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Today's Photo: May 8, 2020




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Today's Photo: May 8, 2020




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Today's Photo: May 8, 2020




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Today's Photo: May 9, 2020




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Today's Photo: May 9, 2020




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Ex-PM Abbasi to brief sugar probe body today

ISLAMABAD: Former prime minister and senior leader of the Pakistan Muslim League-Nawaz (PML-N) Shahid Khaqan Abbasi will appear on Saturday (today) before the commission of inquiry investigating the recent shortage and price hike of sugar in the country.

Mr Abbasi told Dawn on Friday he would inform the commission how sugar scandals develop, in the light of his experience as a former chief executive of the country.

He said he had written a letter to the commission, offering his services to it by sharing his experiences in probing scams. “I wrote the letter to the commission, as under the Commission of Inquiry Act any citizen can assist such commissions in investigating such scams,” he said.

Upon receiving the letter, Mr Abbasi said, the commission asked him to provide a written statement, or any other document, that would help in investigating the scandal. “I told the commission that I will not give any written statement or document, but will assist it on the basis of my experience, I being a former member of the Economic Coordination Committee (of the cabinet) and former head of the federal cabinet,” he said.

Mr Abbasi, who served as the prime minister in the last PML-N government, said he would explain to the commission how the sugar crisis occurred.

When asked to share some of the reasons behind the crisis, the former premier said allowing export of the commodity was one of the main reasons. “The commission has to ascertain who gave the approval for export of sugar when its local demand had not been taken care of.”

He said he would request the commission to keep his meeting with its members open to all. Another PML-N leader and former defence minister Khurram Dastagir Khan would be accompanying Mr Abbasi to the meeting.

The commission is investigating the recent shortage of sugar and wheat in the country, in which some key members and allies of the ruling Pakistan Tehreek-i-Insaf were allegedly involved.

Published in Dawn, May 9th, 2020




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HARMAN Showcases Today’s Ultimate In-Vehicle Experiences at CES 2019

CES 2019 - LAS VEGAS, NV – January 7, 2019 – HARMAN International, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, is showcasing at CES 2019 the vehicle’s role...




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Listen Today: HARMAN Launches New Experiences Per Mile Podcast

Consumers are constantly exploring new ways to connect to the world around them both in and outside of their vehicles. At HARMAN, enabling connected experiences is at the core of everything we do. That’s why we’re launching the Experiences Per Mile...




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Jane Goodall: We must protect chimps from being exposed to covid-19

Jane Goodall has tirelessly fought for a better world for humans and wildlife, and with covid-19 we must stay positive, she says 




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Today's global warming is unparalleled in the past 2000 years

We now know that past periods when Earth cooled and warmed were only regional. The finding rebuffs the myth that today's planet-wide warming is a natural blip




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Gymnastics: Italian Lodadio cultivates his garden to stay fit

Gymnasts around the world have been trying to stay fit amid tough restrictions during the COVID-19 crisis, and Italy is no exception.      With the country's gym clubs and training facilities closed for more than two months as part of government measures to contain the spread of the coronavirus, gymnast Marco Lodadio, a silver medallist in the rings event at the 2019 world championships, turned his garden into a fitness studio.      Without the sophisticated faci




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Chicago's Short-Lived 'Soda Tax' Cut Consumption, Boosted Health Care Funds

Title: Chicago's Short-Lived 'Soda Tax' Cut Consumption, Boosted Health Care Funds
Category: Health News
Created: 2/24/2020 12:00:00 AM
Last Editorial Review: 2/25/2020 12:00:00 AM




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Some Diet Sodas May Ward Off Kidney Stones

Title: Some Diet Sodas May Ward Off Kidney Stones
Category: Health News
Created: 4/30/2009 2:00:00 AM
Last Editorial Review: 4/30/2009 12:00:00 AM




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More Babies Today Have Irregular Head Shape: Expert

Title: More Babies Today Have Irregular Head Shape: Expert
Category: Health News
Created: 4/27/2012 4:05:00 PM
Last Editorial Review: 4/30/2012 12:00:00 AM




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Today's Kids May Be Destined for Adult Heart Disease

Title: Today's Kids May Be Destined for Adult Heart Disease
Category: Health News
Created: 5/4/2012 10:05:00 AM
Last Editorial Review: 5/4/2012 12:00:00 AM




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Dropping One Sugary Soda a Day Could Cut Diabetes Risk: Study

Title: Dropping One Sugary Soda a Day Could Cut Diabetes Risk: Study
Category: Health News
Created: 4/30/2015 12:00:00 AM
Last Editorial Review: 5/1/2015 12:00:00 AM




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Coffee, Wine Good for Healthy Gut, Sodas May Be Bad

Title: Coffee, Wine Good for Healthy Gut, Sodas May Be Bad
Category: Health News
Created: 4/28/2016 12:00:00 AM
Last Editorial Review: 4/29/2016 12:00:00 AM




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Diet Sodas May Not Help Kids Cut Calories

Title: Diet Sodas May Not Help Kids Cut Calories
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM




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RNA Binding Motif Protein RBM45 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19 through Binding to Novel Intron Splicing Enhancers

ABSTRACT

During infection of human parvovirus B19 (B19V), one viral precursor mRNA (pre-mRNA) is transcribed by a single promoter and is alternatively spliced and alternatively polyadenylated. Here, we identified a novel cis-acting sequence (5'-GUA AAG CUA CGG GAC GGU-3'), intronic splicing enhancer 3 (ISE3), which lies 72 nucleotides upstream of the second splice acceptor (A2-2) site of the second intron that defines the exon of the mRNA encoding the 11-kDa viral nonstructural protein. RNA binding motif protein 45 (RBM45) specifically binds to ISE3 with high affinity (equilibrium dissociation constant [KD] = 33 nM) mediated by its RNA recognition domain and 2-homo-oligomer assembly domain (RRM2-HOA). Knockdown of RBM45 expression or ectopic overexpression of RRM2-HOA in human erythroid progenitor cells (EPCs) expanded ex vivo significantly decreased the level of viral mRNA spliced at the A2-2 acceptor but not that of the mRNA spliced at A2-1 that encodes VP2. Moreover, silent mutations of ISE3 in an infectious DNA of B19V significantly reduced 11-kDa expression. Notably, RBM45 also specifically interacts in vitro with ISE2, which shares the octanucleotide (GGGACGGU) with ISE3. Taken together, our results suggest that RBM45, through binding to both ISE2 and ISE3, is an essential host factor for maturation of 11-kDa-encoding mRNA.

IMPORTANCE Human parvovirus B19 (B19V) is a human pathogen that causes severe hematological disorders in immunocompromised individuals. B19V infection has a remarkable tropism with respect to human erythroid progenitor cells (EPCs) in human bone marrow and fetal liver. During B19V infection, only one viral precursor mRNA (pre-mRNA) is transcribed by a single promoter of the viral genome and is alternatively spliced and alternatively polyadenylated, a process which plays a key role in expression of viral proteins. Our studies revealed that a cellular RNA binding protein, RBM45, binds to two intron splicing enhancers and is essential for the maturation of the small nonstructural protein 11-kDa-encoding mRNA. The 11-kDa protein plays an important role not only in B19V infection-induced apoptosis but also in viral DNA replication. Thus, the identification of the RBM45 protein and its cognate binding site in B19V pre-mRNA provides a novel target for antiviral development to combat B19V infection-caused severe hematological disorders.




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Learning of bimodal vs. unimodal signals in restrained bumble bees [RESEARCH ARTICLE]

Andre J. Riveros, Anne S. Leonard, Wulfila Gronenberg, and Daniel R. Papaj

Similar to animal communication displays, flowers emit complex signals that attract pollinators. Signal complexity could lead to higher cognitive load, impairing performance, or might benefit pollinators by facilitating learning, memory and decision-making. Here, we evaluate learning and memory in foragers of the bumble bee Bombus impatiens trained to simple (unimodal) vs. complex signals (bimodal) under restrained conditions. Use of a proboscis extension response protocol enabled us to control the timing and duration of stimuli presented during absolute and differential learning tasks. Overall, we observed broad variation in the performance under the two conditions, with bees trained to compound bimodal signals learning and remembering as well as, better, or more poorly than bees trained to unimodal signals. Interestingly, the outcome of training was affected by the specific colour-odour combination. Among unimodal stimuli, the performance with odour stimuli was higher than with colour stimuli, suggesting that olfactory signals played a more significant role in the compound bimodal condition. This was supported by the fact that after 24 h, most bimodal-treatment bees responded to odour but not visual stimuli. We did not observe differences in latency of response, suggesting that signal composition affected decision accuracy, not speed. We conclude that restrained bumble bee workers exhibit broad variation of responses to bimodal stimuli and that components of the bimodal signal may not be used equivalently. The analysis of bee performance under restrained conditions enables accurately control the multimodal stimuli provided to individuals and to study the interaction of individual components within a compound.




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Skoda Enyaq इलेक्ट्रिक SUV बेहतरीन फीचर्स के साथ बाजार में आने को तैयार, जानिए फीचर्स 

Skoda कंपनी जल्द ही अपनी इलेक्ट्रिक एसयूवी Skoda Enyaq को बाजार में लेकर आने की तैयारी है। कंपनी अपनी इस इलेक्ट्रिक एसयूवी को तीन बैटरी साइज और पांच पावर वेरिएंट्स में लेकर आ रही है।




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Vodafone Just Switched On 700Mhz 5G

This week Vodafone Hutchison Australia (VHA) went live with its first 5G trial areas in Sydney. The telco is using 700MHz spectrum at a number of 5G-ready sites around the Parramatta area. In addition to being the only major company to confirm that it won't charge extra for 5G in Australia, it will also offer global 5G roaming... if and when we're allowed to leave the country again. More »
    




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Are Vodafone's NBN Plans Actually Any Good?

Vodafone might be one of Australia’s biggest names in mobile connectivity, but it's relatively new to NBN and has only been offering plans since 2017. While Vodafone has a reputation for offering bang-for-buck mobile plans, is it the same for NBN? Let's take a closer look. More »
    




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Best SIM Only Phone Plans From Telcos That Aren't Telstra, Optus Or Vodafone

While considering a new phone plan your first instinct may be to compare the big three - Telstra, Optus, and Vodafone. But over the past few years smaller telcos have come in swinging with plans that have high data allowances and smaller monthly fees. By looking a little deeper you can grab a great bargain. Here are five of our favourite deals these telcos are packing right now. More »
    




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The Blogger Behind "AI Weirdness" Thinks Today's AI Is Dumb and Dangerous

Janelle Shane talks about the absurdity, perils, and limits of AI



  • robotics
  • robotics/artificial-intelligence

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Boba Fett Might Just Jetpack in to Meet Baby Yoda on The Mandalorian Season 2

Temuera Morrison is appearing on the next season of the show.




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Jio, Airtel और Vodafone के ये हैं लंबी अवधि वाले प्लांस, नहीं कराना पड़ेगा हर बार मोबाइल नंबर रिचार्ज

कोरोना संक्रमण के कारण पूरे देश में लॉकडाउन लगा हुआ है और यह कब खत्म होगा इसका अंदाजा लगाया जाना मुश्किल है। ऐसे में आप भी हर महीने मोबाइल नंबर रिचार्ज करा कर परेशान हो गए हैं, तो यह खबर आपके लिए है।




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Xur Destiny 2 Location: Where is Xur and What is he selling today? May 8



Where is Xur? The Destiny 2 exotic gear merchant's location changes every week. So here's everything you need to know including the latest from Bungie ahead of his arrival on May 8.




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Tender and honest, Tigertail is a beacon of hope in today's tide of anti-Asian bigotry | Georgina Quach

Alan Yang’s film about the lack of understanding between generations strikes a chord, and is so relevant as coronavirus racism spreads

Inflamed by President Trump’s casual phrase “Chinese virus”, anti-Asian sentiment is erupting all over the world. As a British-Vietnamese person who has been spat on because of the colour of her skin, the film Tigertail is a glimmer of hope – a way of showing the truth, and connecting Asian communities at a time when panic and misinformation serve to break us apart. Alan Yang’s multi-generational love story Tigertail weaves in Yang’s cultural self-discovery and features memories of Taiwan, as experienced by the protagonist Pin-Jui. Weighted against the present tide of anti-Asian bigotry, this tender story about honesty and lost love is more relevant than ever.

“American culture has been negligent in portraying Asian-American people as fully realised human beings,” Yang told the Deadline podcast. Yang, who worked on Parks and Recreation before co-creating Master of None, recalled the trepidation he felt in the early days of his career, in a cultural landscape where east Asians were rarely represented, or stereotyped as hardworking automatons. Yang said he had felt restricted to using only white characters in his early pilots, fearing that all-Asian or Asian-American scripts would never be accepted. But this was before the film successes of Crazy Rich Asians, The Farewell and Parasite brought real Asian faces to mainstream culture.

Continue reading...




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7 VCs talk about today’s esports opportunities

Even before the COVID-19 shutdown, venture funding rounds and total deal volume of VC funding for esports were down noticeably from the year prior. The space received a lot of attention in 2017 and 2018 as leagues formed, teams raised money and surging popularity fostered a whole ecosystem of new companies. Last year featured some […]




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Coronavirus outbreak: Eight flights from several countries to fly back stranded Indians today

New Dlehi, May 09: Several Indians, who are stranded in at least seven countries due to coronavirus outbreak, is all set to fly back to their home country on Saturday in special flights under Vande Bharat Mission. According to officials,





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Chris Martin and Mike Shinoda set for mental health awareness festival

Fans can check out the event, which kicks off at 8.30am PT each day, on 320 Festival's Facebook Live and YouTube Live pages.




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Daily crossword: Play today's Crusader Crossword for free - May 9 2020



LOOKING to play a daily crossword online for free? We have great news - you can now play our world-famous Express Crusader Crossword puzzle every day, for free, right here.




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Roku’s 4K HDR Streaming Stick+ is on sale for $39 today

Dealmaster also has deals on Kindles, our top Thunderbolt 3 dock, and more.




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Government's furlough scheme opens today as millions apply for financial support during coronavirus

What is furlough? Read more HERE




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Dr Jane Goodall says warnings of a pandemic were ignored and humanity has 'disrespected the natural world'

Conservationist Dr Jane Goodall has warned of future pandemics if lessons are not learned from the coronavirus crisis.




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Confusion after Government website states 'no coronavirus home tests available for key workers today' despite promising them to millions

The Government's new portal for arranging coronavirus tests has sparked confusion today, following a message suggesting home tests had run out by 9am.




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Mile-wide asteroid to pass Earth today at 19,000mph as NASA sets sights on crashing spacecraft into smaller one

Nasa plans to test potentially lifesaving technology by crashing a spacecraft into a smaller asteroid in 2021




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Donald Trump says US will not renew social distancing guidance after it expires today

Donald Trump has announced that the federal government will not be extending its coronavirus social distancing guidelines after they expire on Thursday.




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Captain Tom Moore thanks public for helping him find 'renewed purpose' as he turns '100 years young' today




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O2 and Vodafone down: Thousands of users unable to make calls with network issues reported

Hundreds of O2 and Vodafone customers have reported problems with the networks.




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What is today's pollen count? London and UK levels for May 7

Warmer weather during summer months usually spells bad news for hay fever sufferers




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What time is the Government's coronavirus press conference today? Daily updates on the briefings

Coronavirus: The symptoms




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'Stood up for liberty and common sense'! Guess where Sen. Ted Cruz got a haircut today [video]




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What Happened Today: Health Care System Crumbles, Testing Questions

Marc Lipsitch, a professor of epidemiology at the Harvard School of Public Health, answers questions about access to testing for COVID-19, false-negative results and the challenges of mass testing.





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'Fat and happy, that's my motto:' Scott Conant dishes up decadence at USA TODAY Wine & Food Experience in Chicago

From creamy gnudi to champagne macarons, the dishes at USA TODAY's Wine & Food Experience in Chicago didn't disappoint.

      






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Trinny Woodall's partner Charles Saatchi unwittingly appears on her live stream naked

The stylist's partner found himself in shot during a Facebook live