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YSRCP leader Ambati Rambabu courts a controversy at Tirumala temple

The YSRCP leader entered the temple of Lord Venkateswara wearing a shirt which carried an image of Y.S. Jaganmohan Reddy




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Two-day 6th National Women’s Conference in Vijayawada from November 22

Objective of the meet is to explain to women their legal right to work in a safe environment; more than 200 delegates working in various public sector organisations to attend




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Hunt continues for tiger in Nallamala forest




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Tirupati universities form cluster to work towards conserving biodiversity

IIT-T, IISER Tirupati, SPMVV and Dravidian University comes together to create campus biodiversity registers as part of APSCHE-IIC research programme




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Construction of one lakh houses under PMAY 1.0 scheme to be completed by December: Kolusu Parthasarathy

During a review of the Housing Department in Chittoor and Tirupati districts, he says that construction work was not completed in certain places due to lack of sand supply or heavy rains




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P3MOT-decorated metal-porphyrin-based zirconium-MOF for the efficient electrochemical detection of 4-nitrobenzaldehyde

Anal. Methods, 2024, 16,2093-2100
DOI: 10.1039/D4AY00152D, Paper
Wen-yi Chen, Xin-yu Huang, Qian Sun, En-qing Gao
Developed a novel hybrid P3MOT@PCN-222(Fe) via in situ polymerization for 4-NBA detection. Showcased broad detection range, high sensitivity, selectivity and stability, laying groundwork for environmental monitoring.
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Construction of a three-mode sensor based on gold nanoparticles and carbon quantum dots as probes for the detection of thiosemicarbazone

Anal. Methods, 2024, 16,2127-2134
DOI: 10.1039/D4AY00256C, Paper
Zhili Liu, Xiaojun Wang, Jing Li, Wenfeng Zhou, Haixiang Gao, Runhua Lu
A three-mode sensor for thiocarbazone (TSC) was constructed based on gold nanoparticles and carbon quantum dots (CQDs). (A) Synthesis process of CQDs using ginkgo leaves. (B) Colorimetric and chrominance TSC detection. (C) Fluorescence detection of TSC.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Nanocubic cobalt-containing Prussian blue analogue-derived carbon-coated CoFe alloy nanoparticles for noninvasive uric acid sensing

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00121D, Paper
Yunting Qin, Dan Xiao, Xilan Gao, Xicui Zhang, Yanxue Xu
This work describes an electrochemical sensor for the fast noninvasive detection of uric acid (UA) in saliva.
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PCB-C4D coupled with paper-based microfluidic sampling for the rapid detection of liquid conductivity

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00198B, Paper
Mingpeng Yang, Mingyi Cao, Zhixuan Zhang, Chaofan Wang
A solution conductivity detection method, using PCB-C4D coupled with paper-based microfluidic sampling, has been proposed for the rapid and in situ analysis of raw solution with particle filtration, improving detection consistency and reliability.
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Simple and convenient preconcentration procedure for the isotopic analysis of uranium in seawater

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY01381B, Paper
Minami Abe, Noriaki Seko, Hiroyuki Hoshina, Shigeki Wada, Shinya Yamasaki, Keisuke Sueki, Aya Sakaguchi
Amidoxime adsorbent was synthesised by graft polymerisation. The adsorbent was efficient for collection of U in seawater for both the adsorption and desorption steps, thus affording a new strategy for measurement of U isotopes.
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Discrimination of Diptera order insects based on their saturated cuticular hydrocarbon content using a new microextraction procedure and chromatographic analysis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00214H, Paper
Open Access
Lixy Olinda León-Morán, Marta Pastor-Belda, Pilar Viñas, Natalia Arroyo-Manzanares, María Dolores García, María Isabel Arnaldos, Natalia Campillo
The nature and proportions of hydrocarbons in the cuticle of insects is characteristic of the species and age. Chemical analysis of cuticular hydrocarbons allows species discrimination, which is of great...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A simple, fast and inexpensive approach to quantify low concentrations of iron in biodiesel by voltammetry after extraction induced by microemulsion breaking

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00342J, Paper
Cristian Henrique Krause, Alexandre Batista Schneider, Leandro Kolling, Lauren Thauani Teixeira Oliveira, Márcia M. Silva
An alternative approach to assay iron (Fe) in biodiesel by differential pulse adsorptive cathodic stripping voltammetry (DPAdCSV) is presented herein. The sample treatment involved a simple, rapid, but effective extraction...
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Converging optical and electrochemical detection strategies for multimodal hydrazine sensing: insights into substituent-driven diverse response

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00063C, Paper
Rikitha S. Fernandes, Sahil Deepak Vasistha, Ritesh Kumar Singh, Sanket Goel, Nilanjan Dey
A pair of pyrene-based chalcogen derivatives have been developed, which demonstrate multimodal ratiometric response towards hydrazine.
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Rapid detection of monkeypox virus and differentiation of West African and Congo Basin strains using endonuclease restriction-mediated real-time PCR-based testing

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00492B, Paper
Juan Zhou, Fei Xiao, Xiaolan Huang, Jin Fu, Nan Jia, Chunrong Sun, Min Chen, Zheng Xu, Hui Huang, Yi Wang
A novel multiplex ET-PCR assay that integrates PCR amplification, restriction endonuclease cleavage and real-time fluorescence detection was devised to diagnose MPXV infection and distinguish the Congo Basin and West Africa MPXV strains.
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A three-dimensional network structure of metal-based nanozymes for the construction of colorimetric sensors for the detection of antioxidants

Anal. Methods, 2024, 16,2292-2300
DOI: 10.1039/D3AY02199H, Paper
Shuo Qin, Bin Liu, Yuting Xue, Ruixue Zhao, Guo Wang, Kai Li, Lirong Zheng, Pingyang Wang, Tianhao Tang, Yue Yang, Zhengbo Chen, Xia Zuo
Although many excellent nanozymes have been developed, designing and synthesizing highly active nanozymes is still challenging.
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Construction of a stable fluorescent sensor based on CsPbBr3/CdS core/shell quantum dots for selective and sensitive detection of tetracycline in ethanol

Anal. Methods, 2024, 16,2267-2277
DOI: 10.1039/D4AY00032C, Paper
Yang He, Yangjie Li, Han Wang, Site Luo, Haihu Yu
Construction of a stable fluorescent sensor based on CsPbBr3/CdS core/shell quantum dots for selective and sensitive detection of tetracycline in ethanol via a mechanism integrating photoinduced electron transfer.
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Dual-functional porphyrinic zirconium-based metal–organic framework for the fluorescent sensing of histidine enantiomers and Hg2+

Anal. Methods, 2024, 16,2386-2399
DOI: 10.1039/D3AY02241B, Paper
Shili Qin, Fanshu Meng, Fenglong Jin, Xidi Xu, Ming Zhao, Hongtao Chu, Lidi Gao, Shuren Liu
L-Cys/PCN-222 as a novel and dual-functional fluorescent sensor was developed. It not only showed a higher chiral fluorescent recognition of L-histidine but also performed as a visual sensor for Hg2+ in actual surface water.
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Construction of coumarin-appended calix[4]arene-based fluorescence sensor for the detection of carbofuran in cabbage

Anal. Methods, 2024, 16,2400-2411
DOI: 10.1039/D4AY00030G, Paper
Heni Soni, Nidhi Verma, Divyesh Y. Chaudhari, Sahaj A. Gandhi, Alok Pandya, Pinkesh G. Sutariya
This study presents a novel approach for the detection of carbofuran (CBF) insecticide by exploring a calix[4]arene-derived fluorescence probe, CouC4S, functionalized with two coumarin-labelled at the narrow edge of the calix[4]arene platform.
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Simple fluorescence “turn-off” assay for Congo red using commercial 2-aminophthalic acid

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00506F, Paper
Jiaqi Qian, Jie Li, Yihan Jiang, Chaoyong Liu, Jiayao Zhu, Liyu Gu, Yongming Guo
2-Aminophthalic acid with a high quantum yield of 38.49% was utilized for fluorescence “turn-off” sensing of Congo red with a linear range of 0.05–50 μM and a limit of detection of 1.72 μM.
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A reaction based carbazole–indolium conjugate probe for the selective detection of environmentally toxic ions

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00301B, Paper
Jayasudha Palanisamy, Mansour K. Gatasheh, Ashraf Atef Hatamleh
Carbazole–indolium based colorimetric probe was designed for detecting cyanide ions in various water samples. An outstanding response was shown by paper test strips prepared using the probe for the easy detection of cyanide in real time.
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The preparation of a boronate affinity-based controlled oriented imprinting coating on a silica nanoparticle surface for the separation and purification of shikimic acid in herbal medicine

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00219A, Paper
Yumin Yang, Daojin Li, Bingqian Liu
Shikimic acid (SA) is one of the most effective drugs against the A (H1N1) virus and has high medicinal value.
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Three-dimensional hotspot structures constructed from nanoporous gold with a V-cavity and gold nanoparticles for surface-enhanced Raman scattering

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00348A, Paper
Yang Xu, Yan Wu, Jianjun Wei, Yuanyu Zhao, Peili Xue
A nanoporous gold V-shaped resonant cavity (NPGVRC) structure constructed with plasmonic resonance coupling effect. The NPGVRC has excellent SERS performance and 3D hotspot properties.
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Filestack: A File Uploader and Powerful APIs to Deliver and Transform App Content

[Sponsored] If you’re building an app that requires a lot of user-generated content and media that needs to be processed, tagged, filtered, or otherwise manipulated in real-time, you definitely want a solution that’s fast and seamless and doesn’t get in the way of your app’s primary functionality. Filestack is a service you’ll want to consider. Here’s what Filestack offers:

The post Filestack: A File Uploader and Powerful APIs to Deliver and Transform App Content appeared first on Impressive Webs.




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NPR and Aadhaar - a confused process




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Worsening Aadhaar conundrum




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​For a fair probe: On the Kejriwal bail order and CBI conduct

Kejriwal bail order is a reminder to CBI to dispel perception of bias




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Third front: On the expanding nature of the conflict in West Asia

Israel’s fighting three enemy militias at once highlights the pressing need for a ceasefire




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A fair share: On the concerns of high performing States

The Sixteenth Finance Commission must address the concerns of high-performing States




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It is an offence: On Supreme Court clarification on online content on child sex abuse

Court has done well to clarify law on online content showing child sex abuse




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​Rogue state: On Israel’s conflict with Hezbollah  

Israel is choosing war over peace, escalation over compromise 




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​Kashmir conflict: On the J&K elections

The political divide between national parties and regional parties is clear 




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​Judge and prejudice: On conduct in judicial proceedings

Judicial officers must be mindful of language that reveal bias




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​Inflection point: On the escalation in the multi-party West Asia conflict

West Asia needs the intervention of major world powers for peace 




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Taking guard: On the RBI and growth concerns

The central bank’s price worries may be warranted but growth concerns are emerging




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Deeper role: On the U.S. and West Asia conflicts   

The escalating conflict cycle in West Asia could have disastrous consequences




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Fate of nations: On the 2024 Economics Nobel

The 2024 Nobel recognises the need for ‘inclusive’ institutions




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​West versus the rest: On western conduct and India

The West must not tolerate terror threats in the name of free speech 




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Growth prescription: On the latest World Economic Outlook 

The IMF’s ‘mediocre’ medium-term outlook merits policy attention




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​Escalation ladder: On conflict between Israel and Iran

Iran should show strategic restraint; and the world should rein in Israel




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​Beautifully vague: On the Tamilaga Vettri Kazhagam’s inaugural conference  

Actor Vijay seems to be targeting both the BJP and the DMK 




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Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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The role of silicon in drug discovery: a review

RSC Med. Chem., 2024, 15,3286-3344
DOI: 10.1039/D4MD00169A, Review Article
Open Access
Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van Otterlo
This review aims to highlight the role of silicon in drug discovery.
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Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells

RSC Med. Chem., 2024, 15,3418-3432
DOI: 10.1039/D4MD00170B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van Tran
Madecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.
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Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate

RSC Med. Chem., 2024, 15,3485-3494
DOI: 10.1039/D4MD00246F, Research Article
Shouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng Xu
A novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
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Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00608A, Research Article
Sunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo Mathew
A total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.
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Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00617H, Research Article
Aida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü Beydemir
In this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.
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Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00562G, Research Article
Open Access
Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens
Flow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.
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A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article
Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
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