. […]

The post How Signal Decoders Are Used in Radio Broadcasting appeared first on Chart Attack.

Signal users may be familiar with the problem of creating group chats just for a group call, but that’s about to become a thing of the past. You can now share a call link and let up to 50 people hop in, all in the span of a few seconds. The days of selecting contacts one by one are over.

Now, all you have to do is create a call link after going to the Calls tab and send it to whomever you want. The link is also reusable, which is convenient if you have fixed call times. Participants can raise their hands and send emojis. Hosts can set the room up so people must be approved before joining the conversation.

Based on Signal’s blog post, the new group call experience highly resembles Zoom. Those interested in privacy yet desire a conference call-like experience may find the new update helpful. Like Zoom, the desktop app offers more options.

Besides Zoom, these features will be familiar to frequent users of Microsoft Teams, Google Meet and some WhatsApp users. Raising hands is found on all three platforms as a non-verbal way to signal the speaker. WhatsApp does have a lower participant count of 32 people after an update in June. While there’s no raise hands function, doing certain gestures can send emojis for all to see. It’s worth noting that many apps with group call functionality are adopting similar features.

These new features are available on Android, iOS, Windows and macOS. If you don’t see them yet, we recommend updating your Signal app.

London, UK (SPX) Nov 13, 2024
Mangrove forests in the Maldives are facing a severe threat as they succumb to rising sea levels and climate changes, according to a new study led by Northumbria University researchers and published in *Scientific Reports*. The study highlights that the Maldives, known for its low-lying islands, experienced significant mangrove dieback since 2020 due to rapid sea-level rise and the effects

medlinkCancer/medlink-causing mutations in prostate cancer hyperactivate PI3K signaling, leading to cancer cell growth. PLEKHS1, a largely unknown

A groundbreaking 3 medlinkmalaria vaccine/medlink (!--ref1--) is set to be administered to African babies, potentially paving the way for eradicating the disease within a decade.

More than 30% of adults globally suffer from hypertension, a major controllable risk factor for medlinkcardiovascular disease/medlink and mortality.

A variant of avian flu virus, commonly found in Chinese poultry farms, is undergoing mutations that raise concerns about potential human transmission,

Researchers have identified changes in the gut microbiome makeup that lead to the onset of rheumatoid arthritis, providing a window of opportunity for targeted treatments.

MobileCoin, the startup known for building Signal’s crypto payments feature, has appointed a new CEO as it works on expanding its encrypted money transfer service to global users in need of a more modern remittance solution. Sara Drakeley is taking the helm as MobileCoin’s new chief executive officer. Replacing her previous role as the firm’s […]

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To temper elevated inflation, Federal Reserve Chairman Jerome Powell said the central bank intends to raise short-term interest rates in mid-March. Photo: Federal Reserve

Shiba Inu Coin’s recent surge, and subsequent fall in value, is part of a growing trend of meme coins that are rivaling some of the largest digital tokens in the world. WSJ retail investing reporter Caitlin McCabe explains why investors are pouring money into this meme based cryptocurrency. Photo: Amber Bragdon/Getty Images

Our planet is full of the unknown. Time and again we have seen instances which are baffling. In an unprecedented event, a peculiar seismic phenomenon resonated around the planet for an astonishing nine-day period. Scientists initially thought it was produced by

San Francisco officials said they would investigate Twitter after six former employees alleged that the company broke laws by turning its headquarters into a ‘Twitter Hotel’

The Indian IT sector, while traditionally emphasising cost-effective outsourcing, is gradually evolving to enhance RPE and profitability through investments in upskilling and digital innovation

Executive Chairman of Signal Technology Foundation Brian Acton spoke with WIRED's Steven Levy as part of WIRED25, WIRED's second annual conference.

Housing, infrastructure, roads and transport get massive benefits, says K. Sukumaran

If resetting your router or perhaps installing DD-WRT hasn’t helped to fix spotty Wi-Fi, you need a booster. This device sucks the current Wi fi signal, amplifies it, and rebroadcasts the signals on its own network, supplying you with a stronger connection to http://lunchboxguitars.com/what-are-the-best-ransomware-protection-tools all of your devices. A enhancer is a good approach to […]

The impact of the turnout remains to be seen

OneSignal has evolved over the years. We started out as a gaming company and learned about the importance of engaging and retaining customers. Then we pivoted to become the biggest push notification service for developers. Today we’re the market-leading customer engagement solution for marketers, product teams, and developers.

Our previous logo did a great job of representing our brand in our early startup days. Since then, we’ve grown to serve over a million businesses, and we felt it was time to give our logo a modern update.

See The Logo

Demand to appoint trained technician for the job; standardised operation of the whole signal network for the urban area sought

National Bureau of Economic Research