SONY/ATV NASHVILLE has hired two new executives. CAM CALDWELL joins as VP/Business Affairs and COURTNEY PENDER comes aboard as VP/Human Resources. CALDWELL previously spent 10 years in … more

CUMULUS MEDIA’s WESTWOOD ONE NASHVILLE will celebrate the start of Summer and salute service men and women with its annual “Summer Kickoff with DUSTIN LYNCH” Memorial Day … more

The city of NASHVILLE is hosting a songwriting competition, titled "NASHVILLE Needs A Song," to help inspire and uplift Nashvillians as they navigate the challenges of the COVID-19 … more

Sala de prensa sobre el COVID-19 de la AHA DALLAS, 3 de abril del 2020 – El COVID-19 está generando preguntas y preocupaciones generalizadas sobre el mayor riesgo que implica para aquellos con cardiopatías y sobrevivientes de accidentes...

Personas are antiquated… this coming from someone who has relied on and written about them for years. For years at 3.7 Designs, we’ve created personas during the design discovery phase. I recently realized that the traditional marketing persona is no longer a relevant practice. The keyword here is “traditional.” At 3.7 we’ve adopted a practice […]

The post Why personas are antiquated (and what you should use instead) appeared first on Psychology of Web Design | 3.7 Blog.

Daily Photo – Exploring the Old Rockets at NASA If you’re a rocket enthusiast, then the museums at NASA are a must. I’m a little bit of a rocket nerd so I found it pretty exciting. That, plus being a photo nerd, was a perfect combo. Also, you get a leeway when it comes to […]

How much do you really know about your customers? Learn why buyer personas are the foundation of your business & how to create your own in just four steps.

The post How to Create Buyer Personas for Your Online Store appeared first on WooCommerce.

Welcome back to another Illustrator tutorial from our retro hardware series! In this how-to, we’re going to learn to create a NAS Icon (or a Network-Attached Storage icon) using some simple geometric shapes and tools. So, get your software up and running let’s jump straight into it! Tutorial Details: How to Create a NAS Icon Program: Adobe […]

The post Create a NAS Icon in Just 30 Minutes Using Adobe Illustrator appeared first on Vectips.

Personas are antiquated… this coming from someone who has relied on and written about them for years. For years at 3.7 Designs, we’ve created personas during the design discovery phase. I recently realized that the traditional marketing persona is no longer a relevant practice. The keyword here is “traditional.” At 3.7 we’ve adopted a practice […]

The post Why personas are antiquated (and what you should use instead) appeared first on Psychology of Web Design | 3.7 Blog.

Dark-schemed One Pager built using Webflow for product designer Cai Cardenas. Neat touch with the waving emoji animation and how the links match the brand colors. Full Review

In this paper, we present three distributed algorithms to solve a class of generalized Nash equilibrium (GNE) seeking problems in strongly monotone games. The first one (SD-GENO) is based on synchronous updates of the agents, while the second and the third (AD-GEED and AD-GENO) represent asynchronous solutions that are robust to communication delays. AD-GENO can be seen as a refinement of AD-GEED, since it only requires node auxiliary variables, enhancing the scalability of the algorithm. Our main contribution is to prove converge to a variational GNE of the game via an operator-theoretic approach. Finally, we apply the algorithms to network Cournot games and show how different activation sequences and delays affect convergence. We also compare the proposed algorithms to the only other in the literature (ADAGNES), and observe that AD-GENO outperforms the alternative.

Summer Camps 2020 Adventure Gymnastics Camp This popular camp is now in its 17th year, offering themed days of challenges and adventures in gymnastics, like scavenger hunts and obstacle courses, costumes and more.…

The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Disclosed embodiments provide pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.

The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a benzo[1,3]dioxolil group,W is a group of formula —NH—SO2—R2 or heteroaryl group or NHR3 group where R3 is hydrogen or heteroaryl; and n is 1, 2, 3 or 4. Furthermore, the present invention is directed to pharmaceutical composition containing at least one compound of general formula (I) and/or pharmaceutically acceptable salts or solvates thereof and for the use of them for the preparation of pharmaceutical compositions for the prophylaxis and/or the treatment of protein kinase related, especially CDK9-related diseases e.g. cell proliferative disease, infectious disease, pain, cardiovascular disease and inflammation.

Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

The present invention provides 4,6-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.

Provided are compounds of Formula I wherein R1, R2, Y, Z and G are as defined herein, that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

A hermetic terminal for an active implantable medical device (AIMD), includes an RF distance telemetry pin antenna, a capacitor conductively coupled between the antenna and a ground for the AIMD, and an inductor electrically disposed in parallel with the capacitor and conductively coupled between the antenna and a ground for the AIMD. The capacitor and the inductor form a band pass filter for attenuating electromagnetic signals through the antenna except at a selected frequency band. Values of capacitance and inductance are selected such that the band pass filter is resonant at the selected frequency band. In an alternative form, the band pass filter is coupled in series with the telemetry pin antenna for attenuating MRI signals of a selected frequency band.

The present invention relates to a wireless communication system. More particularly, the present invention relates to a method and to an apparatus for transmitting an SRS in a multi-antenna system. The method comprises the steps of: acquiring specific information for discriminating a first antenna group and a second antenna group from among a plurality of antennas, wherein said first antenna group includes one or more antennas which are set to a turned-on state to perform communication with a base station, and said second antenna group includes one or more other antennas which are set to a turned-off state; transmitting an SRS to the base station if a predetermined condition is satisfied, under the condition that the second antenna group is set to the turned-off state; and setting the second antenna group to a turned-off state after the transmission of the SRS.

The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA.

The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.

A splint for use in stabilizing the nasal septum of a subject following the completion of a septoplasty procedure has a longitudinal axis and is formed of a substantially rigid sheet having a longitudinal length, an anterior end, and a posterior end. The sheet is labeled with a plurality of guide markings that guide a user in shaping the splint prior to implantation of the splint within a nasal passage of the subject.

Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method of producing such arginase conjugate has a main step of genetically modifying the gene encoding an arginase so that the PEG moiety can attach to the enzyme at a predetermined, specific intended site. This is achieved by removing the PEG attaching amino acid residues at undesirable sites while keeping (or adding, if necessary) the one at the desirable site of the enzyme. Two exemplary mono-pegylated arginase conjugates so produced are human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys45 of the enzyme and Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys161 of the enzyme.

A method and apparatus for euthanizing poultry by rapidly impacting the spinal column of the bird.

The invention concerns a method for optimizing antenna pattern assignment for a first wireless communication device forming a wireless network with at least one second wireless communication device, each of said communication device being equipped with a multi-sector antenna, an antenna pattern being a combination of said antenna sectors, said communication devices being adapted for sending a request and for receiving a response using a current antenna pattern assignment, said method comprising a step of: evaluating by said first communication device a first value;sending by said first communication device to said second communication device a broadcast request comprising said valuereceiving by said first communication device, a response to said broadcast request, said response being sent by said second communication device, said response depending on a second value evaluated by said second device;Switching or not, by said first communication device, to a new antenna sector assignment depending on said response; According to the invention the first value is evaluated by minimizing a first local function according to the received signal strength received by said first communication device having said current antenna pattern assignment and the second value is evaluated by minimizing a second local function according to the received signal strength received by said second communication device for its own current antenna pattern assignment.

A rover processor determines position of a rover based upon the interaction between multiple antennas located at the rover and multiple antennas located at a base. The rover antennas may include a rover master antenna having a phase center located at the centroid of the antennas patterns of at least two auxiliary rover antennas. The rover processor may determine the position of the rover master antenna based upon the relative positions of at least two rover antennas (e.g., the rover master antenna and at least one rover auxiliary antenna, or at least two rover auxiliary antennas) with respect to at least two antennas of a base transceiver.

This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV bispecific binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

Various methods, apparatus, devices and systems are provided for electrically short antennas for efficient broadband transmission. In one example, among others, a system includes a segmentally time-variant antenna and a segment controller that can control conductivity of individual segments of the segmentally time-variant antenna. The conductivity of the individual segments is modulated to allow a pulse to propagate from the proximal end to the distal end of the segmentally time-variant antenna and impede a reflection of the pulse from propagating back to the proximal end of the segmentally time-variant antenna. In another embodiment, a method includes injecting a pulse at a first end of a segmentally time-variant antenna and modulating conductivity of individual segments to allow the pulse to propagate to a second end of the segmentally time-variant antenna and impede a reflection of the pulse from propagating back to the first end.

Disclosed herein are vials and devices containing a ketorolac solution for intranasal administration and a head space comprising no more than about 10% v/v oxygen and which vials and devices are stored in an oxygen-impermeable pouch. Also disclosed are processes for preparing the vials and devices.

A gas ventilation mask includes an anesthesia nasal mask and a mouth mask defining respectively a nasal chamber and an oral chamber, detachably connected to one another so that the nasal mask and the mouth mask may be used either separately as a nasal mask or as a mouth mask, or as a combination nasal-mouth mask. Also provided is a mask anchor for holding a face mask on a patient, includes a head support for engaging a back of a patient's head, a posterior head strap that originates from behind the patient's head, in contact with the patient's head and attaches either directly or indirectly to the mask when the mask is on the patient's face, wherein the strap can be tightened to create a seal to allow for positive pressure ventilation or left loose and for providing supplement oxygen. Also provided is an anesthesia mask strap system having a first expandable strap portion having the ability to extend; second and third non-expandable strap sections fixed to ends of the first expandable strap section; and an adhesion section for fixing a length of the strap system when the second and third non-expandable strap sections are pulled to tension the expandable strap section.

A smart oronasal mask for a positive-airway-pressure device includes a mask body and a temperature sensor. The mask body has an air inlet and an air outlet. The temperature sensor is deposited in the mask body and located between the air inlet and the air outlet for sensing a temperature of a mixture formed by gas entering the mask body through the air inlet of the mask body and gas entering the mask body through the air outlet of the mask body. Then the positive airway pressure device adjusts air feed according to the temperature sensed by the temperature sensor in a real-time manner, so as to help keep a patient's respiratory tract clear.

The invention relates to a method for automatically adjusting a plurality of tunable passive antennas, for instance a plurality of tunable passive antennas of a radio transceiver using several antennas simultaneously. The invention also relates to an automatically tunable antenna array using this method. An automatically tunable antenna array of the invention has 4 user ports, and comprises: 4 tunable passive antennas, the 4 tunable passive antennas operating simultaneously in a given frequency band and forming a multiport antenna array; 4 sensing units; 4 feeders; a signal processing unit delivering a tuning instruction; and a tuning control unit, the tuning control unit receiving the tuning instruction from the signal processing unit, the tuning control unit delivering tuning control signals to the tunable passive antennas, the tuning control signals being determined as a function of the tuning instruction.

A device comprising: a substrate; a transmit antenna fabricated on the substrate and configured to transmit radio-frequency (RF) signals; a receive antenna fabricated on the substrate and configured to receive RF signals; and circuitry, disposed on the substrate and differentially coupled to the transmit and receive antennas, and configured to provide to the transmit antenna RF signals to be transmitted by the transmit antenna and to process RF signals received by the receive antenna, wherein the substrate comprises material for reducing harmonic coupling between the transmit antenna and the receive antenna.

Reconfigurable antennas in an ad-hoc network are provided where all nodes employ MIMO/SIMO/MISO communication techniques. Three types of reconfigurable antennas: Reconfigurable Printed Dipole Array (RPDA), Reconfigurable Circular Patch Antenna (RCPA) and Two-Port Reconfigurable CRLH Leaky Wave Antennas are used. The RPDA, RCPA and the CRLH Leaky Wave antennas have a different number of configurations as well as different degrees of pattern diversity between possible configurations. To effectively use these antennas in a network, the performance of centralized and decentralized antenna configuration selection schemes are quantified for reconfiguration at one or both link ends. The sum capacity of the network is used as a metric to quantify the performance of these antennas in measured and simulated network channels.

A surface scattering antenna with a tightly-coupled or tightly-connected array of radiators provides an adjustable antenna with broadband instantaneous bandwidth.

Compositions and methods for detecting Trichomonas vaginalis are provided.

Mutazione , a quirky game created by the studio Die Gute Fabrik, has one of the most laidback soundtracks ever. From his very relaxed studio on Sardinia, Alessandro Coronas created a wonderful mix of low-fi, accoustic and synth sounds to accompany young Kai on her voyage to save her grandfather on a very unusual island. Mutazione has been in development for ten years! Alessandro says the initial concepts remained from the beginning. They included the magical seeds the player can select for their various healing properties and musical sounds. That allows you to create your own soundtrack, too. Alessandro is also the sound designer for the game, so he was able to grow the music out of the sounds of the game world. He says working with the small team of Die Gute Fabrik, and especially artist Nils Deneken, was a wonderful experience because of the freedom and synergy they all had. The four-hour soundtrack, which includes extended suites adapted from the musical cues, is available through

Audio File Edit | Remove Saturday marks 50 years since the first moon landing. Now, NASA is tapping a team from Stony Brook University to investigate how going to space impacts human health. The team is one of eight NASA has selected to help further exploration of our solar system with robots and astronauts. Timothy Glotch, a professor of geosciences at Stony Brook, leads the team. Professor Glotch, thank you for joining All Things Considered. What do you hope to find in your research? So the overall goal of the RISE2 team, which is the name of our team, is to help pave the way for humans to safely return to the moon and explore and get back safely to Earth. So as you mentioned one of our goals is to try and understand the health effects of exploration. We have a team of geochemists working with folks in the medical school at Stony Brook University to understand the reactivity of dust on the moon, and how if you breathe that in how that might lead to potential health effects. And how

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Laura Benanti, Harvey Fierstein, Vanessa Williams, Beanie Feldstein and many others, in the meantime, will celebrate Mother's Day with a Broadway Does Mother's Day show.

NASA's administrator confirms the 'Mission: Impossible' actor is having discussions about shooting a film at the International Space Station with Musk's SpaceX.

Tuning in to the 'Gooba' rapper's livestream which marks his first public appearance since his prison release, the 'Old Town Road' can't help gushing about how 'cute' he is.

Laura Benanti, Harvey Fierstein, Vanessa Williams, Beanie Feldstein and many others, in the meantime, will celebrate Mother's Day with a Broadway Does Mother's Day show.

Tuning in to the 'Gooba' rapper's livestream which marks his first public appearance since his prison release, the 'Old Town Road' can't help gushing about how 'cute' he is.

Authorities seized 400 grams of fentanyl during two investigations in Nassau County this week.

This week, we have an in-depth interview with a legend who needs no introduction, Nas. We talk to him about his new album Life Is Good, his most puzzling lyrics, his relationship with Amy Winehouse, and more.

See http://theciphershow.com/episode/8/ for full show notes and comments.

This episode, we talk to Dan Charnas, industry veteran, prolific music journalist, screenwriter, and most recently author of The Big Payback, the definitive history of hip hop business. Charnas began in the mailroom of the seminal rap label Profile Records, eventually becoming Rap A&R and Promotion Manager — working on projects from Run-D.M.C., Dana Dane, Special Ed, Rob Base, Special Ed and DJ Quik. He was one of the first writers for The Source, part of the movement to create hip hop journalism. He was hired by Rick Rubin to run the rap department of his new Warner Bros joint venture, American Recordings. He went on to play many more roles within and surrounding the hip hop industry, getting deeply involved in projects including Sir Mix-A-Lot’s double-platinum single “Baby Got Back”, DJ Kool’s gold anthem “Let Me Clear My Throat,” and Chino XL’s acclaimed “Here To Save You All”.

As an incredibly talented writer and incredibly savvy man, Charnas set out about 4 years ago to begin constructing a complete history of hip hop business. What began as a potential news article quickly took a life of its own and this year he finally saw the completion of his work, acclaimed by the New York Times as “epic” and by Forbes as “a mature, Pulitzer-worthy work, an integral account of essential urban history”. The book contains detailed accounts of major transitions and deals made within the hip hop industry that would shape the music landscape for years to come.

We talk the dichotomy between being rich and being real, black capital in America, Bronx based beat hip hop vs. DJ Hollywood’s “club rap”, and more.

See http://theciphershow.com/episode/64/ for full show notes and comments.