Just a couple more gadgets and USB-C might really feel universal.

Location: Engineering Library- TK7874.84.R47 2016

Redhall Jex is nearing completion of a nine month contract to build a bio-energy plant located within a new facility on the Aston University site in Birmingham.

Over the past two weeks, we've watched the country grapple with questions about race and policing. And while those questions might be new to some, they're ones we've been thinking about since the very beginning of Code Switch. As we said in a recent episode , it can be hard to find something new to say about the cycle of police brutality, black death and the resulting protests. To describe what's happening right now as a "moment" in the country's racial history doesn't feel right; the stories of black people killed by police have dominated news cycles before, as did calls for changes to policing. But it's also clear that what's happening right now— protests in all 50 states and around the world, and widespread calls for defunding police departments —feels different. As my colleague Karen Grigsby Bates wrote , the unique circumstances of a pandemic and historic recession have fomented tensions beyond anything she's seen before. To help explain how the United States got to this point, we

A new photo ID requirement is the latest in a Republican-controlled state. The law also does away with the state’s presidential primaries in favor of a series of caucuses.

The Denver radio station has been ringing in the spirit of the season for 22 years.

HSBC Bermuda has announced that “single-use plastic cards will be a thing of the past as the bank replaces them with cards made from recycled materials.” A spokesperson said, “The move is part of HSBC’s global strategy to reduce carbon emissions and achieve the Bank’s net zero goal by 2050. “The cards comprise of 85% […]

REVIEW – It’s a punch-to-the-gut, sinking, black hole feeling to reach into a pocket, pack, or purse and find your missing wallet. Adding a SwitchBot Wallet Finder is a remedy to a common problem that fits the pocketbook – pun intended!  ???? What is it? The SwitchBot Wallet Finder card is a Bluetooth device that […]

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This is more like one of those hack and slash Musou type games for anyone that isn't usually interested in Fire Emblem. Metacritic 80 with an 89 user score.

Mark Fisher was co-founder of the Rhode Island chapter of BLM. He voted for Joe Biden in 2020. Does he have buyers remorse? Yeah, you could say so. His viral video is causing a stir... but there's more to that story.

The post Former BLM Chapter Co-Founder Switches To Trump In ’24 … What Changed His Mind? appeared first on Clash Daily.

Recent studies have suggested that innate immune responses exhibit characteristics associated with memory linked to modulations in both vertebrates and invertebrates. However, the diverse evolutionary paths taken, particularly within the invertebrate taxa, should lead to similarly diverse innate immunity memory processes. Our understanding of innate immune memory in invertebrates primarily comes from studies of the fruit fly Drosophila melanogaster, the generality of which is unclear. Caenorhabditis elegans typically inhabits soil harboring a variety of fatal microbial pathogens; for this invertebrate, the innate immune system and aversive behavior are the major defensive strategies against microbial infection. However, their characteristics of immunological memory remains infantile. Here we discovered an immunological memory that promoted avoidance and suppressed innate immunity during reinfection with bacteria, which we revealed to be specific to the previously exposed pathogens. During this trade-off switch of avoidance and innate immunity, the chemosensory neurons AWB and ADF modulated production of serotonin and dopamine, which in turn decreased expression of the innate immunity-associated genes and led to enhanced avoidance via the downstream insulin-like pathway. Therefore, our current study profiles the immune memories during C. elegans reinfected by pathogenic bacteria and further reveals that the chemosensory neurons, the neurotransmitter(s), and their associated molecular signaling pathways are responsible for a trade-off switch between the two immunological memories.

After ejaculation, mammalian spermatozoa must undergo a process known as capacitation in order to successfully fertilize the oocyte. Several post-translational modifications occur during capacitation, including sialylation, which despite being limited to a few proteins, seems to be essential for proper sperm-oocyte interaction. Regardless of its importance, to date, no single study has ever identified nor quantified which glycoproteins bearing terminal sialic acid (Sia) are altered during capacitation. Here we characterize sialylation during mouse sperm capacitation. Using tandem MS coupled with liquid chromatography (LC–MS/MS), we found 142 nonreductant peptides, with 9 of them showing potential modifications on their sialylated oligosaccharides during capacitation. As such, N-linked sialoglycopeptides from C4b-binding protein, endothelial lipase (EL), serine proteases 39 and 52, testis-expressed protein 101 and zonadhesin were reduced following capacitation. In contrast, mitochondrial aconitate hydratase (aconitase; ACO2), a TCA cycle enzyme, was the only protein to show an increase in Sia content during capacitation. Interestingly, although the loss of Sia within EL (N62) was accompanied by a reduction in its phospholipase A₁ activity, a decrease in the activity of ACO2 (i.e. stereospecific isomerization of citrate to isocitrate) occurred when sialylation increased (N612). The latter was confirmed by N612D recombinant protein tagged with both His and GFP. The replacement of Sia for the negatively charged Aspartic acid in the N612D mutant caused complete loss of aconitase activity compared with the WT. Computer modeling show that N612 sits atop the catalytic site of ACO2. The introduction of Sia causes a large conformational change in the alpha helix, essentially, distorting the active site, leading to complete loss of function. These findings suggest that the switch from oxidative phosphorylation, over to glycolysis that occurs during capacitation may come about through sialylation of ACO2.

Bilingual individuals demonstrate different personality characteristics when speaking different languages. Marketers making media and language decisions when addressing multilingual markets should add this finding to their list of influencing factors.

The post Cultural Frame Switching: Different Language, Different Personality appeared first on Neuromarketing.

Two rural North Dakota school districts will switch to a four-day school week to save costs and improve student and teacher morale.

The Kyoto museum will feature interactive exhibits, gaming artifacts, workshop spaces and oversized controllers inspired by iconic video games

Company purchases 80 licenses of SolidWorks after benchmark testing demonstrates 3x to 7x performance advantage

Monorail and plant automation company uses SolidWorks software to work faster and smarter, and detect collisions earlier

New 3D CAD software increases productivity, quality, and efficiency

Software will ease design of complex surfaces, speed innovations to market

North America's largest supplier of switches, plugs, lighting management systems, etc. to standardize on 300 licenses of SOLIDWORKS 3D CAD software

A kill switch can help prevent your privacy from being breached when your encrypted VPN connection stops working. This is why your VPN needs it.

The Transform outreach team in Durres witnesses God's light over the city.

Hi,

I need to design EPC8002 eGaN switch in cadence. Can someone provide me step by step guide on hoe to add EPC8002 into my cadence. I am working on BCD180.

Thank you 

Ihsan

Hello everyone,

I hope you're all doing well. I’ve set up two testbenches (TB1 and TB2) for my Design Under Test (DUT) using Cadence IC6.1.8-64b.500.21 tools, as shown in the attached figure. The DUT has multiple views available: schematic, Calibre, Maestro, and Symbol, and each testbench uses the same DUT in different scenarios. Currently, I have to manually switch between these views, but I would like to streamline this process.

My goal is to use a single config view that allows me to switch between the schematic and the extracted (Calibre) views. Ideally, I would like to have a configuration file where making changes once would update both testbenches (TB1 and TB2) automatically. In other words, when I modify one config, both testbenches should reflect this update for a single simulation run.

I would really appreciate it if you could guide me on the following:

1. How to create a config view for my DUT that can be used to easily switch between the schematic and extracted views, impacting both TB1 and TB2.
2. Where to specify view priorities or other settings to control which view is used during simulation.
3. Best practices for using a config file in this scenario, so that it ensures consistency across multiple testbenches.

Please refer to the attached figure to get a better understanding of the setup I’m using, where both TB1 and TB2 include the same DUT with multiple available views.

Thank you so much for your time and assistance!

Qatar is arguing that it won’t act as a mediator any longer, threatening the fate of the hostages because a deal would be harder without Doha in the middle.

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