Cardinal Pell said in a statement yesterday that he was "surprised" by some of the views of the royal commission about his actions, and that "these views are not supported by evidence".

Labor frontbencher Anthony Albanese announces he will contest the party's leadership.

The findings are expected to reveal what the royal commission made of the evidence put before it about whether Cardinal Pell could or should have done more to prevent children from being abused by priests in the 1970s and 80s.

A botched effort at censoring a scathing report on Tasmania's juvenile detention centre reveals a litany of shortcomings, including "very little real security", CCTV that is "rarely monitored", inadequate reporting of force being used and a fence that would not stop an escape attempt, only "slow it down".

Ghost netting in South Australia's pristine waters is causing a headache for the local council and the fishing, tourism, and recycling industries.

With their combination of raw talent, heart and drive, their coach says they could go all the way. But life could have been very different for these Indigenous siblings from Victoria.

Discoveries of rare animals are sparking mini tourism booms in remote Australia, but they're also causing some headaches for Aboriginal rangers and their conservation efforts.

(United States Fifth Circuit) - Held that an excess insurer could not sue an insured's lawyers for negligent misrepresentation. The insurer claimed that the lawyers led it to believe that a product liability suit posed no threat of exposure to its policy. Concluding that the law firm was immune from suit under these circumstances, the Fifth Circuit reversed the denial of a motion to dismiss and rendered a judgment of dismissal.

(United States Ninth Circuit) - Held that makers of vitamin E supplements did not violate California laws against false advertising. A consumer alleged that the product labels made untrue health claims. Affirmed summary judgment against a proposed class action.

(United States Seventh Circuit) - Held that a consumer reporting agency lawfully disclosed the plaintiff's decades-old criminal record for battery to a landlord when she applied to rent an apartment. Affirmed summary judgment against her claim under the Fair Credit Reporting Act.

The Atlanta rapper reflected on his career.

The Atlanta-based rappers perform their 2002 hit.

Ludacris give an important lesson in handwashing.

The government loves its secrets. It loves them so much it does stupid things to, say, "secure the nation..." or "protect the integrity of deliberative processes" or whatever the fuck. We should not trust the government's reasoning when it chooses to redact information from documents it releases to FOIA requesters. These assertions should always be challenged because the government's track record on redactions is objectively awful.

Here's the latest case-in-point: Emma Best -- someone the government feels is a "vexatious" FOIA filer -- just received a completely stupid set of redactions from the Secret Service. Best requested documents mentioning darknet market Hansa, which was shut down (along with Alpha Bay) following an investigation by US and Dutch law enforcement agencies.

The documents returned to Best contained redactions. This is unsurprising given the nature of the investigation. What's surprising is what the Secret Service decided to redact. As Best pointed out on Twitter, the Secret Service decided public press releases by the DOJ were too sensitive to be released to the general public.

Here's one of the redactions [PDF] the Secret Service applied to a press release that can be found unaltered and unedited at the Justice Department's publicly-accessible website:

And here's what the Secret Service excised, under the bullshit theory that a publicly-released press statement is somehow an "inter-agency or intra-agency memorandums or letter which would not be available by law to a party other than an agency in litigation with the agency."

“This is likely one of the most important criminal investigations of the year – taking down the largest dark net marketplace in history,” said Attorney General Jeff Sessions. “Make no mistake, the forces of law and justice face a new challenge from the criminals and transnational criminal organizations who think they can commit their crimes with impunity using the dark net. The dark net is not a place to hide. The Department will continue to find, arrest, prosecute, convict, and incarcerate criminals, drug traffickers and their enablers wherever they are. We will use every tool we have to stop criminals from exploiting vulnerable people and sending so many Americans to an early grave. I believe that because of this operation, the American people are safer – safer from the threat of identity fraud and malware, and safer from deadly drugs.”

Um. Is Jeff Sessions being Yezhoved by the Secret Service? Does the agency consider him to be enough of a persona non grata after his firing by Trump to be excised from the Secret Services' official recollection of this dark web takedown? This insane conspiracy theory I just made up makes as much sense as anything the Secret Service could offer in explanation for this redaction. The redaction removed nothing but the sort of swaggering statement Attorney Generals always make after a huge bust.

Needless to say, Emma Best is challenging the Secret Service's redactions. Pithily.

I am appealing the integrity of the redactions, as you withheld public press releases under b5, which is grossly inappropriate.

Yeah. That's an understatement. The Secret Service has no business redacting publicly-available info. Even if this was a clerical error, it's so bad it's insulting. And that's why you can't trust the government on things like this: when it's not being malicious, it's being stupid.

“Thank you all very much for being here and for all the support that you have given me over the years: as the mayor of this great city, as Vermont’s only congressman and now as a U.S. senator. Thanks also … Continue reading →

La enfermedad de Parkinson es un trastorno neurológico degenerativo crónico que afecta a una de cada 100 personas mayores de 60 años. Se estima que más de 5 millones de personas en el mundo tienen Parkinson y el número está aumentando con la población actual que envejece.

Okay here goes with my first blog post ever.I'm two and a half days into my adventure and I'm still alive so that's a great start. The first thing that needs to be said which I'm sure most everyone has heard before is that the smog here is crazy

A DAC, or digital to analog converter, makes all the difference when streaming on a phone or laptop. You don't have to spend a ton, our music critic says.

Despite working in three different states, Leigh Diffey, Townsend Bell and Paul Tracy have IndyCar's iRacing events looking and sounding close to normal.

Faith, family and basketball lead Jordache Mavunga back home to UIndy

A lack of high demand spectrum has been a long-running complaint by SA telecoms groups, who say that it is needed to reduce data prices and increase speed.

Here is some insight into the first ever blockchain advert

The Trump administration’s decision to terminate the Deferred Action for Childhood Arrivals (DACA) deportation-relief program launched in 2012 has sparked new urgency to find a longer-term fix for "DREAMers," the unauthorized immigrants brought to the United States as children. This Policy Beat article examines movement in the courts and in Congress on the DREAM Act and similar proposals, exploring likely paths forward.

The fate of the Deferred Action for Childhood Arrivals (DACA) program has ping ponged between all three branches of government. But with the Supreme Court poised to decide DACA's future in spring 2020, Congress may finally be forced to act to resolve the status of DREAMers after nearly two decades of considering various DREAM Act bills. Could this break the long stalemate Congress has had on passing substantive immigration legislation, and pave the way for other actions?

An average of 915 DACA recipients every day will lose their work authorization and protection from deportation once the phaseout of the program moves into full force in spring 2018, MPI estimates. This fact sheet also offers U.S. and state estimates of the school enrollment and educational attainment, workforce participation, and industries and occupations of employment for the nearly 690,000 current DACA holders.

The future of the Deferred Action for Childhood Arrivals (DACA) program is uncertain, amid skepticism from the Trump administration about its merits and the promise of legal challenge from ten state attorneys general. This issue brief presents a profile of young adults eligible for DACA in terms of their educational attainment and labor force participation, as well as what is at stake should the program be terminated.

By winding down DACA over six months, President Trump may have addressed a short-term political dilemma. But this action ensures debate will rage on in search of a lasting solution, as many in Congress and beyond recognize the loss of work authorization and deportation relief will affect not only DACA recipients and their families, but also employers, universities, and communities alike, as this commentary explores.

In addition to a delay, Wisconsin had to eliminate certain questions from its Smarter Balanced exam, after opting not to use the adaptive testing feature of the test.

Mitau : G.A. Reyher, 1848.

Argentorati : Sumtibus Amandi Koenig, 1786-1787.

Wien : Holder, 1889.

Romae [Rome] : Apud Carolum Losi, Anno 1773.

Over 500 000 children in the United States sustain a traumatic brain injury (TBI) each year. Headaches are commonly reported after TBI in adults, but little is known about the epidemiology of headache after pediatric TBI.

Headaches are more common 3 months after pediatric TBI than after arm injury. The frequency of headache after TBI is related to patient gender, age, and injury severity. Headaches after mild TBI were most common among girls and teenagers. (Read the full article)

Several studies have investigated the prevalence of chronic daily headache (CDH) and analyzed the risk factors for its persistence. However, the etiologic factors that lead to new-onset CDH remain unsettled in adolescents.

This study was the first incidence study of CDH conducted in young adolescents. We reported the incidence rates and found that some risk factors for incident chronic migraine and chronic tension-type headache were different. (Read the full article)

Although unnecessary for children with headache and normal history, computed tomography (CT) scans are widely used. Fewer than 1% of pediatric brain abnormalities present with headache as the only symptom. Furthermore, repeated CT scans may increase lifetime risk of cancer.

CT scans continue to be used to diagnose isolated pediatric headaches despite existing practice parameters. Although emergency department visits were correlated with greater likelihood of CT scan use, these scans were widely used across a variety of clinical settings. (Read the full article)

Use of complementary and alternative medicine (CAM) is increasingly common among American youth; however, information on use of CAM among youth with recurrent headache (HA) is limited.

Youth across a range of chronic conditions experience HA. These youth are more likely to use CAM. Use and expenditures for conventional medical care, and increased difficulties in activity and functioning are greater for youth with HA who use CAM. (Read the full article)

Although headache is a common symptom after minor blunt head trauma in children, controversy exists whether the presence of headache increases the risk of traumatic brain injury.

Clinically important traumatic brain injuries are rare, and traumatic brain injuries on computed tomography are very uncommon in children with minor blunt head trauma when headaches are their only sign or symptom. (Read the full article)

The justices hear arguments Nov. 12 on the Trump administration's effort to end deportation relief under Deferred Action for Childhood Arrivals, in a case pitting the administration and GOP-leaning states against a host of education and advocacy groups.

Gepotidacin, a triazaacenaphthylene bacterial type II topoisomerase inhibitor, is in development for treatment of uncomplicated urinary tract infection (uUTI). This Phase 2a study in female participants with uUTI evaluated the pharmacokinetics (primary objective), safety, and exploratory efficacy of gepotidacin. Eligible participants (N = 22) were confined to the clinic at baseline, received oral gepotidacin 1,500 mg twice daily for 5 days (on-therapy; Days 1 to 5), and returned to the clinic for test-of-cure (Days 10 to 13) and follow-up (Day 28±3). Pharmacokinetic, safety, clinical, and microbiological assessments were performed. Maximum plasma concentrations were observed approximately 1.5 to 2 hours postdose. Steady state was attained by Day 3. Urinary exposure over the dosing interval increased from 3,742 μg.h/ml (Day 1) to 5,973 μg.h/ml (Day 4), with trough concentrations of 322 to 352 μg/ml from Day 3 onward. Gepotidacin had an acceptable safety-risk profile with no treatment-limiting adverse events and no clinically relevant safety trends. Clinical success was achieved in 19 (86%) and 18 (82%) of 22 participants at test-of-cure and follow-up, respectively. Eight participants had a qualifying baseline uropathogen (growth; ≥10⁵ CFU/ml). A therapeutic (combined clinical and microbiological [no growth; <10³ CFU/ml]) successful response was achieved in 6 (75%) and 5 (63%) of 8 participants at test-of-cure and follow-up, respectively. Plasma area under the free-drug concentration-time curve over 24 hours at steady state divided by the MIC (fAUC_0-24/MIC) and urine AUC_0-24/MIC ranged from 6.99 to 90.5 and 1,292 to 121,698, respectively. Further evaluation of gepotidacin in uUTI is warranted. (NCT03568942)

Omadacycline is a novel aminomethylcycline with activity against Gram-positive and -negative organisms, including Haemophilus influenzae, which is one of the leading causes of community-acquired bacterial pneumonia (CABP). The evaluation of antimicrobial agents against H. influenzae using standard murine infection models is challenging due to the low pathogenicity of this species in mice. Therefore, 24-hour dose-ranging studies using a one-compartment in vitro infection model were undertaken with the goal of characterizing the magnitude of the ratio of the area under the concentration-time curve (AUC) to the MIC (AUC/MIC ratio) associated with efficacy for a panel of five clinical H. influenzae isolates. These five isolates, which had MIC values of 1 or 2 mg/L, were exposed to omadacycline total-drug epithelial lining fluid (ELF) concentration-time profiles based on those observed in healthy volunteers following intravenous omadacycline administration. Relationships between change in log₁₀ colony forming units (CFU) from baseline at 24 hours and total-drug ELF AUC/MIC ratio for each isolate and the isolates pooled together were evaluated using Hill-type models and non-linear least squares regression. As evidenced by the high coefficient of determination (r²) of 0.88 to 0.98, total-drug ELF AUC/MIC ratio described the data well for each isolate and the isolates pooled together. The median total-drug ELF AUC/MIC ratio associated with net bacterial stasis and 1- and 2-log₁₀ CFU/mL reductions from baseline at 24 hours was 6.91, 8.91, and 11.1, respectively. These data were useful to support the omadacycline dosing regimens selected for the treatment of patients with CABP, as well as susceptibility breakpoints for H. influenzae.

Omadacycline, a novel aminomethylcycline antibiotic with activity against Gram-positive and -negative organisms, including tetracycline-resistant pathogens, received FDA approval in October, 2018 for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). A previously-developed population pharmacokinetic (PK) model based on Phase 1 intravenous and oral PK data was refined using data from infected patients. Data from 10 Phase 1 studies used to develop the previous model were pooled with data from three additional Phase 1 studies, a Phase 1b uncomplicated urinary tract infection study, one Phase 3 CABP study, and two Phase 3 ABSSSI studies. The final population PK model was a three-compartment model with first-order absorption using transit compartments to account for absorption delay following oral dosing and first-order elimination. Epithelial lining fluid (ELF) concentrations were modeled as a sub-compartment of the first peripheral compartment. A food effect on oral bioavailability was included in the model. Sex was the only significant covariate identified, with 15.6% lower clearance for females relative to males. Goodness-of-fit diagnostics indicated a precise and unbiased fit to the data. The final model, which was robust in its ability to predict plasma and ELF exposures following omadacycline administration, was also able to predict the central tendency and variability in concentration-time profiles using an external Phase 3 ABSSSI dataset. A population PK model, which described omadacycline PK in healthy subjects and infected patients, was developed and subsequently used to support pharmacokinetic-pharmacodynamic (PK-PD) and PK-PD target attainment assessments.

SIM-swap fraud complaints seem to be on the rise with a growing number of victims coming forward to share their dreadful experiences. Vodacom offers some helpful tips.

Air pollution has been choking Delhi and its residents. The air quality has deteriorated substantially. The decrease was so huge that the people were bound to wear masks or stay indoors. Schools were shut till November 5 and people suffered with burning eyes, teary eyes, headaches, coughs etc. Take

Many Indian students need financial help to pursue a master’s degree at the University level in the USA, but cannot apply for a student loan. They are forced to take a loan in India and pledge their home as collateral.Starting the journeyInspired by…

Over 40 countries, including the US, which had been one of the last holdouts, grounded airliner’s newest version after a second fatal crash proved one too many.