If Bernie Sanders wants to say that Fidel Castro occasionally did something good, while acknowledging that he often did things that were very bad, I think that’s a reasonable position. (It might also be reasonable to say that Adolf Hitler occasionally did something good, though offhand I can’t think of a good example.) But surely […]

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Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumoral microenvironment evolves in an immunocompetent brain is unclear. We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epileptogenesis during tumor infiltration with in vivo electrophysiology and GCAMP7 calcium imaging, revealing a reproducible progression from hyperexcitability to convulsive seizures. Long before seizures, coincident with loss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expression, and reactive astrocytosis, we detected local Iba1+ microglial inflammation that intensified and later extended far beyond tumor boundaries. Hitherto unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumoral region may provide a mechanism for transient neurological deficits. Early blockade of glial xCT activity inhibited later seizures, and genomic reduction of host brain excitability by deleting MapT suppressed molecular markers of epileptogenesis and seizures. Our studies confirmed xenograft tumor–driven pathobiology and revealed early and late components of tumor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowing the complex dissection of tumor versus host pathogenic seizure mechanisms.

Microsoft plans to add trackpad and mouse support to its Word, Excel, and PowerPoint apps for iPad by the fall, according to TechCrunch and The Verge.

iPadOS 13.4 introduced trackpad and mouse support on all iPad models released in the past four to five years. Keyboards with trackpads include Apple's Magic Keyboard and Brydge's Pro+ for the iPad Pro and Logitech's Combo for the 10.2-inch iPad and the 10.5-inch iPad Air.

When using a trackpad, the cursor displays as a circle on the screen, popping up only when you have a finger on the trackpad. The circle then morphs into various other shapes when hovering over app icons, text fields, or other on-screen elements.

Undone by Blood #3 is now due out June 10.

The post EXCLUSIVE: More meta revenge in UNDONE BY BLOOD #3 appeared first on The Beat.

Telstra Corporation Limited (Telstra) was awarded the 2008 Excellence Award in the ‘Best Practices - Service Provider’ category by the TeleManagement Forum (TM Forum).

Co-founder and designer Erik Haldi discusses the company's first Star Wars enamel pin: Luke Skywalker on his tauntaun.

Evaluation report for the inter-authority learning exchange between Shetland Islands, Falkirk and Glasgow Councils throughcare and aftercare teams. In February 2014 a member of the Throughcare and Aftercare team from Shetland, spent two weeks in each host authority as a means of developing and sharing practice, experience and learning. The report describes the planning process, in-situ experience, and post-exchange learning of participants, it also report highlights the positive learning outcomes and benefits achieved for all participating local authorities. The report identifies ideas for future applications of such a learning and practice exchange model to improve practice for looked after young people and care leavers.

The daily numbers probably give a relatively accurate picture of the trends (taking differences is a useful trick for this stuff), but the overall true numbers are certainly higher and quite like much much higher.

New data released by the State of New Jersey suggests the true toll of COVID-19 may be much greater than previously thought.

Vital statistics released by the state show the total number of deaths by any cause between March and April rose from 12,567 last year to 23,070 this year. The 10,503 additional deaths recorded this year represent an 83% increase over 2019.

Nothing can quite compare to that first-real-job euphoria :)

No new cases expected at London's NHS Nightingale

An American woman goes to the police in Las Vegas. She claims she has been raped by an athlete: global football star Cristiano Ronaldo. What really happened has never been resolved because lawyers settled the case with a payment of $375,000 by the Real Madrid star. By SPIEGEL Staff

One EU country after the other is moving to restrict public life. The Dutch government has opted for less drastic measures, hoping for herd immunity and relying on the common sense of its people. But the country has still had to make adjustments to its policies.

Over the next 20 years more than a quarter of the nation’s currently owner-occupied homes will be on the market as owners pass on with Orlando being one of the top impacted areas.

City Council Member Debi Rose (D - Staten Island) said city students shouldn’t feel obligated to march with their schools or bands in the parade while event organizers refuse to let the Staten Island Pride Center march.

The Los Angeles City Council is rushing a major law that would dictate how businesses rehire workers after layoffs.

"Never in my wildest dreams did I think it would be my brother until I saw everything the next day and saw his name," said Rosemary Gomez, 38. “I was like, ‘No, it can’t be him, it can’t be him.' Then his (estranged) wife called me. She was in a state of shock."

"Stealing Home: Los Angeles, the Dodgers, and the Lives Caught in Between" examines the lives forever changed by the building of Dodger Stadium.

State Department says it is curtailing passport services over coronavirus pandemic

Jerry Azzinaro was the only UCLA assistant coach with an expiring contract who received just a one-year deal, his counterparts all receiving two-year extensions.

First-year UCLA gymnastics coach Chris Waller knew the Bruins would face challenges, but he's pleased with what the team accomplished.

Millions of people around the world might be working from home for a while. Try to enjoy it.