LG announced the Stylo 5 last June and it seems the company will soon unveil its successor Stylo 6 that has appeared in a press render shared by reliable leakster Evan Blass. Unlike its predecessor, the LG Stylo 6 packs a notched display surrounded by slimmer bezels at the top and bottom. On the back, the Stylo 6 features a triple camera setup placed horizontally as opposed to the single camera on the Stylo 5. The back of the Stylo 6 also houses a fingerprint scanner for biometric authentication. LG Stylo 6 • LG Stylo 5 On the right side of the Stylo 6 is the power button...

China should drastically increase its stockpile of nuclear warheads to dissuade the United States from pursuing its strategic ambitions abroad, the editor of the Global Times has urged.
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The Triple Beat analysis is similar to Rapid IP2/IP3 analysis except that it uses three tones instead of two. It is used in cases where two closely-spaced small-signal inputs from a transmitter leak in to the receiver along with an intended small-signal RF input signal. (read more)

The world needs to triple the energy it gets from renewables, nuclear reactors and power plants that use emissions-capture technology to avoid dangerous levels of global warming, United Nations scientists said.

Billionaire Rubens Ometto’s Cosan SA has the potential to triple its power generation by burning sugar-cane leftovers if the government offers power-purchase contracts for biomass producers.

Kim Sang-jo, Chairman of the Fair Trade Commission, said, "Our commission will soon announce plans to stop the practice of large companies using technology of small enterprises without proper compensation." He held a press conference on August 13 at the Sejong government complex in relation to his agency's bid to root out unfair practices in the retail industry and said, "The biggest obstacle for small- and medium-sized enterprises for their further development is the uneven relationship with...

The Nagpur Municipal Corporation (NMC) has proposed a penalty of threefold property tax on residential structures lacking the Occupancy Certificate (OC). As the Nagpur Municipal Corporation (NMC) plans to levy threefold property tax on residential structures lacking the Occupancy Certificates (OCs), it may affect as many as 90 percent of the buildings in the city. Tukaram Mundhe, Commissioner, NMC, avers that the occupancy certificate is mandatory as per the building byelaws stated under the Maharashtra Regional and Town Planning (MRTP) Act, 1966. Therefore, all the building owners should obtain OC to avoid penalties. Nagpur has around 3,000 buildings that were served notices under the MRTP Act, but penalties were not levied until […]

East Africa's "triple threat" — the coronavirus, locusts, and floods — are not mutually exclusive. In fact, each is inextricably linked.

ADB tripled the size of its response to the COVID-19 pandemic to $20 billion and approved measures to streamline its operations for quicker and more flexible delivery of assistance, says ADB President Masatsugu Asakawa.

Jellyfish have been equipped with embedded electronics that let researchers remotely control their motion, and the next version could add sensors for monitoring ocean conditions

Title: Births of Triplets, Quadruplets on Decline in U.S.: Report
Category: Health News
Created: 4/28/2016 12:00:00 AM
Last Editorial Review: 4/28/2016 12:00:00 AM

Title: FDA Approves Trodelvy for Metastatic Triple-Negative Breast Cancer
Category: Health News
Created: 4/24/2020 12:00:00 AM
Last Editorial Review: 4/24/2020 12:00:00 AM

Triple-negative breast cancer (TNBC) accounts for 10 to 20% of breast cancer, with chemotherapy as its mainstay of treatment due to lack of well-defined targets, and recent genomic sequencing studies have revealed a paucity of TNBC-specific mutations. Recurrent gene fusions comprise a class of viable genetic targets in solid tumors;...

Triple-negative breast cancer (TNBC) is characterized by its aggressive biology, early metastatic spread, and poor survival outcomes. TNBC lacks expression of the targetable receptors found in other breast cancer subtypes, mandating use of cytotoxic chemotherapy. However, resistance to chemotherapy is a significant problem, encountered in about two-thirds of TNBC patients, and new strategies are needed to mitigate resistance. In this issue of the Journal of Biological Chemistry, Geck et al. report that TNBC cells are highly sensitive to inhibition of the de novo polyamine synthesis pathway and that inhibition of this pathway sensitizes cells to TNBC-relevant chemotherapy, uncovering new opportunities for addressing chemoresistance.

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor and together they regulate transcription of actin cytoskeleton genes. MKL1 is associated with hematologic malignancies and immunodeficiency, but its role in B cells is unexplored. Here we examined B cells from monozygotic triplets with an intronic deletion in MKL1, two of whom had been previously treated for Hodgkin lymphoma (HL). To investigate MKL1 and B-cell responses in the pathogenesis of HL, we generated Epstein-Barr virus-transformed lymphoblastoid cell lines from the triplets and two controls. While cells from the patients with treated HL had a phenotype close to that of the healthy controls, cells from the undiagnosed triplet had increased MKL1 mRNA, increased MKL1 protein, and elevated expression of MKL1-dependent genes. This profile was associated with elevated actin content, increased cell spreading, decreased expression of CD11a integrin molecules, and delayed aggregation. Moreover, cells from the undiagnosed triplet proliferated faster, displayed a higher proportion of cells with hyperploidy, and formed large tumors in vivo. This phenotype was reversible by inhibiting MKL1 activity. Interestingly, cells from the triplet treated for HL in 1985 contained two subpopulations: one with high expression of CD11a that behaved like control cells and the other with low expression of CD11a that formed large tumors in vivo similar to cells from the undiagnosed triplet. This implies that pre-malignant cells had re-emerged a long time after treatment. Together, these data suggest that dysregulated MKL1 activity participates in B-cell transformation and the pathogenesis of HL.

Purpose:

Preclinical data demonstrating androgen receptor (AR)–positive (AR⁺) triple-negative breast cancer (TNBC) cells are sensitive to AR antagonists, and PI3K inhibition catalyzed an investigator-initiated, multi-institutional phase Ib/II study TBCRC032. The trial investigated the safety and efficacy of the AR-antagonist enzalutamide alone or in combination with the PI3K inhibitor taselisib in patients with metastatic AR⁺ (≥10%) breast cancer.

Alexandria Cimoch starred on the show with her siblings

A two-week course of antiviral therapy with interferon beta-1b plus lopinavir-ritonavir and ribavirin, started within 7 days of showing COVID-19 symptoms, is safe and more effective at reducing the duration of viral shedding than lopinavir-ritonavir alone in patients with mild to moderate illness, according to the first randomized trial of this triple combination therapy involving 127 adults (aged 18 and older) from six public hospitals in Hong Kong.

Customers who rely on cellular connections to access the internet say they're being hit with unfair overage fees when many are required to work and study from home. They want better price breaks and say promises to beef up high-speed access outside major cities haven’t resulted in action.

(MedPage Today) -- Triple therapy -- with methotrexate, hydroxychloroquine, and sulfasalazine -- is little used for the treatment of rheumatoid arthritis (RA) in the U.S. today, and clinical outcomes showed less efficacy than regimens combining...

Eight new medicines recommended for approval

Azikiwe Aquart, aka “Z” and “Ziggy,” 32, pleaded guilty on Aug. 26, 2011, to three counts of murder in aid of racketeering.

Vertex Pharmaceuticals announced a plan late Tuesday to begin trials before the end of the year of the third in its so-called “triple combo” of pills designed to treat as much as 90 percent of the 75,000 patients worldwide who suffer from cystic fibrosis. That news, announced in conjunction with the Boston-based drugmaker’s third-quarter financial results last night, spurred a 6 percent stock increase after hours, implying the company’s market cap could increase by about half a billion dollars…

The U.N. triples its fundraising target for fighting the coronavirus, even as President Trump plans to freeze U.S. aid to its principal health agency.

Throughout its tumultuous four decades of rule, the Islamic Republic has shown remarkable longevity, despite regular predictions of its im- pending demise. However, the fact that it has largely failed to deliver on the promises of the 1979 revolution, above all democracy and social justice, continues to haunt its present and future. Iran’s post-revolutionary history…

Throughout its tumultuous four decades of rule, the Islamic Republic has shown remarkable longevity, despite regular predictions of its im- pending demise. However, the fact that it has largely failed to deliver on the promises of the 1979 revolution, above all democracy and social justice, continues to haunt its present and future. Iran’s post-revolutionary history…

A cluttered apartment room becomes a modern place to sleep and play for three siblings.

Investing in delivery in recent years, including a rewards program and digital ordering, has paid off for Bloomin' in the long run and will continue to pay off going forward, Deno said.

Alexander Lacik, CEO and president of Pandora, discusses the Danish jeweler's earnings.

Representational Image

Researchers have developed a remedy to thwart the metastatic spread of breast cancer, a leading cause of death among women. The findings, published in the journal Nature Communications, showed that by inhibiting a protein called TAK1, the researchers were able to reduce lung metastasis in mice with triple-negative breast cancer (TNBC).

TNBC is a deadliest type of breast cancer that comprises 20 per cent of breast cancer cases and is particularly difficult to treat.

"For this subtype of breast cancer, few treatment options are available to target metastasis, and typically, these treatments are associated with high toxicity," said co-author Min Yu, Assistant Professor from the University of Southern California.

"A better understanding of tumour cells and their interactions with organs and tissues could help us design targeted therapies specific for metastasis," Yu added.

According to the study, TAK1 enables malignant cells from the breast to survive in the lungs and form new metastatic tumours.

Metastasis are the most common cause of cancer-related death.

There is already a potential drug, called OXO -- that can inhibit TAK1 -- and presumably make it much more difficult for breast cancer cells to form lung metastases. However, OXO is not stable in the blood, and therefore would not work in patients, the researcher said.

The researchers developed a nanoparticle -- consisting of a tiny fatty sac -- that works like a smart bomb to carry drugs through the bloodstream and deliver them directly to tumours.

The scientists loaded this nanoparticle with OXO, and used it to treat mice that had been injected with human breast cancer cells. While OXO did not shrink primary tumours in the breast, it greatly reduced metastatic tumours in the lungs with minimal toxic side effects.

"For patients with triple-negative breast cancer, systemic chemotherapies are largely ineffective and highly toxic. So nanoparticles are a promising approach for delivering more targeted treatments, such as OXO, to stop the deadly process of metastasis," Yu noted.

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The findings, published in the Lancet medical journal, showed that on average, people who got the triple drug reached the point of no detectable virus five days earlier than those in the control group - at 7 days versus 12 days

Triple-pill approach is cheaper and more effective for patients with mild-to-moderate hypertension comparing to usual methods./br These are the

Triple drug combination of antiviral drugs helped relieve symptoms in patients with mild to moderate Covid-19 infection and quickly reduced the amount of virus in their bodies, reports a new study.