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Live imaging of synapse density in the human brain

A new imaging technique may give researchers fresh insights into brain development, function, and disease

The human brain is often said to be the most complex object in the known universe, and there’s good reason to believe that it is. That lump of jelly inside your head contains at least 80 billion nerve cells, or neurons, and even more of the non-neuronal cells called glia. Between them, they form hundreds of trillions of precise synaptic connections; but they all have moveable parts, and these connections can change. Neurons can extend and retract their delicate fibres; some types of glial cells can crawl through the brain; and neurons and glia routinely work together to create new connections and eliminate old ones.

These processes begin before we are born, and occur until we die, making the brain a highly dynamic organ that undergoes continuous change throughout life. At any given moment, many millions of them are being modified in one way or another, to reshape the brain’s circuitry in response to our daily experiences. Researchers at Yale University have now developed an imaging technique that enables them to visualise the density of synapses in the living human brain, and offers a promising new way of studying how the organ develops and functions, and also how it deteriorates in various neurological and psychiatric conditions.

Related: Brain’s immune cells hyperactive in schizophrenia

Related: 3D model of a nerve terminal in atomic detail | Mo Costandi

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Encouraging smaller churches in Russia

Dorothea, from Germany, joins the one-year programme with OM Russia, which includes visiting Siberian villages to help churches and sharing the Gospel with locals.




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Living and engaging in a Muslim community

After discovering his freedom in Christ and being discipled, former drug addict Ruslan wants to share hope with the least reached.




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Tragic accident brings salvation to village

A Roma man’s cry to God for mercy to spare his son’s life transforms his future and the future of his small town.




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Encouraging local believers

OM Riverboat community members encourage local believers who are struggling with their faith.




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Mahesh Babu Appointed Managing Director And CEO, Mahindra Electric

Mahesh has been with Mahindras for over 20 years and has worked in design and development of engine and vehicle platforms from frugal 3-wheelers to flagship models.




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Investors have already started changing their strategy: Bhaskar Majumdar, Managing Partner, Unicorn India Ventures

Cash flows will be tight and they may also experience delay in the investment cycle, but this is a temporary phase, says Bhaskar Majumdar, managing partner, Unicorn India Ventures (UIV), a Mumbai-based fund house.




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Instagram Live: Make your ‘Live’ totally engaging

Instagram Live allows users to stream video to followers and engage with them in real time. Here are some cool tips to make your quarantine a little more interesting.




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How messaging app Reliance JioChat makes a mark; check out the top 6 features

A key feature is the peer-to-peer money transfer facility within the app.




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Across The Aisle: Imagination is everything in war against reality

On May 3, the governments would have got 40 days time to do those things; the question is, do governments need more time?




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Rescuing real estate: Developers must take bold and agile action to survive Corona shock

For ‘Act Now’, company leadership should create a “war room” with a senior cross-functional team, focused on scenario planning, prioritising crisis response, and managing initiatives in with dynamism and agility.




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COVID-19: Scientists identify new dominant strain of SARS-CoV-2, say it could be more contagious

The study said that the increase in frequency of this strain is happening at an alarming rate, which indicates that this strain has an advantage over the original strain from Wuhan in terms of fitness.




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Marketing Is Aging Like a Fine Wine [Infographic]

The discipline is projected to mature into a rich blend of social media and mobile engagement.




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Managing the Risks of Renewable Energy Projects in Developing Countries

Driven by rapid expansion in developing countries, renewables are becoming a significant source of the world’s power.  According to the United Nations Environmental Programme’s (UNEP) 9th “Global Trends in Renewable Energy Investment 2015,” investment in developing countries was up 36 percent in 2014, totaling $131.3 billion.




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‘Mutated’ coronavirus more contagious, new study suggests

Researchers fear if the coronavirus does not subside in the summer, it could mutate further and potentially limit the effectiveness of vaccines.

The post ‘Mutated’ coronavirus more contagious, new study suggests appeared first on Premium Times Nigeria.




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Packaging with a view….prize!

The text version of this document in not available. You can...




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Chill wind of pandemic ravaging economies everywhere

More and more indicators are spelling out the scale of economic damage being wreaked by Covid-19 and the containment measures taken to tackle it, writes Robert Shortt.



  • Analysis and Comment

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New coronavirus strain more contagious than original - study


The strain was originally seen spreading in Europe, after which it spread to the rest of the world and is currently the most common strain.




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The Chinese chameleon reimagined in the age of Covid-19

The West’s perceptions of China hold up a mirror to its own preoccupations. More nuanced analysis is much-needed

The post The Chinese chameleon reimagined in the age of Covid-19 appeared first on The Mail & Guardian.




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Curtain falls on man smitten with John F Kennedy magic

He was a beneficiary of the Kennedy Airlifts, a project in the late 1950s and early 60s.




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Sea cucumbers a fragile, fading source of income for Sierra Leones divers

Prized in Asia as a luxury food, marine creature numbers could be dwindling





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Imagine Being Pulled Off Death Row and Then Being Put Back on It

In 1994, Marcus Robinson, who is black, was convicted of murder and sentenced to death for the 1991 killing of Erik Tornblom, a white teenager, in Cumberland County, North Carolina. He spent nearly 20 years on death row, but in 2012 his sentence was changed to life without a chance of parole. He was one of four death row inmates whose sentences were commuted by a judge who found that racial discrimination had played a role in their trials.

The reason their cases were reviewed at all was because of a 2009 North Carolina law known as the Racial Justice Act, which allowed judges to reduce death sentences to life in prison without parole when defendants were able to prove racial bias in their charge, jury selection, or sentence.

"The Racial Justice Act ensures that when North Carolina hands down our state's harshest punishment to our most heinous criminals," former Gov. Bev Perdue said when she signed the bill into law, "the decision is based on the facts and the law, not racial prejudice."

At 21, Robinson was the youngest person sentenced to death in North Carolina. When he was three, he was hospitalized with severe seizures after being physically abused by his father and was diagnosed with permanent brain dysfunction. However, those weren't the only troubling aspects of his case.

Racial discrimination in jury selection has been prohibited since it was banned by the Supreme Court in its 1986 Supreme Court decision Batson v. Kentucky, but Robinson's trial was infected with it. The prosecutor in the case, John Dickson, disproportionately refused eligible black potential jurors. For example, he struck one black potential juror because the man had been once charged with public drunkenness. However, he accepted two "nonblack" people with DWI convictions. Of the eligible members of the pool, he struck half the black people and only 14 percent of the nonblack members. In the end, Robinson was tried by a 12-person jury that included only three people of color—one Native American individual and two black people.

Racial discrimination in jury selection was not uncommon in the North Carolina criminal justice system. A comprehensive Michigan State University study looked at more than 7,400 potential jurors in 173 cases from 1990 to 2010. Researchers found that statewide prosecutors struck 52.6 percent of eligible potential black jurors and only 25.7 percent of all other potential jurors. This bias was reflected on death row. Of the 147 people on North Carolina's death row, 35 inmates were sentenced by all-white juries; 38 by juries with just one black member.

Under the Racial Justice Act, death row inmates had one year from when the bill became law to file a motion. Nearly all the state's 145 death row inmates filed claims, but only Robison and three others—Quintel Augustine, Tilmon Golphin, and Christina Walters—obtained hearings. In 2012, Robinson's was the first. At the Superior Court of Cumberland County, Judge Gregory Weeks ruled that race had played a significant role in the trial and Robinson was resentenced to life without parole. North Carolina appealed the decision to the state's Supreme Court.

An immediate outcry followed the decision. The North Carolina Conference of District Attorneys issued a statement saying, "Capital cases reflect the most brutal and heinous offenders in our society. Whether the death penalty is an appropriate sentence for murderers should be addressed by our lawmakers in the General Assembly, not masked as claims (of) racism in our courts."  

The ruling attracted lots of publicity from across the country and North Carolina lawmakers were outraged. "There are definitely signs in the legislative record that there were some [lawmakers] that really wanted to see executions move forward," Cassandra Stubbs, the director of the ACLU Capital Punishment Project who also represents Robinson, says. Legislative staffers circulated talking points for lawmakers with arguments that the RJA turns "district attorneys into racists and convicted murderers into victims," describing the law as "an end-run around the death penalty and an indefinite moratorium on capital punishment."

The day Judge Weeks resentenced Robinson, the Senate president pro tempore for the state Legislature, Phillip Berger, expressed concern that Robinson could be eligible for parole. He suggested Robinson—who had just turned 18 when he committed the crime and would not have been considered a juvenile—would be ineligible for life in prison without a chance of parole, citing a US Supreme Court ruling that prohibited juveniles from receiving life sentences without parole. "We cannot allow cold-blooded killers to be released into our community, and I expect the state to appeal this decision," he said. "Regardless of the outcome, we continue to believe the Racial Justice Act is an ill-conceived law that has very little to do with race and absolutely nothing to do with justice."

The state Legislature took on the challenge and voted to repeal the Racial Justice Act in 2013. This made it impossible for those on death row to even attempt to have their sentences reviewed for racial bias, but it left the fates of the four who had been moved to life imprisonment unclear. "The state's district attorneys are nearly unanimous in their bipartisan conclusion that the Racial Justice Act created a judicial loophole to avoid the death penalty and not a path to justice," Gov. Pat McCrory said in a statement at the time.

Even though the law was still in effect when the four inmates' sentences were reduced, they weren't safe from death row just yet. Robinson's sentenced had been legally reduced, but the legal battle was just beginning.

In 2015, after nearly two years from the initial hearing, the North Carolina Supreme Court ordered the Superior Court to reconsider the reduced sentences for Robinson, Augustine, Golphin, and Walters, saying the judge failed to give the state enough time to prepare for the "complex" proceedings.

This past January, Superior Court Judge Erwin Spainhour ruled that because the RJA had been repealed, the four defendants could no longer use the law to reduce their sentences. "North Carolina vowed to undertake an unprecedented look at the role of racial bias in capital sentencing," says Stubbs. But now, "the state Legislature explicitly turned from its commitment and repealed the law."

Robinson is back on death row at Central Prison in the state's capital of Raleigh. In the petition to the state Supreme Court, Robinson's lawyers point out that the Double Jeopardy Clause—the law that prevents someone from being tried twice for the same crime—bars North Carolina from trying to reimpose the death penalty because the 2012 RJA hearing acquitted him of capital punishment.

"He's never been resentenced to death," Stubbs says. "They have no basis to hold him on death row."



  • Politics
  • Crime and Justice
  • Race and Ethnicity

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Video Friday: Startup Unveils Agile Robot Dog That Costs Less Than $10k

Your weekly selection of awesome robot videos




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Imagine if we beat Kaizer Chiefs twice in those two matches - Bidvest Wits' Alexander eyes PSL title

The experienced midfielder believes they can clinch the title right under the noses of favourites Amakhosi and Masandawana






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Ruthie Ann Miles Welcomes Baby Girl Two Years After Tragic Accident

It's a girl! And her name is Hope Elizabeth. Tony-award-winning Broadway star Ruthie Ann Miles and her husband Jonathan Blumenstein welcomed a new member to the family recently,...




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Ruthie Ann Miles Welcomes Baby Girl Two Years After Tragic Accident

It's a girl! And her name is Hope Elizabeth. Tony-award-winning Broadway star Ruthie Ann Miles and her husband Jonathan Blumenstein welcomed a new member to the family recently,...




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Ruthie Ann Miles Welcomes Baby Girl Two Years After Tragic Accident

It's a girl! And her name is Hope Elizabeth. Tony-award-winning Broadway star Ruthie Ann Miles and her husband Jonathan Blumenstein welcomed a new member to the family recently,...




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Close your eyes and imagine seeing the art world's treasures as if for the first time | Laura Cumming

The museums of Europe have begun reopening their doors to art lovers desperate to see old favourites and new works

I am cursing my bad luck not to be stuck in lockdown in the Prado. A friend wishes she had stowed away in a closet before they bolted the doors of the National Gallery. Others would give anything for a week in the Rijksmuseum, a day in the Uffizi, an hour with Rembrandt or Vermeer, even just a few minutes with a Samuel Palmer moonscape in the Ashmolean or a Turner sunrise at Tate Britain. Museums are places of the heart.

We see art in time and place; we cannot see it otherwise. Of course there are other whereabouts of the works we most long to set eyes on again, during this evil pandemic: the cave paintings at Chaumet in France, Fra Angelico’s Annunciation in a Florentine monastery, Robert Smithson’s Spiral Jetty coiled in the glistening waters of the Great Salt Lake in Utah. These were all chosen in an unofficial and entirely self-selecting Twitter survey (mine), along with Leonardo’s The Last Supper and James Turrell’s Deer Shelter Skyspace, framing the blue heavens above Yorkshire Sculpture Park.

Continue reading...




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The Magic of Christmas

It's that time of the year when magic fills the air - a magic that heralds the beautiful month of December - and Christm




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Game based learning camouflaging fun with learning

Organisations of the modern era require proper and effective training materials which carry the potential to enhance the skills and knowledge of employees. Proper training systems can...




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Canada: Leveraging Training and Skills Development in SMEs - An analysis of two urban regions Montreal and Winnipeg

This paper looks at a study carried out among 80 small and medium sized enterprises (SMEs) in two Canadian cities, Montréal and Winnipeg, based on a survey and case studies, which show the importance of innovation among Canadian SMEs. These innovations in turn create new demands for skill development, both through formal training and in informal activities.




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OSAA-OECD high-level event on leveraging pension funds for financing infrastructure development in Africa

Addis Ababa - Part of the 3rd International Conference on Financing for Development, this event explored strategies to leverage Africa’s pension funds and other sources of private financing to develop Africa’s infrastructure. Ways to improve the investment climate in Africa using the recently updated Policy Framework for Investment were also be addressed.




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Financial system risk is elevated and global standards are essential in managing cross-border infrastructure investment

A new OECD report, the 2018 Business and Finance Outlook, highlights a number of major risks having the potential to disrupt global economic growth. It notes that the gradual normalisation of monetary policy in an environment of growing debt will be a major test of whether the Basel III regulatory reforms have achieved their goal of ensuring safety and soundness in the financial system.




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Cybersecurity: Managing risks for greater opportunities

While the nature of cyber attacks continues to include criminal activities motivated by financial gain, the main emerging threats are large-scale denial of service attacks, information leaks, targeted cyber espionage, and the disruption of critical infrastructures.




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OSAA-OECD high-level event on leveraging pension funds for financing infrastructure development in Africa

Addis Ababa - Part of the 3rd International Conference on Financing for Development, this event explored strategies to leverage Africa’s pension funds and other sources of private financing to develop Africa’s infrastructure. Ways to improve the investment climate in Africa using the recently updated Policy Framework for Investment were also be addressed.




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Seminar on pension foresight: Envisaging retirement income plans of the future

21 June 2017, Paris: Co-organised by the International Network for Pensions, Aging, and Retirement Research (INPARR), the OECD and IOPS, this seminar provided a window into the latest thinking and research that sheds light on where pension plans and designs are headed in the future and challenges to their future sustainability and efficiency.




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The Contribution of Reinsurance Markets to Managing Catastrophe Risk

This report makes use of a unique set of data on premiums and claims provided by global reinsurance companies to examine the contribution that reinsurance has made to enhancing the capacity of the primary insurance market to manage catastrophe risk and to reducing the economic and insurance market disruption that often follows catastrophic events.




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Managing our natural resources: can we build more with less? - Insights Blog

For World Environment Day on 5 June 2014, the OECD Environment Directorate looks at how we use and manage natural resources.




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The Business Climate Has Changed: Imagining New Approaches for Our Climate

In his remarks to the Business & Climate Summit, the Secretary-General said that business lies at the heart of what we need to achieve on climate action. If Governments produce clear, credible and coherent national policies and clear messages and signals, the full transformative power of business, markets and human ingenuity will be unleashed.




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Understanding and Managing the Unequal Consequences of Environment Pressures and Policies - Insights blog

The consequences of degradation of environmental quality as well as the consequences of environmental policies are typically unevenly distributed. In general, poorer countries and lower income households are more severely affected by environmental degradation and at the same time have less capacity to adapt.




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The Business Climate Has Changed: Imagining New Approaches for Our Climate

In his remarks to the Business & Climate Summit, the Secretary-General said that business lies at the heart of what we need to achieve on climate action. If Governments produce clear, credible and coherent national policies and clear messages and signals, the full transformative power of business, markets and human ingenuity will be unleashed.




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Managing Hospital Volumes: Germany and Experiences from OECD Countries

To help inform the Conference on Managing Hospital Volumes, co-organised by the German Federal Ministry of Health and the OECD, and held on the 11th April 2013 in Berlin, the OECD Secretariat produced a paper to provide an international perspective on Germany’s situation and the current policy debate.




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Canada: Leveraging Training and Skills Development in SMEs - An analysis of two urban regions Montreal and Winnipeg

This paper looks at a study carried out among 80 small and medium sized enterprises (SMEs) in two Canadian cities, Montréal and Winnipeg, based on a survey and case studies, which show the importance of innovation among Canadian SMEs. These innovations in turn create new demands for skill development, both through formal training and in informal activities.




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Call for papers: Engaging employers in Skills development and utilisation

The work will seek to identify good practices for employer engagement in the areas of both developing and utilising skills, including setting up innovative workplace learning methods, designing effective employer partnerships with the employment and training system as well as financing mechanisms for employer-led training, including how best to reach SMEs.




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Conference on engaging employers in building better local jobs and creating a more responsive skills system

This conference organised jointly by the OECD, Warwick University, the Work Foundation, and the Centre for Cities brought together stakeholders from national government departments, cities, Local Enterprise Partnerships (LEPs) as well as business, NGOs and research institutions to discuss the key challenges facing the United Kingdom in building more and better quality jobs




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'Billy Lynn's Long Halftime Walk': Engaging But Not Exceptional

Director: Ang Lee; Cast: Joe Alwyn, Kristen Stewart, Chris Tucker, Garrett Hedlund, Makenzie Leigh, Vin Diesel, Steve Martin, Brain "Astro" Bradley, Arturo Castro.




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OECD Global Conference on Governance Innovation: Towards Agile Regulatory Frameworks in the Fourth Industrial Revolution

Conference to exchange information on the need for and experience with governance innovation in the context of different sectors and different countries, both within and outside of the OECD, and to inform future OECD work.




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Regulatory Quality and COVID-19: Managing the Risks and Supporting the Recovery

Regulatory decisions are vital at nearly every stage of resolving the health crisis and its social and economic effects. The current situation makes the need for trusted, evidence-based, internationally co-ordinated and well-enforced regulation particularly acute.