Measles-containing vaccines are associated with several types of adverse events. Because measles-mumps-rubella-varicella (MMRV) versus separate measles-mumps-rubella (MMR) and varicella (MMR + V) vaccine increases a toddler’s risk for febrile seizures, we investigated whether MMRV is riskier than MMR + V and whether either vaccine elevates risk for additional safety outcomes.

Comparing MMRV with MMR + V, no increased risk of immune thrombocytopenia purpura, anaphylaxis, ataxia, arthritis, meningitis/encephalitis, acute disseminated encephalomyelitis, and Kawasaki disease was detected. No new safety concerns were identified after either vaccine, and most outcomes studied were unlikely after either vaccine. (Read the full article)

Topical corticosteroids are often used to treat atopic dermatitis (AD) in infants, although compliance is poor due to concerns over side effects. Pimecrolimus was shown to be a safe and effective noncorticosteroid treatment of AD in infants in short-term studies.

The Petite Study shows that long-term management of mild-to-moderate AD in infants with pimecrolimus or topical corticosteroids was safe without any effect on the developing immune system. Pimecrolimus had similar efficacy to topical corticosteroids and a marked steroid-sparing effect. (Read the full article)

More than a quarter of child deaths in the United Kingdom are estimated to have identifiable failures in care. Although children account for 40% of the family practice workload, little is known about iatrogenic harm to children in this setting.

This is the first analysis of nationally collected pediatric safety incident reports from family practice. To mitigate harm to children, priority areas requiring improvement include medication provision, referral of unwell children, provision of evidence-based treatment, and adequate diagnosis and assessment. (Read the full article)

Prophylactic vaccination of young women 16 to 26 years of age with the 9-valent human papillomavirus (HPV)–like particle (9vHPV) vaccine prevents infection and disease with vaccine HPV types.

These data support bridging the efficacy findings with 9vHPV vaccine in young women 16 to 26 years of age to girls and boys 9 to 15 years of age and implementation of gender-neutral HPV vaccination programs in preadolescents and adolescents. (Read the full article)

The routine childhood immunization schedule is crowded during the first 2 years, leading to deferred doses and limiting the addition of new vaccines. Combination vaccines can reduce the "shot burden" and improve coverage rates and timeliness.

Antibody response rates to antigens contained in an investigational hexavalent vaccine (DTaP5-IPV-Hib-HepB) were noninferior to licensed comparator vaccines when given as a 3-dose infant series. The safety profile was similar to control except for increased rates of mild-to-moderate, self-limited fever. (Read the full article)

Children with marked cerebral palsy (CP) are considered at greater risk of adverse events (AEs) after intramuscular injections of BoNT-A. To date there has been no randomized controlled trial examining safety of intramuscular BoNT-A injections in children with marked CP.

Children with nonambulatory CP had no greater risk of moderate or serious AEs after intramuscular injections of BoNT-A compared with a sham/control group. There was no greater risk of AEs for children receiving 2 compared with 1 episode of BoNT-A. (Read the full article)

Previous studies have evaluated separately the effects of brief education and reminder/recall intervention strategies to increase human papillomavirus vaccine coverage. None have examined if intervention effects varied by race/ethnicity.

When compared with a general adolescent vaccine brochure, human papillomavirus vaccine-specific educational materials increased 1-dose coverage among Hispanic but not black individuals. Recalls for doses 2 and 3 were effective in increasing 3-dose coverage for both racial/ethnic groups. (Read the full article)

Durlobactam (DUR, also known as ETX2514) is a novel β-lactamase inhibitor with broad activity against Ambler class A, C, and D β-lactamases. Addition of DUR to sulbactam (SUL) in vitro restores SUL activity against clinical isolates of Acinetobacter baumannii. The safety and pharmacokinetics (PK) of DUR alone and with SUL and/or imipenem/cilastatin (IMI/CIL) were evaluated in healthy subjects. This was a randomized, placebo-controlled study. In Part A, subjects including an elderly cohort (DUR 1 g) received single ascending doses of DUR 0.25-8 g. In Part B, multiple ascending dose of DUR 0.25-2 g were administered every 6 hours (q6h) for 29 doses. In Parts C and D, the drug-drug interaction (DDI) potential, including safety, of DUR (1 g) with SUL (1 g) and/or IMI/CIL (0.5/0.5 g) was investigated after single and multiple doses. Plasma and urine concentrations of DUR, SUL, and IMI/CIL were determined. Among 124 subjects, DUR was generally safe and well tolerated either alone or in combination with SUL and/or IMI/CIL. After single and multiple doses, DUR demonstrated linear dose proportional exposure across the studied dose ranges. Renal excretion was a predominant clearance mechanism. No drug:drug interaction potential was identified between DUR and SUL and/or IMI/CIL. SUL-DUR, 1 g (of each component) administered q6h with a 3 hour IV infusion, is under development for the treatment of serious infections due to A. baumannii.

Gepotidacin, a triazaacenaphthylene bacterial type II topoisomerase inhibitor, is in development for treatment of uncomplicated urinary tract infection (uUTI). This Phase 2a study in female participants with uUTI evaluated the pharmacokinetics (primary objective), safety, and exploratory efficacy of gepotidacin. Eligible participants (N = 22) were confined to the clinic at baseline, received oral gepotidacin 1,500 mg twice daily for 5 days (on-therapy; Days 1 to 5), and returned to the clinic for test-of-cure (Days 10 to 13) and follow-up (Day 28±3). Pharmacokinetic, safety, clinical, and microbiological assessments were performed. Maximum plasma concentrations were observed approximately 1.5 to 2 hours postdose. Steady state was attained by Day 3. Urinary exposure over the dosing interval increased from 3,742 μg.h/ml (Day 1) to 5,973 μg.h/ml (Day 4), with trough concentrations of 322 to 352 μg/ml from Day 3 onward. Gepotidacin had an acceptable safety-risk profile with no treatment-limiting adverse events and no clinically relevant safety trends. Clinical success was achieved in 19 (86%) and 18 (82%) of 22 participants at test-of-cure and follow-up, respectively. Eight participants had a qualifying baseline uropathogen (growth; ≥10⁵ CFU/ml). A therapeutic (combined clinical and microbiological [no growth; <10³ CFU/ml]) successful response was achieved in 6 (75%) and 5 (63%) of 8 participants at test-of-cure and follow-up, respectively. Plasma area under the free-drug concentration-time curve over 24 hours at steady state divided by the MIC (fAUC_0-24/MIC) and urine AUC_0-24/MIC ranged from 6.99 to 90.5 and 1,292 to 121,698, respectively. Further evaluation of gepotidacin in uUTI is warranted. (NCT03568942)

Tedizolid has demonstrated its efficacy and safety in clinical trials, however, data concerning its tolerability in long-term treatments is scarce. The aim of the study was to assess the indications and to describe the long-term safety profile of tedizolid.

A multicentric, retrospective study of patients who received tedizolid for more than 6-days was conducted. Adverse events (AEs) were identified from patients' medical records and laboratory data. The World Health Organization causality categories were used to discern AEs probably associated with tedizolid.

Eighty-one patients, treated with tedizolid 200mg once-daily for a median (IQR) duration of 28 (14-59) days, were included, 36 (44.4%) had previously received linezolid. Most common reasons for selecting tedizolid were to avoid linezolid potential toxicities or interactions (53.1%) or due to previous linezolid-related toxicities (27.2%). Most common indications were off-label, including prosthetic joint infections, osteomyelitis and respiratory infections (77.8%). Overall, 9/81 patients (11.1%) experienced a probably associated AE. Two patients (2.5%) developed gastrointestinal disorders, 1 (1.2%) anemia and 6 thrombocytopenia (7.4%) after a median (IQR) duration of treatment of 26.5 (17-58.5) days. Four (5%) patients discontinued tedizolid due to AEs. Among 23 patients with chronic renal failure (CRF) the rate of mielotoxicity was 17.4% and only 8.7% had to stop tedizolid and 20 out of 22 with previous linezolid-associated toxicity had no AE.

Long-term tedizolid treatments had good tolerance with rates of gastrointestinal AE and hematological toxicity lower than those reported with linezolid, particularly in patients with CRF and in those with a previous history of linezolid-associated toxicity.

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 patients, mostly children enrolled in a multicentre trial from 10 sites in Africa. A linear relationship described the QTc-prolonging effect of piperaquine, estimating a 5.90ms mean QTc-prolongation per 100ng/mL increase in piperaquine concentration. The effect of piperaquine on absolute QTc-interval estimated a mean maximum QTc-interval of 456ms (EC₅₀=209ng/mL). Simulations from the pharmacokinetic-pharmacodynamic models predicted 1.98-2.46% risk of having QTc-prolongation > 60ms in all treatment settings. Although piperaquine administration resulted in QTc-prolongation, no cardiovascular adverse events were found in these patients. Thus, the use of dihydroartemisinin-piperaquine should not be limited by this concern.

Geopolitical factors and economic uncertainty make some investors shift away from equities into what they perceive to be the safety of higher-quality bonds.

Penn State Health St. Joseph opened a curbside, chest X-ray service at the medical center’s main entrance at 2500 Bernville Road on May 4. This new service is part of its continued efforts to increase patient safety during the coronavirus pandemic.

The city used the federal Safe Routes to School program to improve the safety of children's trips to school.

The House appropriations committee voted Wednesday to advance a bill providing a slight funding increase for the U.S. Department of Education, bringing overall funding to about $71 billion.

GroupM’s John Montgomery tells Sonam Saini that while marketers are more cognizant of ad frauds, much more needs to be done to ensure brand safety.

As part of National Fire Prevention Month in October, Smokey Bear will be visiting classrooms with the Delaware Forest Service's yearly fire prevention education programs targeted to first-grade students in the state's private, public, and charter schools. Ashley Peebles coordinates the successful effort that reaches around 9,000 students annually.

535 kindergarten students at McIlvaine Early Childhood Center in Magnolia learned fire safety from Smokey Bear as part of the Delaware Forest Service's annual education program. Located in the Caesar Rodney School District, McIlvaine is the largest kindergarten program in the First State.

Agricultural entrepreneurs who want to produce certain foods in their on-farm kitchens can receive food safety training and become certified under Delaware law at an upcoming workshop. The eight-hour Food Safety for Entrepreneurs program will be Saturday, Feb. 28, 8 a.m. to 4:30 p.m. at the Department of Agriculture offices near Camden, 2320 South DuPont Highway.

Agricultural entrepreneurs who want to produce certain foods in their on-farm kitchens can receive food safety training and become certified under Delaware law at an upcoming workshop.

Agricultural entrepreneurs who want to produce certain foods in their on-farm kitchens can receive food safety training and become certified under Delaware law at an upcoming workshop.

Fruit and vegetable growers who want to learn about produce safety, Good Agricultural Practices (GAPs), developing food safety plans and the Food Safety Modernization Act (FSMA) Produce Safety Rule are encouraged to attend several upcoming workshops. On March 16 and 17, the “Delaware FSMA Produce Safety Alliance Training, Produce Food Safety Updates, and Food Safety Plan Writing Workshop” will be held at the Delaware State Fairgrounds in Harrington. The workshop will be from 8 a.m. to 4:00 p.m. each day. Lunch will be provided and registration is free, courtesy of the USDA Specialty Crop Block Grant and the Delaware Department of Agriculture.

Agricultural entrepreneurs who want to produce certain foods in their on-farm kitchens can receive food safety training and become certified under Delaware law at an upcoming workshop jointly sponsored by the University of Delaware Cooperative Extension and the Delaware Department of Agriculture. The eight-hour “Food Safety for Entrepreneurs” program presented by Dr. Sue Snider of the University of Delaware will take place Saturday, March 25, at the Delaware Department of Agriculture, from 8 a.m. to 4:30 p.m.

Delaware fruit and vegetable growers can now receive financial support in obtaining a third party audit to verify they are following effective food safety practices. The Delaware Department of Agriculture (DDA) is extending its Food Safety Audit Cost-Share Program for growers to include any third party food safety audit, not just USDA Harmonized GAP audits.

DOVER, Del. – The Delaware Department of Agriculture is offering two one-day courses in March to help farmers growing fruits and vegetables comply with the Food Safety Modernization Act (FSMA) Produce Safety Rule. “About 1 in 6 Americans gets sick each year from foodborne illness,” said Secretary of Agriculture Michael T. Scuse. “The Food Safety […]

Delaware Thoroughbred Racing Commission (DTRC) Chairman W. Duncan Patterson announced at the Commission meeting on March 8, 2018 that two candidates, Cynthia L. Smith and Robert E. Colton had been selected for the positions of Associate State Steward and Safety Steward respectively. "Both of these individuals have a deep respect for the racing industry and the people involved in racing," said DTRC Executive Director John F. Wayne. "They will fit in well, maintaining the high level of regulatory oversight that the Delaware Thoroughbred Racing Commission expects and deserves.”

DOVER, Del. – The Delaware Department of Agriculture (DDA) Food Products Inspection was granted statutory authority on June 11, 2019 to enforce compliance with the Produce Safety Rule in the Food Safety Modernization Act (FSMA). The Food Safety Modernization Act is a proactive approach to prevent foodborne illnesses by strengthening the food supply. These regulations, […]

Many of us are currently working from home and getting adjusted to this new way of working. If you’re an employee working on the shop floor of a manufacturing facility, however, working from home is not an option. Among the many hard decisions manufacturing leaders have had to make during [...]

Increase employee safety with production planning optimization  was published on SAS Voices by Chris Hartmann

The Delaware Division of Public Health (DPH) recommends that residents take steps to keep family, friends, and pets safe during Fourth of July gatherings.

Wilmington --

Starting Thursday, April 2, DART will limit the number of passengers allowed on each bus at any given time, based on bus seating capacity. Passenger boardings will be through the rear door with fares waived. Riders needing boarding assistance will be allowed to continue boarding through the front door. [More]

Starting Thursday, April 2, DART will limit the number of passengers allowed on each bus at any given time, based on bus seating capacity. Passenger boardings will be through the rear door with no fare collection. Riders needing boarding assistance will be allowed to continue boarding through the front door.

In order to accommodate riders, DART will operate additional timing buses, as well as have additional operators on standby.

If you are feeling sick, please do not visit public facilities and avoid public transportation. For more information on the state's response to the Coronavirus, visit de.gov/coronavirus.

A chemical plant where a gas leak killed 11 and left 1,000 sick in Andhra Pradesh's Visakhapatnam may face investigation on whether its safety protocols were in place and whether it followed all...

Beginning Thursday, April 2, DART will limit the number of passengers allowed on each bus at any given time, based on bus seating capacity. Passenger boardings will be through the rear door with no fare collection. Riders needing boarding assistance will be allowed to continue boarding through the front door. In order to accommodate riders, DART […]

Car subscriptions will continue to evolve and grow into more flexible plans and longer durations of leases ending 12, 24, or 36 months.

Ford India has asked its dealership personnel to wear protective medical equipment at all times and to also maintain social distancing.

While the factory has restarted operations, it is at a partial stage and same is the case with dealerships.

FOR IMMEDIATE RELEASE Media Contacts: Cynthia Cavett, Marketing Specialist & Public Information Officer Delaware Office of Highway Safety Cynthia.Cavett@delaware.gov 302-744-2743 DUI Initiative Running From July 3rd Through July 7th DOVER, De. (July 1, 2019) – The Delaware Office of Highway Safety (OHS) is pleased to announce that it is reactivating its SoberLift program, in partnership […]

FOR IMMEDIATE RELEASE Media Contacts: Cynthia Cavett, Marketing Specialist & Public Information Officer Delaware Office of Highway Safety Cynthia.Cavett@delaware.gov 302-744-2743 DOVER, Del. (September 15, 2019) – Child Passenger Safety Week is a vital awareness campaign that runs nationwide to promote kids being secured in the right car seat for their age, height, and weight. This […]

Cooperative statewide effort to reduce pedestrian deaths and encourage safe walking habits.

Media Advisory:  November 22, 2019 Initiative reinforces the importance of safe driving behaviors during one of the busiest times of the year WHAT: The Delaware Office of Highway Safety (OHS) is launching its new Safe Family Holiday Campaign, as well as reactivating the SoberLift initiative ahead of Thanksgiving weekend. Through a combination of tactics – traditional […]

WILMINGTON, Del. –  Governor John Carney announced on Friday that Secretary Robert Coupe – a longtime leader in Delaware law enforcement – will step down from his current role as the head of the Delaware Department of Safety and Homeland Security next month to join the Office of the Attorney General. “There are few people […]

Office of Highway Safety Suspends SoberLift® Program for St. Patrick’s Day *MEDIA ALERT* March 15, 2020  WHAT: The Delaware Office of Highway Safety (OHS) is suspending its SoberLift program as of 9 p.m. on Sunday, March 15, through Wednesday, March 18 at 2 a.m., statewide, due to growing concern for the health and safety of […]

Effective Immediately – March 25, 2020 (Dover, Del.) – Governor John Carney ordered all non-essential businesses to close by Tuesday morning, March 24, 2020, at 8 a.m. and for all Delawareans to stay at home whenever possible to help fight the spread of COVID-19. As a safety precaution for customers and staff, the Delaware Office of […]

You may park a portion of your funds in a high-rated liquid fund while you wait for the current volatility in the markets to play out

Conor McGregor will be a keen observer of this weekend's UFC 249 event according to his manager Audie Attar, who says that the Irishman wants to gauge the UFC's health and safety measures before entertaining a return to the cage.
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At present, different applicability thresholds exist for welfare provisions like creche, canteen, first-aid, etc. in different Acts.

Social distancing will be maintained in lines for amenities, in restaurants, on rides and other facilities and sanitization and disinfection will be boosted, the company said in a news release.

Expecting many stranded non-resident Keralites to be evacuated from the Middle East stating Thursday onwards, the Cochin International Airport Limited (CIAL) is gearing up with several safety measures!