BACKGROUND The anti–programmed cell death 1 (anti–PD-1) antibody pembrolizumab is clinically active against non–small cell lung cancer (NSCLC). In addition to T cells, human natural killer (NK) cells, reported to have the potential to prolong the survival of patients with advanced NSCLC, also express PD-1. This study aimed to investigate the safety and efficacy of pembrolizumab plus allogeneic NK cells in patients with previously treated advanced NSCLC.METHODS In total, 109 enrolled patients with a programmed death ligand 1 (PD-L1) tumor proportion score (TPS) of 1% or higher were randomly allocated to group A (n = 55 patients given pembrolizumab plus NK cells) or group B (n = 54 patients given pembrolizumab alone). The patients received i.v. pembrolizumab (10 mg/kg) once every 3 weeks and continued treatment until the occurrence of tumor progression or unacceptable toxicity. The patients in group A continuously received 2 cycles of NK cell therapy as 1 course of treatment.RESULTS In our study, patients in group A had longer survival than did patients in group B (median overall survival [OS]: 15.5 months vs. 13.3 months; median progression-free survival [PFS]: 6.5 months vs. 4.3 months; P < 0.05). In group A patients with a TPS of 50% or higher, the median OS and PFS was significantly longer. Moreover, the patients in group A treated with multiple courses of NK cell infusion had better OS (18.5 months) than did those who received a single course of NK cell infusion (13.5 months).CONCLUSIONS Pembrolizumab plus NK cell therapy yielded improved survival benefits in patients with previously treated PD-L1+ advanced NSCLC.TRIAL REGISTRATION ClinicalTrials.gov NCT02843204.FUNDING This work was supported by grants from the National Natural Science Foundation of China (NSFC) – Guangdong Joint Foundation of China (no. U1601225); the NSFC (no. 81671965); the Guangdong Provincial Key Laboratory Construction Project of China (no. 2017B030314034); and the Key Scientific and Technological Program of Guangzhou City (no. 201607020016).

Treating neuropathic pain is challenging and novel non–opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the spinal cord following traumatic nerve injury. Genetic and immunopharmacological approaches demonstrated that GPR160 inhibition in the spinal cord prevented and reversed neuropathic pain in male and female rodents without altering normal pain response. GPR160 inhibition in the spinal cord attenuated sensory processing in the thalamus, a key relay in the sensory discriminative pathways of pain. We also identified cocaine- and amphetamine-regulated transcript peptide (CARTp) as a GPR160 ligand. Inhibiting endogenous CARTp signaling in spinal cord attenuated neuropathic pain, whereas exogenous intrathecal CARTp evoked painful hypersensitivity through GPR160-dependent ERK and cAMP response element–binding protein (CREB). Our findings de-orphanize GPR160, identify it as a determinant of neuropathic pain and potential therapeutic target, and provide insights into its signaling pathways. CARTp is involved in many diseases including depression and reward and addiction; de-orphanization of GPR160 is a major step forward understanding the role of CARTp signaling in health and disease.

BACKGROUND The live attenuated BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colonization in animal models. Here we report on the responses in humans receiving a single intranasal administration of BPZE1.METHODS We performed multiple assays to dissect the immune responses induced in humans (n = 12) receiving BPZE1, with particular emphasis on the magnitude and characteristics of the antibody responses. Such responses were benchmarked to adolescents (n = 12) receiving the complete vaccination program of the currently used acellular pertussis vaccine (aPV). Using immunoproteomics analysis, potentially novel immunogenic B. pertussis antigens were identified.RESULTS All BPZE1 vaccinees showed robust B. pertussis–specific antibody responses with regard to significant increase in 1 or more of the following parameters: IgG, IgA, and memory B cells to B. pertussis antigens. BPZE1–specific T cells showed a Th1 phenotype, and the IgG exclusively consisted of IgG1 and IgG3. In contrast, all aPV vaccines showed a Th2-biased response. Immunoproteomics profiling revealed that BPZE1 elicited broader and different antibody specificities to B. pertussis antigens as compared with the aPV that primarily induced antibodies to the vaccine antigens. Moreover, BPZE1 was superior at inducing opsonizing antibodies that stimulated ROS production in neutrophils and enhanced bactericidal function, which was in line with the finding that antibodies against adenylate cyclase toxin were only elicited by BPZE1.CONCLUSION The breadth of the antibodies, the Th1-type cellular response, and killing mechanisms elicited by BPZE1 may hold prospects of improving vaccine efficacy and protection against B. pertussis transmission.TRIAL REGISTRATION ClinicalTrials.gov NCT02453048, NCT00870350.FUNDING ILiAD Biotechnologies, Swedish Research Council (Vetenskapsrådet), Swedish Heart-Lung Foundation.

Amazon is taking up to $100 off the Apple Watch Series 5 this week, with prices starting at $299.99 for the 40mm GPS models. Only the Gold Aluminum Case with Pink Sport Band is available at this price. If you order today, the Apple Watch should arrive sometime next week.

Note: MacRumors is an affiliate partner with Amazon. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.

The Apple Watch Series 5 was released in September 2019 with a new OLED screen that supports an always-on feature, which represents the biggest change to the Series 5 models. The newest Apple Watch is available in 40mm and 44mm sizes, and it has the overall same design as the Series 4 models.

$100 OFF

Apple Watch S5 (40mm, GPS) for $299.99

If you're shopping for a cellular model, there are also a few solid discounts on Amazon for these devices. You can get the Gold Aluminum Case with Pink Sport Band (40mm) for $399.00, down from $499.00. Likewise, the Silver Aluminum Case with White Sport Band (40mm) is $399.00 right now.

For the 44mm cellular models, a solid deal is the Space Gray Aluminum Case with Black Sport Band at $429.00, down from $529.00. You'll find the same price on the Silver Aluminum Case with White Sport Band and the Gold Aluminum Case with Pink Sport Band.

Across the board, these sales are either new low prices on the Apple Watch Series 5, or they're matching previous low prices seen on these models on Amazon. There are a few other deals going on for different Series 5 models as well, including numerous 44mm cellular devices that are about $50 off Apple's original prices. Be sure to head to Amazon to check out the full sale before these prices expire, or the retailer runs out of stock.

Keep up with all of this week's best discounts on Apple products and related accessories in our dedicated Apple Deals roundup.
This article, "Deals: Apple Watch Series 5 Models Discounted by Up to $100 on Amazon" first appeared on MacRumors.com

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A great many people only experience science fiction by what my mother and millions of others referred to as "monster movies". From Frankenstein to Aliens and beyond, the unknown and the unexplored are often our undoing. Bleak Horizons, edited by Tarl Hoch, is a wonderful collection of 15 stories that mix SF and Horror with various levels of anthropomorphic settings and characters. And, full disclosure, one of those stories is mine. Happily, the mix includes more than just blood thirsty monsters and end of the universe scenarios.

Overall my favorite stories in this anthology are Hardwire, Pentangle, and The Ouroboros Plate. My least favorites are 4/13/2060 and Not Like Us. Below is a short review of all the pieces. I think you should snag a copy, if only to read my favorites and have a taste for this genre. However, I also really enjoyed Carmen Miranda's Ghost Is Haunting Space Station 3 so you have every right to question my taste.

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Erowid Exp113948

6 SaferParty Results (Switzerland)

Accountants CPA Hartford Connecticut LLC:  This is a rush transcript for April 26, 2015. It may contain errors. GEORGE STEPHANOPOULOS, HOST: And the author of “Clinton Clash,” Peter Schweizer, joins us now. Thank you for joining us this morning, Peter. … Continue reading →

On April 30, 2015 Ed Schultz, host of The Ed Show, interviews Senator Bernie Sanders on his announcement that he will run for President of the United States in the Democratic Primary. Continue reading →

Democratic presidential candidate Bernie Sanders (I-VT) on Tuesday unveiled a plan to address income inequality by taxing Wall Street speculation and using the money to eliminate college tuition. Continue reading →

Presidential candidate Bernie Sanders says he wants to offer tuition free at public colleges and universities, paid for with a new tax on Wall Street. Ed Schultz and Sanders discuss the senator’s proposal. Continue reading →

Bill Curry:  “In some ways, you would be [surprised that the polls in Connecticut are busy today]. Last week, on the Democratic side, every story said that it’s all over for Bernie; it’s so difficult to put this nomination together. … Continue reading →

we know how politics works in the United States. Whoever—whatever political party gets into government is going to merge with the bureaucracy pretty damn fast. It will be in a position where it has some levers in its hand. And so, as a result, corporate lobbyists will move in to help control those levers. So it doesn’t make much difference in the end. What does make a difference is political accountability, a general deterrence set to stop political organizations behaving in a corrupt manner. Continue reading →

Connecticut General Assembly Majority Leader Joe Aresimowicz speaking at the 2014 CEUI Convention. Joe Aresimowicz, in speaking to a governmental employee union group in 2014, assured governmental union employees that he would be looking out for them: "You guys have one of your own that sits in the caucus room of the General Assembly. You cannot replicate that." "I will never allow an anti-collective bargaining bill to be called to the House floor. I'm the majority leader. I can make that guarantee." "Please, stand together, stand as brothers and sisters, and be a family. And make sure we are looking out for our own." Continue reading →

Tucker Carlson: Elizabeth Warren's enemies on Wall Street and Big Tech are not really her enemies. Elizabeth Warren is really just this season's Hillary Clinton -- faithful party robot, stalwart defender of the prerogatives of the establishment. Continue reading →

"Lume", новая песня португальской дарк-фолк группы URZE DE LUME, доступна для прослушивания ниже. Этот трек взят из EP "Histórias de Lobos - Entre o Lume e a Escuridão", выход которого запланирован на июнь на Two Moon Records и Equilibrium Music.  #Urze_De_Lume #UrzeDeLume

Группа OZ 24 апреля на Massacre Records выпустила новую работу, получившую название "Forced Commandments". За сведение и мастеринг отвечали Lars Chriss и Mike Lind. Оформлением занимался Carl-André Beckston (Blekkmark Design Studio).

Трек-лист:

"Goin' Down"
"Prison Of Time"
"Switchblade Alley"
"Revival"
"The Ritual"
"Spiders"
"Long And Lonely Road"
"Liar"
"Diving Into The Darkness" (Bonus track on Digipak Edition)
"Break Out" (Bonus track on Digipak Edition)
"Kingdom Of War" (Bonus track on Digipak Edition)


Композиция "Goin' Down" доступна для прослушивания ниже. #Oz #HeavyMetal #Heavy_Metal

As climate change accelerates, IBM is galvanizing the global science community with a massive infusion of computing resources, weather data, and cloud services to help researchers examine the effects of climate change, and explore strategies to mitigate its effects. IBM pledges to help direct the equivalent of up to $200 million for up to five climate-related projects judged to offer the greatest potential impact, and will then broadly share the experiments' results.

A fundraising initiative spearheaded by Canadian comic retailers and creators aims to auction off items in order to support their struggling industry.

The post Zdarsky, Fabok, & more ask you to “Be Our Heroes” for Canadian retailers appeared first on The Beat.

ENGIE, a global leader in energy transition, today announced a new initiative with IBM. This nonexclusive, technological and commercial alliance is designed to improve the management of cities by looking at patterns, event correlation, anomaly detection and real-time data across all parts of cities.

Microsoft recently experienced a significant interruption of their Azure cloud service. Since a decent amount of data was available for this incident, I decided to do a partial root cause analysis. All of my source data came from Microsoft's official Azure blog post on 2014-Nov-24. I did this primarily to create a sample analysis that […]

Clive Palmer spends big on newspaper ads promoting his purchase of the drug hydroxychloroquine.

Take two - Queensland Premier re-enacts a flu shot for the cameras giving birth to a conspiracy.

IBM announced today a new experimental laboratory for nanotechnology research in Brazil. The NanoLab is part of a $4M investment within the recently upgraded IBM Research-Brazil lab in Rio de Janeiro and will focus on projects related to research in Oil & Gas, Agriculture and Health across Latin America.

IBM Security today announced it has been positioned by Gartner, Inc. as a Leader for the sixth consecutive year in the Magic Quadrant for Enterprise Mobility Management Suites1 for its ability to execute and completeness of vision.

IBM today announced that it will help deliver a tailored fan experience through the IBM Cloud at Atlanta’s new Mercedes-Benz Stadium, scheduled to open later this month.

Today, Allianz and IBM concluded an agreement in Munich regarding support for the operation of Allianz's data centers. IBM will be acting as the global provider of IT operation services for Allianz in effect from April 1, 2014, supporting the transformation of the company's global IT infrastructure.

IBM today announced that Dr. Heike Riel, an IBM Fellow and executive director of the IBM Research Frontiers Institute and IoT Technology, was named to the EDITION F - 25 Women Award in Germany. The award focuses on 25 women whose inventions have helped change the world.

IBM today announced that Mammoth Resorts, the leading four-season mountain resort operator in California, is using Watson Customer Engagement solutions on the IBM Cloud to create customized offers that are helping to drive record numbers of visitors to the resort every year.

A new style of wooden fencing has begun to pop up around Sacramento homes

Bank of Montreal (BMO), CaixaBank, Commerzbank and Erste Group have joined an initiative launched by UBS and IBM in 2016 to build a new global trade platform based on blockchain technology. This new platform, called Batavia, is built to be openly accessed by organisations of all sizes anywhere in the world, and can support trade finance for transactions across all modes of trade, whether goods are being transported by air, land or sea.

A.P. Moller –Maersk and IBM today announced their intent to establish a joint venture to provide more efficient and secure methods for conducting global trade using blockchain technology.

IBM today announced a new all-flash, high-performance data and file management solution for enterprise clients running exabyte-scale big data analytics, cognitive and AI applications. The combined flash and storage software solution has been certified with the Hortonworks Data Platform (HDP) to provide clients with more choice in selecting the right platform for their big data analytics on data processing engines like Hadoop and Spark.

The IBM board of directors today declared a regular quarterly cash dividend of $1.50 per common share, payable December 9, 2017 to stockholders of record November 10, 2017.

IBM anunció hoy la primera plataforma de servicios basada en IBM Watson y construida en IBM Cloud para aumentar la inteligencia humana y ayudar a mejorar las operaciones de los proveedores de servicios a través de tecnologías cognitivas.

Este año IBM cumple 90 años de ser un jugador clave en el progreso de México, impulsando a diferentes generaciones a través de la transformación de industrias y profesiones, e impactando el panorama económico, académico y social del país gracias a la estrecha colaboración con todos los actores de la sociedad.

Como parte de las celebraciones del 90 aniversario de IBM en México, la empresa realizó por primera vez en el país, los días 7 y 8 de octubre en el Campus Tecnológico de IBM en Guadalajara, el festival de hackeo para desarrolladores cognitivos: HackaPalooza.

IBM y organizaciones aliadas lanzaron la iniciativa global 'Call for Code', el esfuerzo más grande y ambicioso para reunir a desarrolladores del sector académico y empresarial, para resolver uno de los problemas más acuciantes de la sociedad de nuestro tiempo: prevenir, responder y recuperarse de desastres naturales.

IBM y PAPALOTE MUSEO DEL NIÑO, anunciaron hoy su alianza para desarrollar y ofrecer dos cursos de formación para profesores de la Ciudad de México. El taller estará basado en el portal web teacherstryscience.org de IBM y representa el compromiso de ambas instituciones por contribuir a la enseñanza de la ciencia y en particular de la astronomía, a través de dispositivos en línea.

Apple e IBM lanzaron hoy la primera ola de soluciones IBM MobileFirst para iOS, una nueva clase de apps creadas para los negocios y con soporte para servicios de Cloud, que llevan las capacidades Big Data y Analítica de IBM a los usuarios de iPhone e iPad en las empresas.

Hace posible el cifrado en tiempo real sobre todas las transacciones móviles a escala. Primer sistema mainframe con análisis integrado que proporciona conocimientos de transacciones en tiempo real, 17 veces más rápido en comparación a sistemas competidores en una fracción del costo.

IBM today announced that Westpac New Zealand, part of one of the world’s largest financial services institutions, has selected IBM’s private cloud technology to support its goal to be New Zealand’s leading digital bank. The new five year agreement is part of an extensive services and technology contract which includes Westpac migrating some of its business critical IT systems into IBM’s state-of-the-art Auckland data centre, enabling enhanced customer service.

One in four A/NZ executives believe their organisations excel in leadership development New Zealand executives focusing on bringing back retired employees The Social Network: Largely absent from A/NZ organisations

La Generación Z, conocida también como la primera generación “digitalmente nativa” (aquellos nacidos entre 1995 y 2010), replanteará los nuevos hábitos de consumo. El estudio ‘Uniquely Generation Z’, publicado por IBM (NYSE: IBM) y la Federación Nacional de Retail -NRF por sus siglas en inglés- encontró que el 98% de los jóvenes de esta generación prefiere comprar en tiendas físicas antes que online.

At the Smarter Cities Forum in Shanghai today, IBM announced a collaboration with South China's largest hospital, Guang Dong Hospital of Traditional Chinese Medicine, to apply new analytics technology to help doctors uncover trends and new knowledge about disease treatment from thousands of anonymous Electronic Medical Records (EMR)The tool will also enable clinicians to perform empirical studies on the efficacy of certain traditional Chinese treatments.

Papel San Francisco garantiza la continuidad de operaciones aprovechando Servicios de IBM

IBM (NYSE: IBM) anunció hoy que está trabajando con más de 300 universidades y más de 400 instituciones educativas en toda Latinoamérica para respaldar la inminente necesidad de desarrollar habilidades asociadas a los requerimientos de la transformación digital, ya que el 60% de los ejecutivos se esfuerza hoy por mantener las habilidades de la fuerza laboral actualizadas y relevantes frente al rápido avance tecnológico.

La enfermedad de Parkinson es un trastorno neurológico degenerativo crónico que afecta a una de cada 100 personas mayores de 60 años. Se estima que más de 5 millones de personas en el mundo tienen Parkinson y el número está aumentando con la población actual que envejece.