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Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02321H, Paper
Fangyang Chen, Botao Wang, Xin Sun, Yage Wang, Ruiyan Wang, Kaikai Li
EGT intervention significantly improved D-galactose induced oxidative stress, neuroinflammation, and mitochondrial function, resulting in the alleviation of memory injury.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry





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Anganwadi noonmeal pensioners stage protest in Krishnagiri




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The MAGIC Of Bappi Lahiri

Bappida's softer more creative work got buried in the noise, rues Subhash K Jha as he picks the late lamented composer's most soulful songs.




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The Magical World Of Muzaffar Ali

'I somehow felt that Muzaffar Ali was in Aligarh to feel the pulse of the Muslim youth, especially in the darker and harsher times that India is passing through,' notesMohammad Sajjad.




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The Rohini Godbole way of teaching, talking and engaging with students

Remembering the life and legacy of pioneering physicist Professor Rohini Godbole through the eyes of colleagues and students.




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Let imagination soar

The Little Theatre’s The Garage Gang is a good mix of dance, improv and retelling of classic tales




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The tragic hero

Events leading up to Keechaka’s death was well captured in ‘Keechakavadham’.




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Correction: Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer

Nanoscale, 2024, 16,20354-20355
DOI: 10.1039/D4NR90194K, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ziwei Li, Fan Yang, Di Wu, Yanhong Liu, Yang Gao, Haichen Lian, Hongxin Zhang, Zhibin Yin, Aiguo Wu, Leyong Zeng
The content of this RSS Feed (c) The Royal Society of Chemistry




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Applications of nanotheranostics in the second near-infrared window in bioimaging and cancer treatment

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR03058C, Review Article
Huimin Li, Pengju Li, Jiarui Zhang, Ziyi Lin, Lintao Bai, Heyun Shen
This review summarized the application of the second near-infrared nano-platform in the field of nano-agents design, optical imaging and cancer treatment, aiming at providing profound insights into its development status and future challenges.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Tailored peptide nanomaterials for receptor targeted prostate cancer imaging

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR03273J, Paper
Fátima Santillán, Carlie L. Charron, Betty C. Galarreta, Leonard G. Luyt
This study reports on a cancer targeted nanomaterial created from cyclic octapeptides that is tailored for the optical imaging of prostate cancer. The strategy focuses on the co-assembly of four specific templates into cyclic peptide nanotubes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Aptamer-functionalized Nucleic Acid Nanotechnology for Biosensing, Bioimaging and Cancer Therapy

Nanoscale, 2024, Accepted Manuscript
DOI: 10.1039/D4NR04360J, Review Article
Xiaofang Zheng, Zhiyong Huang, Qiang Zhang, Guoli Li, Minghui Song, Ruizi Peng
Nucleic acids have enabled to fabricate self-assemblies and perform dynamic operations. Among different functional nucleic acids, aptamers can specifically bind to wide range of targets including proteins, viral antigens, living...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Endocrinology plays a vital role in diagnosing, managing and preventing lifestyle disorders like diabetes and thyroid, says Venkaiah Naidu




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Felix Mendelssohn-Bartholdy - Adagio from the Symphony no. 3 “Scottish” (arr. by E. T. Chipp)

Organ sheet music by Felix Mendelssohn-Bartholdy | Adagio from the Symphony no. 3 “Scottish” (arr. by E. T. Chipp)

Reference: BE01190
Title: Adagio from the Symphony no. 3 “Scottish” (arr. by E. T. Chipp)
Composer: Felix Mendelssohn-Bartholdy
Instrument: Organ solo
Price: €10.99
Pages: 11
Format: Portrait - 9” x 12” paper-back
Publication Date: 26-Aug-2024
Edition: New
Editor: W. B. Henshaw
EAN/ISMN: 979-0-2067-1190-9




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PS-1: Mani Ratnam's Magic Works, Yet...

Ponniyin Selvan has everything going for it, yet, there is something missing for a wholesome film experience, observes N Sathiya Moorthy.




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The ancient history of the Egyptians, Carthaginians, Assyrians, Babylonians. Medes and Persians, Macedonians, and Grecians. / by Mr Rollin, Sometime Principal of the University of Paris, afterwards Professor of Eloquence in the Royal College, and Member o

Edinburgh : Printed for Hamilton and Balfour, Kincaid and Donaldson, and W. Gray., MDCCLVIII. [1758]




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Cannes 2024: Nancy Tyagi makes her maiden appearance at festival with self-stitched 20 kg gown

The Delhi-based fashion influencer debuted at the 77th Cannes Film Festival wearing a pink ruffled gown, designed and stitched by herself




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Maize research body seeks funding to undertake research on managing aflatoxin in DDGS

IIMR says various technologies can be used to reduce the aflatoxin




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Honor unveils Magic V2: A foldable phone competing against Apple’s flagships

With a foldable OLED screen and a competitive price, it aims to challenge iPhone’s dominance in the market.



  • Mobiles & Tablets

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Imagine

Surviving Self-Distancing – Day 14




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Honor Magic 7 Series with AI features running on Snapdragon 8 Elite launched

Snapdragon and Honor announced the launch of the AI-powered Honor Magic 7 Series




agi

Solid body wash comes without packaging. But does that make it eco-friendly?

Cosmetics firms appeal to plastic-free consumers with the hybrid of bar soap and liquid body wash




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Polarized light and the magic angle: Scientists making art




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AkzoNobel, Thomas Swan to develop coatings for metal packaging




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Calico and AbbVie advance antiaging efforts




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PTC buys gene-therapy-focused Agilis




agi

L’Oréal launches AI-based Brow Magic. Here’s how it works

L’Oréal confirms that the Brow Magic eyebrow applicator will launch in 2023




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Imagicaa launches indoor trampoline park in theme park expansion 




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Hindalco, Ramco Cements, Sagility India Share Price Highlights November 12, 2024: Ramco Cements stock closes 5% higher, Sagility stock declines 6% on day one of listing

Hindalco, ONGC, Ramco Cements & Ambuja Cements Share Price Highlights; Sagility IPO Listing November 12, 2024




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Sagility India shares debut 3.53% higher

The stock made its debut at ₹31.06, up 3.53 per cent from the issue price on both the BSE and NSE, later, it jumped 7.2 per cent to ₹32.16 on the BSE




agi

Thyagi (1947)

V.N. Janaki, N. Krishnamurthi, V.S. Mani, ‘Stunt’ Somu, K. Devanarayanan, K.S. Angamuthu, Thodi Kannan, Kolathu Mani, T.V. Sethuraman, C.K. Nagaratnam, V. Saroja




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'Magizhchi' at the box-office

Kabali has had the biggest-ever opening for a Tamil film




agi

Maharashtra Assembly elections: Human-leopard conflict to be a raging issue in 4 seats of Pune district




agi

Kareena Looks Simply Magical

She does not hesitate when it comes to experimenting with her makeup.




agi

'Couldn't Imagine Chatting With Kamal'

'I was completely in awe of him. After the shot was okayed, I would quickly run back to my chair and sit quietly till I was called again.'




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BJP, MVA manifestoes and the woman vote: More needs to be imagined and offered to her







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Agilysys Offering Webinar Series Presenting Solutions That Enable The COVID-19 “New Normal”

Guest expectations have changed and Agilysys is ready with contactless and cashless integrated solutions at every step along the hotel guest journey. This webinar will explore: Which Agilysys solutions to use at each step along the guest journey Wha...




agi

Beyond Fingal's cave: Ossian in the musical imagination / James Porter

Lewis Library - ML196.P67 2019






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Here's how NASA engineers piloting the Mars rover are managing their work-life balance during lockdown

  • NASA engineers are continuing to drive the Mars Curiosity Rover while working from home.
  • The job is highly technical and delicate, but the team has already managed to complete a successful operation under lockdown.
  • Business Insider asked two of the rover team how they manage their work-life balance now the rover has colonised their living space.
  • Visit Business Insider's homepage for more stories.

Life during lockdown has meant millions of people having to adapt to their home and work lives colliding. But what's that like when your work involves driving a nuclear-powered robot on the surface of Mars?

Business Insider spoke to two of the NASA technicians currently piloting the Mars Curiosity rover from home. It's a delicate operation that takes careful planning between a team of roughly 75 NASA engineers and scientists. Even while working remotely, the team was able to rig up their home workstations well enough that the rover has already completed a successful drilling operation while its human operators are in lockdown.

Despite doing the most otherworldly job imaginable, the Curiosity rovers are having to contend with familiar stresses of lockdown working life. They told Business Insider their personal tips and tricks for staying focused and healthy as they work from home.

Get comfy

Matt Gildner is the planning team lead for the rover, which means he directs a team of about 20 people who build the commands to send the rover to tell it where to go and what to do. Gildner's day involves staying permanently teleconferenced in to conversations using two headsets, one in each ear. A few times a day he also uses red-blue 3D glasses to examine images sent back by the rover.

His first change to his work-from-home set-up: Get a better chair. "The first week I got here I had an old wooden bank chair that while it looked really nice next to my desk, [was] not very comfortable," said Gildner. He quickly swapped this out for a more comfortable ergonomic chair. He and his wife are also making cold-brew coffee every night, ready to go in the morning.

Make sure you're seeing some kind of change

Gildner's also trying to make sure he doesn't stay glued to his ergonomic chair, making it a point to get up and moving around. "It's really about just getting up and stepping away from the desk for a while," Gildner said. This could be to just go to the kitchen to get a snack or, in Gildner's case, tend to some home baking projects.

"I was already baking some bread before this all happened, but I did kind of up my game in that area," he said. Specifically Gildner (a fan of the YouTube cooking channel "Bon Appetit") has started experimenting with overnight dough fermentation.

"It's nice to go and have something new to see every morning that changed overnight, or you get to see something progress," he said. "That's an important part of mental health and this point in time — to make sure you are having something in your life that is life-changing and dynamic despite your being in the same place."

He draws a parallel between this and his work on the rover. "That is one of the big draws of working a spacecraft operation, especially on Mars, is that every day we're driving to a new place and I get to look at images that no human has ever seen before. And Mars is always throwing us something new."

Keep a firm line between work time and downtime

"I also tend to really shut my computer down and put my phone away for work at the end of the day, just because I want to still try to keep some good separation between work life and home life, even though they're happening in the same place right now," Gildner said.

Project lead Alicia Allbaugh, who oversees the entire team of 75, also likes to draw a clear line between home and work life. She also recommends "not blending home tasks during your work time."

"I try not to deviate too much from what I would've done at work. Because then it can get you distracted and you start pulling away," she said.

Allbaugh also had to divvy up parts of the house with her husband, who also works at NASA. The two didn't want to work in adjacent rooms because they might hear each other's teleconferences through the walls, so Allbaugh works upstairs while her husband gets the kitchen, along with the couple's two rescue bunnies Oreo and Grayce.

In her free time Allbaugh has been tinkering with home improvements, and finished a long-standing project of painting and varnishing some linen-closet doors.

Respect other people's rhythms

As manager of a large team, Allbaugh also has to be sensitive to the fact that everyone has different daily rhythms working from home, especially those with children. Sudden mutes in meetings for children talking and clocks chiming have become the norm.

"We're all very empathetic for each other. I mean we find this adorable. We're not frustrated, whereas if someone came in and interrupted your meeting when you were in the conference room, you may have been like, 'What was that about?'" said Allbaugh.

Keep up the social side of the office

Allbaugh's team has also tried to keep social elements of their office going through virtual happy hours, and she has set up open-office tea break meetings so her team can just come in for a chat, which she thinks is important to keep up even as the lockdown drags on. "Because at first it's novel, and then it's okay — now it's a marathon," she said.  

SEE ALSO: NASA engineers explain what it's like to drive a nuclear-powered Mars rover from home during the pandemic

Join the conversation about this story »

NOW WATCH: A cleaning expert reveals her 3-step method for cleaning your entire home quickly




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Managing the Emergence of Rising Powers: A Western Response

Research Event

22 May 2014 - 5:00pm to 6:15pm

Chatham House, London

Event participants

Trine Flockhart, Senior Fellow, Transatlantic Academy
Patrick W Quirk, Fellow, Transatlantic Academy
Chair: Dr Leslie Vinjamuri, Senior Lecturer in International Relations, SOAS

This event will present the findings of the Transatlantic Academy’s new report, Liberal Order in a Post-Western World, which examines the future of international liberal order in a world shaped by the rise of emerging powers and a transatlantic community dealing with internal challenges. Produced by collaboration between scholars from Europe and North America, it recommends ways to build an enduring rules-based order for the 21st century.

Department/project




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Glycation-mediated inter-protein cross-linking is promoted by chaperone-client complexes of {alpha}-crystallin: Implications for lens aging and presbyopia [Glycobiology and Extracellular Matrices]

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.




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Re: Prognosis of unrecognised myocardial infarction determined by electrocardiography or cardiac magnetic resonance imaging: systematic review and meta-analysis




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Developing a Road Map for Engaging Diasporas in Development: A Handbook for Policymakers and Practitioners in Home and Host Countries

This practical handbook highlights policies and programs that can magnify the resources, both human and financial, that emigrants and their descendants contribute to development. It gives concrete examples of policies and programs that have been effective, and pulls out both useful lessons and common challenges associated with the topics at hand.




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Managing Borders in an Increasingly Borderless World

This edited volume showcases approaches toward border management in Europe, Central America, and North America, and reflects on the challenges that countries in these regions face in managing their borders. The book brings together perspectives from both sides of the Atlantic on what border security means in practice, the challenges that continue to evade policymakers, and what policies have been the most (and least) successful in achieving “secure” borders.




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Grid cells come into play when the imagination runs away

New research suggests that neurons which track our movements are also involved in imaginary navigation

Brain cells involved in spatial navigation and mapping the environment also fire when we merely imagine moving through familiar surroundings, according to a new study by researchers at University College London. The research, published today in the journal Current Biology, shows that memory and imagination are intimately linked in the brain at the cellular level, and could help to explain some of the changes that occur in the early stages of Alzheimer’s Disease.

Related: The fly's neural compass works just like a mammal's

Related: 3D compass cells found in the bat brain

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