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Why Women May Be More Susceptible to Mood Disorders

New research in mice suggests that a pregnancy hormone contributes to brain and behavioral changes caused by childhood adversity

-- Read more on ScientificAmerican.com




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Signs of Modern Human Cognition Were Found in an Indonesian Cave

Painted images of intriguing human-animal hybrids are signs of modern thought

-- Read more on ScientificAmerican.com




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Five Types of Research, Underexplored until Recently, Could Produce Alzheimer's Treatments

Research into the brain’s protein-disposal systems, electrical activity and three other areas looks promising

-- Read more on ScientificAmerican.com




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A Harder Look at Alzheimer's Causes and Treatments

Amyloid, the leading target for dementia therapy, faces skepticism after drug failures

-- Read more on ScientificAmerican.com




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What the Bard and Lear Can Tell a Leader About Yes Men

In Shakespeare's "King Lear," a powerful man comes to a tragic end because he surrounds himself with flatterers and banishes the friends who will not varnish the truth to please him.




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Wondering Wall Street's Mood? Look Up

Forget about buying low and selling high. If you are worried about the recent volatility in the stock market, perhaps you should let the weather be your guide.




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Reminders of Mortality Bring Out the Charitable Side

Scrooge crept towards it, trembling as he went; and following the finger, read upon the stone of the neglected grave his own name, Ebenezer Scrooge . . . "Spirit!" he cried, tight clutching at its robe, "hear me! I am not the man I was. I will not be the man I must have been . . . "




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Why Voters Play Follow-the-Leader

What do you think is more dangerous? Terrorists getting their hands on a biological weapon that can be smuggled into the country or another hurricane like Katrina? Which is the smarter way to keep Social Security solvent? Raise the retirement age or raise taxes? How can the current economic crisi...




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The Rational Underpinnings of Irrational Anger

"I know how unpopular it is to be seen as helping banks right now, especially when everyone is suffering in part from their bad decisions. I promise you, I get it. But I also know that in a time of crisis, we cannot afford to govern out of anger."




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Borderline Irrelevant: Why Reforming the Dublin Regulation Misses the Point

European policymakers are fixated on reform of the Dublin Regulation, the contentious rules that carve up responsibility for asylum claims between EU states. They see it not only as a long-term prophylactic against future fluctuations in irregular migration, but as a marker of the success or failure of solidarity in Europe overall. Yet rather than doggedly working to salvage Dublin, policymakers need to stop and consider why they regard it as so integral to European cooperation, as this commentary explores.




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Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils [Computational Biology]

Over the last several years it has become clear that higher order assemblies on membranes, exemplified by signalosomes, are a paradigm for the regulation of many membrane signaling processes. We have recently combined two-color direct stochastic optical reconstruction microscopy (dSTORM) with the (Clus-DoC) algorithm that combines cluster detection and colocalization analysis to observe the organization of 5-lipoxygenase (5-LO) and 5-lipoxygenase–activating protein (FLAP) into higher order assemblies on the nuclear envelope of mast cells; these assemblies were linked to leukotriene (LT) C4 production. In this study we investigated whether higher order assemblies of 5-LO and FLAP included cytosolic phospholipase A2 (cPLA2) and were linked to LTB4 production in murine neutrophils. Using two- and three-color dSTORM supported by fluorescence lifetime imaging microscopy we identified higher order assemblies containing 40 molecules (median) (IQR: 23, 87) of 5-LO, and 53 molecules (62, 156) of FLAP monomer. 98 (18, 154) molecules of cPLA2 were clustered with 5-LO, and 77 (33, 114) molecules of cPLA2 were associated with FLAP. These assemblies were tightly linked to LTB4 formation. The activation-dependent close associations of cPLA2, FLAP, and 5-LO in higher order assemblies on the nuclear envelope support a model in which arachidonic acid is generated by cPLA2 in apposition to FLAP, facilitating its transfer to 5-LO to initiate LT synthesis.




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Silt Part 1 - land and time under the sea

Warning: The Broomway is unmarked and very hazardous to pedestrians.
 
Warning: Do not approach or touch any object as it may explode and kill you.
 
 
The "Silt" chapter of the book contains some of Macfarlane's most hypnotic writing. It is also the chapter that made me realize that I am not innately the adventurous type of person. Unlike Macfarlane, I'm just not going to walk over unmarked mud paths at low time while running the risk of accidentally being sucked into the undertow and drowned(since he did the walk on a Sunday, he didn't have to worry about being accidentally shot by the Ministry of Defense). But I admire him for doing so.
 
The Broomway is called the deadliest path in Britain. It gets its name from 400 brooms which were used to mark the path to Foulness. When the tide comes in twice a day, other markers are swept away. Until compasses were affordable, people who walked the Broomway carried thread with them. As they passed a broom, they tied the end of the thread to the broom and continued walking. If they felt they had missed the next broom, they could follow the thread back to the previous broom.
 
Macfarlane walked the Broomway with his friend David Quentin, a book dealer turned tax lawyer who prefers to walk barefoot. In the end the mud was bad enough that Macfarlane also walked barefoot to save his sneakers. He left them at their starting point and was able to refind them when they doubled back to the beginning of their path.
 
As Macfarlane walked, he recollected that the land under the Broomway had once been called Doggerland, the home of Megolithic hunter-gatherers. This in turn made him recall the fact that the sea coasts of Norfolk and Suffolk in England are being eroded. Entire towns are being swallowed up by the sea, and houses that were once inland are now being abandoned because they are too close to the shore.
 
Although Macfarlane remembers many historical and geographical facts as he walks, he is also sucked in by the queer atmosphere of the The Broomland. Not entirely land, not entirely water, it exists in a liminal state. To Macfarlane:
 
"These borders do not correspond to national boundaries, and papers and documents are unrequired at them.Their traverse is generally unbiddable, and no reliable map exists of their routes and outlines. They exist even in unfamiliar landscapes: there when you cross a certain watershed, treeline or snowline, or enter rain, storm, or mist, or pass from boulder clay onto sand, or chalk onto greenstone. Such moments are rites of passage that reconfigure local geographies, leaving known placed outlandish or quickened, revealing continents within countries." (p. 78)
 
Space, distance, and direction become distorted because of the light over the sands, the movement of the tides, and the constant erosion of the land. A simple walk over the sea shore is a trek that could easily end in disaster where Macfarlane joins the dead of a drowned country.





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Understanding Which English Learners Are Counted on School Accountability Measures—and When

WASHINGTON – The federal Every Student Succeeds Act of 2015 (ESSA) requires states to publicly report annual performance and graduation rates for students in a range of areas, breaking out results for subgroups with unique characteristics, including English Learners (ELs). The objective is to help schools identify and close achievement gaps experienced by historically underserved groups of students.




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As U.S. Health Care System Sags under Strain of Pandemic, Immigrants and Refugees with Degrees in Health Care Could Serve as an Important Resource

WASHINGTON – Even as 1.5 million immigrants and refugees are already employed in the U.S. health care system as doctors, registered nurses and pharmacists, another 263,000 foreign-born health care graduates are on the sidelines during the COVID-19 pandemic—many of them because of difficulties getting their credentials accepted by employers and licensing bodies.




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An Uneven Landscape: The Differing State Approaches to English Learner Policies under ESSA

Experts share how states have approached Every Student Succeeds Act (ESSA) implementation, and areas where the law and state efforts to support English Learners can be improved.




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The Patchy Landscape of State English Learner Policies under ESSA

All 50 states, the District of Columbia, and Puerto Rico have developed blueprints to meet their commitments under the Every Student Succeeds Act—including requirements that aim to raise the profile of English Learners (EL) in state accountability systems. This report breaks these plans down, comparing the significant diversity of approaches taken on everything from EL identification to tracking academic achievement.




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Which English Learners Count When? Understanding State EL Subgroup Definitions in ESSA Reporting

States publish a wealth of data about their English Learner students’ academic achievement and other outcomes such as graduation rates. But the answer to the question “Who is an EL?” is not always the same. This brief explains how the EL subgroup varies across states and types of data, and why it is important to understand these differences when making decisions about how ELs and schools are faring.




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Badrijani - Grilled Eggplants with a coriander and garlic Aioli

This recipe was featured on Foodie Tuesday, a weekly segment with Raf Epstein on Drive, 774 ABC Melbourne, 3:30 PM, courtesy of Alice in Frames. www.aliceinframes.com




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Fish Chowder

20 unsalted butter. 1 tbs vegetable oil 4 rashes bacon, finely chopped (optional) 1 brown onion, diced 2 garlic cloves, crushed 500g potatoes, peeled, cut into 1cm chunks 1L chicken stock 500g firm white fish fillets (such as ling or snapper), cut into 3cm chunks 1 cup frozen corn kernels 1/2 cup thickened cream 2 tablespoons chopped flat-leaf parsley




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Slow-cooked pork shoulder with apples and crackling

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Justine Schofield. Justine's latest book is "Dinner With Justine".




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GINGER AND CORIANDER CHUTNEY

TIS TIME TO DUST OFF THOSE CASSEROLE DISHES AND GET BRAISING FOR A DROP IN TEMPRATURE. THIS FLAVOURSIM CHUTTNEY IS A GREAT ENHANCMENT WITH CURRY DISHES, OR EVEN GREAT LIGHTLY SPREAD ON A WARM BAQUETTE WITH CHICKEN, LETTUCE ETC.




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Flinders island lamb saddle, crushed peppered turnip, fried salt bush

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of David Hall of Pure South Dining




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Indian cauliflower rice and coriander pesto

Cauliflower rice: 1 head cauliflower, cut into florets 2 tbsps. ghee Coriander pesto: 1 large bunch coriander 1 garlic clove 1/4 cup cashews 2 tbsps. parmesan, finely grated 1 lime, zested and juiced 3 tbsps. coconut oil




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As More Migrants from Africa and Asia Arrive in Latin America, Governments Seek Orderly and Controlled Pathways

Growing numbers of African and Asian migrants are moving through Latin America, many hoping to reach the United States or Canada after expensive, arduous, and often dangerous journeys that can take months or even years. As more extracontinental migrants transit through South and Central America, Colombia, Panama, and Costa Rica have developed the most comprehensive policies to manage these flows, sometimes working in coordination with the U.S. government.




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Federer charges to fifth Basel title

Roger Federer has returned to winning mode 10 months after his last title, as the home tennis hero schooled Japanese wild card Kei Nishikori 6-1, 6-3 to win a fifth Swiss Indoors title in Basel.




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Ponting takes aim at 'underdone' Proteas

Ricky Ponting believes South Africa could suffer from a lack of first-class preparation in the opening Test in Cape Town on Wednesday.




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Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study

OBJECTIVE

Data regarding the effects of sodium–glucose cotransporter 2 inhibitors in the elderly (age ≥65 years) and very elderly (age ≥75 years) are limited.

RESEARCH DESIGN AND METHODS

The Dapagliflozin Effect on Cardiovascular Events (DECLARE)–TIMI 58 assessed cardiac and renal outcomes of dapagliflozin versus placebo in patients with type 2 diabetes. Efficacy and safety outcomes were studied within age subgroups for treatment effect and age-based treatment interaction.

RESULTS

Of the 17,160 patients, 9,253 were <65 years of age, 6,811 ≥65 to <75 years, and 1,096 ≥75 years. Dapagliflozin reduced the composite of cardiovascular death or hospitalization for heart failure consistently, with a hazard ratio (HR) of 0.88 (95% CI 0.72, 1.07), 0.77 (0.63, 0.94), and 0.94 (0.65, 1.36) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.5277). Overall, dapagliflozin did not significantly decrease the rates of major adverse cardiovascular events, with HR 0.93 (95% CI 0.81, 1.08), 0.97 (0.83, 1.13), and 0.84 (0.61, 1.15) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.7352). The relative risk reduction for the secondary prespecified cardiorenal composite outcome ranged from 18% to 28% in the different age-groups with no heterogeneity. Major hypoglycemia was less frequent with dapagliflozin versus placebo, with HR 0.97 (95% CI 0.58, 1.64), 0.50 (0.29, 0.84), and 0.68 (0.29, 1.57) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.2107). Safety outcomes, including fractures, volume depletion, cancer, urinary tract infections, and amputations were balanced with dapagliflozin versus placebo, and acute kidney injury was reduced, all regardless of age. Genital infections that were serious or led to discontinuation of the study drug and diabetic ketoacidosis were uncommon, yet more frequent with dapagliflozin versus placebo, without heterogeneity (interaction P values 0.1058 and 0.8433, respectively).

CONCLUSIONS

The overall efficacy and safety of dapagliflozin are consistent regardless of age.




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Inoreader v13 is Here With Improved Looks and New Features!

Since the beginning, Inoreader was meant to be a power-user tool, pushing the boundaries of what RSS readers can do.…




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Declutter Your Inbox. Subscribe to Email Newsletters Straight Into Inoreader

You have mail! Inoreader now allows you to subscribe to Email Newsletters just as regular RSS feeds. By creating a…




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Inoreader mobile apps updated to support Automatic Night Mode, Microblogs, Sort by Magic and popularity indicators.

Hey, it’s been quite some time without updates on this front, but our latest updates to our Android and iOS…




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Get Free Local COVID-19 Alerts with Inoreader

Everyone is concerned as the novel Coronavirus spreads at rapid rates across all countries of the world. We believe every…




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Get Your Friends Into RSS With Inoreader’s New Invite Feature

Have you ever tried to convince somebody to start using an RSS reader, only to hear back from them something…




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Convert Almost Any Webpage Into RSS Feed With Inoreader’s Web Feeds

So, you wanted to follow this nice website for new content, but it doesn’t have an RSS feed yet? Don’t…




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Keep Your YouTube Subscriptions in Sync With Inoreader

Did you know you can subscribe to YouTube channels and playlist in Inoreader? Simply paste the URL of the channel…




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An Uneven Landscape: The Differing State Approaches to English Learner Policies under ESSA

Experts share how states have approached Every Student Succeeds Act (ESSA) implementation, areas where the law and state efforts to support English Learners can be improved, and findings from the compendium, The Patchy Landscape of State English Learner Policies under ESSA




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Expert Podcast: Understanding How English Learners Count in ESSA Reporting

This podcast features a discussion between MPI's Margie McHugh and Julie Sugarman about how to understand the varying composition of states' English Learner (EL) subgroup under ESSA, and why understanding these technical differences matters when making decisions about how ELs and schools are faring. They also talk about different groups of ELs: newcomers, students with interrupted formal education, and long-term ELs, and data collection around these different cohorts.




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Immigration and the U.S.-Mexico Border during the Pandemic: A Conversation with Members of Congress

In this bipartisan discussion, two border-state members of Congress—Rep. Veronica Escobar and Rep. Dan Crenshaw—discuss the response to the coronavirus outbreak, how it is affecting the interconnected border region, and what the future might hold.
 




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As U.S. Health-Care System Buckles under Pandemic, Immigrant &amp; Refugee Professionals Could Represent a Critical Resource

In a time of critical shortages of U.S. health-care workers during the COVID-19 pandemic, retired doctors are being called back to work and medical students are graduating on a fast track. There is another important pool that could be tapped: Immigrants and refugees who have college degrees in health fields but are working in low-skilled jobs or out of work. MPI estimates 263,000 immigrants are experiencing skill underutilization and could be a valuable resource.




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Reflections on Business, Leadership, and Branding: Shelly Lazarus ’70

Much has changed in the world of advertising from the picture painted by Mad Men. Shelly Lazarus ’70, Chairman Emeritus, Ogilvy & Mather, was one of the women helping pioneer these changes. Making the journey from ‘the only woman in the room’ to CEO and Chairman of Ogilvy gives Lazarus a lot to reflect on […]




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Diapression: An Integrated Model for Understanding the Experience of Individuals With Co-Occurring Diabetes and Depression

Paul Ciechanowski
Apr 1, 2011; 29:43-49
Feature Articles




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Insulin Strategies for Primary Care Providers

Karen L. Herbst
Jan 1, 2002; 20:
Feature Articles




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Diabetes Self-Management in a Community Health Center: Improving Health Behaviors and Clinical Outcomes for Underserved Patients

Daren Anderson
Jan 1, 2008; 26:22-27
Bridges to Excellence




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Standards of Medical Care in Diabetes--2019 Abridged for Primary Care Providers

American Diabetes Association
Jan 1, 2019; 37:11-34
Position Statements




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Standards of Medical Care in Diabetes--2016 Abridged for Primary Care Providers

American Diabetes Association
Jan 1, 2016; 34:3-21
Position Statements




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Standards of Medical Care in Diabetes--2018 Abridged for Primary Care Providers

American Diabetes Association
Jan 1, 2018; 36:14-37
Position Statements




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Standards of Medical Care in Diabetes--2017 Abridged for Primary Care Providers

American Diabetes Association
Jan 1, 2017; 35:5-26
Position Statements




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Standards of Medical Care in Diabetes--2015 Abridged for Primary Care Providers

American Diabetes Association
Apr 1, 2015; 33:97-111
Position Statements




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The Heroic Leadership Imperative

Allison, S. T. & Goethals, G. R. (2020). The heroic leadership imperative: How leaders inspire and mobilize change. West Yorkshire: Emerald. Our next book describes a new principle that we call the heroic leadership imperative. We show how leaders who fulfill the imperative will inspire followers and initiate social change.   The imperative consists of … Continue reading The Heroic Leadership Imperative



  • Our latest books on HEROIC LEADERS

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Forthcoming in JHBS: Quêtelet on Deviance, McClelland on Leadership, Psychological Warfare, and More

A number of articles now in press at the Journal of the History of the Behavioral Sciences will be of interest to AHP readers. Full details below. “Uncovering the metaphysics of psychological warfare: The social science behind the Psychological Strategy Board’s operations planning, 1951–1953,” Gabrielle Kemmis. Abstract: In April 1951 president Harry S. Truman established … Continue reading Forthcoming in JHBS: Quêtelet on Deviance, McClelland on Leadership, Psychological Warfare, and More




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The Paradox of Online Dating: Too Many Options Makes It Harder to Invest in a Relationship

In any relationship, you’re bound to discover that your partner has one or two (or maybe ten or twenty) quirks that eventually come to annoy you. In these situations, it's tempting to think that you might be happier with someone else—someone who doesn’t have the same set of peccadillos. However, according to behavioral economist Dr. Dan Ariely, this kind of thinking can set you up for a lifetime of disappointment.