Market-leading impact protection brand D3O is a common denominator in three ISPO 2019 award-winning products

Saturday's 14-race Florida Derby Day card gets under way at 11:30 a.m. from Gulfstream Park in Hallandale Beach, Fla., and the Grade 1 Derby will feature a full field of 3-year-olds competing for $750,000 and 170 qualifying points for the Kentucky Derby, now scheduled for Sept. 5 (100 points to the winner, 40 to second, […]

The post Triple Crown News Minute Presented By Kentucky Equine Research: Closer Look At Florida Derby Contenders appeared first on Horse Racing News | Paulick Report.

In this edition of the Triple Crown News Minute, Paulick Report publisher Ray Paulick takes a look at the first division of Saturday's Grade 1 Arkansas Derby at Oaklawn in Hot Springs, Ark. The Arkansas Derby is an official points race on the road to the Kentucky Derby that offers a total of 170 points […]

The post Triple Crown News Minute Presented By Kentucky Equine Research: Can Anyone Beat Charlatan? appeared first on Horse Racing News | Paulick Report.

By all accounts, the second division of Saturday's Grade 1 Arkansas Derby from Oaklawn in Hot Springs, Ark., going as the 13th race on the 14-race closing-day program, is much deeper in quality than the first division, which is dominated by the Speightstown colt Charlatan, likely an odds-on favorite. Nadal, who like Charlatan is an […]

The post Triple Crown News Minute Presented By Kentucky Equine Research: Arkansas Derby’s Deeper Division appeared first on Horse Racing News | Paulick Report.

A three link block of information with rollover effect.

By Jessica Corbett Common Dreams “The most robust study of the ice mass balance of Antarctica to date,” scientists say, “now puts Antarctica in the frame as one of the largest contributors to sea-level rise.” Scientists are expressing alarm over … Continue reading →

We prove that, given a constant $K> 2$ and a bounded linear operator $T$ from a JB$^*$-triple $E$ into a complex Hilbert space $H$, there exists a norm-one functional $psiin E^*$ satisfying $$|T(x)| leq K , |T| , |x|_{psi},$$ for all $xin E$. Applying this result we show that, given $G > 8 (1+2sqrt{3})$ and a bounded bilinear form $V$ on the Cartesian product of two JB$^*$-triples $E$ and $B$, there exist norm-one functionals $varphiin E^{*}$ and $psiin B^{*}$ satisfying $$|V(x,y)| leq G |V| , |x|_{varphi} , |y|_{psi}$$ for all $(x,y)in E imes B$. These results prove a conjecture pursued during almost twenty years.

ErdH{o}s and Hajnal constructed a 4-coloring of the triples of an $N$-element set such that every $n$-element subset contains 2 triples with distinct colors, and $N$ is double exponential in $n$. Conlon, Fox and R"odl asked whether there is some integer $qge 3$ and a $q$-coloring of the triples of an $N$-element set such that every $n$-element subset has 3 triples with distinct colors, and $N$ is double exponential in $n$. We make the first nontrivial progress on this problem by providing a $q$-coloring with this property for all $qgeq 9$, where $N$ is exponential in $n^{2+cq}$ and $c>0$ is an absolute constant.

The disclosure relates generally to triple-redundant sequential state (TRSS) machines formed as integrated circuits on a semiconductor substrate, such as CMOS, and computerized methods and systems of designing the triple-redundant sequential state machines. Of particular focus in this disclosure are sequential state elements (SSEs) used to sample and hold bit states. The sampling and holding of bits states are synchronized by a clock signal thereby allowing for pipelining in the TRSS machines. In particular, the clock signal may oscillate between a first clock state and a second clock state to synchronize the operation of the SSE according to the timing provided by the clock states. The SSEs has a self-correcting mechanism to protect against radiation induced soft errors. The SSE may be provided in a pipeline circuit of a TRSS machine to receive and store a bit state of bit signal generated by combinational circuits within the pipeline circuit.

This invention relates to a novel rotary control valve with new joint methods and flow control mechanisms, inline-reparability and fully metal seals more particularly to a triple offset butterfly valve or ball valve with those features used for on-off and flow controlling under multiple extreme conditions or in severe services; such as the integrated gasification combined cycle under high temperature and pressure, Fluid Catalytic Cracking under high temperature over 1200 F with hard diamond like catalytic particles, shale fracking process under extreme high pressure and high velocity fluid with solid particles and corrosive additives and other critical applications for products life lasting 5 to 30 years like deepsea flow control systems and nuclear power plants and for the applications of millions cycles like jet or rocket turbine engine fuel delivery systems with high velocity fuel fluid mixed with highly oxidative gas under temperature 1365 F.

The disclosure relates generally to sequential state elements (SSEs), triple-mode redundant state machines (TMRSMs), and methods and systems for testing triple-mode redundant pipeline stages (TMRPSs) within the TMRSMs using triple-mode redundant SSEs (TMRSSEs). The SSEs, TMRSMs, TMRPSs, and TMRSSEs may be formed as integrated circuits on a semiconductor substrate. Of particular focus in this disclosure are SSEs used to sample and hold bit states. Embodiments of the SSEs have a self-correcting mechanism to protect against radiation-induced soft errors. The SSE may be provided in a pipeline circuit of a TMRSM to receive and store a bit state of a bit signal generated by combinational circuits within the pipeline circuit. More specifically, the SSEs may be provided in a TMRSSE configured to perform self-correction. Also disclosed are methods for using the TMRSSE to test redundant pipeline stages of the TMRSM.

A frequency tripler device is disclosed. The frequency tripler device includes a first graphene based field effect transistor (FET) of a first dopant type, having a gate, a drain, and a source, and a second graphene based FET of a second dopant type, having a gate, a drain, and a source, the gate of the first FET coupled to the gate of the second FET and coupled to an input signal having an alternating current (AC) signal of a first frequency, the combination of the first and second FETs generates an output signal with a dominant AC signal of a frequency of about three times the first frequency.

A press felt includes: a base fabric comprising a plurality of repeat units, each of the repeat units comprising a plurality of exterior machine direction (MD) yarns, each of which includes an upper run and a lower run merging with seam loops at each end, a plurality of middle MD yarns positioned between the upper and lower runs of the exterior MD yarns, a plurality of cross machine direction (CMD) yarns interwoven with the exterior MD yarns and the middle MD yarns in a predetermined regular weave pattern, the seam loops defining the longitudinal ends of the press felt; and a batt layer overlying the base fabric.

The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer (“TIMS”) is used as the ion mobility separation device coupled to a triple quadrupole mass filter assembly. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with upstream substance separator. TIMS, in particular equipped with parallel accumulation, provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species such as to improve the quality of the fragment ion spectra.

Triple Spiral Audio has announced the release of Paradox Lost Redux, a unique Kontakt instrument library by Beautiful Void Audio based on strange, beautiful, and bizarre soundscapes, drones and “simple” tones. At times the sounds capture a fitting, paradoxical cross between evolving and static, beautiful and dirty, dark and light. Some sounds will seem familiar […]

The post Triple Spiral Audio launches Paradox Lost Redux by Beautiful Void Audio appeared first on rekkerd.org.

Cresco Labs Inc. said it has completed the expansion project for its cultivation and manufacturing facility located in Brookville, Pennsylvania, enabling the company to triple its cannabis cultivation capacity in the state.

Mother’s Day at Sydney Zoo will be three times as special this year as the park celebrates the births of a trio of ­little girls.

The small SA town of Lucindale prepares to balloon to 40 times the size of its population as it hosts a free concert drawing in music-lovers and road-trippers from across the country.

Australia's top musicians joined a 15,000-strong crowd in Lucindale for triple j's One Night Stand, marking the small town's biggest day ever. Some of the best moments happened off-stage.

With the help of 15,000 festival goers at the weekend's triple j One Night Stand donating more than $22,000, Lucindale's pool is now weeks away from opening.

Widespread soaking rain in the New South Wales Central West has upped farmers' confidence for a bumper winter cropping season.

Triple murderer Matthew De Gruchy has been driven away from Sydney's Long Bay jail after serving 23 years of his 28-year sentence for bludgeoning to death his mother and younger brother and sister.

Montreal Hip-hop Collective Triple-R Has Signed With Squash Comp And Released Their Debut Album “Red Rum Records”

Montreal Hip-hop Collective Triple-R Has Signed With Squash Comp And Released Their Debut Album “Red Rum Records”

Ma'am, Are you in need of roadside assistance?

Researchers used artificial intelligence to reevaluate elevations vulnerable to rising sea levels.

A small oil town in Southern California is pummeled by the economy during the coronavirus outbreak and economic downturn

Late Tuesday night, police officers in Visalia, a San Joaquin Valley city about 40 miles southeast of Fresno, responded to a report of shots fired at a high school.

The United Nations wants the money to help people in 63 countries, mainly in Africa and Latin America.

strataconf: Moving to the open healthcare graph http:// http://t.co/YYTUDN3Vzn Achieving the triple aim in healthcare: better, cheaper, safer #stratarx

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

Alexander Kolpakov and Sinai Robins
Math. Comp. 89 (2019), 2031-2046.
Abstract, references and article information

Numerous recent works highlight the limited utility of established tumor cell lines in recapitulating the heterogeneity of tumors in patients. More realistic preclinical cancer models are thought to be provided by transplantable, patient-derived tumor xenografts (PDX). Inter- and intra-tumor heterogeneity of PDX, however, present several challenges in developing optimal quantitative pipelines to assess response to therapy. The objective of this work was to develop and optimize image metrics of FDG-PET to assess response to combination docetaxel/carboplatin therapy in a co-clinical trial involving triple negative breast cancer (TNBC) PDX. We characterize the reproducibility of SUV metrics to assess response to therapy and optimize a preclinical PERCIST (µPERCIST) paradigm to complement clinical standards. Considerations in this effort included variability in tumor growth rate and tumor size; solid tumor vs. tumor heterogeneity and necrotic phenotype; and optimal selection of tumor slice versus whole tumor. A test-retest protocol was implemented to optimize the reproducibility of FDG-PET SUV thresholds, SUVpeak metrics, and µPERCIST parameters. In assessing response to therapy, FDG-PET imaging was performed at baseline and +4 days following therapy. The reproducibility, accuracy, variability, and performance of imaging metrics to assess response to therapy were determined. We defined an index—"Quantitative Response Assessment Score (QRAS)"—to integrate parameters of prediction and precision, and thus aid in selecting optimal image metrics of response to therapy. Our data suggests that a threshold value of 25% (SUV25) of SUVmax was highly reproducible (<9% variability). Concordance and reproducibility of µPERCIST were maximized at α=0.7 and β=2.8 and exhibited high correlation to SUV25 measures of tumor uptake. QRAS scores favor SUV25 followed by SUVP14 as optimal metrics of response to therapy. Additional studies are warranted to fully characterize the utility of SUV25 and µPERCIST SUVP14 as image metrics of response to therapy across a wide range of therapeutic regiments and PDX models.

Triple negative breast cancer (TNBC) remains the most aggressive subtype of breast cancer leading to the worst prognosis. Because current therapeutic approaches lack efficacy, there is a clinically unmet need for effective treatment alternatives. Herein, we demonstrate a promising strategy utilizing a tumor-targeting alkylphosphocholine (NM600) radiolabeled with ¹⁷⁷Lu for targeted radionuclide therapy (TRT) of TNBC. In two murine syngeneic models of TNBC, we confirmed excellent tumor targeting and rapid normal tissue clearance of the PET imaging analog ⁸⁶Y-NM600. Based on longitudinal PET/CT data acquired with ⁸⁶Y-NM600, we estimated the dosimetry of therapeutic ¹⁷⁷Lu-NM600, which showed larger absorbed doses in the tumor compared to normal tissues. Administration of ¹⁷⁷Lu-NM600 resulted in significant tumor growth inhibition and prolonged overall survival in mice bearing syngeneic 4T07 and 4T1 tumors. Complete response was attained in 60% of 4T07 bearing mice, but animals carrying aggressive 4T1 tumor grafts succumbed to metastatic progression. The injected activities used for treatment (9.25 and 18.5 MBq) were well tolerated, and only mild transient cytopenia was noted. Overall, our results suggest that ¹⁷⁷Lu-NM600 TRT has potential for treatment of TNBC and merits further exploration in a clinical setting.

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with very limited therapeutic options. We have recently shown that the combined inhibition of EGFR and ROCK in TNBC cells results in cell death, however, the underlying mechanisms remain unclear. To investigate this, here we applied a mass spectrometry-based proteomic approach to identify proteins altered on single and combination treatments. Our proteomic data revealed autophagy as the major molecular mechanism implicated in the cells' response to combinatorial treatment. We here show that EGFR inhibition by gefitinib treatment alone induces autophagy, a cellular recycling process that acts as a cytoprotective response for TNBC cells. However, combined inhibition of EGFR and ROCK leads to autophagy blockade and accumulation of autophagic vacuoles. Our data show impaired autophagosome clearance as a likely cause of antitumor activity. We propose that the inhibition of the autophagic flux on combinatorial treatment is attributed to the major cytoskeletal changes induced on ROCK inhibition, given the essential role the cytoskeleton plays throughout the various steps of the autophagy process.

Triple-negative breast cancer (TNBC) is characterized by poor response to therapy and low overall patient survival. Recently, Estrogen Receptor beta (ERβ) has been found to be expressed in a fraction of TNBCs where, because of its oncosuppressive actions on the genome, it represents a potential therapeutic target, provided a better understanding of its actions in these tumors becomes available. To this end, the cell lines Hs 578T, MDA-MB-468 and HCC1806, representing the claudin-low, basal-like 1 and 2 TNBC molecular subtypes respectively, were engineered to express ERβ under the control of a Tetracycline-inducible promoter and used to investigate the effects of this transcription factor on gene activity. The antiproliferative effects of ERβ in these cells were confirmed by multiple functional approaches, including transcriptome profiling and global mapping of receptor binding sites in the genome, that revealed direct negative regulation by ERβ of genes, encoding for key components of cellular pathways associated to TNBC aggressiveness representing novel therapeutic targets such as angiogenesis, invasion, metastasis and cholesterol biosynthesis. Supporting these results, interaction proteomics by immunoprecipitation coupled to nano LC-MS/MS mass spectrometry revealed ERβ association with several potential nuclear protein partners, including key components of regulatory complexes known to control chromatin remodeling, transcriptional and post-transcriptional gene regulation and RNA splicing. Among these, ERβ association with the Polycomb Repressor Complexes 1 and 2 (PRC1/2), known for their central role in gene regulation in cancer cells, was confirmed in all three TNBC subtypes investigated, suggesting its occurrence independently from the cellular context. These results demonstrate a significant impact of ERβ in TNBC genome activity mediated by its cooperation with regulatory multiprotein chromatin remodeling complexes, providing novel ground to devise new strategies for the treatment of these diseases based on ligands affecting the activity of this nuclear receptor or some of its protein partners.

Triple-negative breast cancer (TNBC) is characterized by its aggressive biology, early metastatic spread, and poor survival outcomes. TNBC lacks expression of the targetable receptors found in other breast cancer subtypes, mandating use of cytotoxic chemotherapy. However, resistance to chemotherapy is a significant problem, encountered in about two-thirds of TNBC patients, and new strategies are needed to mitigate resistance. In this issue of the Journal of Biological Chemistry, Geck et al. report that TNBC cells are highly sensitive to inhibition of the de novo polyamine synthesis pathway and that inhibition of this pathway sensitizes cells to TNBC-relevant chemotherapy, uncovering new opportunities for addressing chemoresistance.

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

Atherosclerosis-related CVD causes nearly 20 million deaths annually. Most patients are treated after plaques develop, so therapies must regress existing lesions. Current therapies reduce plaque volume, but targeting all apoB-containing lipoproteins with intensive combinations that include alirocumab or evinacumab, monoclonal antibodies against cholesterol-regulating proprotein convertase subtilisin/kexin type 9 and angiopoietin-like protein 3, may provide more benefit. We investigated the effect of such lipid-lowering interventions on atherosclerosis in APOE*3-Leiden.CETP mice, a well-established model for hyperlipidemia. Mice were fed a Western-type diet for 13 weeks and thereafter matched into a baseline group (euthanized at 13 weeks) and five groups that received diet alone (control) or with treatment [atorvastatin; atorvastatin and alirocumab; atorvastatin and evinacumab; or atorvastatin, alirocumab, and evinacumab (triple therapy)] for 25 weeks. We measured effects on cholesterol levels, plaque composition and morphology, monocyte adherence, and macrophage proliferation. All interventions reduced plasma total cholesterol (37% with atorvastatin to 80% with triple treatment; all P < 0.001). Triple treatment decreased non-HDL-C to 1.0 mmol/l (91% difference from control; P < 0.001). Atorvastatin reduced atherosclerosis progression by 28% versus control (P < 0.001); double treatment completely blocked progression and diminished lesion severity. Triple treatment regressed lesion size versus baseline in the thoracic aorta by 50% and the aortic root by 36% (both P < 0.05 vs. baseline), decreased macrophage accumulation through reduced proliferation, and abated lesion severity. Thus, high-intensive cholesterol-lowering triple treatment targeting all apoB-containing lipoproteins regresses atherosclerotic lesion area and improves lesion composition in mice, making it a promising potential approach for treating atherosclerosis.

Triple-negative breast cancer (TNBC) is characterized by its aggressive biology, early metastatic spread, and poor survival outcomes. TNBC lacks expression of the targetable receptors found in other breast cancer subtypes, mandating use of cytotoxic chemotherapy. However, resistance to chemotherapy is a significant problem, encountered in about two-thirds of TNBC patients, and new strategies are needed to mitigate resistance. In this issue of the Journal of Biological Chemistry, Geck et al. report that TNBC cells are highly sensitive to inhibition of the de novo polyamine synthesis pathway and that inhibition of this pathway sensitizes cells to TNBC-relevant chemotherapy, uncovering new opportunities for addressing chemoresistance.

The United Nations more than tripled its humanitarian aid appeal on Thursday from $2 billion to $6.7 billion to accommodate its updated global plan to help the poorest nations fight the coronavirus pandemic.

OBJECTIVE

The vast number of antihyperglycemic medications and growing amount of evidence make clinical decision making difficult. The aim of this study was to investigate the safety of antihyperglycemic dual and triple therapies for type 2 diabetes management with respect to major adverse cardiovascular events, severe hypoglycemia, and all-cause mortality in a real-life clinical setting.

2 cups of fresh ricotta 4 eggs 2 tbsp. sugar Zest of 1 orange, 1lime and 1 lemon 1 cup of plain flour 60 g soft butter

Triple Citrus Syrup

Joblessness now stands at the most since the Great Depression era of the 1930s after the coronavirus pandemic brought the US economy to a standstill.