Tanner Correia has been recognised by the Bermuda Karting Association [BKA] after winning the Junior Cadet class and the Junior Highest Points trophy after an impressive Rubis National Championships season. Correia, who also shared the 9 Lives Good Sportsmanship Award with Hildegard Thomas, was presented with his trophies at the recent BKA awards ceremony at […]

2024 was a banner year for the cross-country riders on Team USA.
( Photos: 5, Comments: 40 )

Accumulation of the microtubule-associated protein tau is associated with Alzheimer's disease (AD). In AD brain, tau is abnormally phosphorylated at many sites, and phosphorylation at Ser-262 and Ser-356 plays critical roles in tau accumulation and toxicity. Microtubule affinity–regulating kinase 4 (MARK4) phosphorylates tau at those sites, and a double de novo mutation in the linker region of MARK4, ΔG316E317D, is associated with an elevated risk of AD. However, it remains unclear how this mutation affects phosphorylation, aggregation, and accumulation of tau and tau-induced neurodegeneration. Here, we report that MARK4ΔG316E317D increases the abundance of highly phosphorylated, insoluble tau species and exacerbates neurodegeneration via Ser-262/356–dependent and –independent mechanisms. Using transgenic Drosophila expressing human MARK4 (MARK4wt) or a mutant version of MARK4 (MARK4ΔG316E317D), we found that coexpression of MARK4wt and MARK4ΔG316E317D increased total tau levels and enhanced tau-induced neurodegeneration and that MARK4ΔG316E317D had more potent effects than MARK4wt. Interestingly, the in vitro kinase activities of MARK4wt and MARK4ΔG316E317D were similar. When tau phosphorylation at Ser-262 and Ser-356 was blocked by alanine substitutions, MARK4wt did not promote tau accumulation or exacerbate neurodegeneration, whereas coexpression of MARK4ΔG316E317D did. Both MARK4wt and MARK4ΔG316E317D increased the levels of oligomeric forms of tau; however, only MARK4ΔG316E317D further increased the detergent insolubility of tau in vivo. Together, these findings suggest that MARK4ΔG316E317D increases tau levels and exacerbates tau toxicity via a novel gain-of-function mechanism and that modification in this region of MARK4 may affect disease pathogenesis.

Court-ordered school desegregation has been more successful in the South than in any other region of the country, but researchers have noted a new threat: the growing number of communities that are seceding from larger school districts to form their own.

World Cup Champion Noelle Pikus-Pace Turns To Local Metal Shop – And Her Husband – For Innovative New Sled

Flipped classrooms have been getting attention as a way for teachers to find more time for activities and individual support during the regular school day, but a new study cautions that the model could trade short-term gains for wider achievement gaps.

Read the in depth Review of Acer Iconia A1-811 Tablets. Know detailed info about Acer Iconia A1-811 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Acer Aspire 7 Gaming Laptops. Know detailed info about Acer Aspire 7 Gaming configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Acer Boundless 50 inch 4K LED Smart TV TV. Know detailed info about Acer Boundless 50 inch 4K LED Smart TV configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Acer Nitro 5 gaming Laptops. Know detailed info about Acer Nitro 5 gaming configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Acer I Series 55 Inch 4K Android TV (55UHD) TV. Know detailed info about Acer I Series 55 Inch 4K Android TV (55UHD) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

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This blog explores how Virtuoso Studio Net Tracer can help you perform a design review.

We’ll use the net connectivity option, which allows the user to get a clean highlighted net. You can use the Net Tracer tool to highlight the nets. You can find the Net Tracer command under the connectivity pulldown menu in the layout window.

Trace manager and the ability to display different islands on the same net with other colors, you can identify and connect the unconnected islands as you wish.

The Net Tracer utility traces the nets in the physical view (layout). The trace is a highlighted net, which is a non-selectable object. The Net Tracer utility is available from Virtuoso Layout Suite XL onwards. You can use this utility based on your specific needs and preferences.

For a better understanding of the Net Tracer feature, let’s see one scenario between the circuit designer and layout engineer for a layout design review.

Circuit designer: Can we go through the routed input nets “inm” and “inp”?

Layout engineer: From the below layout view where they are highlighted using the XL connectivity, today I will use Net Tracer utility for the design review.

Circuit designer: I have never heard of this feature. Let's see how it works.

Layout engineer: Sure, now we turn on the Net Tracer toolbar using the below option.

You see the Net Tracer options form here:

As you can see on my screen, I have opened the layout view and engaged the Net Tracer utility.

Net Tracer allows shapes to be traced on a net in two tracing modes, namely, physical and logical, where shapes on the same net are physically or logically connected.

Physical tracing gathers all the shapes physically connected on the same net.

Logical tracing gathers all the shapes assigned to the same net. It highlights the net as in the source design (schematic). It will highlight shapes on the same net, even if they are isolated shapes that are not physically connected.

For this scenario, let us use physical tracing for input nets “inm” and “inp."

Highlighted nets are shown below:

Net “inm”                    Net “inp”                   Nets “inm” and “inp” 

Net Tracer has features like physical and logical tracing, preview, step-by-step mode, ease of tracing a net on a shape out of multiple underlying shapes, and so on.

Let us explore logical tracing for output nets “outm” and “outp”:

Here, you can see how to enable true color and halo before enabling logical tracing to identify the metal route. After enabling the true color halo, enable the logical trace.

Here, I am opening the trace manager to search “outm” and “outp” and click trace. That will trace the particular nets as shown.

Net Tracer has a preview feature, which is helpful in terms of the number of previewed objects. This preview capability hints at how the trace would appear when you create it. This useful feature in Virtuoso Studio highlights both completed and incomplete nets, helping the user better understand the status of the highlighted nets.

Circuit designer: Thanks for the design review. You have done good work. Net Tracer clearly shows both types of tracing, and it was even easy for the circuit designer to understand.

Layout engineer: Let me share the link to the Net Tracer RAK, where other layout engineers can explore many more amazing features of the Net Tracer.

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La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Critical levels of nationwide hunger in Sudan has only increased to critical levels since the start of the Sudanese civil war in April 2023. Escalated hostilities between the Sudanese Armed Forces (SAF) and the Rapid Support Forces (RSF) have led to limited mobility and repeated blockages of humanitarian aid. This, coupled with the volatile floods […]

Introduction

Exacerbation of COPD complicated by respiratory acidaemia is the commonest indication for noninvasive ventilation (NIV). The NIV outcomes (NIVO) score offers the best estimate of survival for those ventilated. Unfortunately, two-thirds of cases of COPD are unrecognised, and patients may present without COPD having been confirmed by spirometry.

Background

Exacerbations of noncystic fibrosis bronchiectasis (bronchiectasis) are associated with reduced health-related quality of life and increased mortality, likelihood of hospitalisation and lung function decline. This study investigated patient clinical characteristics associated with exacerbation frequency.

Intrapatient intermetastatic heterogeneity (IIH) has been demonstrated in metastatic castration-resistant prostate cancer (mCRPC) patients and is of the utmost importance for radiopharmaceutical therapy (RPT) eligibility. This study was designed to determine the prevalence of IIH and RPT eligibility in mCRPC patients through a triple-tracer PET imaging strategy. Methods: This was a multisite prospective observational study in which mCRPC patients underwent both ¹⁸F-FDG and ⁶⁸Ga-prostate-specific membrane antigen (PSMA)–617 PET/CT scans. A third scan with ⁶⁸Ga-DOTATATE, a potential biomarker of neuroendocrine differentiation, was performed if an ¹⁸F-FDG–positive/⁶⁸Ga-PSMA–negative lesion was found. Per-tracer lesion positivity was defined as having an uptake at least 50% above that of the liver. IIH prevalence was defined as the percentage of participants having at least 2 lesions with discordant features on multitracer PET. Results: IIH was observed in 81 patients (82.7%), and at least 1 ¹⁸F-FDG–positive/⁶⁸Ga-PSMA–negative lesion was found in 45 patients (45.9%). Of the 37 participants who also underwent ⁶⁸Ga-DOTATATE PET/CT, 6 (16.2%) had at least 1 ⁶⁸Ga-DOTATATE–positive lesion. In total, 12 different combinations of lesion imaging phenotypes were observed. On the basis of our prespecified criteria, 52 (53.1%) participants were determined to be eligible for PSMA RPT, but none for DOTATATE RPT. Patients with IIH had a significantly shorter median overall survival than patients without IIH (9.5 mo vs. not reached; log-rank P = 0.03; hazard ratio, 2.7; 95% CI, 1.1–6.8). Conclusion: Most mCRPC patients showed IIH, which was associated with shorter overall survival. On the basis of a triple-tracer PET approach, multiple phenotypic combinations were found. Correlation of these imaging phenotypes with genomics and treatment response will be relevant for precision medicine.

Solar storms have the ability to harm astronauts and force massive blackouts

New study highlights the potential negative impact of climate change on the health of individuals with brain conditions. Emphasizing urgency, their article

The Arctic is warming at a rate three to four times faster than the global average. However, a new study suggests that a slowdown in a critical ocean

1. Mohammed Shami Is Back! Star Pacer Set To Play For Bengal In Ranji Trophy  News18
2. "360 Days Is A...": Mohammed Shami Posts Picture From Airport. Ex-India Star Says "Brother..."  NDTV Sports
3. Live Cricket Update - RLYS vs TN Elite, Group D - Ranji Trophy blog: Round 5, day 1: Shami set for return in Indore  ESPNcricinfo
4. Can a fit Mohammed Shami make a late entry into India's Test squad in Australia?  The Times of India
5. Mohammed Shami makes Ranji Trophy comeback, plays first match with brother Kaif for Bengal  The Indian Express

Joe Biden came to office promising he'd take a tough stance with Vladimir Putin, but his foreign policy decisions to date haven't deterred Russia amassing thousands of troops in readiness to invade Ukraine. Images: Getty Images/Maxar Composite: Mark Kelly

RCB batting coach Dinesh Karthik predicted a massive price for one South African cricketer in the IPL 2025 mega auction.

ప్రముఖ ల్యాప్‌టాప్‌లు, గ్యాడ్జెట్‌ల తయారీ సంస్థ ఏసర్‌ భారత్‌ మార్కెట్‌లో రెండు ట్యాబ్లెట్‌లను లాంచ్‌ చేసింది. Acer Iconia 8.7 మరియు Acer Iconia 10.36 పేర్లతో విడుదల అయ్యాయి. ఈ రెండు ట్యాబ్లెట్‌లు ఆండ్రాయిడ్‌ 14 ఆధారిత OS, మీడియాటెక్‌ చిప్‌సెట్‌తో పనిచేస్తాయి. డిజైన్‌ పరంగా ఆకట్టుకుంటున్నాయి. మరియు రూ.15000 కంటే తక్కువ ధరలో భారత్‌

Mohammed Shami set to return to competitive cricket after a hiatus of nearly a year through Bengal's Ranji Trophy match against Madhya Pradesh in Indore from Wednesday, announced Cricket Association of Bengal.

Edmonton, Alberta : Brush Education Inc., [2023]

The Predator Helios 300 is priced at ₹84,999 and The Predator Triton 300 at ₹89,999

Powered by the latest AMD Ryzen mobile processors

It has launched new Predator Triton and Helios Series gaming notebooks

The new range also comes with Office 2021 pre-loaded on it

Dixon factory at Noida has capacity to produce upto 5,00,000 Acer laptops annually

The premium gaming laptop supports glasses-free 3D gaming

Looking for a fun-to-drive hatchback? The Tata Altroz Racer nearly ticks all the boxes

Rahul made a hundred on his debut tour to Australia in 2015, a 110 at Sydney, but his overall performance Down Under remains scratchy, evidenced by an average of 20.77 across four Tests.

Porel’s four-for and Sindhu’s three-wicket haul help the visitor bundle out the host for 221 before reaching 127 for three in its second essay at the end of day three