This week David Price is in the presenter chair for the jolliest tech podcast of the year. David is joined by Miriam Harris, staff writer at Digital Arts, to talk about the design trends set to shape 2017. Then online editor at Techworld Scott Carey runs through the hottest tech gifts this Christmas, including games consoles, VR, Amazon gadgets and Star Wars merch (14:30). Finally, staff writer at PC Advisor Dom Preston makes his UKTW debut to chat about the latest Star Wars movie, Rogue One, which includes spoilers (29:00). This is the last UK Tech Weekly podcast of the year. Thank you for listening and we will be back in 2017 to chat about the hottest tech topics all over again.  

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Momentous scenes as the pod celebrates its Golden Jubilee. Matt Egan is joined by some very special guests to congratulate the gang on the milestone while indulging in some points based tech quizzing. Join Chris Martin, Charlotte Jee, Dom Preston and Henry Burrell to recap questions from pods gone by with a new twist, and have a long hard think about what tech will be 50 more episodes from now. The prize? A small bronze jug. Obviously. NB. May not actually be 50 minutes, sorry.  

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We finally get the IoT acronym the pod has been waiting for as we discuss Bitcoin and 17th century Dutch finance. Charlotte Jee informs Henry Burrell, David Price and Scott Carey.

Scott then leads us down the winding road of the so-called platform wars, in a week when Google blocked the Amazon Echo Show from streaming YouTube. Is this a bump in the road or will services be cut from rival hardware?

And finally, led by David, the pod discusses its favourite tech of the year and what you might consider buying for friends and family for Christmas.

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Colorectal cancer (CRC) arises as the consequence of progressive changes from normal epithelial cells through polyp to tumor, and thus is an useful model for studying metabolic shift. In the present study, we studied the metabolomic profiles using high analyte specific gas chromatography/mass spectrometry (GC/MS) and liquid chromatography tandem mass spectrometry (LC/MS/MS) to attain a systems-level view of the shift in metabolism in cells progressing along the path to CRC. Colonic tissues including tumor, polyps and adjacent matched normal mucosa from 26 patients with sporadic CRC from freshly isolated resections were used for this study. The metabolic profiles were obtained using GC/MS and LC/MS/MS. Our data suggest there was a distinct profile change of a wide range of metabolites from mucosa to tumor tissues. Various amino acids and lipids in the polyps and tumors were elevated, suggesting higher energy needs for increased cellular proliferation. In contrast, significant depletion of glucose and inositol in polyps revealed that glycolysis may be critical in early tumorigenesis. In addition, the accumulation of hypoxanthine and xanthine, and the decrease of uric acid concentration, suggest that the purine biosynthesis pathway could have been substituted by the salvage pathway in CRC. Further, there was a step-wise reduction of deoxycholic acid concentration from mucosa to tumors. It appears that to gain a growth advantage, cancer cells may adopt alternate metabolic pathways in tumorigenesis and this flexibility allows them to adapt and thrive in harsh environment.

1 January 2007 ,

An ageing population in Europe makes the opinion of young people about their continent’s future even more important. Leading international figures, including the President of the United Nations General Assembly, have been expressing concern over the limited role of young people in shaping policy. With this in mind, The World Today and the National Association for Gifted and Talented Youth have given students the opportunity to share their vision through a competition on Europe: The Next Fifty Years. The three finalists have been invited to an International Economics Programme workshop at Chatham House next month.

“The United States has launched a stunning attack on Cuba’s medical-aid missions, with the Trump administration pressing countries to reject them during the coronavirus pandemic,” Steve Sweeny reported in the Morning Star, March 26, 2020. Given...

Pan American Health Organization (PAHO) director, Dr Carissa Etienne, is warning that lifting COVID-19 restrictions too soon could accelerate the spread of the virus and open the door for a dramatic upsurge in countries of the region. The warning...

Night shift work, behavioral rhythms, and the common MTNR1B risk single nucleotide polymorphism (SNP), rs10830963, associate with type 2 diabetes; however, whether they exert joint effects to exacerbate type 2 diabetes risk is unknown. Among employed participants of European ancestry in the UK Biobank (N = 189,488), we aimed to test the cross-sectional independent associations and joint interaction effects of these risk factors on odds of type 2 diabetes (n = 5,042 cases) and HbA_1c levels (n = 175,156). Current shift work, definite morning or evening preference, and MTNR1B rs10830963 risk allele associated with type 2 diabetes and HbA_1c levels. The effect of rs10830963 was not modified by shift work schedules. While marginal evidence of interaction between self-reported morningness-eveningness preference and rs10830963 on risk of type 2 diabetes was seen, this interaction did not persist when analysis was expanded to include all participants regardless of employment status and when accelerometer-derived sleep midpoint was used as an objective measure of morningness-eveningness preference. Our findings suggest that MTNR1B risk allele carriers who carry out shift work or have more extreme morningness-eveningness preference may not have enhanced risk of type 2 diabetes.

On the campaign trail, Donald Trump made immigration the centerpiece of his campaign, offering a more detailed policy agenda than on any other issue. In the year since the election that propelled the Republican into the White House, how has the Trump administration’s record matched up with the rhetoric? This policy brief examines the executive orders and other changes to existing policy and practice made during 2017.

Sunder Mudaliar
Jul 1, 2016; 39:1115-1122
Diabetes Care Symposium

Ele Ferrannini
Jul 1, 2016; 39:1108-1114
Diabetes Care Symposium

California, Iowa, Pennsylvania and Rhode Island are among states that are loosening coronavirus restrictions Friday to gradually revive their economies.

An unannounced sweep of 98 convenience stores by U.S. immigration authorities—resulting in the arrest of 21 unauthorized workers—may signal a new approach to worksite enforcement under the Trump administration, moving away from a strategy of paper-based audits that resulted in higher employer fines and fewer worker arrests. This article explores worksite enforcement over recent decades.

Here’s my Q&A column from the WSJ this week — and if you have any questions for me, you can tweet them to @danariely with the hashtag #askariely, post a comment on my Ask Ariely Facebook page, or email them to AskAriely@wsj.com. ___________________________________________________ Hi Dan, I have a hard time watching...

Taylor Swift announced her City of Lover concert, which took place in Paris, will air on ABC on May 17 at 10 p.m.

Long a country of emigration—13 million Italians went abroad between 1880 and 1915—Italy has also experienced significant inflows of Middle Eastern and sub-Saharan African workers in recent decades. Italy has also been on the frontlines of Europe's refugee crisis. This country profile examines Italy's shifting migration patterns, policy responses over time, and debates.

Being female is a risk factor for Alzheimer’s. Why?

-- Read more on ScientificAmerican.com

What did you get your mother for Mother's Day? Was it beautifully thoughtful, or a rush job you fixed with a few clicks of the mouse and a credit card?

If you happen to stop by a Victoria's Secret store this Wednesday evening, on the eve of Valentine's Day, you will learn something fascinating about human nature that will tell you a lot about people and relationships.

Marking the release of an MPI brief that articulates a new adult education program model, this webinar features a discussion among immigration and legal services, adult education, and digital learning experts. The webinar includes a discussion of strategies to implement the English Plus Integration model, which would maintain a central focus on English language acquisition while also building skills necessary for successful immigrant integration.

To successfully integrate, immigrants and refugees need a variety of skills and knowledge—from English proficiency to understanding how school systems and local services work. Yet the adult education programs in place to support them have narrowed in scope. This policy brief proposes a new instructional model, English Plus Integration, to help states more comprehensively meet the diverse needs of their adult immigrant learners.

Taking stock of weaknesses in the WIOA-driven design of most adult basic education programming, MPI analysts draw on research from the integration, adult education, and postsecondary success fields in arguing for the adoption of an “English Plus Integration” (EPI) adult education program model, and discuss strategies for implementation. 

Roger Federer has returned to winning mode 10 months after his last title, as the home tennis hero schooled Japanese wild card Kei Nishikori 6-1, 6-3 to win a fifth Swiss Indoors title in Basel.

When it comes to big life problems, we often stand at a crossroads: either believe we're powerless against great change, or we rise to meet the challenge. In an urgent call to action, political strategist Tom Rivett-Carnac makes the case for adopting a mindset of "stubborn optimism" to confront climate change -- or whatever crisis may come our way -- and sustain the action needed to build a regenerative future. As he puts it: "Stubborn optimism can fill our lives with meaning and purpose."

Some districts are using new “response lessons” to identify the talented students that traditional assessments miss.

An internationally known gifted-education center is scouting—and helping to develop—gifted students in after-school programs and pullout classes in one of Maryland’s most challenged school districts.

Dougherty County, a largely black school district in an region heavily affected by coronavirus, is no longer subject to desegregation orders first imposed in 1963.

Washington lawmakers last week reached a deal to lift the state's "levy lid," blunting tighter limits on voter-approved local taxes for schools that were set to take effect this year. Gov. Jay Inslee, a Democrat, was expected to sign the legislation that Republicans had criticized.

Berlin : A. Hirschwald, 1865.

Gottingen : Dieterich, 1843.

Berlin : A. Hirschwald, 1899.

Berlin : A. Hirschwald, 1894.

Berlin : A. Hirschwald, 1874.

Braunschweig : Vieweg, 1900.

Gottingen : Dieterich, 1827-

Hannover : Hahn, 1869.

Stuttgart : A. Bonz, 1879.

Berlin : Hirschwald, 1905.

Berlin : A. Hirschwald, 1879.

Tubingen : H. Laupp, 1867.

Wiesbaden : J.F. Bergmann, 1885.

Munchen : In der literarisch artistischen Anstalt, 1831-1842.

Berlin : Hirschwald, 1905.

Manchester : J. Heywood, 1888.

In remote regions of rural Alaska, both schools and the students themselves have to work harder to put together an education that meets students' needs.

[Manchester] : [James Mudd], [between 1800 and 1899]