Clinical functional proteomics of intercellular signalling in pancreatic cancer  Nature.com

ISLAMABAD: Following a disruption that rendered virtual private networks (VPNs) dysfunctional across the country, the Pakistan Telecommunication Authority (PTA) on Wednesday said that VPN usage would be restricted in the future to curb access to pornographic content.

In a statement, the authority claimed it had so far blocked 100,183 URLs containing blasphemous content, as well as 844,008 pornographic websites.

The statement by PTA highlighting its performance came a day after the Ministry of Religious Affairs and Interfaith Harmony wrote to the regulator to ask it to block blasphemous and pornographic content.

“In addition to PTA’s proactive efforts, individuals and government organisations also report such sites,” the statement added.

The telecom regulator also claimed that approximately 20 million attempts were made from within the country to access pornographic websites on a daily basis, which were blocked at the international gateway level.

“However, users bypass restrictions via VPNs and access porn contents, PTA remains fully committed to curbing this issue, taking all necessary measures to block this content effectively,” the statement added.

In another statement, the telecom regulator said it had organised a consultation on the issue of VPN use, attended by representatives from the Ministry of IT & Telecommunication (MoIT&T), the Pakistan Software Export Board (PSEB), and the Pakistan Software Houses Association (P@SHA).

“The PTA introduced a stre­amlined VPN registration process, allowing legitimate users to register their VPNs through a new online portal at ipregistration.pta.gov.pk,” the statement said.

However, a senior executive from an internet service provider — in response to a Dawn query — said the authority was “making excuses”.

“How would they know that people are watching porn through VPNs? They have no capability to [monitor traffic through] VPNs, otherwise they would not block it,” the executive said.

He said the main target was blocking access to X and other social media platforms.

Published in Dawn, November 14th, 2024

А вот это неиллюзорно шедевр
https://www.youtube.com/watch?v=pP4Cct_1di8
Steve Brenner - Signals (1985) [full album]
https://stevebrenner.bandcamp.com/album/s-i-g-n-a-l-s

Типа имитация Tangerine Dream синхронного периода,
но сильно лучше, чем все, что они сделали после 1984,
причем записано (в домашней студии, насколько я понимаю)
на порядок чище и яснее, чем TD писали, со всеми их сотнями
тысяч долларов, вбуханных в аппаратуру.

Я долго тыкался в биографию автора, пытаясь выяснить,
1985 это не мистификация ли, так и не понял. В принципе,
что сейчас подобной ретрофутуристической музыки пишут
очень много, с реверансами в сторону 1970-х и 1980-х,
лепят на альбом фальшивую датировку, и выкладывают на ютюб,
зарабатывая миллионы прослушиваний.

Вообще Ютюб разрушил централизованную систему музыкальной
критики и прессы, раньше люди шли читать про группы в
Питчфорк или Wire, и покупали альбом, а сейчас тыкают
в рекоммендации Ютюба. Это породило с десяток новых жанров,
свободных от кураторства музкритика, с изобретенной
(и часто целиком фальсифицированной) историей. Походу
появилась масса "групп", датированных на 30-40 лет
раньше, чем на самом деле, и зачастую сгенерированных
через AI, с имитацией всякого ретро; наиболее смешной
образчик вот, с ним-то все яснее ясного

https://bannedvinyl.bandcamp.com/
https://www.youtube.com/watch?v=VcDeZWIF1kY
https://www.youtube.com/@bannedvinyl

но вообще имитаций-мистификаций на ютюбе появилось
очень много, спасибо AI, и в основном оно весьма трудно распознается.

В любом случае, "Signals" Бреннера, безотносительно
к его аутентичности, совершенно прекрасен; особенно
если вы послушали весь доступный Танжерин Дрим и
желаете еще.

Привет

1. Global carbon market gets green signal at COP29 under Paris Agreement's Article 6  The Hindu
2. Why India and China have pushed against climate change-related trade measures at COP29  The Indian Express
3. COP29: G77, China agree to use new NCQG draft text as basis for finance negotiations  The New Indian Express
4. Video | UN Scientists Warn Of 'Rising Emissions' Worldwide  NDTV
5. COP29 gets momentum with consensus on creation of carbon credits standards, India wants to conclude work  The Times of India

On February 29, 2024, Rare Disease Day will take place worldwide to raise awareness for rare diseases. Only 5% of the approximately 6,000 to 10,000 known rare diseases are currently treatable. The research and development of targeted therapeutic approaches is time-consuming, so that many companies shy away from the financial outlay in view of the low number of patients.

Small business sentiment is on the rise to kick off 2020, with confidence nearing all-time highs, according to data from CNBC and SurveyMonkey. The CNBC/SurveyMonkey Small Business Confidence Index climbed two points in the first quarter, from 59 to 61, as concerns over trade policy impacts lessened, thanks to a trade deal with China and the signing of the USMCA. This is a sharp turnaround from the lows seen last summer as trade turmoil weighed on Main Street’s outlook.

complete article

While telecom carriers are continuing to expand coverage areas and add cellular towers, most cell phone users still experience dropped calls and spotty coverage at times.

Many external factors and things out of your control can inhibit cell phone reception. Fully understanding the variety of factors that can cause poor cell signal may assist you in knowing how to improve a poor cell phone signal.

The following can all impact the strength of a cell signal:
How to Improve Cell Phone Signal

Categoría: Chat:Mensajería Instantánea
Signal es una aplicación de mensajería instantánea sencilla diseñada para chatear de forma segura y privada, con todas las características que esperas de una...

[Business Day Africa] Kenya and the United States have signalled their commitment to the Kenya-led mission in Haiti, dispelling concerns over a potential policy shift under incoming U.S. President Donald Trump.

De toekomst van satelliettelevisie staat opnieuw ter discussie nadat de twee grootste aanbieders in de VS, Dish en DirecTV, het eindelijk eens zijn geworden over een fusie...

It feels like just yesterday Google announced its plan to phase out the third-party cookie and sent the entire advertising industry into a tailspin.

The ability to share secure links for video calls is just one of the privacy-focused messaging app's new features.

Alien-like signal from 2023 has been decoded. The next step is to figure out what it means  CNN

Aiming at the problem of aggravation of traffic congestion caused by unstable signal control of traffic signal control system, the Multi-Agent Deep Deterministic Policy Gradient-based Traffic Cyclic Signal (MADDPG-TCS) control algorithm is used to control the time and data dimensions of the signal control scheme. The results show that the maximum vehicle delay time and vehicle queue length of the proposed algorithm are 11.33 s and 27.18 m, which are lower than those of the traditional control methods. Therefore, this method can effectively reduce the delay of traffic signal control and improve the stability of signal control.

After new ventures have exhausted the limited financial resources of founders, family, and friends, they often pursue initial external capital. To secure investment, entrepreneurs can signal about their venture's latent potential by aligning themselves with reliable third parties. Such affiliations affirm the new venture's legitimacy and provide substantive benefits in the form of mentoring, access to resources, and ongoing monitoring. However, early stage financing is an especially "noisy" signaling environment owing to the large number of startups seeking funding, many of which will not survive. The real value of third party affiliations in this context resides in their ability to unlock the potential of other more pedestrian signals, such as the entrepreneur's characteristics and actions that might otherwise go unnoticed. We borrow from the sensemaking literature to explain how third party affiliation signals disambiguate signals with multiple possible interpretations so that potential investors interpret them positively. Findings support our theory that a startup's characteristics and actions are signals that remain relatively unnoticed unless a startup combines them with a third party affiliation that enhances the signal's value, thus increasing the likelihood of receiving external capital.

This article extends the understanding of what impels buyers to contact particular sellers in online business-to-business (B2B) marketplaces, which are typically characterized by sparse social structures and concomitant limitations in observing social cues. Integrating an institutional perspective with signaling theory, our core argument is that offline seller characteristics that are visible online—in particular, geographic location and legal status—convey credible signals of seller behavior because they provide buyers with information on sellers' local institutional quality and the institutionally-induced obligations and controls acting on sellers. Using unique data from a large Italian online B2B marketplace between the fourth quarter of 1999 and July 2001, we find that both sellers' local institutional quality and their legal statuses affect a buyer's likelihood of contacting a seller. Moreover, consistent with the idea that a buyer's own local institutional quality generates a relevant reference point against which sellers are evaluated, we find that a buyer is progressively more likely to contact sellers the higher their local institutional quality relative to the buyer. Jointly, our findings imply that in online B2B marketplaces, signals conveyed by sellers' geographic locations and legal statuses may be substantive sources of competitive heterogeneity and market segmentation.

Labor codes have been voluntarily adopted and used by manufacturers in emerging economies for the past two decades, as a means of ensuring minimally acceptable or core labor standards for workers. However, far too little is known of the potential benefits from the voluntary adoption of labor codes to the manufacturer, and prior human resource management research has been virtually silent on the business implications of their use for emerging economy manufacturers participating in global supply chains. Drawing on previous work across multiple disciplines and proposing a framework that extends human resource management theory more explicitly and rigorously to the context of emerging economy manufacturing, I theorize and demonstrate that the voluntary adoption of a labor code may constitute an effective human resource investment in emerging economies in improving establishment-level employee outcomes and operational and financial performance. The hypotheses are tested using longitudinal data on a sample of apparel manufacturing plants in Sri Lanka. Implications of this study include providing insight into how to expand the scope and relevance of human resource management theory to better understand research and practice in emerging economies.

The state weather bureau has placed several areas under Signal No. 2 as Typhoon Ofel makes its way to Northern Luzon.

As the saying goes, the arc of morale judgment is long, but it does bend towards justice. And even if we accept such an optimistic worldview is relevant in this year of our lord, 2024, that certainly doesn’t mean we can’t bitch about how long that damned arc is. It’s been over two years since […]

Seattle, Washington, is widely seen as a pro-immigrant city. So many residents were shocked to learn that a nearby airport has been used to deport some 34,000 people in the last eight years. Now King County, where the airport is located, is signalling its opposition to those deportations. We also learn about a subversive hand sign adopted from Hollywood and used in Thailand; we visit a radio program whose signals connect families split between central California and southern Mexico; we meet a teacher who’s helping kids feel proud to communicate in their native tongues; we hear from a man who learned how to deal with a misreading of his name; and we hear the music of a man who won’t yield to pressure to spell it all out.

(Detainees are loaded onto a Swift Air charter flight at King County International Airport (Boeing Field) in Seattle, WA, for a February 26 ICE Air flight. Credit: Still image from video by Alex Montalvo and Wadii Boughdir for the University of Washington Center for Human Rights)

Fire alarm signaling devices are integral to the health and safety of a building and its occupants. Experts weigh in on the latest trends, codes and products.

Customized Emergency Signaling Systems are designed to quickly alert and mobilize emergency response teams to personnel who are using emergency safety showers and eye/facewash fixtures.

Intended for use wherever warnings and information for machines, equipment, rooms or areas need to be displayed, the updated PYRA LED series features an RGB LED with selectable colors available to indicate multiple situations in one light.

Advanced Signal Corp. has moved to a newly renovated facility in Weymouth, improving its operational efficiency and service capabilities.

The Signaller Training Station is a simulation-based solution that allows trainers to simultaneously engage multiple students in a single exercise.

Washington — Railroads must develop certification and training programs for train dispatchers and signal employees, under new Federal Railroad Administration final rules.

SignalTech, a new brand of audible and visual industrial signaling products, is a price-competitive product offering for general signaling safe area markets.

As part of an on-going effort to stay current on key industry issues and market trends, National Floor Trends sponsors several market studies each year.

Laminate flooring is a segment growing in usage and profitability in some areas, but losing ground in others.

[Politics] :
The South Korean military announced Tuesday that North Korea has attempted to disrupt GPS signals in the western inter-Korean border region for the fifth straight day. During a regular press briefing, Joint Chiefs of Staff(JCS) spokesperson Lee Sung-jun said the latest GPS-jamming attempts occurred ...

[more...]

X-ray and electron scattering from free gas-phase molecules is examined using the independent atom model (IAM) and ab initio electronic structure calculations. The IAM describes the effect of the molecular geometry on the scattering, but does not account for the redistribution of valence electrons due to, for instance, chemical bonding. By examining the total, i.e. energy-integrated, scattering from three molecules, fluoroform (CHF3), 1,3-cyclohexadiene (C6H8) and naphthalene (C10H8), the effect of electron redistribution is found to predominantly reside at small-to-medium values of the momentum transfer (q ≤ 8 Å−1) in the scattering signal, with a maximum percent difference contribution at 2 ≤ q ≤ 3 Å−1. A procedure to determine the molecular geometry from the large-q scattering is demonstrated, making it possible to more clearly identify the deviation of the scattering from the IAM approximation at small and intermediate q and to provide a measure of the effect of valence electronic structure on the scattering signal.

Signal-to-noise ratio and spatial resolution are quantitatively analysed in the context of in-line (propagation based) X-ray phase-contrast imaging. It is known that free-space propagation of a coherent X-ray beam from the imaged object to the detector plane, followed by phase retrieval in accordance with Paganin's method, can increase the signal-to-noise in the resultant images without deteriorating the spatial resolution. This results in violation of the noise-resolution uncertainty principle and demonstrates `unreasonable' effectiveness of the method. On the other hand, when the process of free-space propagation is performed in software, using the detected intensity distribution in the object plane, it cannot reproduce the same effectiveness, due to the amplification of photon shot noise. Here, it is shown that the performance of Paganin's method is determined by just two dimensionless parameters: the Fresnel number and the ratio of the real decrement to the imaginary part of the refractive index of the imaged object. The relevant theoretical analysis is performed first, followed by computer simulations and then by a brief test using experimental images collected at a synchrotron beamline. More extensive experimental tests will be presented in the second part of this paper.

Fragment-based drug design using X-ray crystallography is a powerful technique to enable the development of new lead compounds, or probe molecules, against biological targets. This study addresses the need to determine fragment binding orientations for low-occupancy fragments with incomplete electron density, an essential step before further development of the molecule. Halogen atoms play multiple roles in drug discovery due to their unique combination of electronegativity, steric effects and hydrophobic properties. Fragments incorporating halogen atoms serve as promising starting points in hit-to-lead development as they often establish halogen bonds with target proteins, potentially enhancing binding affinity and selectivity, as well as counteracting drug resistance. Here, the aim was to unambiguously identify the binding orientations of fragment hits for SARS-CoV-2 nonstructural protein 1 (nsp1) which contain a combination of sulfur and/or chlorine, bromine and iodine substituents. The binding orientations of carefully selected nsp1 analogue hits were focused on by employing their anomalous scattering combined with Pan-Dataset Density Analysis (PanDDA). Anomalous difference Fourier maps derived from the diffraction data collected at both standard and long-wavelength X-rays were compared. The discrepancies observed in the maps of iodine-containing fragments collected at different energies were attributed to site-specific radiation-damage stemming from the strong X-ray absorption of I atoms, which is likely to cause cleavage of the C—I bond. A reliable and effective data-collection strategy to unambiguously determine the binding orientations of low-occupancy fragments containing sulfur and/or halogen atoms while mitigating radiation damage is presented.

AlphaFold2 has revolutionized structural biology by offering unparalleled accuracy in predicting protein structures. Traditional methods for determining protein structures, such as X-ray crystallography and cryo-electron microscopy, are often time-consuming and resource-intensive. AlphaFold2 provides models that are valuable for molecular replacement, aiding in model building and docking into electron density or potential maps. However, despite its capabilities, models from AlphaFold2 do not consistently match the accuracy of experimentally determined structures, need to be validated experimentally and currently miss some crucial information, such as post-translational modifications, ligands and bound ions. In this paper, the advantages are explored of collecting X-ray anomalous data to identify chemical elements, such as metal ions, which are key to understanding certain structures and functions of proteins. This is achieved through methods such as calculating anomalous difference Fourier maps or refining the imaginary component of the anomalous scattering factor f''. Anomalous data can serve as a valuable complement to the information provided by AlphaFold2 models and this is particularly significant in elucidating the roles of metal ions.

The TIR (Toll/interleukin-1 receptor) domain represents a vital structural element shared by proteins with roles in immunity signalling pathways across phyla (from humans and plants to bacteria). Decades of research have finally led to identifying the key features of the molecular basis of signalling by these domains, including the formation of open-ended (filamentous) assemblies (responsible for the signalling by cooperative assembly formation mechanism, SCAF) and enzymatic activities involving the cleavage of nucleotides. We present a historical perspective of the research that led to this understanding, highlighting the roles that different structural methods played in this process: X-ray crystallography (including serial crystallography), microED (micro-crystal electron diffraction), NMR (nuclear magnetic resonance) spectroscopy and cryo-EM (cryogenic electron microscopy) involving helical reconstruction and single-particle analysis. This perspective emphasizes the complementarity of different structural approaches.

Precision time signals sent through the Global Positioning System (GPS) synchronize cellphone calls, time-stamp financial transactions, and support safe travel by aircraft, ship, train and car.

read more

Ameren signed a supply deal with a data center with a power capacity of 250 megawatt (MW). It has also received expansion commitments and executed new contracts for more 85 MW of additional load for smaller data centers and other industries across Missouri and Illinois.

LYNX Technik AG, provider of modular interfaces will showcase its new bluBox signal processing series at CCW 2012, booth 1164

Independent Medical Facilities Are Positioned as the New Wealth Vehicles for Investors

Yuriy A. Reznik, PhD, is lauded for his leadership expertise as the vice president of research at Brightcove Inc.

Signals: A Game-Changing Innovation for the Hospitality Industry

Inflammation is the body’s natural response to injury and infections.  It promotes healing through immune cell activation to target bacteria and