Several medical trade groups are asking California Gov. Gavin Newsom for extraordinary immunity for their triage decisions.

Jenn attempts to make the rice pudding from Pasjoli in Santa Monica.

As pandemic slams the world economy, Musk tweets that "The coronavirus panic is dumb."

Times entertainment columnist Glenn Whipp and film critic Justin Chang sat down to reminisce about their favorite movies and moviegoing experiences of the season.

WME agent Richard Weitz's "Quarantunes" events are more than just the hottest ticket in town; they're a model for celebrity fundraising during COVID-19.

Amazon has a new three-year deal to stream the NFL's "Thursday Night Football" telecasts, which includes the rights to an exclusive game in the 2020 season.

The Times was there as Ryan Murphy's new Netflix series, "Hollywood," filmed its rousing finale, set at the 1948 Oscars ceremony.

BUNGLING Dundee United face being docked points and fined after fielding an ineligible player during last week’s 3-2 win at Inverness.

Cricket bosses are confident they can salvage the international summer insisting they can be good to go ‘behind closed doors' in just four weeks.

The Ryder Cup remains scheduled to take place in September despite other major golf tournaments being postponed.

Stuart Lancaster spoke to Daily Express Chief Sports Writer about his season with Leinster.

THE choice of John Hughes to be Inverness Caley Thistle manager raised a few eyebrows in Scottish football.

Ryan Christie will head to Celtic much earlier than expected after being ruled out for at least a month with a knee injury.

Newcastle are closing in on a £300m takeover which could see the club transformed into a major player.

The "Andy Griffith"-inspired movie "Mayberry Man" reached its fundraising goal. Here are more opportunities to be involved with the film in Indiana.

Within an eight hour period, IMPD officers have been involved the fatal shooting of two suspects and the death of a pregnant pedestrian.

Indiana Congressman Trey Hollingsworth says it's a false choice between accepting widespread casualties or reopening the economy.

In a tense conversation, Indianapolis Police Chief Randal Taylor speaks with Dreasjon Reed's family near where he was fatally shot by police.

Within an eight hour period, IMPD officers have been involved the fatal shooting of two suspects and the death of a pregnant pedestrian.

IndyStar went inside IU Health Methodist Hospital for an exclusive look at its COVID-19 units in the midst of the coronavirus pandemic.

The fire broke out shortly after 2 a.m. in medium brush between Gaviota State Beach and the Hollister Ranch guard gate.

Cartoonists who have lampooned both administrations take aim differently now.

The former press secretary is reportedly writing a book about her tenure — adding to a growing list of White House advisers with stories to sell.

A discussion about the impeachment hearings turned into a showdown between the co-hosts.

Kicking people off food stamps this late in the business cycle makes no sense.

Life as an Exchange Student in Northern Italy

The following article, NY Shame: Workers Who Tested Positive For COVID-19 Were Allowed To Remain On The Job At Nursing Homes, As Death Toll For Nursing Home Patients Exceeds 3,000, was first published on 100PercentFedUp.com.

The coronavirus crisis at New York’s nursing homes is even worse than previously thought. Monday night, the state Department of Health issued new data, adding more than 1,600 people who were presumed to have died of the virus in nursing homes, but did not have a confirmed diagnosis, to the official toll. As of May […]

Continue reading: NY Shame: Workers Who Tested Positive For COVID-19 Were Allowed To Remain On The Job At Nursing Homes, As Death Toll For Nursing Home Patients Exceeds 3,000 ...

Jesper V. Olsen
Jun 1, 2004; 3:608-614
Technology

JP Segrest
Feb 1, 1992; 33:141-166
Reviews

S-Palmitoylation is a reversible post-translational lipid modification that dynamically regulates protein functions. Voltage-gated sodium channels are subjected to S-palmitoylation and exhibit altered functions in different S-palmitoylation states. Our aim was to investigate whether and how S-palmitoylation regulates Nav1.6 channel function and to identify S-palmitoylation sites that can potentially be pharmacologically targeted. Acyl-biotin exchange assay showed that Nav1.6 is modified by S-palmitoylation in the mouse brain and in a Nav1.6 stable HEK 293 cell line. Using whole-cell voltage clamp, we discovered that enhancing S-palmitoylation with palmitic acid increases Nav1.6 current, whereas blocking S-palmitoylation with 2-bromopalmitate reduces Nav1.6 current and shifts the steady-state inactivation in the hyperpolarizing direction. Three S-palmitoylation sites (Cys1169, Cys1170, and Cys1978) were identified. These sites differentially modulate distinct Nav1.6 properties. Interestingly, Cys1978 is exclusive to Nav1.6 among all Nav isoforms and is evolutionally conserved in Nav1.6 among most species. Cys1978 S-palmitoylation regulates current amplitude uniquely in Nav1.6. Furthermore, we showed that eliminating S-palmitoylation at specific sites alters Nav1.6-mediated excitability in dorsal root ganglion neurons. Therefore, our study reveals S-palmitoylation as a potential isoform-specific mechanism to modulate Nav activity and neuronal excitability in physiological and diseased conditions.

Publication Date: May 4 2020 On May 1, 2020, Nasdaq adopted Rule 5636T, operative through, and including, June 30, 2020, to provide listed companies with a temporary exception from certain shareholder approval requirements. A Company must submit an application to Nasdaq’s Listing Qualifications Department demonstrating that the transaction satisfies the requirements in Rule 5636T and must provide the Notification Form: Listing of Additional Shares (“LAS Form”) required by...

S-Palmitoylation is a reversible post-translational lipid modification that dynamically regulates protein functions. Voltage-gated sodium channels are subjected to S-palmitoylation and exhibit altered functions in different S-palmitoylation states. Our aim was to investigate whether and how S-palmitoylation regulates Nav1.6 channel function and to identify S-palmitoylation sites that can potentially be pharmacologically targeted. Acyl-biotin exchange assay showed that Nav1.6 is modified by S-palmitoylation in the mouse brain and in a Nav1.6 stable HEK 293 cell line. Using whole-cell voltage clamp, we discovered that enhancing S-palmitoylation with palmitic acid increases Nav1.6 current, whereas blocking S-palmitoylation with 2-bromopalmitate reduces Nav1.6 current and shifts the steady-state inactivation in the hyperpolarizing direction. Three S-palmitoylation sites (Cys1169, Cys1170, and Cys1978) were identified. These sites differentially modulate distinct Nav1.6 properties. Interestingly, Cys1978 is exclusive to Nav1.6 among all Nav isoforms and is evolutionally conserved in Nav1.6 among most species. Cys1978 S-palmitoylation regulates current amplitude uniquely in Nav1.6. Furthermore, we showed that eliminating S-palmitoylation at specific sites alters Nav1.6-mediated excitability in dorsal root ganglion neurons. Therefore, our study reveals S-palmitoylation as a potential isoform-specific mechanism to modulate Nav activity and neuronal excitability in physiological and diseased conditions.

After you submit a stored process from the SAS Stored Process Web Application, the generated URL is placed into a cell in a Microsoft Excel worksheet. When you click this URL, you expect that the stored process is sub

E xcess Love, a song by Nigerian gospel artiste Mercy Chinwo, has found favour with both Christians and non-Christians alike and has been flooding the airwaves since last year. Joanna Walker, the Jamaica Cultural Development Commission's (JCDC)...

Research Event

Event participants

Emanuela-Chiara Gillard, Associate Fellow, International Law Programme, Chatham House
Ezequiel Heffes, Thematic Legal Adviser, Geneva Call
Sigrid Redse Johansen, Judge Advocate General, The Norwegian Armed Forces
Chair: Elizabeth Wilmshurst, Distinguished Fellow, Chatham House
Further speakers to be announced. 

Research Event

Event participants

Emanuela-Chiara Gillard, Associate Fellow, International Law Programme, Chatham House
Ezequiel Heffes, Thematic Legal Adviser, Geneva Call
Sigrid Redse Johansen, Judge Advocate General, Norwegian Armed Forces
Andrew Murdoch, Legal Director, UK Foreign & Commonwealth Office
Chair: Elizabeth Wilmshurst, Distinguished Fellow, International Law Programme, Chatham House