Knight Construction & Supply Co. has won a $3.7 million contract from the U.S. Army Corps of Engineers to rehabilitate spillway gates at the Blue River Dam in Oregon.

The North Carolina Attorney General's Office has filed a court injunction against the German ownership group that owns the damaged Woodlake Dam in an effort to make it pay for dam safety repairs.

Humans are causing irreversible damage to the planet from burning fossil fuels, the biggest ever study of the available science concluded in a report designed to spur the fight against climate change.

For many mining companies, the rallying cry for investigating solar or wind energy options has been that the price of oil and other conventional fuels is too high — and will almost certainly rise over time. Now, though, with oil prices having taken a dramatic nosedive, this argument no longer packs quite the same punch that it once did.

GE Renewable Energy and Future Wind said this week that they have signed an agreement to install the first Haliade-X 12-MW wind turbine prototype in Maasvlakte-Rotterdam this summer. The deal includes five years of testing and a 15-year full service Operation and Maintenance agreement.

Humans are causing irreversible damage to the planet from burning fossil fuels, the biggest ever study of the available science concluded in a report designed to spur the fight against climate change.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

On 13 September 2017, EDF and ERDF lost their fight to declare null and void the contracts they entered into further to bids that were rigged by Nexans France (“Nexans”), Prysmian Energies Câbles et Systèmes (“Prysmian...

Bunge SA v Nidera BV [2015] UKSC 43 This case was first brought to the attention of the Commercial Court in June 2013, when an appeal on the ruling of the first arbitral panel was sought by the Claimant, Bunge SA (“Bunge”). The matter at...

Senator representing Adamawa North Senatorial district, Elisha Ishaku Abbo has accused governor Ahmadu Fintiri of making false claims over the donation of transformers to some communities in the State. The lawmaker said the transformers were donated by the newly established Northeast Development Commission (NEDC) through the intervention of his Committee. He frowned at the publication […]

Senator Abbo accuses Adamawa Governor of ‘false claims’ over NEDC projects

Kim Sang-jo, Chairman of the Fair Trade Commission, said, "Our commission will soon announce plans to stop the practice of large companies using technology of small enterprises without proper compensation." He held a press conference on August 13 at the Sejong government complex in relation to his agency's bid to root out unfair practices in the retail industry and said, "The biggest obstacle for small- and medium-sized enterprises for their further development is the uneven relationship with...

Diyaaraddii ku buburtey Berdaale ee nooceedu ahaa xamuulka ayaa la xaqiijiyey in ciidamada Itoobiya ee halkaas ku sugan ay ku rideen hubka lidka diyaaradaha kadibna sidaas ku burburtey. War ka soo baxay AMISOM ee la xiriira baaritaanka wada jirka ah ee la sameynaayey ayaa lagu sheegay in diyaaradda aysan soo ridin ciidamada AMISOM ee ay […]

The post Diyaaraddii Berdaale ku dhacdey oo la xaqiijiyey in Ciidamada Itoobiya soo rideen appeared first on Horseed Media • Somali News.

Ciidamada PSF ayaa Bosaso ku qabtey gaari lagu soo raray waxyaabaha qaraxa dhaliya, iyo bobooyinka gacanta laga tuuro. Wararku waxay sheegayaan in ciidanka PSF ay muddo ku dabo jireen shabakad argagixiso ah oo doonaayey in ay qaraxyo ka fuliyaan gudaha Puntland. War ka soo baxay ciidanka amniga Puntland ee PSF ayaa sheegay Intii hawlgalku socday, […]

The post Ciidamada PSF oo fashiliyey weerar argagixiso gudaha Boosaaso appeared first on Horseed Media • Somali News.

Strongman Haftar denies Tripoli government claims shelling by his forces caused civilian casualties

The text version of this document in not available. You can...

The text version of this document in not available. You can...

Sanderson Limited v Simtom Food Products Limited [2019] EWHC 442 (TCC) Summary Whatever the sector, IT transformation can deliver superior services, development of dynamic business models, increased customer satisfaction, returns and cost savings. ...

Ethiopia is set to begin filling GERD reservoir in June and July raising serious concerns.

[Dalsan Radio] The International Rescue Committee has warned that many cases are going untested and undetected. Somalia has faced decades of violence and cycles of drought and floods, leaving its health care system ill-equipped to respond to this outbreak. The International Rescue Committee (IRC) has been preparing for the spread of coronavirus by training health care staff to screen patients for symptoms and safely isolate potential cases.

The attack was the fifth case of vandalism or intimidation in 2 ½ years.

Contractor expresses confidence about project but notes effects of the pandemic.

1

1

1

With timely and well-targeted programs, policy makers can prevent the health crisis from deepening into a wider economic and financial crisis. This could sow the seeds of economic recovery.  

If you're struggling to understand the mysteries of quantum physics and relativity, you need all the help you can get – even borrowing Buddhist mysticism, shows a new book

Retailers usually expect a nearly $20 billion bonanza on a Valentine's Day weekend -- but with an Arctic chill forecast for parts of the United States, will paramours be able to keep alive the retail heat? Mana Rabiee reports.

A Reuters examination has found that widespread crop damage covering millions of acres of Midwestern farmland has its roots in weak regulatory oversight and corporate secrecy.

An aerial view of crabeater seals in Antarctica, mating damselflies and a twilight rocket launch were among the most lauded entries to the inaugural Nature TTL Photographer of the Year award

Extreme storms Hurricane Florence and Typhoon Mangkhut have caused destruction and taken lives across the globe this week, forcing millions to evacuate their homes

An aerial view of crabeater seals in Antarctica, mating damselflies and a twilight rocket launch were among the most lauded entries to the inaugural Nature TTL Photographer of the Year award

The covid-19 pandemic has many of us stuck at home. The result could completely reshape how we use the internet, writes Annalee Newitz

Six dancers from the Dutch National Ballet headed out into the empty streets of Amsterdam this week to perform their parts in a piece of choreography inspired by the coronavirus lockdown.

Title: Tysabri May Treat Myelin Sheath Damage From MS
Category: Health News
Created: 4/29/2009 2:00:00 AM
Last Editorial Review: 4/29/2009 12:00:00 AM

Title: Chewing Khat Linked to Severe Liver Damage
Category: Health News
Created: 4/28/2010 6:10:00 PM
Last Editorial Review: 4/29/2010 12:00:00 AM

Title: Beastie Boy Adam Yauch Dies, Had Salivary Cancer
Category: Health News
Created: 5/4/2012 5:32:00 PM
Last Editorial Review: 5/4/2012 12:00:00 AM

Title: Type 2 Diabetes May Damage Hearing, Study Finds
Category: Health News
Created: 4/27/2016 12:00:00 AM
Last Editorial Review: 4/28/2016 12:00:00 AM

Title: AHA News: Domestic Abuse May Do Long-Term Damage to Women's Health
Category: Health News
Created: 2/18/2020 12:00:00 AM
Last Editorial Review: 2/19/2020 12:00:00 AM

ABSTRACT

Bacillus anthracis is a spore-forming bacterium that causes devastating infections and has been used as a bioterror agent. This pathogen can survive hostile environments through the signaling activity of two-component systems, which couple environmental sensing with transcriptional activation to initiate a coordinated response to stress. In this work, we describe the identification of a two-component system, EdsRS, which mediates the B. anthracis response to the antimicrobial compound targocil. Targocil is a cell envelope-targeting compound that is toxic to B. anthracis at high concentrations. Exposure to targocil causes damage to the cellular barrier and activates EdsRS to induce expression of a previously uncharacterized cardiolipin synthase, which we have named ClsT. Both EdsRS and ClsT are required for protection against targocil-dependent damage. Induction of clsT by EdsRS during targocil treatment results in an increase in cardiolipin levels, which protects B. anthracis from envelope damage. Together, these results reveal that a two-component system signaling response to an envelope-targeting antimicrobial induces production of a phospholipid associated with stabilization of the membrane. Cardiolipin is then used to repair envelope damage and promote B. anthracis viability.

IMPORTANCE Compromising the integrity of the bacterial cell barrier is a common action of antimicrobials. Targocil is an antimicrobial that is active against the bacterial envelope. We hypothesized that Bacillus anthracis, a potential weapon of bioterror, senses and responds to targocil to alleviate targocil-dependent cell damage. Here, we show that targocil treatment increases the permeability of the cellular envelope and is particularly toxic to B. anthracis spores during outgrowth. In vegetative cells, two-component system signaling through EdsRS is activated by targocil. This results in an increase in the production of cardiolipin via a cardiolipin synthase, ClsT, which restores the loss of barrier function, thereby reducing the effectiveness of targocil. By elucidating the B. anthracis response to targocil, we have uncovered an intrinsic mechanism that this pathogen employs to resist toxicity and have revealed therapeutic targets that are important for bacterial defense against structural damage.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

Mutations in X-linked methyl-CpG-binding protein 2 (MECP2) cause Rett syndrome (RTT). To identify functional pathways that could inform therapeutic entry points, we carried out a genetic screen for secondary mutations that improved phenotypes in Mecp2/Y mice after mutagenesis with N-ethyl-N-nitrosourea (ENU). Here, we report the isolation of 106 founder animals that show suppression of Mecp2-null traits from screening 3177 Mecp2/Y genomes. Whole-exome sequencing, genetic crosses, and association analysis identified 22 candidate genes. Additional lesions in these candidate genes or pathway components associate variant alleles with phenotypic improvement in 30 lines. A network analysis shows that 63% of the genes cluster into the functional categories of transcriptional repression, chromatin modification, or DNA repair, delineating a pathway relationship with MECP2. Many mutations lie in genes that modulate synaptic signaling or lipid homeostasis. Mutations in genes that function in the DNA damage response (DDR) also improve phenotypes in Mecp2/Y mice. Association analysis was successful in resolving combinatorial effects of multiple loci. One line, which carries a suppressor mutation in a gene required for cholesterol synthesis, Sqle, carries a second mutation in retinoblastoma binding protein 8, endonuclease (Rbbp8, also known as CtIP), which regulates a DDR choice in double-stranded break (DSB) repair. Cells from Mecp2/Y mice have increased DSBs, so this finding suggests that the balance between homology-directed repair and nonhomologous end joining is important for neuronal cells. In this and other lines, two suppressor mutations confer greater improvement than one alone, suggesting that combination therapies could be effective in RTT.