triple

Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
The content of this RSS Feed (c) The Royal Society of Chemistry




triple

Metal-free synthesis of N-fused quinazolino-quinazoline-diones as a MALAT1 RNA triple helix intercalator

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00614C, Research Article
Vijay Babu Pathi, Pranotosh Das, Abhyuday Guin, Manish Debnath, Biswadip Banerji
The development of chemical scaffolds that target highly conserved MALAT1 RNA received attention due to its significance in splicing, nuclear organization, and gene expression in disease progression pathways.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




triple

603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth

Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web.




triple

Network interactions simultaneously enhance stiffness and lubricity of triple-network hydrogels

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00969J, Paper
Nabila Ali, Connor J. Demott, Olivia F. Dingus, Melissa A. Grunlan, Alison C. Dunn
Tough hydrogels with a charge-variable third network were assessed for biomimicking lubricity in both water and FBS solution.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




triple

Shriram Properties to quadruple profit, triple revenue by FY27

“Shriram Properties will embrace the new era under the banner SPLNxT to reposition the brand; enhance focus on mid-market and mid-premium segments, and accelerate growth”




triple

Poorva wins triple jump gold with meet record; men’s pole vault final postponed as pit reaches late




triple

Triple-shelled Ni@MnO/C hollow spheres with enhanced performance for rechargeable zinc-ion capacitors

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02303J, Paper
Tao Xiang, Zaiting Qu, Daohong Zhang, Chenglong Hu, Zhen Chen, Qiufan Wang
Ni/MnO@C nanospheres with different core–shell structures are obtained by using Ni3Mn-MOFs as templates, exhibiting excellent electrochemical properties as cathodes in zinc-ion storage.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




triple

Tunability of triplet excited states and photophysical behaviour of bis-cyclometalated iridium(III) complexes with imidazo[4,5-f][1,10]phenanthroline

Dalton Trans., 2024, 53,17934-17947
DOI: 10.1039/D4DT01996B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katarzyna Choroba, Joanna Palion-Gazda, Mateusz Penkala, Patrycja Rawicka, Barbara Machura
The impact of cyclometalating ligands on the photophysical behaviour of heteroleptic Ir(III) complexes with imidazo[4,5-f][1,10]phenanthroline. [Ir(ppy)2(imphen)]+ is a 3MLLCT emitter, while [Ir(pybzth)2(imphen)]+ has a predominant 3LCN∩C character.
The content of this RSS Feed (c) The Royal Society of Chemistry




triple

Beyond the triple bond: unlocking dinitrogen activation with tailored superbase phosphines

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02703E, Paper
Vilakkathala U. Krishnapriya, Cherumuttathu H. Suresh
Dinitrogen activation has long been a challenging goal in chemistry. Tailored superbase phosphines offer a promising approach to overcome this challenge by going beyond the traditional triple bond.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




triple

COVID-19 triples across Europe on past six weeks; hospitalisations double: World Health Organisation

WHO's Europe director Dr. Hans Kluge described COVID-19 as “a nasty and potentially deadly illness” that people should not underestimate.




triple

Stress regulation via surface micro-etching and reconstruction for enhancing triple-cation perovskite solar cells with an efficiency of 25.54%

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE04248D, Paper
Yang Ding, Erming Feng, Siyuan Lu, Jianhui Chang, Caoyu Long, Sichao Tong, Hengyue Li, Junliang Yang
A surface micro-etching and reconstruction strategy is developed to regulate the stresses in a perovskite film, achieving a benign transition from tensile stress to compressive stress.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




triple

Industrial AI firm Avathon to focus on India for R&D growth, aims to triple workforce in two years

India will play a pivotal role in our expansion, serving as a hub for product engineering, delivery, support and R&D, says CEO Johan




triple

Free drug and ROS-responsive nanoparticle delivery of synergistic doxorubicin and olaparib combinations to triple negative breast cancer models

Biomater. Sci., 2024, 12,1822-1840
DOI: 10.1039/D3BM01931D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Robert J. Cavanagh, Patrícia F. Monteiro, Cara Moloney, Alessandra Travanut, Fatemeh Mehradnia, Vincenzo Taresco, Ruman Rahman, Stewart G. Martin, Anna M. Grabowska, Marianne B. Ashford, Cameron Alexander
Combinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose) polymerase inhibitor olaparib offer potential drug–drug synergy for treatment of triple negative breast cancers (TNBC) both in free drug form and when delivered by oxidation-responsive nanoparticles.
The content of this RSS Feed (c) The Royal Society of Chemistry




triple

Light-inducible nanodrug-mediated photodynamic and anti-apoptotic synergy for enhanced immunotherapy in triple-negative breast cancer

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00083H, Paper
Jing Huang, Xingliang Liu, Minzhao Lin, Zecong Xiao, Xintao Shuai
An ROS-labile nanodrug co-encapsulating Ce6 and a Bcl-2 inhibitor enabled PDT and reversed apoptotic resistance, demonstrating a potent inhibitory effect on tumor growth.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




triple

'PS-1 is my triple bonus film'

'First, I get to play a princess, second, it is a Mani Ratnam film and third, it is a period film.'




triple

Infinix Zero Flip to use triple 50 MP lenses with 4K video recording and GoPro compatibility

The Chinese smartphone maker will launch the Zero Flip on October 17 in India




triple

Spatial acid–base–Pd triple-sites of a hierarchical core–shell structure for three-step tandem reaction

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01701A, Communication
Jian Wu, Gang-Gang Chang, You-Qing Peng, Xiao-Chen Ma, Shan-Chao Ke, Si-Ming Wu, Yu-Xuan Xiao, Ge Tian, Tao Xia, Xiao-Yu Yang
We present a hierarchical single catalyst with spatial acid–base–Pd triple-sites showing high catalytic activity and stability for the three-step D–K–H tandem reaction.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




triple

A Full On Triple Rainbow?!!

Let's just assume it's where this guy lives




triple

2020 Triumph Street Triple RS revised India launch date out: Key changes and expected price hike!

Once launched, the new 2020 Triumph Street Triple RS will be one of the first BS6 compliant middleweight naked streetfighters to go on sale here in India.




triple

2020 Triumph Street Triple RS India launch tomorrow: KTM 790 Duke rival with improved styling, features!

One of the prime changes on the new 2020 Triumph Street Triple RS is the engine that offers a better and more solid mid-range now along with better refinement.




triple

2020 Triumph Street Triple RS launched in India: More power, better features, same price

2020 Triumph Street Triple RS India Launch: The new 2020 Street Triple RS has been updated with new design and styling, but most importantly the engine now puts out more torque than the previous model.




triple

2020 Triumph Street Triple RS launched at Rs 11.13 lakh: KTM 790 Duke challenger gets sharper, more feature-rich!

The new 2020 Triumph Street Triple RS is now here, in India! Here is what all has changed apart from a BS6 compliant motor.




triple

Global Renewable Energy Should Triple to Save Climate, UN Panel Says

The world needs to triple the energy it gets from renewables, nuclear reactors and power plants that use emissions-capture technology to avoid dangerous levels of global warming, United Nations scientists said.




triple

Can Malaysia cope with a ‘triple whammy’ economic shock?

There was little sign of cheer in Malaysia last week even as the government began easing the gruelling nationwide lockdown it had put in place to curb the spread of Covid-19, with all eyes now on the bleak economic road ahead.Government data released on Friday showed the unemployment rate in Southeast Asia’s third-largest economy rose to 3.9 per cent in March – the highest rate since 2010, and a 17.1 per cent jump from a year ago. Expectations are that the figure will continue to surge.While…




triple

Aussie sporting brawls – No.6: A triple eye socket break and the most barbaric act in SCG history – When Newtown turned Manly blue

Speak to older relatives and they will tell you everything was better in the eighties. On the subject of fights on a rugby league field – it’s hard to argue any other way especially when you look at Newtown’s semi-final clash with Manly in 1981 which has a deserved place in foxsports.com.au’s Biggest brawls in Aussie sport’ countdown.




triple

‘It’s not some backyard fight’: Cruz rages after Triple C retains title... then retires

Controversy was on the cards when Dominick Cruz lost to a Henry Cejudo TKO in the bantamweight division at UFC 249, before the winner called time on his career.




triple

Triple antiviral drug combo shows promise for treating COVID-19

A two-week course of antiviral therapy that combines the power of three drugs has shown promise in treating hospitalised patients with mild to moderate COVID-19 in a carefully undertaken phase 2 clinical trial.

The results of the trial, published in the journal The Lancet, involved 127 adults from six public hospitals in Hong Kong.

The drug combination tested in the trial included interferon beta-1b, which was developed to treat multiple sclerosis (MS), and lopinavir-ritonavir, which is normally used to treat HIV and ribavirin, an oral hepatitis C virus drug.

The findings of the phase two trial provided evidence that early treatment with triple antiviral therapy alongside standard care is safe and shortens duration of viral shedding (when the virus is detectable and potentially transmissible) compared to lopinavir-ritonavir alone—average seven days vs 12 days—in patients with mild to moderate COVID-19.

"Our trial demonstrates that early treatment of mild to moderate COVID-19 with a triple combination of antiviral drugs may rapidly suppress the amount of virus in a patient's body, relieve symptoms, and reduce the risk to healthcare workers by reducing the duration and quantity of viral shedding," said professor Kwok-Yung Yuen from the University of Hong Kong who led the research.

No new cases in Hong Kong as restrictions ease

Hong Kong recorded no new COVID-19 case on Saturday, a day after the city eased restrictions. Saturday was also the 20th day in a row with no local infections. Health experts earlier suggested that Hong Kong could be considered to be free of local transmission if there were no such cases after 28 days.

Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever




triple

Workshop: Knowledge-Based Entrepreneurship, the Triple Helix and Local Economic Development (London, UK)

The creation of innovative new firms and the development of SME innovation are strongly influenced by the extent to which localities offer environments that favour the transfer of knowledge to local business and provide the other resources required for innovative firm development, including skills, finance, advice, and supply chain partners.




triple

Triple Disadvantage? A first overview of the integration of refugee women

45% of refugees in Europe are women, yet little is known on their integration outcomes and the specific challenges they face. This report summarises prior research on the integration of refugee women, both compared with refugee men and other immigrant women. It also provides new comparative evidence from selected European and non-European OECD countries.




triple

Workshop: Knowledge-Based Entrepreneurship, the Triple Helix and Local Economic Development (London, UK)

The creation of innovative new firms and the development of SME innovation are strongly influenced by the extent to which localities offer environments that favour the transfer of knowledge to local business and provide the other resources required for innovative firm development, including skills, finance, advice, and supply chain partners.




triple

Workshop: Knowledge-Based Entrepreneurship, the Triple Helix and Local Economic Development (London, UK)

The creation of innovative new firms and the development of SME innovation are strongly influenced by the extent to which localities offer environments that favour the transfer of knowledge to local business and provide the other resources required for innovative firm development, including skills, finance, advice, and supply chain partners.




triple

Hacking attacks on educational portal tripled in Q1 amid online learning




triple

Triple antiviral drug combo shows promise for treating COVID-19




triple

Discovery triples number of stars in universe

The team discovered that there are about 20 times more red dwarfs in elliptical galaxies than in the Milky Way, said Charlie Conroy of the Harvard-Smithsonian Center for Astrophysics.

The post Discovery triples number of stars in universe appeared first on Smithsonian Insider.




triple

Tiger numbers could triple if large-scale landscapes are protected

The tiger reserves of Asia could support more than 10,000 wild tigers – three times the current number – if they are managed as large-scale […]

The post Tiger numbers could triple if large-scale landscapes are protected appeared first on Smithsonian Insider.




triple

Triple Play: What An Abbreviated 2020 MLB Season Might Look Like

People sit on a hill overlooking Dodger Stadium on what was supposed to be Major League Baseball's opening day, now postponed due to the coronavirus, on March 26, 2020 in Los Angeles, California. ; Credit: Mario Tama/Getty Images

AirTalk®

Had the 2020 MLB season started at the end of March like it was scheduled to, at this point we’d be starting to see divisions shape up, star pitchers and position players separating themselves from the rest of the league and a first look at who this year’s contenders and pretenders really would be. Sadly, the COVID-19 outbreak forced the league to postpone the start of the season, and now the question has become if there will be a season, not when. 

Not to be dragged down by the idea of no baseball, Wall Street Journal sports writer Jared Diamond took a recent proposal the league floated for an abbreviated 2020 campaign and gamed out how that might look in real life. The league’s idea would do away with the National and American Leagues and divide all 30 MLB teams into three divisions of 10 teams separated by region, and those teams would play in empty stadiums and only against other teams in their geographic division in the interests of reducing travel. But how viable is this, really? And what other considerations would the league and players union have to take with regards to testing and protocol for what happens if someone were to contract COVID-19? Is there a world where baseball still happens this year?

Today on AirTalk, Jared Diamond joins the Triple Play of Larry Mantle, Nick Roman and A Martinez to talk about what a shortened 2020 MLB season might look like, which teams stand to win and lose the most from the realignment and what other precautions the league would have to take against the spread of COVID-19.

Guests:

Jared Diamond, national baseball writer for the Wall Street Journal; his new book is "Swing Kings: The Inside Story of Baseball's Home Run Revolution” (William Morrow, March 2020); he tweets @jareddiamond

Nick Roman, host of KPCC’s “All Things Considered”; he tweets @RomanOnTheRadio

A. Martinez, host of KPCC’s “Take Two”; he tweets @amartinezLA

This content is from Southern California Public Radio. View the original story at SCPR.org.




triple

Hacking attacks on educational portal tripled in Q1 amid online learning

DDoS attacks during the first three months of this year have seen a significant spike in attacks on educational websites.




triple

Hacking attacks on educational portal tripled in Q1 amid online learning

DDoS attacks during the first three months of this year have seen a significant spike in attacks on educational websites.




triple

Simple re-seeding projects can triple grassland biodiversity

Researchers have recommended new, improved ways of increasing the ecological value of European grasslands. Plant diversity ??? or species richness ??? can be increased by a factor of three through sowing grass and wildflower seed mixtures, together with a carefully controlled plan for animal grazing.




triple

I-66 Eastbound between Groveton Road and Sudley Road in Manassas Overnight Traffic Stoppages and Triple Lane Closure May 11




triple

The Arab world's triple crisis

A mere change of governments will not make Arab countries’ economic problems go away. Indeed, the converging effects of population growth, climate change, and




triple

Antarctic ice loss has tripled in the last 5 years, and here's why that matters

Antarctica ice loss was only contributing 0.2 millimeters per year to sea level rise, but that number has jumped to 0.6 millimeters since 2012.



  • Wilderness & Resources

triple

Urban sprawl expected to triple by 2030

Urban development is set to triple in the first three decades of this century, the largest cityscape expansion in human history, according to a new study that f



  • Wilderness & Resources

triple

In Portland, a triple-decker tiny house for a family of 3 [Video]

By keeping things compact, Matt Kirkpatrick and Katherine Bovee were able to splurge and have some fun when designing their boxy, prefab abode.



  • Remodeling & Design

triple

Urban treehouse triplex in Atlanta offers shady sanctuary

Environmentalist Peter Bahouth shares the inspiration behind Atlanta's most leafy and lovely Airbnb listing.



  • Remodeling & Design

triple

Cycling triples, driving down 50% in London

The culture of transportation in our cities is changing. Will our cities change with it?




triple

Men's Online Dating Email Tips - Triple Your Dating!

Six email tips that will triple your response and dates online.




triple

Philanthropist Chauncey Lufkin Lends his Foundation's Support to Help Children Affected by Domestic Violence with a "Triple Play" Sponsorship of Joe Torre Safe at Home Foundation's "All Star Evening."

We applaud Joe and Ali Torre for their leadership and dedication. The invasive effects of early childhood trauma on the development of youth cannot be overlooked." Chauncey Lufkin.




triple

Triple Winner: Jackson Design and Remodeling Honored with Three Chrysalis Awards including "Decade of Excellence"

JDR Earns a Rarely Bestowed Decade of Excellence Award, a National Award for a Bold, Mondrian-Inspired Whole Home, and a Regional Award for a Colorful Historic Home




triple

Triple Heir Claims Its Throne with Essential Streetwear, Bold Design

Amid COVID-19 quarantine, creativity reigns supreme