What makes a website effective? Is it the design? Is it the copy? Is it the speed? Yes, yes, and yes. But honestly, focusing on design, copy, and speed singularly gets you nowhere. You need to take a more holistic approach and think critically about the entire user experience of your website. That’s what we’re […]

The post 21 Sites That Pay You $400 Weekly to Write Short Stories appeared first on DailyBlogTips.com.

The Nedstat Sitestat counter was installed on the workshop Web site. Nedstat are a sponsor of the workshop and will be taking part in one of the parallel sessions. [2005-05-20]

Creative Composites Group's acquisition of Enduro will add to CCGs suite of manufacturing capabilities and geographic reach.

Richard L. Sites discusses his new book Understanding Software Dynamics, which offers expert methods and advanced tools for understanding complex, time-constrained software dynamics in order to improve reliability and performance. Philip Winston spoke with Sites about the five fundamental computing resources CPU, Memory, Disk, Network, and Locks, as well as methods for observing and reasoning when investigating performance problems using the open-source utility KUtrace.

Best psychological information resource websites and sites of distinction selected by Dr. William E. Benet.

WARSAW / BUCHAREST, 2 August 2016 – Michael Georg Link, Director of the OSCE Office for Democratic Institutions and Human Rights (ODIHR) and Ambassador Mihnea Constantinescu, Chair of the International Holocaust Remembrance Alliance (IHRA), called today for greater efforts to protect endangered memorial sites related to the Roma and Sinti genocide during World War II.

Speaking on the occasion of the commemoration of the liquidation of the “Gypsy family camp” at Auschwitz-Birkenau in 1944, when the close to 3,000 remaining Roma and Sinti in the camp were murdered, they stressed that states have to do more to demonstrate their sincere and strong commitment to education about and remembrance of the genocide.

“Positively, we have seen increasing attention in recent years on the part of OSCE participating States to commemorate the Roma and Sinti genocide, and to educate people about this horrible event. This practice and these experiences should be widely shared and replicated,” Director Link said. “Promoting understanding of the Holocaust and its effect on different communities can help to create empathy and promote equality and non-discrimination for all.”

“Accurate and ethical education about the Holocaust includes the respectful and dignified preservation of memorial sites,” said Ambassador Constantinescu. “States have to take resolute action to protect endangered memorial sites and continue to do more to commemorate the Roma and Sinti victims. The history of these endangered sites should be included as part of broader efforts to educate about the consequences of indifference to racism.”

They called on governments to ensure that endangered memorial sites for Roma and Sinti victims are preserved and protected, to include this history as an integral part of civic and human rights education in their countries. They stressed that current developments, including a disturbing rise in xenophobic public rhetoric and racism, mean it is even more essential to build strong alliances among different communities.

In 2003, with the Action Plan on Improving the Situation of Roma and Sinti within the OSCE Area, the OSCE participating States committed themselves to strengthen education about the Roma and Sinti genocide. Through its Contact Point for Roma and Sinti Issues, ODIHR promotes knowledge about and recognition of the plight of Roma and Sinti during the Holocaust to counter present-day discrimination and racism, and to promote tolerance. According to ODIHR’s recent publication Teaching about and Commemorating the Roma and Sinti Genocide: Practices within the OSCE Area, seven OSCE participating States officially commemorate the Roma and Sinti genocide on 2 August, while a larger number of states commemorate the Roma and Sinti victims on the International Holocaust Memorial Day, 27 January.

The International Holocaust Remembrance Alliance is an inter-governmental organization and the foremost international network of political leaders and professionals advancing and shaping Holocaust education, remembrance and research. Its 31 member countries are committed to the tenets of the Stockholm Declaration. The IHRA Committee on the Genocide of the Roma aims to increase the commitment of IHRA Member Countries to educate, research and commemorate the genocide of the Roma.

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WARSAW / BUCHAREST, 2 August 2016 – Michael Georg Link, Director of the OSCE Office for Democratic Institutions and Human Rights (ODIHR) and Ambassador Mihnea Constantinescu, Chair of the International Holocaust Remembrance Alliance (IHRA), called today for greater efforts to protect endangered memorial sites related to the Roma and Sinti genocide during World War II.

Speaking on the occasion of the commemoration of the liquidation of the “Gypsy family camp” at Auschwitz-Birkenau in 1944, when the close to 3,000 remaining Roma and Sinti in the camp were murdered, they stressed that states have to do more to demonstrate their sincere and strong commitment to education about and remembrance of the genocide.

“Positively, we have seen increasing attention in recent years on the part of OSCE participating States to commemorate the Roma and Sinti genocide, and to educate people about this horrible event. This practice and these experiences should be widely shared and replicated,” Director Link said. “Promoting understanding of the Holocaust and its effect on different communities can help to create empathy and promote equality and non-discrimination for all.”

“Accurate and ethical education about the Holocaust includes the respectful and dignified preservation of memorial sites,” said Ambassador Constantinescu. “States have to take resolute action to protect endangered memorial sites and continue to do more to commemorate the Roma and Sinti victims. The history of these endangered sites should be included as part of broader efforts to educate about the consequences of indifference to racism.”

They called on governments to ensure that endangered memorial sites for Roma and Sinti victims are preserved and protected, to include this history as an integral part of civic and human rights education in their countries. They stressed that current developments, including a disturbing rise in xenophobic public rhetoric and racism, mean it is even more essential to build strong alliances among different communities.

In 2003, with the Action Plan on Improving the Situation of Roma and Sinti within the OSCE Area, the OSCE participating States committed themselves to strengthen education about the Roma and Sinti genocide. Through its Contact Point for Roma and Sinti Issues, ODIHR promotes knowledge about and recognition of the plight of Roma and Sinti during the Holocaust to counter present-day discrimination and racism, and to promote tolerance. According to ODIHR’s recent publication Teaching about and Commemorating the Roma and Sinti Genocide: Practices within the OSCE Area, seven OSCE participating States officially commemorate the Roma and Sinti genocide on 2 August, while a larger number of states commemorate the Roma and Sinti victims on the International Holocaust Memorial Day, 27 January.

The International Holocaust Remembrance Alliance is an inter-governmental organization and the foremost international network of political leaders and professionals advancing and shaping Holocaust education, remembrance and research. Its 31 member countries are committed to the tenets of the Stockholm Declaration. The IHRA Committee on the Genocide of the Roma aims to increase the commitment of IHRA Member Countries to educate, research and commemorate the genocide of the Roma.

Related Stories

• OSCE/ODIHR Director concerned about reported rise of hate incidents in the United Kingdom, supports calls for tolerance in a challenging time
• OSCE/ODIHR Director Michael Link expresses shock over Orlando shootings, commends calls for unity in face of hatred and terror
• OSCE workshop in Kosovo focuses on improving the recording of hate crimes

Use of ICTsites to support environmental sensing

Smart energy solution for telecom sites

Many online shopping sites offer free international shipping, which can save you a fortune when shopping online! Here are 20.

The U.S. Office of Public Affairs issued a statement on 4 September 2024 regarding the seizure of 32 websites that are believed to be part of the so-called "Doppelganger" campaign.

People often contract schistosomiasis through water contaminated with infected snails and feces.

Location: Electronic Resource- 

Location: Engineering Library- QC463.P5S64 2016

Location: Engineering Library- TA409.L346 2016

Location: Electronic Resource- 

Santa Clara County fraudster Dennis Fountaine fled sentencing last month. Fountaine was convicted of three felony counts of grand theft by fraud. He also admitted to the aggravated white-collar enhancement for defrauding four victims of over $350,000.

Scientists modified Toxoplasma gondii to deliver a potential Rett Syndrome therapeutic to the mouse brain. 

Researchers found that Toxoplasma gondii increased the host cell’s metabolic activity, offering insights into potential treatment strategies. 

State Rep. Jenny Graham (R-Spokane) called me on my cellphone the day the Inlander published my story about her unwittingly linking to conspiracy theory posts on Facebook. I called her back immediately — while she was still leaving a voicemail — and was greeted with two blasts of profanity. "You cocksucker!…

Pupils from St Columba’s Catholic Primary School received a lesson in site safety from local housebuilder St. Modwen Homes;

Happy New Year. Please check out all the new shows and their websites:

18 to Life

Republic of Doyle

Death Comes to Town - Kids in the Hall

One of the most significant cultural events in all of Africa is about to take place in the Kingdom of Eswatini, the southern African nation formerly known as Swaziland.

The People for a New America organization has announced the inaugural Unity, Peace & Freedom Festival

Center for Biological Diversity is suing sued the state health department over two Crestone Peak sites.

Why do you Place Social Buttons on a Website? During a discussion on LinkedIn, a gentleman posed the question about not being able to understand the reason social media buttons are on main business websites. I thought it might be nice to cover some of the main purposes of social media strategies and what can […]

Okay, recently there has been some discussion surrounding the Google Authorship and Publisher topic. So I figured what a great time to cover another article for the topic since it has been part of an update being done for some websites I am working on. First off, there has been some more talk about the […]

Modern commerce is a highly complex global business that is always evolving – and the pace of change is only accelerating. If you work in digital commerce, it’s crucial to stay up-to-date with the latest developments in technology, business, shopper behavior and trends, laws and regulations, payments, logistics and more. How can you stay on […]

If you run an eCommerce website, you may prefer to use a graphic as the call-to-action button for your subscription-style products or services. Below you can find a number of different subscription buttons suitable for use on a website’s landing page or the product page. Want some Buy Now button or Add to Cart button […]

The post Subscription Button Graphics for eCommerce Websites appeared first on Tips and Tricks HQ.

In this blog post, you can find a range of different ‘Buy Now’ buttons that can be used on a website as the ‘call-to-action’ button for a product or service you are trying to sell. There is a range of different size buttons, in a number of different colors to fit with the aesthetics of […]

The post Buy Now Button Graphics for eCommerce Websites appeared first on Tips and Tricks HQ.

Ivan Matic
Jan 1, 2008; 7:132-144
Research

Yi Zhang
Sep 1, 2005; 4:1240-1250
Research

Sebastian A. Wagner
Oct 1, 2011; 10:M111.013284-M111.013284
Research

Yu Xue
Sep 1, 2008; 7:1598-1608
Research

The life cycle of malaria parasites in both their mammalian host and mosquito vector consists of multiple developmental stages that ensure proper replication and progeny survival. The transition between these stages is fueled by nutrients scavenged from the host and fed into specialized metabolic pathways of the parasite. One such pathway is used by Plasmodium falciparum, which causes the most severe form of human malaria, to synthesize its major phospholipids, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine. Much is known about the enzymes involved in the synthesis of these phospholipids, and recent advances in genetic engineering, single-cell RNA-Seq analyses, and drug screening have provided new perspectives on the importance of some of these enzymes in parasite development and sexual differentiation and have identified targets for the development of new antimalarial drugs. This Minireview focuses on two phospholipid biosynthesis enzymes of P. falciparum that catalyze phosphoethanolamine transmethylation (PfPMT) and phosphatidylserine decarboxylation (PfPSD) during the blood stages of the parasite. We also discuss our current understanding of the biochemical, structural, and biological functions of these enzymes and highlight efforts to use them as antimalarial drug targets.

Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins. In vivo, proteolysis may modulate amyloidogenesis and fibril stability. In light chain (AL) amyloidosis, fragmented light chains (LCs) are abundant components of amyloid deposits; however, site and timing of proteolysis are debated. Identification of the N and C termini of LC fragments is instrumental to understanding involved processes and enzymes. We investigated the N and C terminome of the LC proteoforms in fibrils extracted from the hearts of two AL cardiomyopathy patients, using a proteomic approach based on derivatization of N- and C-terminal residues, followed by mapping of fragmentation sites on the structures of native and fibrillar relevant LCs. We provide the first high-specificity map of proteolytic cleavages in natural AL amyloid. Proteolysis occurs both on the LC variable and constant domains, generating a complex fragmentation pattern. The structural analysis indicates extensive remodeling by multiple proteases, largely taking place on poorly folded regions of the fibril surfaces. This study adds novel important knowledge on amyloid LC processing: although our data do not exclude that proteolysis of native LC dimers may destabilize their structure and favor fibril formation, the data show that LC deposition largely precedes the proteolytic events documentable in mature AL fibrils.

Mass spectrometry-based glycoproteomics has gone through some incredible developments over the last few years. Technological advances in glycopeptide enrichment, fragmentation methods, and data analysis workflows have enabled the transition of glycoproteomics from a niche application, mainly focused on the characterization of isolated glycoproteins, to a mature technology capable of profiling thousands of intact glycopeptides at once. In addition to numerous biological discoveries catalyzed by the technology, we are also observing an increase in studies focusing on global protein glycosylation and the relationship between multiple glycosylation sites on the same protein. It has become apparent that just describing protein glycosylation in terms of micro- and macro-heterogeneity, respectively the variation and occupancy of glycans at a given site, is not sufficient to describe the observed interactions between sites. In this perspective we propose a new term, meta-heterogeneity, to describe a higher level of glycan regulation: the variation in glycosylation across multiple sites of a given protein. We provide literature examples of extensive meta-heterogeneity on relevant proteins such as antibodies, erythropoietin, myeloperoxidase and a number of serum and plasma proteins. Furthermore, we postulate on the possible biological reasons and causes behind the intriguing meta-heterogeneity observed in glycoproteins.

O-GlcNAcylation, the addition of a single N-acetylglucosamine residue to serine and threonine residues of cytoplasmic, nuclear, or mitochondrial proteins, is a widespread regulatory post-translational modification. It is involved in response to nutritional status and stress and its dysregulation is associated with diseases ranging from Alzheimer’s to diabetes.  While the modification was first detected over thirty-five years ago, research into the function of O-GlcNAcylation has accelerated dramatically in the last ten years due to the development of new enrichment and mass spectrometry techniques that facilitate its analysis.  This article summarizes methods for O-GlcNAc enrichment, key mass spectrometry instrumentation advancements, particularly those that allow modification site localization, and software tools that allow analysis of data from O-GlcNAc modified peptides.

Oct. 24, 2024 — The San Diego Supercomputer Center (SDSC), part of the School of Computing, Information and Data Sciences at UC San Diego, has been leading the Open Storage Network (OSN) program for years, and along […]

The post SDSC Leads Expansion of Open Storage Network to More Campus Computing Sites appeared first on HPCwire.

Three sites in China - an ancient tea-producing area, a nomadic livestock-rearing region and a rain-fed stone terrace farming system - were formally recognised  as Globally Important Agricultural Heritage [...]

Rome - Two new sites in Japan - an inland fisheries and associated paddy farming system centred on the country’s largest lake and a traditional fruit-growing area  believed to have been the [...]

Rome – The newly released Annual Report for 2020, 2021 and 2022 raises the visibility of the Organization's Resource Partners, including FAO Members, international financial institutions (IFIs), United Nations entities, [...]

Indonesia and Sao Tome and Principe receive their first designations from FAO along with Austria’s second system

Pathogens are more common in polar bears living in the Chukchi Sea now than they were three decades ago, a new study suggests—but it's not yet clear what that means for the mammals' health

The U.S. Department of Justice has received reports that fraudsters are creating websites mimicking unemployment benefit websites, including state workforce agency (SWA) websites, and Facebook pages to unlawfully capture consumers’ personal information.   To lure consumers to these fake websites, fraudsters send spam text messages and emails purporting to be from an SWA and containing […]

Effective June 1, outdoor gatherings of more than 25 people will be permitted at Delaware’s state forests, subject to compliance with the Division of Public Health's "Guidance on Outdoor Gatherings." While the state's ban on short-term rentals will be lifted on June 1, camping at Blackbird State Forest and Redden State Forest, as well as the Redden Lodge, will be closed to the public until further notice. Plans are underway to implement a new online, fee-based reservation system expected to be operational later this summer. There is no fixed date on the launch of the new system, which will include the addition of two new camp sites each at both Blackbird and Redden. The new system will also handle advance bookings for the popular and historic Redden Lodge. Users can make camping and lodge reservations for future dates, receive electronic confirmations, and make payments and receive refunds via credit card.