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Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00621F, Research Article
Chunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei Mao
A series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00724G, Research Article
Zhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei Mao
A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan

Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago




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Farmers demand withdrawal of Tamil Nadu Land Consolidation Act

The Coordination Committee of All Farmers’ Associations of Tamil Nadu says the State government has created a situation where industries can acquire fertile lands




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Bids invited for setting up International Dugong Conservation Centre at Manora

The proposed centre, to be set up at an estimate of ₹41 crore, is being established to conserve endangered Dugong species and its habitat in the Palk Bay




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Consultant to be appointed soon to design Kalaignar grand library in Tiruchi

The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events




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Art and literary contests lined up for District Central Library’s National Library Week




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557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life

When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life.




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558: Esoteric Weird Content Editable Problems with Kristin Valentine

Kristin Valentine from Vox joins the show to talk about text editor CMS fun across multiple sites, Vox's Chorus, The Verge redesign, sharing Design Systems, theming articles, and a fun new game called "Can Your Text Editor Do This??"




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568: Display Contents, Passkeys Follow Up, Yellow Fade Technique, and TOTK Talk

Macho Man Randy Standards stops by for a quick chat, Passkeys follow up, discussing the safety of Display: contents, the yellow fade technique, how hot CSS is right now (so hot), and a check in on how everyone's doing with Tears of the Kingdom.




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603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth

Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web.




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617: Economic & AI Vibes with Jason Grigsby

We're chatting with Jason Grigsby about what a white-collar recession means, how the sources and methods of consuming news shape our perspectives, whether the current economic conditions represent a market correction and if a rebound is imminent. We explore the critical decision of whether to embrace AI advancements or risk being left behind. We also talk about AI-generated voices, large language models and ethics, and the impact of social media signals in an AI world.




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631: Dave’s Second Brain Idea, Notion Thoughts, and Google’s LLM in Chrome

Dave's got an idea for a second brain app that's customized to his brain, where we're at with Notion and other notes apps, and accessibility on LLM's in browsers.




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640: Navigating the Pros and Cons of Web Components

Riffing off a Dave Rupert blog post, Chris and Dave talk through the pros and cons of web components, when to use them, when it's a bad idea to use them, what would it take to make the Next.js of web components, and how long until we don't need anymore frameworks?




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Can Chennai change its energy consumption patterns?

In creating energy-efficient cities, India will do well to model its development on its own age-old techniques, says Durganand Balsavar




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Bikes for last mile connectivity

The Japanese are increasingly shunning cars to help the urban environment get greener.




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Homes with a ‘conscience’

Around 5,000 homes in the city shun BWSSB water supply and produce enough power of their own. By M.A. Siraj




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Gunning for a slice of billion-dollar defence contracts 

How a college project birthed a bootstrapped manufacturer of components for the armed forces 




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The pros and cons of spouses teaming up as co-founders

How do married co-founders navigate the personal and professional ties at work




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A doctor-AI collab for detailed, patient consultations

Jivi.ai taps GenAI to optimise available medical resources and widen healthcare access




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Getting the gig economy to care for its backbone

Why startups in India cannot afford to take a hands-off approach towards the armies of gig workers they have created




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Concussion: FIFA kicks off ‘suspect and protect’ drive 

Campaign raises awareness that concussion is a traumatic brain injury and a risk to every player on the pitch




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Economic results in a year of elections

Nearly half the world voted this year to choose governments and fiscal roadmaps 




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‘Focused on building a high-conviction portfolio’

How fund house Cactus Partners ensures its capital goes toward growth rather than just keeping operations running




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Attempts to douse Alipur warehouse fire continue on second day




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Police constable among two mowed down by DTC bus in Delhi

The DTC bus climbed a pavement, collided with a billboard pole before hitting the two men and finally came to a halt after crashing into a road divider on Ring Road




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Police constable among two mowed down by DTC bus




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Haryana Congress to move court over ‘violations’ by BJP during Assembly poll

Panel to gather information from party’s candidates about various violations




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Chhath Puja: BJP, Cong. slam Delhi govt. over bad air, water




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Delhi election: AAP to hold nine-day convention for party workers




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Delhi’s air pollution: vehicular emissions top contributor, says study  




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Congress gears up for Delhi poll battle with month-long ‘Nyay Yatra’

Maken, Sukhu flag off foot march; Kharge, Rahul expected to join at different junctures; yatra scheduled to end on Dec. 4; people won’t forget Cong.’s tie-up with AAP in Lok Sabha election: BJP




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Demonising Constitutional institutions pastime for some: Vice-President Jagdeep Dhankhar

Addressing an event of an educational institution in New Delhi, the Vice-President said it is time to "bid adieu to this"




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Congress holds 25-km ‘Nyay Yatra’ in old Delhi




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Delhi Assembly elections | Congress leader Mateen Ahmed joins AAP, AAP leader Harsharan Singh Balli returns to BJP

Setback for Congress as five-time MLA Mateen Ahmed jumps ship to Aam Aadmi Party, days after his son, daughter-in-law join Kejriwal-led party; former Minister Balli quits AAP and returns to BJP




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1984 anti-Sikh riots case: Delhi HC says murder trial to continue against Congress leader Jagdish Tytler

Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court would continue with the hearing on November 29




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DMRC launches bike taxis for last-mile connectivity




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Delhi HC says murder trial to continue against Jagdish Tytler in 1984 riots case

Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court will continue with the hearing on November 29




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2024 Pacificon Inspires Next Generation of Radio Amateurs




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Dream Rig Contest Underway

The 5th annual Youth "Dream Rig" Essay Contest has begun to accept submissions.

The contest is sponsored by The Intrepid-DX Group, a U.S.-based 501 (c) (3) nonprofit organization that promotes amateur radio activities around the world and recognizes the importance of including youth in the amateur radio hobby.

Contestants must be USA or Canadian amateur radio license holders aged 19 or younger. A...




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Learning from US gig economy debate

What are the implications for India in terms of non-formal employment, labour laws and social security?




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Economic reforms’ eventful journey

Bimal Jalan gives a bird’s eye view of how the Indian economy and polity evolved since 1991




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16 leaders, as many economic verities

Vince Cable profiles 16 personalities who rung in deep rooted economic change in their societies




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The economics of everyday life

An economics book shorn of jargon, equations and graphs




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Conversations that shape today’s world

This collection of interviews with public figures holds a mirror to our world




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Triumphs and travails of a consultant

The book is a detailed job description for anybody wanting to make consulting their career




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Data and its discontents

The quality of the statistics of a country is a measure of its goodness, say the authors




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Policy prescription for economic and political maladies

Bimal Jalan delves deep into issues that are critical to the country with suggestions on how to overcome challenges 




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Booming Digital Stars: 11 Inspiring Journeys from India’s Creator Economy 

Lessons from the exciting success stories of social media influencers