An entry-level DAC and headphone amplifier at a very attractive price point

It was a sunny, Sunday afternoon in Anaheim (across from Disneyland). That combination of weather and entertainment didn't sway a group of 35 engineers from participating in the DFMC (Design for Manufacturability Coalition) Workshop at DAC 2010. On...(read more)

Magyarország lett az OECD Fejlesztési Segítségnyújtási Bizottságának (DAC) 30. tagja. A Bizottság a kétoldalú fejlesztési együttműködést szolgáltató államok vezető nemzetközi fóruma.

Hungary has become the 30th member of the OECD Development Assistance Committee (DAC), the leading international forum for bilateral providers of development co-operation.

Respected breeders will perform DNA screening but potential owners could be duped into buying unhealthy pets from unscrupulous puppy farms abroad.

Respected breeders will perform DNA screening but potential owners could be duped into buying unhealthy pets from unscrupulous puppy farms abroad.

When Fatima Chhipa leaves home, in the congested by-lanes of the Belan Market area, she carries her work trousers and shirt in a plastic bag.

Archives, Room Use Only - TK5261.N38 1928

If you haven’t, you should immediately read Jeremy’s post titled A responsive mind. Not because he says some incredibly kind things about yours truly, but, well, of bits like this:

That’s the thing about responsive web design: you can’t just think of it as a sprinkle of pixie dust that can be applied to any site. It requires the right mindset. It requires that sites be built on solid foundations of best practice. If those foundations are in place—a flexible layout, flexible images, optimised performance—then responsive web design can work its magic.

There are so many wonderful, quotable points that I’m doing Jeremy a disservice by even excerpting that one. If you’d like to understand why a responsive approach would be right for your project (or, perhaps as importantly, why it might not), I urge you to read the whole thing.

Stephen Kershaw, David J. Morgan, James Boyd, David G. Spiller, Gareth Kitchen, Egor Zindy, Mudassar Iqbal, Magnus Rattray, Chris M. Sanderson, Andrew Brass, Claus Jorgensen, Tracy Hussell, Laura C. Matthews, and David W. Ray

Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) to regulate immunity, energy metabolism, and tissue repair. Upon ligand binding, activated GR mediates cellular effects by regulating gene expression, but some GR effects can occur rapidly without new transcription. We show GCs rapidly inhibit cell migration, in response to both GR agonist and antagonist ligand binding. The inhibitory effect on migration is prevented by GR knockdown with siRNA, confirming GR specificity, but not by actinomycin D treatment, suggesting a non-transcriptional mechanism. We identified a rapid onset increase in microtubule polymerisation following glucocorticoid treatment, identifying cytoskeletal stabilisation as the likely mechanism of action. HDAC6 overexpression, but not knockdown of αTAT1, rescued the GC effect, implicating HDAC6 as the GR effector. Consistent with this hypothesis, ligand-dependent cytoplasmic interaction between GR and HDAC6 was demonstrated by quantitative imaging. Taken together, we propose that activated GR inhibits HDAC6 function and thereby increases the stability of the microtubule network to reduce cell motility. We therefore report a novel, non-transcriptional mechanism whereby GCs impair cell motility through inhibition of HDAC6 and rapid reorganization of the cell architecture.

The Trump administration asked the Supreme Court to block Congress from seeking the materials, saying, "The government will suffer irreparable harm absent a stay."; Credit: Andrew Harnik/AP

The Supreme Court has temporarily put on hold the release of redacted grand jury material from the Russia investigation to a House panel.

The Trump administration is trying to block the release.

Last October, a district court judge ruled the Justice Department had to turn over the materials, which were blacked out, from former special counsel Robert Mueller's report into Russian interference in the 2016 election.

An appeals court upheld the decision, but the Trump administration, hoping to keep the evidence secret, appealed to the Supreme Court.

Chief Justice John Roberts' order temporarily stops the process. Lawyers for the House Judiciary Committee have until May 18 to file their response to the Justice Department's attempts to keep the materials from the House panel.

The Justice Department had until Monday to turn over the material following the appeals court order. But on Thursday, the Trump administration asked the Supreme Court to block Congress from seeking it, saying, "The government will suffer irreparable harm absent a stay."

This content is from Southern California Public Radio. View the original story at SCPR.org.

The Trump administration asked the Supreme Court to block Congress from seeking the materials, saying, "The government will suffer irreparable harm absent a stay."; Credit: Andrew Harnik/AP

The Supreme Court has temporarily put on hold the release of redacted grand jury material from the Russia investigation to a House panel.

The Trump administration is trying to block the release.

Last October, a district court judge ruled the Justice Department had to turn over the materials, which were blacked out, from former special counsel Robert Mueller's report into Russian interference in the 2016 election.

An appeals court upheld the decision, but the Trump administration, hoping to keep the evidence secret, appealed to the Supreme Court.

Chief Justice John Roberts' order temporarily stops the process. Lawyers for the House Judiciary Committee have until May 18 to file their response to the Justice Department's attempts to keep the materials from the House panel.

The Justice Department had until Monday to turn over the material following the appeals court order. But on Thursday, the Trump administration asked the Supreme Court to block Congress from seeking it, saying, "The government will suffer irreparable harm absent a stay."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Debuted earlier this month at the International Space University, this short film invites a new generation to imagine and explore the universe's secrets.

President Obama has a tricky balancing act to perform as BP plans to resume offshore drilling in the Gulf of Mexico.

Chuck Leavell, the keyboardist for the Rolling Stones and the cofounder of MNN, interviews rapper Ludacris about recycling, water conservation, and his foundati

If a bird has zygodactyl feet, that means two toes point forward and two point back. This makes life easier for woodpeckers, owls, parrots and ospreys.

A synthetic form of alcohol called "alcosynth" that doesn't cause hangovers could replace normal booze by 2050.

Atlanta Rolls Out Red Carpet for Local and National Celebrities

World-renowned dentist Dr. Ira Shapira provides headache relief for patients suffering from TMJ dysfunction and other issues

A new paper in CRANIO Journal explains how the Sphenopalatine Ganglion is a common thread linking these disorders. Self-Administration of SPG Blocks and Neuromodulation on the Ganglion can dramtically improve patients quality of life.

Dr. Narouze channels a plethora of experience into his work with the American Interventional Headache Society, The American Society of Regional Anesthesia and Pain Medicine, the Northeast Ohio Medical School and Western Reserve Hospital

The Sphenopalatine Ganglion Block has been called "The Miracle Block" due to effectiveness in treating all types of headaches and migraines including TACs. This autonomic block is also useful for a wide variety of eye, nose, and sinus issues.

June is Migraine and Headache Awareness Month

During this urgent medical time, The Head Foundation has partnered with Ludacris and The Ludacris Foundation to donate $200,000.00 worth of medical equipment and supplies to hurricane ravaged islands in Northern Bahamas.

North Korea-linked hacking group Lazarus has been leveraging a Mac variant of the Dacls Remote Access Trojan (RAT), Malwarebytes reports.

read more

Scott Berinato, HBR senior editor, featuring the ideas of Yale economist Robert Shiller, journalist Gregg Easterbrook, and Pulitzer Prize-winning columnist Ellen Goodman.

Over the past few years, the company has had meditation sessions, K-pop dance routines, and puppy tricks punctuate its weekly, Wednesday-afternoon meeting.

Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.

Deficiencies in existing attempts at educational software solutions are addressed by providing systems, methods, and devices that both replicate and facilitate the necessary elements of successful classroom-based learning, while taking advantage of the platform-specific benefits of handheld computing devices. Various applications address the issue of the limited screen size of mobile devices by using the motion sensors of the devices both to move from one part of a program to another, thus eliminating the need for on-screen navigation buttons and allowing the entire screen to be used for content, and also to reinforce learning through the use of mnemonics. In these applications, the user rotates the device after completing each step, in sequence, of a process-based series of problem solving techniques. Group learning dynamics are also reproduced through a study group feature.

A multi-level DAC includes first and second level resistor ladders, and a dual-switch ladder interconnect reduces DNL at tap-point transitions between first-level ladder resistors. For each first level resistor N, the switch-interconnect network includes dual (first/second) switches connectable to a resistor-top node NT, and dual (third/fourth) switches selectively connectable to a resistor-bottom node NB. The first switch is operable to connect NT to a top tap switch operable to select NT as a top tap point, and the fourth interconnect switch is operable to connect NB to a bottom tap switch operable to select NB as a bottom tap point. The first and fourth switches are connected, forming an outer loop that includes top and bottom tap points. The second switch connects to a top second-level resistor RT, and the third switch connects to a bottom second-level resistor RB, forming an inner loop that includes the series-connected second-level resistors.

For analog-to-digital converters (ADCs) which utilize a feedback digital-to-analog converter (DAC) for conversion, the final analog output can be affected or distorted by errors of the feedback DAC. A digital measurement technique can be implemented to determine timing mismatch error for the feedback DAC in a continuous-time delta-sigma modulator (CTDSM) or in a continuous-time pipeline modulator. The methodology utilizes cross-correlation of each DAC unit elements (UEs) output to the entire modulator output to measure its timing mismatch error respectively. Specifically, the timing mismatch error is estimated using a ratio based on a peak value and a value for the next tap in the cross-correlation function. The obtained errors can be stored in a look-up table and fully corrected in digital domain or analog domain.

For analog-to-digital converters (ADCs) which utilize a feedback digital-to-analog converter (DAC) for conversion, the final analog output can be affected or distorted by errors of the feedback DAC. A digital measurement technique can be implemented to determine switching mismatch error for the feedback DAC in a continuous-time delta-sigma modulator (CTDSM) or in a continuous-time pipeline modulator. The methodology forces each DAC unit elements (UEs) to switch a certain amount times and then use the modulator itself to measure the errors caused by those switching activities respectively. The obtained errors can be stored in a look-up table and fully corrected in digital domain or analog domain.

Jeff Sessions, then the Attorney General, announced in 2017 the cancellation of the Obama-era policy known as DACA—Deferred Action for Childhood Arrivals. A number of plaintiffs sued, and their case goes to the Supreme Court next week. The New Yorker’s Jonathan Blitzer spoke with two of the attorneys who will argue for it. The noted litigator Ted Olson is generally a champion of conservative issues, but he is fighting the Trump Administration on this case. He told Blitzer, “It’s a rule-of-law case—not a liberal or conversative case—involving hundreds of thousands of individuals who will be hurt by an abrupt and unexplained and unjustified change in policy.” And Blitzer also spoke with Luis Cortez, a thirty-one-year-old from Seattle who is arguing his first Supreme Court case. Cortez is an immigration lawyer who is himself an undocumented immigrant protected by DACA status; if he loses his case, he will be at risk of deportation. 

The Supreme Court has temporarily put on hold the release of redacted grand jury material from the Russia investigation to a House panel. The Trump administration is trying to block the release. Last October, a district court judge ruled the Justice Department had to turn over the materials, which were blacked out, from former special counsel Robert Mueller's report into Russian interference in the 2016 election. An appeals court upheld the decision , but the Trump administration, hoping to keep the evidence secret, appealed to the Supreme Court. Chief Justice John Roberts' order temporarily stops the process. Lawyers for the House Judiciary Committee have until May 18 to file their response to the Justice Department's attempts to keep the materials from the House panel. The Justice Department had until Monday to turn over the material following the appeals court order. But on Thursday, the Trump administration asked the Supreme Court to block Congress from seeking it, saying, "The

Karen and Bradley play and discuss Loïc Dachary's FOSDEM 2012 talk, Can for-profit companies enforce copyleft without becoming corrupt like MySQL AB? from the FOSDEM 2012 Legal and Policy Issues DevRoom.

Show Notes:

Segment 0 (00:35)

Bradley and Karen discuss FOSDEM again.

Segment 1 (10:10)

Unfortunately, we don't have Loïc's slides.

Segment 2 (32:03)

Bradley and Karen comment on Loïc's talk.

Send feedback and comments on the cast to <oggcast@faif.us>. You can keep in touch with Free as in Freedom on our IRC channel, #faif on irc.freenode.net, and by following Conservancy on on Twitter and and FaiF on Twitter.

Free as in Freedom is produced by Dan Lynch of danlynch.org. Theme music written and performed by Mike Tarantino with Charlie Paxson on drums.

The content of this audcast, and the accompanying show notes and music are licensed under the Creative Commons Attribution-Share-Alike 4.0 license (CC BY-SA 4.0).

Jenn Wasner of Flock of Dimes and Wye Oak takes you through why Joni Mitchell's "Amelia" both comforts and terrifies her. And Lucy Dacus explains how the Cure's "Just Like Heaven" is a friendly ghost in her life, and how Prince's "I Would Die 4 You," helped expand her idea of how cool a song about God could be.

Daconstilltalking V.017.

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The biggest, gaudiest, craziest — and oh, yeah, the fakest — event ever held at the ballpark on the corner of Edgar Martinez Drive and Dave Niehaus Way took place 17 years ago, on March 30, 2003.