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provocateur




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Ken and Robin Talk About Stuff: That’s How You Get Your Grants Approved

In the latest episode of their dark and stormy podcast, Ken and Robin talk Gothic F20, Elon Musk's pig brain implants, and a contactless edition of Ken's Bookshelf.



  • Ken and Robin Talk About Stuff

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Beijing and Washington stops provide clues for Indonesia's direction under Prabowo Subianto - ABC News

  1. Beijing and Washington stops provide clues for Indonesia's direction under Prabowo Subianto  ABC News
  2. Prabowo pledges co-operation with Trump  The Australian Financial Review
  3. Indonesian president meets Biden and speaks with Trump  The Canberra Times
  4. At White House, Indonesia's new leader straddles US-China rivalry  VOA Asia
  5. Will Prabowo Subianto cosy up to Donald Trump or to China?  The Economist




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5 Ways to Improve Your Fundraising Now.

Excellent fundraisers, as well as average ones often find themselves reaching a plateau when it comes to their fundraising abilities and the dollar amounts that they raise.  On a plateau, it is just as easy to move upward as it is to slip backwards; losing progress. Fundraisers are only interested in moving in one direction; upward.

pla•teau (plæˈtoʊ; esp. Brit. ˈplæt oʊ) 
n., pl. -teaus, -teaux (-ˈtoʊz, -toʊz) 
v. -teaued, -teau•ing. n.1. a land area having a relatively level surface considerably raised above adjoining land on at least one side.
2. a period or state of little or no growth or decline, esp. one in which increase or progress ceases: to reach a plateau in one's career.v.i.3. to reach a state or level of little or no growth or decline; stabilize

Definitions #2 and #3 have the most significance in fundraising, but definition #1 can be a useful visualization tool.

So how do we get beyond the fundraising plateau?


  1. Go back to basics. Find something in your fundraising routine that can be improved and work on it. Can your greeting be made more friendly? Can your donation requests be tightened up? What ever it is, work on it. Working on any one issue has the added benefit of providing new perspectives on other issues.
  2. Ask the donor. Ask donors, whether, they give or not, what they thought of your performance. Most will provide at least one useful bit of information. Some donors will provide so much valuable criticism that you may find yourself reexamining your entire fundraising strategy.
  3. Ask another fundraiser. Sometimes we let shyness, pride or professional competition get in the way of improving our skills. Every fundraiser, at every stage, goes through the plateau problem. Reach out to your fellow fundraisers and get their advice.
  4. Become an expert. Often after fundraising for a certain cause for a long time, fundraisers began to feel like experts on the issue. There is always more to learn. Find books magazine articles and any other materials that you can. The more you know about your issue, the better you can fund raise for it.
  5. Remember, Plateaus aren't permanent. Keep slugging away, doing the best job that you possibly can. Eventually, you will begin to see some progress.
These are just a few of the ways to overcome getting into a rut. Actually the only limitations to becoming a better fundraiser are your imagination and the amount of effort that you are willing to put into improving. Remember, plateau or not, there is always room for improvement.






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For parts: Lunar rover, never used

NASA has canceled VIPER, a rover designed to seek out water ice and other resources in the lunar south pole.




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1995 Range Rover Classic 300TDI






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Providence's Oswin Erhunmwunse throws down a POWERFUL two-hand dunk vs. Hampton

Providence Friars' Oswin Erhunmwunse threw down a powerful two-handed dunk against the Hampton Pirates.




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Bensley Joseph finds Corey Floyd Jr. for a TOUGH ALLEY-OOP dunk as Providence leads 47-43 vs. Hampton

Providence Friars' Bensley Joseph found Corey Floyd Jr. for a tough alley-oop dunk against the Hampton Pirates.




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'Nancy Pelosi Ripping Paper' Proves The Political Memes Aren't Going Anywhere

While we would love for election season to be over right about now, we've gotta admit that the resulting political memes have been top-notch. The internet has been loving this particular dank meme, which shows Speaker of the House Nancy Pelosi ripping up Donald Trump's State of the Union speech.





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Another major healthcare provider files for Chapter 11 bankruptcy




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How to Improve Your NAP for Better Local Placement

Okay, Hopefully you are Awake.  The article is for sure helpful, especially if you are looking to increase your SEO Local presence.  Some simple strategies for finding out more about your competition is to just simply locate the competitors on the local 7-Pack listing in the results and copy and past the address in the […]




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China's Mars rover Zhurong finds possible shoreline of ancient Red Planet ocean

Data from China's Zhurong rover has revealed what appears to be an ancient shoreline streaking through Mars' northern hemisphere.




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Somebody at LEGO Needs to Get the Stamp of Approval on This Steampunk AT-AT Walker




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Keeping it Personal: Improving person-centred care

The People Powered Health and Wellbeing Programme (PPHW), delivered by the Health and Social Care ALLIANCE Scotland is contributing towards the Scottish Government’s ambition to create a safe, effective and person-centred health and social care system.

Each of the PPHW programme partners explored different facets of the PPHW aim. The Iriss project – Keeping It Personal (KiP) – explored the use of person-centred approaches when designing improvements to the delivery of health and social care services. 

read more




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Impact of antiretroviral therapy on liver disease progression and mortality in patients co-infected with HIV and hepatitis C: systematic review and meta-analysis

Systematic review produced by the EPPI-Centre in 2015.This systematic review aimed to evaluate the effect of HAART and ARV monotherapy on liver disease progression and liver-related mortality in individuals co-infected with HIV and hepatitis C, including in patients with haemophilia.




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Coalition of Care and Support Providers in Scotland (CCPS)

CCPS is the Coalition of Care and Support Providers in Scotland. Their mission is to identify, represent, promote and safeguard the interests of third sector and not-for-profit social care and support providers in Scotland, so that they can maximise the impact they have on meeting social need.




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Sharing practice to improve outcomes for care leavers. Evaluation report on an inter-authority learning exchange

Evaluation report for the inter-authority learning exchange between Shetland Islands, Falkirk and Glasgow Councils throughcare and aftercare teams. In February 2014 a member of the Throughcare and Aftercare team from Shetland, spent two weeks in each host authority as a means of developing and sharing practice, experience and learning. The report describes the planning process, in-situ experience, and post-exchange learning of participants, it also report highlights the positive learning outcomes and benefits achieved for all participating local authorities. The report identifies ideas for future applications of such a learning and practice exchange model to improve practice for looked after young people and care leavers.




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A review of respite / short break provision for adult carers of adults in the Highland Partnership area

As part of the implementation of the Equal Partners in Care (EPiC) Highland Carer’s Strategy 2014-2017 it was agreed to undertake a review of respite for Adult Carers of Adults (aged 16+). Independent consultants were commissioned by NHS Highland through Connecting Carers to undertake this work. There are four groups of people – totalling an estimated 200 people - with whom conversations have taken place during the review: Carers and staff from carer support organisations – more than 75 carers have given their views Health and social care workforce – we have met with just over 50 people who have given their views and shared our initial findings with more than 60 others Respite providers – we have met with staff from 15 organisations that are providers of respite Those staff responsible for overseeing the commissioning, planning and administration of respite.




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Natural Disasters Aren’t Gender Neutral – Hurricanes Milton and Helene Prove It

Photo by NASA Natural disasters don’t just ravage landscapes—they also expose and deepen systemic inequalities. Recent hurricanes, Milton and Helene, tore through Florida, Georgia, and the Carolinas, destroying homes, businesses, and the lives built across generations. While governments rush to repair infrastructure and restore housing, they often overlook the people most impacted in the long term—especially […]

The post Natural Disasters Aren’t Gender Neutral – Hurricanes Milton and Helene Prove It appeared first on Feminist Majority Foundation.




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What can you do in your own home to improve air quality?

If you live in an urban area with cars, industry and unpleasant city smells, you might retreat to your house for safety from environmental pollutants. But how good is your air quality at home?[...]




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The ROI of Security Investments: How Cybersecurity Leaders Prove It

Cyber threats are intensifying, and cybersecurity has become critical to business operations. As security budgets grow, CEOs and boardrooms are demanding concrete evidence that cybersecurity initiatives deliver value beyond regulation compliance. Just like you wouldn’t buy a car without knowing it was first put through a crash test, security systems must also be validated to confirm their value.





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Endowment continues to provide foundation for Princeton’s groundbreaking research, innovative scholarship and national leadership on college affordability

In the Class of 2028, 71.5% of students qualify for financial aid and 21.7% of the class are lower-income students eligible for federal Pell grants.




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"Eclipse" - Scrappy Improvisational Quilt

When my brother, Thom Atkins, visited last fall, he showed me (and a few quilting buddies) his new method for designing and constructing "scrappy improv wall quilts," a technique that turned out to be a lot of fun for me, especially given my long history with an improvisational, intuitive approach to bead embroidery.

Basically, what we did was to empty our bags or boxes of scraps onto a large table and start pawing through them, pulling out ones that appealed to us at that moment. For me it was all about color - red, magenta, fuchsia, with hints of pink, golden-yellow, orange, lavender, and dark green. All of the fabrics were in my scrap box. We had two days of Thom's demonstrations and guidance. During that time, each of us in our small group produced a unique and very pleasing "piece" or "block," measuring roughly 18 x 21 inches, the size of a fat quarter.

One of my red scraps, cut in a nice arc at one end, was the start of it all because I liked the shape and the color. Next I picked up a small strip of yellow, and held it behind the arc of red. Ooooh! Nice enough to repeat. The scrap of orange/red batik was large enough to cut a similar arc, and the strip of yellow was long enough to go behind that one too. These two arcs formed the basis of my piece.

You can see the two arcs above; the lower right was the first. The yellow strip was only about 3" wide, not enough to go all the way around the arcs, but I cut two shapes that would echo the top of each of the arcs. I layered the remaining scraps from that on top of the arcs along the vertical edges of the design. Then I put a dark green scrap behind the arcs and the yellow, which set them off nicely. The rest was just filling to the edges of the quilt with more scraps, including fussy-cut leaves and flowers.

The next step was to glue it all together along the 1/4" seam overlap, working in layers from bottom to top, and cutting away the excess fabric from the underside after each piece is glued. Cutting away the excess fabric leaves a double layer of fabric only at the seams; the rest is a single layer. The glue is Elmer's School Glue, Disappearing Purple, as shown below. It is an organic stick glue, relatively easy to sew through, repositionable, (in case you change your mind), and purple when first applied, drying to transparent (so you can see where exactly you are putting it).

Thom's method is a type of raw edge applique, typically accomplished with heat-fusible web, such as "wonder under." The typical method, given a complex, layered design such as mine, would have resulted in a thick, stiff, multi-layer surface, which would be difficult to quilt, even with a machine. In Thom's method, there is no web, and in most places only one or two layers of fabric. Like all raw edge techniques, the raw edges must be sewn down, and the resulting quilts are not very suitable for bed quilts unless there is heavy stitching over the raw edges (for example, dense, zig-zag, machine stitching).

After gluing my original (shown above) quilt top, I assembled the quilt, using a spray glue to layer the backing, batting and top. The next step was to stitch along the "seams," the overlapping, glued edge of each piece. From there, it was up to each of us as to how to finish the quilt, perhaps with machine quilting, such as stippling or contour stitches, or perhaps with beading, all of which Thom does on his quilts.

A couple of months went by after getting to the unfinished stage shown above. I liked it, but didn't know what to do with it, until one day when I was at our Senior Center, getting foot care from a trained nurse who comes a couple times a week to help those who need it. Her treatment room, about the size of a walk-in closet, has no windows. Her client faces the door to the room, a plain, wooden door.  "That door needs a quilt," I told her. The rest is history; my scrappy improv quilt, Eclipse,  hangs there now.

Only first I had to finish it. Above is the finished quilt, Eclipse. Below I'll tell you some of the finishing steps and about how I transformed it from looking flat and ordinary to sharp and textured using embroidery embellishments. Please click on the photo so you can see the details!

You might have noticed that the finished quilt is longer (better suited for hanging on a door) than the original piece. That was a challenge, although less than you might expect, because Thom had demonstrated for us how he sometimes extends the size of his quilts. In short, I roughly planned out the addition, the mock-up shown below, then created it using the same process and scraps as the original piece.


I used fusible "tape" made for butt-joining pieces of batting, to add a new piece of batting to the bottom edge of batting on the original (upper) part of the quilt. The horizontal strip of striped fabric overlaps the two parts of the quilt and the joined batting underneath. As you can see below, I added a fussy-cut flower over the striped fabric to break up the horizontal strip and visually join the two parts.


Confession time... I'm not good at machine quilting, and don't even have a proper quilting foot for my old machine (1972 Pfaff). I tried stitching around the fussy cut flowers to secure the glued edges, but failed miserably. What to do? Ah, hand-sew with embroidery stitches and floss? Yes! It took a few tries, but eventually I found stitch and thread combinations that worked.

It looked so good that I decided to add stitching and knots to the yellow arcs next. Wow! That popped the eclipse look! In the photo below, you can see bits of all the embroidery stitches I added. Not only does the embroidery provide embellishment and emphasis, it also further quilts the piece. Click the photo to see the detail and better read the stitch identification.


Here are two more detail photos of the finished quilt (without the text boxes).



Lots of fun, and I like the results! Will I do another one? Well, right now I've finally returned to my hexie project, where I'm likely to remain for many months, but after that, scrappy improv may be just what I need!






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Board approves new faculty appointments

Two full professors and four assistant professors have been newly appointed to the Princeton University faculty.




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Board approves 14 new faculty appointments

The Princeton University Board of Trustees has approved the appointment of 14 faculty members, including two full professors, two associate professors and 10 assistant professors.




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Board approves 22 new faculty appointments

The Princeton University Board of Trustees has approved the appointment of 22 faculty members, including five full professors, one associate professor and 16 assistant professors.




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Euphoric Whispers: Improvisations for Tanbur and Percussion

Euphoric Whispers This event is free, but a ticket is required to attend. To reserve a ticket, use the University Ticketing website. This concert features a rare NJ appearance of Ali Akbar Moradi and Pejman Hadadi, two of Iran’s most renowned musicians. Moradi is the greatest living master of the tanbour, an ancient 2-stringed long-necked fretted lute traditionally used in religious ceremonies. Hadadi is the innovative percussionist (tombak, daf) who has been a member of the Dastan Ensemble for over 20 years and has collaborated with countless master musicians in Persian and world traditions. They will perform ecstatic and trance-inducing Kurdish music from western Iran – music that is little known in the US. Featured are meditative improvisations based on the repertoire of the Yarsan people, and the beauty and complexities of the art of this region. “Love, spirituality, intoxication with the divine and the power of music…With one string providing a drone, everything else rides on a single string of the tanbour, and in Mr. Moradi’s hands, that string encompasses an expressive universe.” - New York Times "The masterful Hadadi delivers an astonishing array of sounds." - Los Angeles Times Aliakbar Moradi Aliakbar Moradi, often hailed as “the best tanbour player alive” (Songlines Magazine, Issue 26, 2004), was born in 1957 in Guran, near Kermanshah, the central city of Kermanshah Province, Iran. Encouraged by his grandfather and father, he began studying the Tanbur at the age of six. Under the guidance of masters such as Sayyed Hachem Kafashyan, Sayed Mahmoud Alavi, Ali Mir Darvishi, Allah Morad Hamidi, and Sayyed Vali Hosseyni, he not only mastered the instrument but also delved deeply into the Kurdish maqam repertoire. Moradi gave his first recital at the age of 14 in Kermanshah. A year later, he established the first Tanbur group within the cultural department of Kermanshah. He then embarked on tours across Iran and later co-founded the renowned Shams Tanbur Ensemble. In 1991, he won first prize at the String Instrument Festival. Starting in 1992, he conducted extensive research on the ancient maqams of the Tanbur, resulting in a significant publication: a set of four CDs and a booklet released in 2002 by Maison des Cultures du Monde. Over the years, Moradi has published more than 23 recordings and books. He has collaborated with numerous esteemed musicians, including Shahram Nazeri, Kaykhosro Pournazeri, Kayhan Kalhor, Ardeshir and Bijan Kamkar, Pejman Hadadi, Erdal Erzincan, Ulaş Özdemir, Pezhham Akhavass, Mehdi Bagheri, and Arash and Kourosh Moradi. In addition to his research, recordings, and performances, Moradi teaches Tanbur in Tehran and Kermanshah. Currently residing in Kurdistan, Iran, he founded the cultural center The House of Tanbur in Guran. This center offers year-round music classes and hosts annual Tanbur and Kurdish music festivals to preserve and promote the rich cultural heritage of the region. Pejman Hadadi Pejman Hadadi, a renowned percussionist from Tehran, Iran, began his musical journey at age 10, studying under Master Tombak player Assadollah Hejazi. Influenced by greats like Bahman Rajabi and Hossein Tehrani, he later mastered the Daf, inspired by Bijan Kamkar’s recordings. Moving to the US in 1989, Pejman began his professional career in 1991, collaborating with notable musicians such as Hossein Alizadeh, AliAkbar Moradi, Kayhan Kalhor, Shahram Nazeri, and joining the Dastan Ensemble in 1995. He co-founded ZARBANG, the pioneering Iranian percussion ensemble, in 2000. Pejman’s innovative techniques on the Tombak, including tunable frame drums, and his partnership with REMO to develop synthetic-skin Dafs, have significantly expanded the instruments’ global reach. Dedicated to education, he established Neyreez World Music Institute and has received the Durfee Foundation Master Musician Award twice. Pejman’s compositions span dance and film, including soundtracks for Prince of Egypt and Prince of Persia.




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Improved Photo And Video Posting To Facebook Pages And Groups.

No doubt, media content is very important  when it comes to updating your blogs and social network pages. We totally understand that and constantly improve images and videos processing, either in content feeds or posting campaigns. Today we are glad to introduce one of the latest updates to our Facebook Poster, which improves posting images […]

The post Improved Photo And Video Posting To Facebook Pages And Groups. appeared first on RSSground.com.




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Posting Automation Was Improved

According to your numerous requests, we made posting automation more flexible. Now you can set your posting campaigns to make posts only on weekdays, or to skip posting at night. Also you can change a time zone for your posting campaigns if needed. All existing posting campaigns will keep running and no need to update […]

The post Posting Automation Was Improved appeared first on RSSground.com.




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Interface updates and improvements.

We are glad to introduce some interface updates and improvements. In the Feeds Box you can now see a new Filter icon. Click to filter your content feeds by type, source and status and to use search option.  You can also change the number of feeds per page. We have also added the Reset filters option […]

The post Interface updates and improvements. appeared first on RSSground.com.




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Inside this maximum security prison, a film festival proves 'a little bit healing'

The Sing Sing maximum security prison in New York held its first-ever film festival recently, with incarcerated men invited to judge the five entries.




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New Thermal Material Provides 72% Better Cooling Than Conventional Paste

"Researchers at the University of Texas have unveiled a new thermal interface material that could revolutionize cooling, outperforming top liquid metal solutions by up to 72% in heat dissipation," writes Slashdot reader jjslash. "This breakthrough not only improves energy efficiency but also enables higher-density data center setups, cutting cooling costs and energy usage significantly." TechSpot reports: Thanks to a mechanochemically engineered combination of the liquid metal alloy Galinstan and ceramic aluminum nitride, this thermal interface material, or TIM, outperformed the best commercial liquid metal cooling products by a staggering 56-72% in lab tests. It allowed dissipation of up to 2,760 watts of heat from just a 16 square centimeter area. The material pulls this off by bridging the gap between the theoretical heat transfer limits of these materials and what's achieved in real products. Through mechanochemistry, the liquid metal and ceramic ingredients are mixed in an extremely controlled way, creating gradient interfaces that heat can flow across much more easily. Beyond just being better at cooling, the researchers claim that the higher performance reduces the energy needed to run cooling pumps and fans by up to 65%. It also unlocks the ability to cram more heat-generating processors into the same space without overheating issues. [...] As for how you can get your hands on the material: it's yet to make it out of the labs. The UT team has so far only tested it successfully at small scales but is now working on producing larger batches to put through real-world trials with data center partners. The material has been detailed in a paper published in the journal Nature Nanotechnology.

Read more of this story at Slashdot.




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Two major reforms can improve the VA

(Official Washington Examiner editorial, Nov. 11)  Year after year, presidential administration after administration, people across the political spectrum agree that U.S. military veterans deserve better treatment. Alas, despite genuinely good […]

The post Two major reforms can improve the VA appeared first on Quin Hillyer.




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'PGA Tour card battle provides intriguing Race to Dubai sub-plot'

England's Laurie Canter tells BBC Sport's Iain Carter he feels "lucky" to be in the mix to win one of 10 lucrative PGA Tour cards at the DP World Tour's season finale in Dubai.




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NHS offers 'improved' stop smoking pill

People in England will be able to get free varenicline tablets to help them quit cigarettes.




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Springboks beat Scotland after controversial red

World champions South Africa grind out a gutsy win over spirited Scotland at Murrayfield in the Autumn Nations Series





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PSP or MoR? How to choose the right commerce provider for your business

Today’s buyers are getting more demanding and selling online is getting more and more complex. Both B2B and B2C customers expect a seamless purchase experience and easy access to all the information, products and services they want, on any device and in any country.




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The Efficacy of Digital Media Resources in Improving Children’s Ability to Use Informational Text: An Evaluation of Molly of Denali From PBS KIDS

Informational text — resources whose purpose is to inform — is essential to daily life and fundamental to literacy. Unfortunately, young children typically have limited exposure to informational text. Two 9-week randomized controlled trials with 263 first-grade children from low-income communities examined whether free educational videos and digital games from the PBS KIDS show “Molly of Denali” supported children’s ability to use informational text to answer real-world questions. Study 1 found significant positive intervention impacts on child outcomes; Study 2 replicated these findings.




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Improve the performance of your Joomla articles (part 1)

The performance of the default article system in Joomla really sucks big time, that's a well know fact.

It''s actually one of the reasons we built K2 in the first place.

And as we venture into Joomla 4 territory, instead of seeing performance improvements (finally) for the entire database scheme, we actually witness new ways to mess up performance (if that was even possible). Apparently the Joomla core team likes to exercise who knows PHP's syntax better instead of actually building working code that doesn't break for extension developers every so.

Oh well, we're used to the mess.

Back to our topic.

Wanna improve the performance of the Joomla article system, especially in sites that filter/order content in various ways? Well, for starters add a few indices to the "content" table, e.g. using phpMyAdmin.

ALTER TABLE `#__content` ADD INDEX `idx_publishup` (`publish_up`);
ALTER TABLE `#__content` ADD INDEX `idx_publishdown` (`publish_down`);
ALTER TABLE `#__content` ADD INDEX `idx_modifiedby` (`modified_by`);
ALTER TABLE `#__content` ADD INDEX `idx_created` (`created`);
ALTER TABLE `#__content` ADD INDEX `idx_modified` (`modified`);

Just remember to replace #__ with your actual database prefix for Joomla.

But what's the measurable improvement? Well, something like this after you apply the above changes (on a really busy site that sorts articles by published date, aka 99% of Joomla sites)...

Yeap.

And that's performance tip no.1. We'll come back with more in the future as we delve into the software architectural wonder that is Joomla 4.

Or do yourself a favour & switch to K2 which recently passed 4 million downloads, yeah! :)

To those who might say, hey why aren't you contributing that back to Joomla, well, our answer is that if you've ever contributed in Joomla, you know the painful process & bureaucracy and you juuuust might wish to keep your sanity.

Until next time.




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News24 | SRD R370 grant beneficiaries approved in October still waiting for payment

Nearly three weeks after they were supposed to be paid, a number of SRD grant beneficiaries who had their applications approved in October are still waiting for their payments.




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Video: Merlin's Time & Attention Talk (Improvised Rutgers Edition)

Video: Merlin Mann - "Time & Attention Talk (improvised)"

Audio (mp3): "Merlin Mann - 'Rutgers Time & Attention Talk'"

This is a talk I did at Rutgers earlier this month. I kinda like it, but for a weird reason. Something something, perfect storm of technology Ragnarok, and yadda yadda, I had to start the talk 20 minutes late with no slides. Nothing.

So, I riffed.

And, I ended up talking about a lot of the new stuff you can expect to see in the Inbox Zero book—work culture, managing expectations, the 3 deadly qualities of email, and one surprising reason email's not as much fun as Project Runway.

Some people liked it. I think. I liked it. I hope you do, too.

Here's the slides I would have shown. ;-)

Many thanks, again, to my great pal, Dr. Donald Schaffner, for bringing me in for this visit. I had a great time and met some fantastic, passionate people. Much appreciated.

 

Hey—know anybody who should hear this talk? Hmmm?

I’ll bet. Lucky you, you can hire me to deliver this or any of my other talks to the time- and attention-addled people you work with as well.

Current topics include email, meetings, social media, and future-proofing your passion.

Drop a note if you have an upcoming event where you think we two might be a good fit.


update 2010-04-27_13-50-00

Apologies—my friends at Rutgers (inexplicably) have placed this video under lock and key. Fortunately, I have a lock-picker called Firefox. Samizdat video available soon...

update 2010-04-27_14-42-24

Yay, fixed! Many thanks to my hero, Jesse Schibilia.

Video: Merlin's Time & Attention Talk (Improvised Rutgers Edition)” was written by Merlin Mann for 43Folders.com and was originally posted on April 27, 2010. Except as noted, it's ©2010 Merlin Mann and licensed for reuse under CC BY-NC-ND 3.0. "Why a footer?"



  • Time and Attention
  • Videos
  • world of work

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Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik

Cavtat, Croatia, might be the biggest surprise of your trip! This peaceful seaside town in the far south of Croatia is so close to Dubrovnik, and yet a world away. If you want to visit Dubrovnik but would rather stay somewhere with a quiet, more relaxing atmosphere — oh, and cheaper, too! — Cavtat (pronounced […]

The post Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik appeared first on Adventurous Kate.




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NFL Analyst Michael Strahan Speaks Out After Becoming Embroiled in National Anthem Controversy

One of the greatest pass rushers in NFL history appears to be taking a pass himself when it comes to directly addressing a raging controversy. Pro Football Hall of Famer […]

The post NFL Analyst Michael Strahan Speaks Out After Becoming Embroiled in National Anthem Controversy appeared first on The Western Journal.




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Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the {alpha}/{beta}-fold epoxide hydrolase Alp1U [Enzymology]

Epoxide hydrolases (EHs) have been characterized and engineered as biocatalysts that convert epoxides to valuable chiral vicinal diol precursors of drugs and bioactive compounds. Nonetheless, the regioselectivity control of the epoxide ring opening by EHs remains challenging. Alp1U is an α/β-fold EH that exhibits poor regioselectivity in the epoxide hydrolysis of fluostatin C (compound 1) and produces a pair of stereoisomers. Herein, we established the absolute configuration of the two stereoisomeric products and determined the crystal structure of Alp1U. A Trp-186/Trp-187/Tyr-247 oxirane oxygen hole was identified in Alp1U that replaced the canonical Tyr/Tyr pair in α/β-EHs. Mutation of residues in the atypical oxirane oxygen hole of Alp1U improved the regioselectivity for epoxide hydrolysis on 1. The single site Y247F mutation led to highly regioselective (98%) attack at C-3 of 1, whereas the double mutation W187F/Y247F resulted in regioselective (94%) nucleophilic attack at C-2. Furthermore, single-crystal X-ray structures of the two regioselective Alp1U variants in complex with 1 were determined. These findings allowed insights into the reaction details of Alp1U and provided a new approach for engineering regioselective epoxide hydrolases.




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Women in the Armed Forces: Improving Integration




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Undercurrents: Episode 55 - Benjamin Netanyahu's Trial, and the Identity Politics of Eurovision