Marcus Weldon, chief technology officer of Nokia and president of its research arm Nokia Bell Labs, talks about what guided the decision to set up a new global R&D centre and the company’s strategy for driving innovation.

ENGIE Storage has announced it will supply and operate a 19 MW/38 MWh portfolio of six energy storage sites that will contribute to the Solar Massachusetts Renewable Target Program and participate in ISO-New England wholesale markets.

Crowdfunding has become a popular tool for people and organizations to use to test out their new ideas for green products while securing funds to begin operations. The most well-known crowdfunding websites, Kickstarter and Indiegogo, have helped a significant amount of projects in renewable energy and sustainability get off the ground, projects that have been the focus of previous installments in my ongoing articles series about crowdfunding in energy.

ENGIE Storage has announced it will supply and operate a 19 MW/38 MWh portfolio of six energy storage sites that will contribute to the Solar Massachusetts Renewable Target Program and participate in ISO-New England wholesale markets.

Through its exclusive distributor in China, Puxing Energy, NEC developed two 9-MW battery facilities providing frequency regulation for the Hang-Jin and Feng-Run power plants located in Ordos City, Neimongol Province and Tanshan City.

Newly released figures from Zap-Map, a charging point platform, reveal that the number of public charging locations in the country has now surpassed the number of petrol stations.

ENGIE Storage has announced it will supply and operate a 19 MW/38 MWh portfolio of six energy storage sites that will contribute to the Solar Massachusetts Renewable Target Program and participate in ISO-New England wholesale markets.

Through its exclusive distributor in China, Puxing Energy, NEC developed two 9-MW battery facilities providing frequency regulation for the Hang-Jin and Feng-Run power plants located in Ordos City, Neimongol Province and Tanshan City.

Turkey has been the host to many ancient civilizations and empires for ages. Its heritage can be seen in its preserved sites, inscribed on the UNESCO World Heritage List. Some of them remain largely undiscovered, though. Click through for our list, prepared by İnci Hazal Özcan, including the 16 UNESCO sites in Turkey that you should --but probably did not-- see. (Photos: Alamy)

From the Black Sea region to the serene beauty of the Aegean and the Mediterranean, Turkey offers picturesque camping sites for those seeking a budget-friendly holiday in the wilderness. Click through for our list, prepared by İnci Hazal Özcan, including the best ten camping sites in Turkey that you should know about:

ABSTRACT

Bacteria harbor viruses called bacteriophages that, like all viruses, co-opt the host cellular machinery to replicate. Although this relationship is at first glance parasitic, there are social interactions among and between bacteriophages and their bacterial hosts. These social interactions can take on many forms, including cooperation, altruism, and cheating. Such behaviors among individuals in groups of bacteria have been well described. However, the social nature of some interactions between phages or phages and bacteria is only now becoming clear. We are just beginning to understand how bacteriophages affect the sociobiology of bacteria, and we know even less about social interactions within bacteriophage populations. In this review, we discuss recent developments in our understanding of bacteriophage sociobiology, including how selective pressures influence the outcomes of social interactions between populations of bacteria and bacteriophages. We also explore how tripartite social interactions between bacteria, bacteriophages, and an animal host affect host-microbe interactions. Finally, we argue that understanding the sociobiology of bacteriophages will have implications for the therapeutic use of bacteriophages to treat bacterial infections.

ABSTRACT

The protozoan parasites that cause malaria infect a wide variety of vertebrate hosts, including birds, reptiles, and mammals, and the evolutionary pressures inherent to the host-parasite relationship have profoundly shaped the genomes of both host and parasite. Here, we report that these selective pressures have resulted in unexpected alterations to one of the most basic aspects of eukaryotic biology, the maintenance of genome integrity through DNA repair. Malaria parasites that infect humans continuously generate genetic diversity within their antigen-encoding gene families through frequent ectopic recombination between gene family members, a process that is a crucial feature of the persistence of malaria globally. The continuous generation of antigen diversity ensures that different parasite isolates are antigenically distinct, thus preventing extensive cross-reactive immunity and enabling parasites to maintain stable transmission within human populations. However, the molecular basis of the recombination between gene family members is not well understood. Through computational analyses of the antigen-encoding, multicopy gene families of different Plasmodium species, we report the unexpected observation that malaria parasites that infect rodents do not display the same degree of antigen diversity as observed in Plasmodium falciparum and appear to undergo significantly less ectopic recombination. Using comparative genomics, we also identify key molecular components of the diversification process, thus shedding new light on how malaria parasites balance the maintenance of genome integrity with the requirement for continuous genetic diversification.

IMPORTANCE Malaria remains one of the most prevalent and deadly infectious diseases of the developing world, causing approximately 228 million clinical cases and nearly half a million deaths annually. The disease is caused by protozoan parasites of the genus Plasmodium, and of the five species capable of infecting humans, infections with P. falciparum are the most severe. In addition to the parasites that infect people, there are hundreds of additional species that infect birds, reptiles, and other mammals, each exquisitely evolved to meet the specific challenges inherent to survival within their respective hosts. By comparing the unique strategies that each species has evolved, key insights into host-parasite interactions can be gained, including discoveries regarding the pathogenesis of human disease. Here, we describe the surprising observation that closely related parasites with different hosts have evolved remarkably different methods for repairing their genomes. This observation has important implications for the ability of parasites to maintain chronic infections and for the development of host immunity.

While flagella have been studied extensively as motility organelles, with a focus on internal structures such as the axoneme, more recent research has illuminated the roles of the flagellar surface in a variety of biological processes. Parasitic protists of the order Kinetoplastida, which include trypanosomes and Leishmania species, provide a paradigm for probing the role of flagella in host-microbe interactions and illustrate that this interface between the flagellar surface and the host is of paramount importance. An increasing body of knowledge indicates that the flagellar membrane serves a multitude of functions at this interface: attachment of parasites to tissues within insect vectors, close interactions with intracellular organelles of vertebrate cells, transactions between flagella from different parasites, junctions between the flagella and the parasite cell body, emergence of nanotubes and exosomes from the parasite directed to either host or microbial targets, immune evasion, and sensing of the extracellular milieu. Recent whole-organelle or genome-wide studies have begun to identify protein components of the flagellar surface that must mediate these diverse host-parasite interactions. The increasing corpus of knowledge on kinetoplastid flagella will likely prove illuminating for other flagellated or ciliated pathogens as well.

Background:

Historically, some chiropractors have been critical of vaccination, and this has been the subject of recent media attention in Canada. We explored the association between media attention and public dissemination of vaccination information on Canadian chiropractors’ websites.

The new complexes Zn(ITZ)₂Cl₂ (1) and Zn(ITZ)₂(OH)₂ (2) were synthetized by a reaction of itraconazole with their respective zinc salts under reflux. These Zn-ITZ complexes were characterized by elemental analyses, molar conductivity, mass spectrometry, ¹H and ¹³C{¹H} nuclear magnetic resonance, and UV-vis and infrared spectroscopies. The antiparasitic and antifungal activity of Zn-ITZ complexes was evaluated against three protozoans of medical importance, namely, Leishmania amazonensis, Trypanosoma cruzi, and Toxoplasma gondii, and two fungi, namely, Sporothrix brasiliensis and Sporothrix schenckii. The Zn-ITZ complexes exhibited a broad spectrum of action, with antiparasitic and antifungal activity in low concentrations. The strategy of combining zinc with ITZ was efficient to enhance ITZ activity since Zn-ITZ-complexes were more active than the azole alone. This study opens perspectives for future applications of these Zn-ITZ complexes in the treatment of parasitic diseases and sporotrichosis.

The repetitive immunization at multiple sites (RIMMS) protocol capitalizes on the animal's innate immune system, which is genetically preprogrammed to recognize many antigens. By repetitively immunizing the animal, B cells that recognize the antigen are kept continuously expanding until the lymph nodes are harvested for hybridoma generation. This is a good method for making a more diverse repertoire of antibodies or antibodies directed against conformational epitopes.

Parasites are a huge global treat to human life, but some of them could actually help us treat disease. Parasitologist Charlotte Evans explores the secret lives of these frightening organisms.

Hulu debuts Solar Opposites, a new animated sitcom created by Rick and Morty's Justin Roiland and Mike McMahan, but don't expect more of the same.

Coronavirus crisis has forced musicians and others to adapt, says founder of platform

Musicians, artists and writers have turned to crowdfunding sites to make up for lost opportunities in lockdown, and their audiences have followed them, leading to a rise in contributions through platforms such as Patreon.

Since mid-March more than 70,000 extra creators have joined Patreon, which allows fans to give monthly payments to artists in exchange for exclusive content or simply out of a desire to support someone whose work they appreciate.

"Do not sell my info" links popped up on websites New Year's Day as companies scrambled to comply with California's sweeping new consumer privacy protection law.

Global coronavirus vaccine makers have been rolling out details about their manufacturing and launch plans—even ahead of any clinical data. Now, Pfizer says it will draw on three sites in the U.S., plus one in Belgium, for the early stages of a launch, provided its BioNTech-partnered shot wins a green light.

Timothy Kyle Dunaway, 24, of Wichita Falls, Texas, was sentenced today to 41 months in prison by U.S. District Court Judge Reed O’Connor in Wichita Falls for selling counterfeit computer software through the Internet in violation of criminal copyright infringement laws. The software sold by Dunaway had a combined retail value of more than $1 million.

A Middlesex, N.J., industrial pipes, valves and fittings supply company and its co-owner pleaded guilty today to participating in a fraud conspiracy at two U.S. Environmental Protection Agency (EPA)-designated Superfund sites in New Jersey. The sites are Federal Creosote, located in Manville, N.J., and Diamond Alkali, located in Newark, N.J.

A Newark grand jury indicted three individuals for their participation in fraud and kickback conspiracies related to contracts at a U.S. Environmental Protection Agency (EPA)-designated Superfund site, Federal Creosote, located in Manville, N.J.

"We are pleased to announce an important step in our ongoing efforts to protect the interests and safety of consumers, to ensure the strength of our markets, and to safeguard the intellectual property rights of innovators and entrepreneurs."

A Romanian man pleaded guilty today before U.S. District Judge Matthew F. Kennelly in Chicago to one count each of wire fraud and conspiracy for his role in moving and hiding the illicit proceeds of an international fraud scheme.

A Romanian man was sentenced today to 48 months in prison for his role in moving and hiding the illicit proceeds of an international fraud scheme.