The two countries are strengthening collaboration in new areas including technology, energy, renewable energy, connectivity, health and education

Kevin Pillar may have only turned 30 on Jan. 4, but nobody on the Blue Jays' roster has been with the ballclub longer than Pillar, who now is entering his seventh season. Longevity with one team is a source of pride.

A good podcast starts with compelling material – but according to Tyler Moody, VP & GM, WarnerMedia Podcast Network, that’s just the beginning. To launch a successful podcast, Moody says you need:

1.   Content: In a democratized media world content is still king. Maybe more so than ever. The product you deliver to your audience has to be top quality and deliver on its promise.

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In this short series, Matthew examines the three "pillars" of Great Lent and uncovers the essence of love and unity that are inherent in each. He begins with Fasting.

Matthew concludes his short series, examining the final two pillars-- prayer and alms-giving-- with special emphasis on the former.

The number of Orthodox Christians in America is greatly inflated in a recent survey; an anonymous Orthodox comments on a Christian caterpillar; and a Muslim converts to Christianity thanks to antidoron -- all this and more as Fr. Joseph reads letters from AFR listeners.

Fr. John fills in the picture of the Church's early subculture.

This week we consider Jesus’ strengthening words to Philadelphia in Rev 3:7-13, seeking to understand the meaning of the crown, the pillars, and the name of New Jerusalem by reference to various passages in the New Testament and the fathers, and by looking back to Ex 19:6, 1 Kings 7:21, Zec 4, Hos. 2:24 and Is 44:5.

Fr. Gregory preaches on Peter and Paul - Co-founders of the Church at Antioch.

Fr. Gregory Hallam gives the sermon for Sunday, 10 March 2019.

In 2003 I signed the agreement with two other owners to sell our 200-employee construction company via a management buyout to five new owners in a deal that was structured over 10 years. 

‘Green’ is more than a word. It is good business. It is a journey. It is also one of three pillars of sustainability. Using the words “green” and “sustainability” is not a case of “You say ‘po-tay-toe,’ I say ‘po-tah-toe.’” Although the two terms are intricately related, they are not interchangeable.

The crystal structure of a neo­pentyl­oxypillar[5]arene with two pyridine mol­ecules encapsulated in the macrocyclic cavity is reported.

The hydro­thermal synthesis and structural characterization of four novel 3D pillared-layer metal–organic frameworks are studied, revealing how the malleability of copper coordination geometries drives diverse supramolecular isomerism. The findings provide new insights into designing advanced hybrid materials with tailored properties, emphasizing the significant role of reaction conditions and metal ion flexibility in determining network topologies.

The crystal structure of 1,4-bis­(neopent­yloxy)pillar[5]arene, C95H140N2O10 (TbuP), featuring two encapsulated pyridine mol­ecules, reveals significant host–guest inter­actions. Inter­estingly, the pyridine guests are positioned near the neopent­yloxy substituents instead of the electron-rich aromatic core of the pillar[5]arene. This spatial arrangement suggests a preference for the pyridine mol­ecules to engage with the aliphatic regions of the host. Detailed analysis of the structural characteristics of this host–guest system (TbuP·2Py), as well as its packing pattern within the crystal network, is presented and discussed.

For cryo-electron tomography (cryo-ET) of beam-sensitive biological specimens, a planar sample geometry is typically used. As the sample is tilted, the effective thickness of the sample along the direction of the electron beam increases and the signal-to-noise ratio concomitantly decreases, limiting the transfer of information at high tilt angles. In addition, the tilt range where data can be collected is limited by a combination of various sample-environment constraints, including the limited space in the objective lens pole piece and the possible use of fixed conductive braids to cool the specimen. Consequently, most tilt series are limited to a maximum of ±70°, leading to the presence of a missing wedge in Fourier space. The acquisition of cryo-ET data without a missing wedge, for example using a cylindrical sample geometry, is hence attractive for volumetric analysis of low-symmetry structures such as organelles or vesicles, lysis events, pore formation or filaments for which the missing information cannot be compensated by averaging techniques. Irrespective of the geometry, electron-beam damage to the specimen is an issue and the first images acquired will transfer more high-resolution information than those acquired last. There is also an inherent trade-off between higher sampling in Fourier space and avoiding beam damage to the sample. Finally, the necessity of using a sufficient electron fluence to align the tilt images means that this fluence needs to be fractionated across a small number of images; therefore, the order of data acquisition is also a factor to consider. Here, an n-helix tilt scheme is described and simulated which uses overlapping and interleaved tilt series to maximize the use of a pillar geometry, allowing the entire pillar volume to be reconstructed as a single unit. Three related tilt schemes are also evaluated that extend the continuous and classic dose-symmetric tilt schemes for cryo-ET to pillar samples to enable the collection of isotropic information across all spatial frequencies. A fourfold dose-symmetric scheme is proposed which provides a practical compromise between uniform information transfer and complexity of data acquisition.

A host–guest supra­molecular inclusion complex was obtained from the co-crystallization of A1/A2-bromo­but­oxy-hy­droxy difunctionalized pillar[5]arene (PilButBrOH) with adipo­nitrile (ADN), C47H53.18Br0.82O10·C6H8N2. The adipo­nitrile guest is stabilized within the electron-rich cavity of the pillar[5]arene host via multiple C—H⋯O and C—H⋯π inter­actions. Both functional groups on the macrocyclic rim are engaged in supra­molecular inter­actions with an adjacent inclusion complex via hydrogen-bonding (O—H⋯N or C—H⋯Br) inter­actions, resulting in the formation of a supra­molecular dimer in the crystal structure.

A slit-less wavelength-dispersive spectrometer design using a single-bounce monocapillary that aligns the sample on the Rowland circle, enhancing photon throughput and maintaining resolution. The compact design supports flexibility and reconfiguration in facilities without complex beamline infrastructure, significantly improving detection efficiency.

Newly Opened Birch House will operate as a stand-alone property for the week of BoatShow

Dr. Jessica has 18 years of experience as a holistic chiropractor and energy healer.

Celebrating Small Luxury: The Pillars Hotel & Club Earns Prestigious Recognition for Personalized Service and Waterfront Charm

A tangible and intangible heritage that values memory, cooperation, research and sustainable development along its entire route.

Fort Lauderdale's Hidden Gem Earns Coveted Spot Among Florida's Finest Hotels

Compass is bringing CAT equipment in great condition with low hours to auction on February 23.

Micropillar arrays, wide window acquisition and AI-based data analysis improve comprehensiveness in multiple proteomic applications  Nature.com

Longitudinal plasma proteomics reveals biomarkers of alveolar-capillary barrier disruption in critically ill COVID-19 patients  Nature.com

In this excerpt, author Misty Pratt explores emerging research—and her own experience—that suggests remedies like park prescriptions may be as key to mental and physical health as diet, exercise, and sleep.

"¡He sido el último ‘fantasista’! Baggio, Totti y yo", clama, y cuesta discutírselo a quien llegó a entrevistar a la portería del Bernabéu. Lleva 43 años defendiendo el humor como base del oficio, aunque se siente cada vez más solo en la lucha. Leer

During this exclusive CISO Handbook webinar, moderator Justin Doubleday and guest Robert Wood, chief information security officer at Centers for Medicare and Medicaid Services will explore how his agency is implementing zero trust and other modern security practices. In addition, David Chow, global chief technology strategy officer at Trend Micro, will provide an industry perspective.

The post CMS looks to make ‘intentional’ investments in push to underlying zero trust pillars first appeared on Federal News Network.

This song, Caterpillar, is the first single from "Apocalypse Pickin' Party" by The Great Disappointment. I think the central theme/metaphor is pretty obvious. We have also released a lyric video here. CONTENT WARNING: there is no graphic violence shown but it sure is implied.

"It just goes to show, out here at Bandimere, it's a community, but it's more than that -- it's a big family."

Guido De Philippis, Nicola Fusco and Massimiliano Morini
Trans. Amer. Math. Soc. 377 (), 5787-5835.
Abstract, references and article information

Read the series on how FAO increased efficiency, effectiveness and transparency to better support its Members in the transformation of agrifood systems.

A dying caterpillar's unusual reaction to a predatory bug.

Alveolar capillary dysplasia (ACD) is a fatal disorder that typically presents in the neonatal period with refractory hypoxemia and pulmonary hypertension. Lung biopsy is traditionally required to establish the diagnosis. We report a 22-mo-old male who presented with anemia, severe pulmonary hypertension, and right heart failure. He had a complicated hospital course resulting in cardiac arrest and requirement for extracorporeal membrane oxygenation. Computed tomography of the chest showed a heterogenous pattern of interlobular septal thickening and pulmonary edema. The etiology of his condition was unknown, lung biopsy was contraindicated because of his medical fragility, and discussions were held to move to palliative care. Rapid whole-genome sequencing (rWGS) was performed. In 2 d it resulted, revealing a novel FOXF1 gene pathogenic variant that led to the presumptive diagnosis of atypical ACD. Cases of atypical ACD have been reported with survival in patients using medical therapy or lung transplantation. Based on the rWGS diagnosis and more favorable potential of atypical ACD, aggressive medical treatment was pursued. The patient was discharged home after 67 d in the hospital; he is currently doing well more than 30 mo after his initial presentation with only one subsequent hospitalization and no requirement for lung transplantation. Our case reveals the potential for use of rWGS in a critically ill child in which the diagnosis is unknown. rWGS and other advanced genetic tests can guide clinical management and expand our understanding of atypical ACD and other conditions.

At TechCrunch Early Stage, we sat down with Felicis Ventures partners Viviana Faga and Niki Pezeshki to talk about scaling, and why it's crucial to be "10x better" than the incumbents.

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