Shukai Du and Francisco-Javier Sayas
Math. Comp. 89 (2019), 1745-1782.
Abstract, references and article information

(Northwestern University) Northwestern University researchers are using artificial intelligence (AI) to speed up the search for COVID-19 treatments and vaccines. The AI-powered tool makes it possible to prioritize resources for the most promising studies -- and ignore research that is unlikely to yield benefits.

(Uppsala University) Artificial intelligence (AI) may be an aid to interpreting ECG results, helping healthcare staff to diagnose diseases that affect the heart. Researchers at Uppsala University and heart specialists in Brazil have developed an AI that automatically diagnoses atrial fibrillation and five other common ECG abnormalities just as well as a cardiologist. The study has been published in Nature Communications.

(Simon Fraser University) SFU professor Caroline Colijn’s research and data modelling to map the spread of COVID-19 in British Columbia has helped her procure funding from Genome B.C., a non-profit research organization that leads genomics innovation on Canada’s West Coast.

Imperial's disease outbreak centre J-IDEA has launched a pandemic hospital planning tool to help cope with extreme surges in demand from coronavirus.

It is possible that the next time you walk into a bar you may find that there is only standing room, and you are among a handful of persons allowed inside. Prime Minister Andrew Holness said that in addition to having a specific gathering rule,...

Proteins that bind carbohydrate structures can serve as tools to quantify or localize specific glycans in biological specimens. Such proteins, including lectins and glycan-binding antibodies, are particularly valuable if accurate information is available about the glycans that a protein binds. Glycan arrays have been transformational for uncovering rich information about the nuances and complexities of glycan-binding specificity. A challenge, however, has been the analysis of the data. Because protein-glycan interactions are so complex, simplistic modes of analyzing the data and describing glycan-binding specificities have proven inadequate in many cases. This review surveys the methods for handling high-content data on protein-glycan interactions. We contrast the approaches that have been demonstrated and provide an overview of the resources that are available. We also give an outlook on the promising experimental technologies for generating new insights into protein-glycan interactions, as well as a perspective on the limitations that currently face the field.

The development of the HUPO-PSI's (Proteomics Standards Initiative) standard data formats and MIAPE (Minimum Information About a Proteomics Experiment) guidelines should improve proteomics data sharing within the scientific community. Proteomics journals have encouraged the use of these standards and guidelines to improve the quality of experimental reporting and ease the evaluation and publication of manuscripts. However, there is an evident lack of bioinformatics tools specifically designed to create and edit standard file formats and reports, or embed them within proteomics workflows. In this article, we describe a new web-based software suite (The ProteoRed MIAPE web toolkit) that performs several complementary roles related to proteomic data standards. Firstly, it can verify the reports fulfill the minimum information requirements of the corresponding MIAPE modules, highlighting inconsistencies or missing information. Secondly, the toolkit can convert several XML-based data standards directly into human readable MIAPE reports stored within the ProteoRed MIAPE repository. Finally, it can also perform the reverse operation, allowing users to export from MIAPE reports into XML files for computational processing, data sharing or public database submission. The toolkit is thus the first application capable of automatically linking the PSI's MIAPE modules with the corresponding XML data exchange standards, enabling bidirectional conversions. This toolkit is freely available at http://www.proteored.org/MIAPE/.

The ADA's Advisory Task Force on Dental Practice Recovery has developed a toolkit to help dentists return to more normal practice operations while taking precautions to protect staff, patients and themselves from COVID-19 as some states reopen.

When it came to selecting bones for leather-making tools, Neanderthals were surprisingly choosy. New archaeological analysis shows Neanderthals preferentially selected bovine rib bones to make a tool called a lissoir.

BRUSSELS — While the European Union has called on Member States to expand channels for foreign workers as a way to meet labour market needs and potentially tackle spontaneous migration, they have struggled to deliver on this pledge. To date, policies have focused more on attracting high-skilled workers, but less attention has been paid to admission of low- or middle-skilled nationals. Policymakers would do well not to overestimate the potential of legal channels to reduce irregular migration.

WASHINGTON — The Migration Policy Institute (MPI) today published the annual update to its data-rich article, Frequently Requested Statistics on Immigrants and Immigration in the United States, offering readers a wealth of information that can help inform understanding about an issue that is the subject of much conversation.

The coronavirus pandemic is affecting billions of people around the world today. Coronavirus, now called covid 19, is a type of virus that is usually found in animals and is rarely transmitted to humans. According to reports from the World Health Organization, covid 19 likely originated from a seafood and meat market in Wuhan, China, […]

Award-winning short documentary about the benefits of digital health tools for mental health.

Nebraska's education department released an interactive instructional materials map last week, showing what curricula districts have adopted for English-language arts, math, and K-8 science.

The Urban Institute released a toolkit aimed at policymakers and investors interested in using private dollars to pay for public programs, such as prekindergarten.

This paper presents a new open source Python framework for causal discovery from observational data and domain background knowledge, aimed at causal graph and causal mechanism modeling. The cdt package implements an end-to-end approach, recovering the direct dependencies (the skeleton of the causal graph) and the causal relationships between variables. It includes algorithms from the `Bnlearn' and `Pcalg' packages, together with algorithms for pairwise causal discovery such as ANM.

Genetic genealogy -- Handbooks, manuals, etc.

FAO has begun field tests for a new approach to measuring hunger and food insecurity – part of a collaboration with polling specialists Gallup, Inc. The project – known as Voices of the Hungry – is based on a “food insecurity experience scale,” with annual data collected using eight interview questions about people’s experiences of food insecurity over the preceding [...]

The COVID-19 pandemic is currently one of the world’s most pressing issues and one that is increasingly shaping government policies. To help provide policy support and information to member [...]

The bright blue pigment that adorns the Bust of Nefertiti’s crown can now be used to study molecular biology

Billy O'Toole (date: 5/9/2020 - Rank: 2)

The Xenopus oocyte is a unique model system, allowing both the study of complex biological processes within a cellular context through expression of exogenous mRNAs and proteins, and the study of the cell, molecular, and developmental biology of the oocyte itself. During oogenesis, Xenopus oocytes grow dramatically in size, with a mature oocyte having a diameter of ~1.3 mm, and become highly polarized, localizing many mRNAs and proteins. Thus, the mature oocyte is a repository of maternal mRNAs and proteins that will direct early embryogenesis prior to zygotic genome transcription. Importantly, the Xenopus oocyte also has the capacity to translate exogenous microinjected RNAs, which has enabled breakthroughs in a wide range of areas including cell biology, developmental biology, molecular biology, and physiology. This introduction outlines how Xenopus oocytes can be used to study a variety of important biological questions.

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Who wants to work harder, using the same outdated methods, when new tools are available? Not me! There might not always be an “easy button” …. but sometimes there is: 3D Interconnect. Since its introduction in SOLIDWORKS 2017, I have

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Need for Surface Surface Modelling is a method used to create and represent complex shapes with high curvature controls. Generally, surfaces are used as an alternative where a particular feature is difficult to create using solid modeling. It is helpful

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You probably remember last year’s video; The Benefits of the Structure System Tool in SOLIDWORKS 2019. By popular demand, Elite Applications Engineer Colin Murphy is back to highlight the benefits of the Structure System tool in SOLIDWORKS 2020!   What

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This helpful #TechTip is brought to you by our Training Manager John Setzer, and covers using the smart dimension tool when sketching arcs and circles. Find more options available to you, when you want to create a dimension and don’t

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Hi, I’m Mike Dady, Application Engineer for Alignex. As many of you probably know, the Toolbox Add-In is a database that allows for the quick addition of fasteners and other hardware to a SOLIDWORKS Assembly. However, many don’t realize that

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There are 3 main tools that can project our 2D sketch onto a face: Project curve, Split line and Wrap. How should we choose and what is the difference between them? Here are some tips for you. Project curve –

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CONTEXT:

Recommendations conflict regarding universal application of formal screening instruments in primary care (PC) and PC-like settings for autism spectrum disorder (ASD).

An amazing God-given tool to mobilise and inspire people to make a difference: Global Village.

The video-sharing platform is a huge hit with teens and some teachers are beginning to integrate it into their lessons. But cyberbullying and data privacy are big concerns, experts say.

When teachers use more praise and fewer reprimands in the classroom, it seems to help students stay on-task and behave better, according to a new study.

High school teacher Kateryna Haggerty explains how visual aids in her classroom help her English-language learner students write more confidently.

The American Academy of Pediatrics prioritized detection of mental illness in children presenting to emergency departments (ED) by using standardized clinical tools. Only a minority of ED physicians indicate that they use evidence-based screening methods to assess mental health concerns.

This study presents the psychometrics of the HEADS ED (home, education, activities/peers, drugs/alcohol, suicidality, emotions/behavior, discharge resources), a brief, standardized screening tool for pediatric EDs. This tool ensures key information is obtained for decision-making, determining acuity level, and areas of need. (Read the full article)