Have you heard that starting SPB 23.1, Allegro Package Designer Plus (APD+) will be renamed as Allegro X Advanced Package Designer (Allegro X APD)? 

Allegro X APD offers multiple new features and enhancements on topics like Via Structures, Wirebond, Etchback, Text Wizards, 3D Canvas, and more. 

This post presents the new 3DX Canvas introduced in SPB 23.1. This can be invoked from Allegro X APD (from the menu item View > 3DX Canvas). 

Some of the key benefits of the new canvas: 

• This canvas addresses the scale and complexity in large modern package designs. It provides highly efficient visual representation and implementation of packages. 
  
• The new architecture enables high-performance 3D incremental updates by utilizing GPU for fast rendering. 
  
  
• Real-time 3D incremental updates are supported, which means that the 3D view is in sync with all changes to the database. 
  
  
• The new canvas provides 3D visualization support for packaging objects such as wire bonds, ball, die bump/pillar geometries, die stacks, etch back, and plating bar. 
  
  
• This release also introduces the interactive measurement tool for a 3D view of packages. Once you open 3DX Canvas, press the Alt key and you can select the objects you want to measure. 
  
• 3DX Canvas provides new 3D DRC Bond Wire Clearances with Real 3D DRC Checks. True 3D DRC in Constraint Manager has been introduced. If you open Constraint Manager, there will be a new worksheet added. Following DRC checks are supported: 

  Wire to Wire 
  Wire to Finger 
  Wire to Shape 
  Wire to Cline 
  Wire to Component

The Cadence Palladium Emulation Platform is a hardware system that implements the design, accelerating its execution and verification. Itoffers the highest performance and fastest bring-up times for pre-silicon validation of billion-gate designs, using a custom processor built by Cadence.

This Palladium Introduction course is based on the Palladium 23.03 ISR4 version and covers the following modules:

• Introduction
• Palladium flow
• Running a design on the Palladium system

This course starts with an “Introduction” module that explains Palladium and other verification platforms to show its place in the big picture. It also compares Palladium with Protium and simulation and discusses its usage and limitations.

The “Palladium Flow” module includes two stages at a high level, which are Compile and Run. Then, it covers these stages in detail. First, it covers the ICE compile flow and IXCOM compile flow steps in detail. Then it explains Run, which is common for both ICE and IXCOM modes.

The third module, “Running Design on the Palladium System,” covers all the items required for running your design on the Palladium system, including:

• Software stack requirements
• Basic concepts required to understand the flow
• Compute machine requirements

In addition, this course contains labs for both the ICE and IXCOM flows with detailed steps to exercise the features provided by the Palladium system. The lab explains a practical example of multiple counters and exercising their signals for force, monitor, and deposit features, along with frequency calculation using a real-time clock. The course is available on the Cadence support page:

There is also a Digital Badge available. You will find the Badge exam opportunity when you enroll in the Online training or after you have taken the training as "live" training.

For questions and inquiries, or issues with registration, reach out to us at Cadence Training. Want to stay up to date on webinars and courses? Subscribe to Cadence Training emails. To view our complete training offerings, visit the Cadence Training website.

Related Training Bytes

• Palladium: What Are Verification Platforms
• Palladium: What Is Processor Based Emulation
• Palladium: Comparing Emulation (Z2) and Prototyping (X2)
• Palladium: What Are ICE and IXCOM Compile Flow
• Palladium: How to Process a Design to Run on Palladium
• Palladium: XCOM Compile Flow (TB+RTL to Palladium Database)
• Palladium: ICE Compile Flow (RTL to Palladium Database)
• Palladium: Legacy ICE Compile Flow
• Palladium: Cadence Software Releases for Palladium and Protium Flow
• Palladium: Setting of PATHs for Using Palladium
• Palladium: Z2 Hardware Structure (Blade and Boards)
• Palladium: What Is Sourceless and Loadless nets
• Palladium: Design Clocks
• Palladium: Step Count and Step Clock
• Palladium: Steps for Running the Design on Palladium Z2

Related Courses

• Verilog Language and Application Training
• SystemVerilog for Design and Verification
• Xcelium Simulator

Related Blogs

• Training Insights – A New Free Online Course on the Protium System for Beginner and Advanced Users
• It’s the Digital Era; Why Not Showcase Your Brand Through a Digital Badge!
• Training Insights - Free Online Courses on Cadence Learning and Support Portal

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On top of EU access, an impressive quality of life, talented labour and a thriving tourism sector, Madeira offers a white-listed preferential tax regime that is conducive to long-term, productive investments. Sebastian Shehadi reports.

Robotics developers can greatly accelerate their work on AI-enabled robots, including humanoids, using new AI and simulation tools and workflows that NVIDIA revealed this week at the Conference for Robot Learning (CoRL) in Munich, Germany. The lineup includes the general availability of the NVIDIA Isaac Lab robot learning framework; six new humanoid robot learning workflows Read Article

All over the world, women have been clamouring for gender equality, development and peace in the interest of all humanity. The calls reached a crescendo with the Beijing Declaration and Platform for Action (BDPfA) put in place in September 1995 under the auspices of the United Nations (UN). The Beijing Declaration was particularly targeted at ensuring that the voice of women everywhere was heard, while recognising the diversity of women, their roles and the circumstances inhibiting women’s interests. The BDPfA also aimed at ensuring the full implementation of the human rights of women and the girl child as an inalienable, […]

A caravan of approximately 3,000 migrants set off on Tuesday from southern Mexico, headed toward the United States on the day when U.S. voters were deciding between U.S. presidential candidates Kamala Harris and Donald Trump. Immigration has been a key issue in the U.S. election campaign. Before heading northward, the migrants gathered in Tapachula, the capital of the southern Chiapas state, carrying banners with messages such as "NO MORE MIGRANT BLOOD" and images of the Virgin of Guadalupe, an important religious and cultural symbol in Mexico, according to Reuters witnesses. "We want U.S. authorities to see us, to see that we are people who want to work, not to harm anyone," said Honduran migrant Roy Murillo, who joined the caravan with his two children and his pregnant wife. In recent years, several caravans with people hoping to enter the United States have attempted to reach the U.S.-Mexican border, traveling in mass groups for safety. Most have dispersed along the way. "I'm afraid to travel alone with my family. Here, the cartels either kidnap you or kill you. ... That's why we're coming in the caravan," Murillo said. Murillo recounted his unsuccessful attempts to secure an asylum appointment through a mobile app developed by the U.S. Customs and Border Protection agency. Tapachula, a mandatory crossing point for tens of thousands of migrants, has become one of Mexico's most violent cities in recent months, with migrants frequently targeted by organized crime, according to official data. "I feel suffocated here. That's why we decided to leave," said 28-year-old Venezuelan migrant Thais, who spoke on condition that her surname not be used due to safety concerns. She joined the caravan with her husband and 3-year-old daughter. "I wish Mr. Trump and Ms. Kamala would see that we are human beings, that we want to live and support our families," she added. Voters cast ballots on Tuesday in the race between Vice President Harris, a Democrat seeking to become the first female U.S. president, and Trump, a Republican immigration hard-liner aiming to regain the presidency.

Advanced Leadership Program

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

A previous work by the artist, dedicated to the Israeli victims of Hamas, was also vandalized.

This month, the International Monetary Fund (IMF) had an opportunity to end one of its most reviled policies and lift billions of dollars of debt off the backs of crisis-stricken developing countries. It chose not to. The IMF’s ostensible mission is to promote financial stability by providing loans to countries facing economic challenges or crises. […]

Sullivan laid the blame squarely on Hamas, clarifying that the issue was that the group simply didn’t want to make a deal under any terms.

The Beijing Declaration and Platform for Action, adopted in 1995 during the Fourth World Conference on Women, remains a cornerstone in the global pursuit of gender equality and women’s empowerment. With the Asia-Pacific Ministerial Conference on the Beijing+30 Review fast approaching, now is the time to reflect on the progress made and the challenges that […]

Chris Evans hopes to become a great dad somedayChris Evans has recently discussed about fatherhood and marital relation with Alba Baptista. Speaking at upcoming Red One movie premiere on November 11, Evans responded to the question about becoming a superhero father like his co-star Dwayne Johnson...

To support e-commerce, public-private collaboration must prioritize closing the digital divide, supporting small businesses, and promoting environmental sustainability. Strengthening data governance, competition, and tax frameworks are also key to resilient and equitable e-commerce.

As a landlocked country, Uzbekistan’s roads carried 1.24 billion tons, or 90.6% of all freight, in 2020 (rail 5.2%, pipelines 4.2%).

Donald Trump has said he wouldn’t be a dictator — “except for Day 1.” According to his own statements, he’s got a lot to do on that first day in the White House.

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Outlining the energy access disparity women face in Vanuatu, this brief shows how it impacts their health and economic opportunities and explains why mainstreaming gender can increase financial inclusion and drive an equitable green transition.

Netflix’s Ancient Apocalypse peddles the idea that we have overlooked an extraordinary ancient civilisation. Flint Dibble explains why that is wrong, and why real archaeology is more exciting

An analysis of crystals in lava from the 2022 eruption of Mauna Loa has revealed an unknown magma reservoir within the volcano, which could extend forecasts of eruptions from minutes to months

An analysis of crystals in lava from the 2022 eruption of Mauna Loa has revealed an unknown magma reservoir within the volcano, which could extend forecasts of eruptions from minutes to months

Thousands of bones found in a Tibetan cave have been analysed to learn how mysterious ancient humans known as Denisovans lived

Highland and lowland populations in Papua New Guinea have different gene variants derived from Denisovan archaic humans, indicating possible adaptations for lower oxygen levels and higher malaria risk

Ancient humans are said to have evolved to leave the trees, where our primate ancestors lived, in favour of open grassy savannahs – but we may have this idea wrong

Spear-throwing tools called atlatls allow humans to launch projectiles over great distances, but Neanderthals apparently never used them – and an experiment involving a 9-metre-tall platform may explain why

Netflix’s Ancient Apocalypse peddles the idea that we have overlooked an extraordinary ancient civilisation. Flint Dibble explains why that is wrong, and why real archaeology is more exciting

Title: In Early Trial, Targeted Therapy Fights Advanced Melanoma
Category: Health News
Created: 8/25/2010 6:10:00 PM
Last Editorial Review: 8/26/2010 12:00:00 AM

Title: New Drug May Treat Advanced Melanoma
Category: Health News
Created: 8/26/2010 11:04:00 AM
Last Editorial Review: 8/26/2010 11:04:24 AM

Title: Gene Study Helps Advance Diagnosis of Cystic Fibrosis
Category: Health News
Created: 8/26/2013 2:36:00 PM
Last Editorial Review: 8/27/2013 12:00:00 AM

Title: Exercise Is Good Medicine for Advanced Colon Cancer
Category: Health News
Created: 8/28/2019 12:00:00 AM
Last Editorial Review: 8/28/2019 12:00:00 AM

Title: Cases of Advanced Cervical Cancer Keep Rising Among U.S. Women
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM

Title: AHA News: People With Dementia May Be Less Likely to Receive an Advanced Treatment For Stroke
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM

The regulation of drug-metabolizing enzymes and transporters by cytokines has been extensively studied in vitro and in clinic. Cytokine-mediated suppression of cytochrome P450 (CYP) or drug transporters may increase or decrease the systemic clearance of drug substrates that are primarily cleared via these pathways; neutralization of cytokines by therapeutic proteins may thereby alter systemic exposures of such drug substrates. The Food and Drug Administration recommends evaluating such clinical drug interactions during clinical development and has provided labeling recommendations for therapeutic proteins. To determine the clinical relevance of these drug interactions to dose adjustments, trends in steady-state exposures of CYP-sensitive substrates coadministered with cytokine modulators as reported in the University of Washington Drug Interaction Database were extracted and examined for each of the CYPs. Coadministration of cytochrome P450 family 3 subfamily A (CYP3A) (midazolam/simvastatin), cytochrome P450 subfamily 2C19 (omeprazole), or cytochrome P450 subfamily 1A2 (caffeine/tizanidine) substrates with anti-interleukin-6 and with anti-interleukin-23 therapeutics led to changes in systemic exposures of CYP substrates ranging from ~ –58% to ~35%; no significant trends were observed for cytochrome P450 subfamily 2D6 (dextromethorphan) and cytochrome P450 subfamily 2C9 (warfarin) substrates. Although none of these changes in systemic exposures have been reported as clinically meaningful, dose adjustment of midazolam for optimal sedation in acute care settings has been reported. Simulated concentration-time profiles of midazolam under conditions of elevated cytokine levels when coadministered with tocilizumab, suggest a ~six- to sevenfold increase in midazolam clearance, suggesting potential implications of cytokine–CYP drug interactions on dose adjustments of sensitive CYP3A substrates in acute care settings. Additionally, this article also provides a brief overview of nonclinical and clinical assessments of cytokine–CYP drug interactions in drug discovery and development.

Drug–drug interaction (DDI) assessment of therapeutic peptides is an evolving area. The industry generally follows DDI guidelines for small molecules, but the translation of data generated with commonly used in vitro systems to in vivo is sparse. In the current study, we investigated the ability of advanced human hepatocyte in vitro systems, namely HepatoPac, spheroids, and Liver-on-a-chip, to assess potential changes in regulation of CYP1A2, CYP2B6, CYP3A4, SLCO1B1, and ABCC2 in the presence of selected therapeutic peptides, proteins, and small molecules. The peptide NN1177, a glucagon and GLP-1 receptor co-agonist, did not suppress mRNA expression or activity of CYP1A2, CYP2B6, and CYP3A4 in HepatoPac, spheroids, or Liver-on-a-chip; these findings were in contrast to the data obtained in sandwich cultured hepatocytes. No effect of NN1177 on SLCO1B1 and ABCC2 mRNA was observed in any of the complex systems. The induction magnitude differed across the systems (e.g., rifampicin induction of CYP3A4 mRNA ranged from 2.8-fold in spheroids to 81.2-fold in Liver-on-a-chip). Small molecules, obeticholic acid and abemaciclib, showed varying responses in HepatoPac, spheroids, and Liver-on-a-chip, indicating a need for EC₅₀ determinations to fully assess translatability data. HepatoPac, the most extensively investigated in this study (3 donors), showed high potential to investigate DDIs associated with CYP regulation by therapeutic peptides. Spheroids and Liver-on-a-chip were only assessed in one hepatocyte donor and further evaluations are required to confirm their potential. This study establishes an excellent foundation toward the establishment of more clinically-relevant in vitro tools for evaluation of potential DDIs with therapeutic peptides.

Recent studies have demonstrated promising results of fibroblast activation protein (FAP) inhibitor (FAPI) PET in prognosticating and monitoring interstitial lung diseases (ILDs). As a first step toward successful translation, our primary aim was to validate the FAPI PET uptake through immunohistochemistry in patients with advanced ILD who underwent lung transplantation after a FAPI PET scan. Methods: This is a preliminary analysis of a single-center, open-label, single-arm, prospective exploratory biodistribution study of ⁶⁸Ga-FAPI-46 PET imaging in patients with ILD (NCT05365802). Patients with ILD confirmed by high-resolution CT and scheduled for lung transplant were included. Tissue samples of explanted lungs were obtained from both the central and peripheral lung parenchyma of each lobe. Additional samples were obtained from areas of the lung corresponding to regions of FAPI PET activity. Immunohistochemical staining was performed with an anti-FAP antibody. Percentages of FAP immunohistochemistry-positive area were measured semiautomatically using QuPath software. SUVs in the areas of pathologic samples were measured on FAPI PET/CT by referencing the gross photomap of the explanted lung. A Spearman correlation coefficient test was used to assess the relationship between FAPI PET uptake and FAP immunohistochemical expression in each specimen. Results: Four patients with advanced ILD who underwent FAPI PET/CT before lung transplantation were included. The types of ILD were idiopathic pulmonary fibrosis (n = 2), rheumatoid arthritis–associated ILD (n = 1), and nonspecific interstitial pneumonia (n = 1). FAPI uptake was visualized mainly in the fibrotic area on CT. Twenty-nine surgical pathology samples from 3 patients were analyzed. FAP staining was predominantly positive in fibroblastic foci. FAPI PET SUV_max and SUV_mean showed a positive correlation with the immunohistochemical FAP expression score (SUV_max: r = 0.57, P = 0.001; SUV_mean: r = 0.54, P = 0.002). Conclusion: In this analysis conducted in patients who underwent lung transplantation after a FAPI PET scan, FAPI PET uptake was positively correlated with FAP immunohistochemistry. These findings provide a rationale for further investigation of FAPI PET as a potential imaging biomarker for ILD.

This single-center, single-arm, phase II trial (ChiCTR2100050057) investigated the ability of ¹⁸F-labeled fibroblast activation protein inhibitor ([¹⁸F]AlF-NOTA-FAPI-04, denoted as ¹⁸F-FAPI) PET/CT to predict the response to neoadjuvant camrelizumab plus chemotherapy (nCC) in locally advanced esophageal squamous cell carcinoma (LA-ESCC). Methods: This study included 32 newly diagnosed LA-ESCC participants who underwent ¹⁸F-FAPI PET/CT at baseline, of whom 23 also underwent scanning after 2 cycles of nCC. The participants underwent surgery after 2 cycles of nCC. Recorded PET parameters included maximum, peak, and mean SUVs and tumor-to-background ratios (TBRs), metabolic tumor volume, and total lesion FAP expression. PET parameters were compared between patient groups with good and poor pathologic responses, and the predictive performance for treatment response was analyzed. Results: The good and poor response groups each included 16 participants (16/32, 50.0%). On ¹⁸F-FAPI PET/CT, the posttreatment SUVs were significantly lower in good responders than in poor responders, whereas the changes in SUVs with treatment were significantly higher (all P < 0.05). SUV_max (area under the curve [AUC], 0.87; P = 0.0026), SUV_peak (AUC, 0.89; P = 0.0017), SUV_mean (AUC, 0.88; P = 0.0021), TBR_max (AUC, 0.86; P = 0.0031), and TBR_mean (AUC, 0.88; P = 0.0021) after nCC were significant predictors of pathologic response to nCC, with sensitivities of 63.64%–81.82% and specificities of 83.33%–100%. Changes in SUV_max (AUC, 0.81; P = 0.0116), SUV_peak (AUC, 0.82; P = 0.0097), SUV_mean (AUC, 0.81; P = 0.0116), and TBR_mean (AUC, 0.74; P = 0.0489) also were significant predictors of the pathologic response to nCC, with sensitivities and specificities in similar ranges. Conclusion: ¹⁸F-FAPI PET/CT parameters after treatment and their changes from baseline can predict the pathologic response to nCC in LA-ESCC participants.