Staying healthy and happy in Bhutan -- by Sungsup Ra, Rajesh Poddar, Sonalini Khetrapal
Bhutan is using an innovative financing system to ensure its citizens have access to quality affordable health care.
Bhutan is using an innovative financing system to ensure its citizens have access to quality affordable health care.
NORTHRIDGE, Calif.—HARMAN Professional Solutions, the global leader in audio, video, lighting and control systems, today announced the new AKG Podcaster Essentials bundle at the 2020 NAMM show in Anaheim, California and the 2020 CES shows in Las Vegas,...
Consumers are constantly exploring new ways to connect to the world around them both in and outside of their vehicles. At HARMAN, enabling connected experiences is at the core of everything we do. That’s why we’re launching the Experiences Per Mile...
In the midst of the Covid-19 pandemic and the drastic changes in social interaction that it has caused, who among us has not felt the desire to reach out, to engage, to reconnect? At HARMAN, one of our most dearly-held beliefs is that music empowers...
Sauropod dinosaurs grew to 25 metres or more in length and weighed several tonnes – but footprints in Texas seem to suggest they sometimes walked on just two legs
Down is a sci-fi podcast about a crewed mission into a mysterious Antarctic hole that has opened up as a result of climate change, what will the crew find?
Title: Small Study Shows Lipodissolve Works
Category: Health News
Created: 4/28/2010 9:24:00 AM
Last Editorial Review: 4/28/2010 9:24:32 AM
Title: More Kids Being Poisoned by Detergent Pods: Study
Category: Health News
Created: 4/25/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM
Previous studies showed that Cdc42, a member of the prototypical Rho family of small GTPases and a regulator of the actin cytoskeleton, is critical for the normal development and health of podocytes. However, upstream regulatory mechanisms for Cdc42 activity in podocytes are largely unknown.
We used a proximity-based ligation assay, BioID, to identify guanine nucleotide exchange factors that activate Cdc42 in immortalized human podocytes. We generated podocyte-specific ARHGEF7 (commonly known as β-PIX) knockout mice by crossing β-PIX floxed mice with Podocin-Cre mice. Using shRNA, we established cultured mouse podocytes with β-PIX knockdown and their controls.
We identified β-PIX as a predominant guanine nucleotide exchange factor that interacts with Cdc42 in human podocytes. Podocyte-specific β-PIX knockout mice developed progressive proteinuria and kidney failure with global or segmental glomerulosclerosis in adulthood. Glomerular podocyte density gradually decreased in podocyte-specific β-PIX knockout mice, indicating podocyte loss. Compared with controls, glomeruli from podocyte-specific β-PIX knockout mice and cultured mouse podocytes with β-PIX knockdown exhibited significant reduction in Cdc42 activity. Loss of β-PIX promoted podocyte apoptosis, which was mediated by the reduced activity of the prosurvival transcriptional regulator Yes-associated protein.
These findings indicate that β-PIX is required for the maintenance of podocyte architecture and glomerular function via Cdc42 and its downstream Yes-associated protein activities. This appears to be the first evidence that a Rho–guanine nucleotide exchange factor plays a critical role in podocytes.
Manoella Gemaque Cavalcante, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka, and Renata Coelho Rodrigues Noronha
Eukaryotic genomes exhibit substantial accumulation of repetitive DNA sequences. These sequences can participate in chromosomal reorganization events and undergo molecular cooption to interfere with the function and evolution of genomes. In turtles, repetitive DNA sequences appear to be accumulated at probable break points and may participate in events such as non-homologous recombination and chromosomal rearrangements. In this study, repeated sequences of 5S rDNA, U2 snRNA and Tc1/Mariner transposons were amplified from the genomes of the turtles, Podocnemis expansa and Podocnemis unifilis, and mapped by fluorescence in situ hybridization. Our data confirm the 2n=28 chromosomes for these species (the second lowest 2n in the order Testudines). We observe high conservation of the co-located 5S rDNA and U2 snRNA genes on a small chromosome pair (pair 13), and surmise that this represents the ancestral condition. Our analysis reveals a wide distribution of the Tc1/Mariner transposons and we discuss how the mobility of these transposons can act on karyotypic reorganization events (contributing to the 2n decrease of those species). Our data add new information for the order Testudines and provide important insights into the dynamics and organization of these sequences in the chelonian genomes.
WELCOME TO EPISODE 37 OF THE TALENTED LEARNING SHOW! Learn how trade associations and training companies are now pivoting to total digital education due to […]
The post Podcast 37: How to Pivot to Digital Education – With Ashish Rangnekar appeared first on e-Learning Feeds.
If you think you’ve got something of value to share with the world – or maybe you just want a project to tackle to fill the hours – then we’ll take you through what you need to know.
I'm a huge podcast tragic. From true crime to weird radio plays, I like shoving as much of them into my ear holes as possible. But despite my efforts, I realised that I don't listen to as many Australian podcasts as I'd like. Sure, I have a few favourites, but I could be doing more to support local creators. So I asked around the office to find out what the best Aussie podcasts are, and why I (and you) should be listening to them. More »
Star Trek Online is celebrating its third anniversary, but we uncover the sordid coverup that lies between the game’s aft nacelles. Also, you can now...
EA loves microtransactions. Anna loves farming sims. Square Enix loves trademarks. Chris loves pirates. Mac addicts love…well…any game ports. Manny loves Devil Summoner. Zenimax loves...
It’s the live Extra Life 2013 special. How many times will Chris die in Dark Souls this year? Will RPGamer make its goal? Can you...
Video games aren’t the only things that can be speedrun. Listen as we struggle to find news for 2014. Marvel at how many games Chris...
Alex, Anna Marie, Jon, and Chris bring you the latest in RPG news. I’m sorry, you’re out of energy. To listen to more, please use...
Jon, Alex, Anna, and Chris spend a quiet Saturday away from speed runs and soccer balls to bring you the latest in RPG happenings around...
Mark Lawson and Dan Milmo discuss the sustainability of the streaming service. Plus: Lara Spirit on why you should register to vote before Tuesday’s deadline
Netflix has risen from obscurity to be one of the most powerful media companies in the world with more than 150 million global subscribers. It has launched critically acclaimed hits such as House of Cards, The Crown and Unbelievable, as well as showcasing the back catalogues of popular television series. But as part of its rapid growth, the company has racked up huge debts.
Joining Anushka Asthana to discuss the long-term sustainability of Netflix are the TV critic Mark Lawson and the Guardian’s deputy business editor Dan Milmo.
Continue reading...Ed Pilkington looks ahead to Weinstein’s court battle where he faces charges of rape and sexual assault, which he denies. And Jamie Grierson on why counter-terror police have listed Extinction Rebellion as a ‘key threat’
The film producer Harvey Weinstein will stand trial this week in New York City accused of five charges, including rape and sexual assault. Weinstein denies all allegations. The trial, expected to last about six weeks, will focus on the witness accounts of two alleged victims who claim they were assaulted by Weinstein.
The Guardian’s Ed Pilkington has been in court for the jury selection process in which 2,000 potential jurors were whittled down to 12 who will decide Weinstein’s fate. He tells Anushka Asthana that the case will cause a sensation in the US and around the world, but that it should not be seen as #MeToo on trial.
Continue reading...Like dozens of women in the entertainment industry, the actor, model and writer Zoë Brock has claimed she had a traumatic encounter with the film producer Harvey Weinstein. Now she is faced with a settlement offer that she believes would allow him to escape blame for the alleged assaults. Also today: Lily Kuo on the spread of the deadly coronavirus in China
The actor, model and writer Zoë Brock was on a retreat in the New Zealand bush in 2017 when an email pinged into her inbox. It was from a friend sending a link to a breaking news story of allegations against Harvey Weinstein. The claims from several women against the film producer were eerily familiar to an incident that Brock alleges happened to her.
This week, Weinstein goes on trial charged with rape and sexual assault. But for dozens of women with claims against him, their only recourse is to civil courts. Brock tells Anushka Asthana that while she is part of the class action suit against Weinstein, she is deeply unhappy with the terms of the proposed settlement, which she believes would allow him to accept no blame for the allegations.
Continue reading...Following a strikingly white and male list of Bafta nominees, this year’s Academy Awards shortlists are barely more diverse. It’s a chronic problem in an industry running out of excuses for its slow pace of change. Lanre Bakare examines why the Oscars are still so white. Plus: Joan E Greve on a hectic week of US politics
When the lists of nominees for the major film awards in 2020 were announced, there was, once again, a glaring anomaly. Not a single person of colour was nominated in the Bafta acting categories, while the Oscars managed only Cynthia Erivo for her part in Harriet.
It is an issue that the industry is well aware of: in 2015, the ceremony saw #OscarsSoWhite trending on Twitter, while actors such as Eddie Murphy were rebuking the academy from the stage back in the 1990s. So what explains the glacial pace of change? Guardian arts and culture correspondent Lanre Bakare tells Anushka Asthana that there have been plenty of false dawns over the years in the quest for greater diversity.
Continue reading...According to The Verge, popular music app Spotify is testing...
The post Spotify Is Testing Video Podcasts With YouTube Stars appeared first on Man's World India.
Fox News Media, a unit of Fox Corp, said on Tuesday it has partnered with digital streaming services company Spotify Technology SA to distribute its podcast catalogue featuring more than 20 original series.
After a string of studies that highlight the possible link between air pollution and Covid-19 deaths, Ian Sample hears from Prof Anna Hansell about the complicated relationship between pollution, health and infection with Sars-CoV-2
Continue reading...Hannah Devlin speaks to Prof Sabra Klein about why women are much less likely to become seriously ill or die from Covid-19, and what the implications of this knowledge for future treatments might be
Continue reading...As hay fever season approaches, Nicola Davis asks Prof Stephen Durham about the differences between the immune response to an allergen, such as pollen, and a pathogen, like Sars-CoV-2. Should those with allergies should be concerned about Covid-19?
Continue reading...As the coronavirus outbreak continues to be our focus on Science Weekly, we also want to try look at other science stories. In this episode, Nicola Davis speaks to Dave Krause about the 66-million-year-old fossil of a cat-sized mammal dubbed ‘crazy beast’. A giant in its day, we hear how this now extinct branch of mammals – known as Gondwanatherians – offers new insights into what could have been
Continue reading...From the intricate storytelling of online culture podcast 'Reply All' to the relaxed gossip of reality star Gemma Collins, Annie Lord ranks the best podcasts to listen to while in quarantine
From quarantine vino survival guides to sharing a glass with celebs, these are the best wine podcasts to know
Paul Scholes has been labelled "dumb and dumber" on the official Manchester United podcast after a comical misunderstanding.
Sometimes being creative involves getting burnt. It's a lesson two gay podcasters in Sydney learnt the hard way.
Veteran tech journalists Mike Malone and Scott Budman celebrate their 50th episode in the latest installment of their podcast, The Silicon Insider. This week, the topics include: Not every company is suffering these days: consider the video game industry. Game companies from our remote past – Electronic Arts? Activision? Zynga? – are enjoying spectacular profits, stock prices and usage as bored and quarantined Millennials revisit their past. And don’t even ask about Peloton: every 1 percenter…
It’s a Microsoft heavy week! This week, Devindra and Cherlynn are joined by Alex Cranz, Gizmodo’s Senior Consumer Tech Editor, to chat about the bevy of new Surface devices. In particular, they explore why the Surface Go 2 and Book 3 are a bit disapp...