Did you keep waiting for the moment where something was going to go horribly wrong?

Yeah, me too.

Deion Sanders argues why Travis Hunter is a top contender for the Heisman this year, highlighting his unique talent and impact on Colorado’s success.

Qwen2.5-Coder-32B is an LLM that can code well that runs on my Mac 12th November 2024 There’s a whole lot of buzz around the new Qwen2.5-Coder Series of open source (Apache 2.0 licensed) LLM releases from Alibaba’s Qwen research team. On first impression it looks like the buzz is well…

YouTube is testing a new feature that will let creators use AI to “restyle” licensed songs for their shorts. The small group of creators with access can enter a prompt to change up different elements in a song, such as its mood or genre, and the expansion of YouTube’s Dream Track AI feature will…

How did you feel? Well, considering I spent almost no time doing anything but working on the business, this is sorta a tough one to answer. Most of the time when I want to unplug I may disappear for an entire weekend to get away from the daily work habits that flow over into the […]

Why can Google just not index these web directories they believe to be not so worthy? Google can still let company’s submit to directories but do not have to index these directories. Sure Google can still then chose which ones are valid or not.  So what is now considered an honest legitimate directory for safe […]

We all have big dreams and ambitious goals we’d love to accomplish, like getting that major promotion while still having quality family time, getting fit and healthy despite a crazy busy schedule, or saving up enough to retire early and pursue our passions. The problem is that these huge, life-changing objectives can feel so daunting ... Read more

The post What is a Milestone? A SMART-er Approach to Achieving Your Life Goals appeared first on LifeHack.

Stoner, gaymer, surfer lover. What say you? Smash or Pass?

The post Smash or Pass appeared first on QueerClick.

The post Smartphone Photography: The Essential Guide (+ 15 Tips) appeared first on Digital Photography School. It was authored by Karthika Gupta.

These days, you don’t need professional photography equipment to take stunning photos. The smartphone in your pocket has the power to capture the kind of high-quality shots you can find in magazines – and it’s extremely easy to use, too! That said, smartphone photography involves more than grabbing that iPhone or Google Pixel, turning on […]

The post Smartphone Photography: The Essential Guide (+ 15 Tips) appeared first on Digital Photography School. It was authored by Karthika Gupta.

Is it too early to start talking about Christmas decor? Probably. But when IKEA drops a genius item like the VINTERFINT Wall Decoration, we can’t keep it under wraps. This space-saving tree is exactly the kind of clever solution we at IKEAhackers love. While nothing quite matches the magic of a traditional live tree, the VINTERFINT offers a chic alternative for those with tight spaces. As homes shrink and urban living spaces become more compact, the traditional Christmas tree is […]

The post IKEA’s New Charming Christmas Tree Is Winning Over Small-Space Dwellers appeared first on IKEA Hackers.

An ongoing campaign is targeting npm developers with hundreds of typosquat versions of their legitimate counterparts in an attempt to trick them into running cross-platform malware. The attack is notable for utilizing Ethereum smart contracts for command-and-control (C2) server address distribution, according to independent findings from Checkmarx, Phylum, and Socket published over the past few

Two NASA telescopes helped an international team of astrophysicists peer far enough back in time to gain new insight on how black holes form.

This is me, preparing for an evening of copyediting articles for The Pomegranate: The International Journal of Pagan Studies. There is in fact a small shrine within arm’s length of my desktop computer, but I usually don’t have so many … Continue reading →

Edited by Dver, a.k.a. Sarah Kate Istra Winter, Small Gods: An Anthology of Everyday Animism is projected to be an annual zine “featuring art, poetry, and essays describing our relationship with, and giving praise to, the smallest of gods — those … Continue reading →

The NFB film earned its Oscars qualification by winning the Helen Hill Award for animated short at the New Orleans Film Festival.

Adopting a healthy lifestyle by making positive changes is not always easy. It involves setting realistic goals and making gradual changes that lead to significant achievements. Generally, small positive changes are more sustainable than sudden ones. Therefore, anyone seeking to improve their diet and lifestyle should consider making minor changes that eventually have a significant ... Read more

The post The Power of Nutrition: Small Changes That Make a Big Difference appeared first on Star Two.

We have already shared our thoughts on why people do blog and why blogging is still afloat despite the rise of social media. We have also reasoned the help of automated blogging and even its necessity. And after RSS Ground has updated all of its automated posters we would like to dwell in more detail […]

The post Smart Way To Set Up Automated Blog Posting appeared first on RSSground.com.

Improving organic traffic can sometimes be challenging, but if you apply the correct SEO strategies, the hard work will eventually pay off. Search engine traffic is great because it’s relevant and targeted. For most websites, organic traffic converts much better than traffic from social media or other sources. Another great advantage is that visits from […]

The post 10 Smart Ways To Increase Organic Traffic To A Website appeared first on RSSground.com.

A parasite that causes the most common form of malaria is evolving to be undetectable by current tests. Some scientists want to zero in on compounds in patients’ breath instead.

One small Ohio town designed a butterfly garden as a symbol of recovery for former flood land and for people who have struggled with addiction.

SEO can be a confusing topic. It can also be a very expensive topic, especially for Gold Coast...

The post SEO Tips for Small Businesses with Small Budgets appeared first on Ignition Media.

In this guide, we have put together the best 5 Android smart TVs with Android TV pre-installed. You can install Kodi right onto these TVs easily. These TVs are available from Amazon and can be purchased worldwide.

Jos Buttler hits a blistering 83 from 45 balls as England cruise to a seven-wicket win over West Indies in the second T20.

A friend of the New York Republican said September's accident left him paralysed from the chest down.

Lizelle Lee sets a new record for the highest individual score in the Women's Big Bash League with 150 not out for Hobart Hurricanes.

President Trump fired back at Democratic presidential nominee Joe Biden intelligence after the former Vice President took a jab at his rival response to the coronavirus pandemic, stating the president needs “to get a lot smarter” or more people are going to die. The first of many sparring moments between the two candidates during the […]

The post Trump To Biden: ‘There’s Nothing Smart About You, Joe’ appeared first on Hispolitica.

Smart-Home Tech Can Achieve ‘Toothbrush-Ready’ Status

Generative AI Is Your Ally for Smart Staging, Selling

Businessman Alix Didier Fils-Aime was sworn in as Haiti's new prime minister on Monday as a gun attack on a passenger jet at the capital's airport underscored the utter breakdown in law and order in the Caribbean country.

Apple's smart home device, featuring AI and FaceTime, could enter the market by March, Bloomberg reported, and could compete with Google and Amazon.

Donald Trump's proposed tariffs would hit the consumer tech sector, raising prices on US consumers' favorite gadgets, an October report found.

Google is investing in the development of the next generation of nuclear power, backing a company that’s building small modular reactors and agreeing to purchase energy once the sites start supplying US grids.

The Verge's roundup of smart rings seems representative of a general consensus: Oura is just ahead of the game when it comes to these inconspicious gadgets. The competition is either too rough in one repect or another, be it software, syncing or the basic credibility of measurements, and the best is a model from Samsung that requires other Samsung stuff to work right. — Read the rest

The post Oura the best smart ring, say testers appeared first on Boing Boing.

A North Texas man recently spent $4000 on a guitar he believed was signed by Taylor Swift at the Ellis County Wild Game Dinner in Waxahachie, Texas, and then immediately destroyed it with a hammer. Sounds like the guitar was an imposter. — Read the rest

The post Texas man wastes $4k smashing a Taylor Swift "themed" guitar appeared first on Boing Boing.

Marcelo Campos, Matthew Jenssen, Marcus Michelen and Julian Sahasrabudhe
J. Amer. Math. Soc. 38 (), 179-224.
Abstract, references and article information

The cystic fibrosis transmembrane conductance regulator (CFTR) is a plasma membrane anion channel that plays a key role in controlling transepithelial fluid movement. Excessive activation results in intestinal fluid loss during secretory diarrheas, whereas CFTR mutations underlie cystic fibrosis (CF). Anion permeability depends both on how well CFTR channels work (permeation/gating) and on how many are present at the membrane. Recently, treatments with two drug classes targeting CFTR—one boosting ion-channel function (potentiators) and the other increasing plasma membrane density (correctors)—have provided significant health benefits to CF patients. Here, we present an image-based fluorescence assay that can rapidly and simultaneously estimate both CFTR ion-channel function and the protein's proximity to the membrane. We monitor F508del-CFTR, the most common CF-causing variant, and confirm rescue by low temperature, CFTR-targeting drugs and second-site revertant mutation R1070W. In addition, we characterize a panel of 62 CF-causing mutations. Our measurements correlate well with published data (electrophysiology and biochemistry), further confirming validity of the assay. Finally, we profile effects of acute treatment with approved potentiator drug VX-770 on the rare-mutation panel. Mapping the potentiation profile on CFTR structures raises mechanistic hypotheses on drug action, suggesting that VX-770 might allow an open-channel conformation with an alternative arrangement of domain interfaces. The assay is a valuable tool for investigation of CFTR molecular mechanisms, allowing accurate inferences on gating/permeation. In addition, by providing a two-dimensional characterization of the CFTR protein, it could better inform development of single-drug and precision therapies addressing the root cause of CF disease.

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