The EPA’s current framework for evaluating the scientific evidence used to set national air quality standards is effective, reliable, and scientifically defensible, according to a new National Academies report.

In a new NAE Perspective, authors Barbara B. Simons and Poorvi L. Vora argue that systematic manual examination of ballots, rigorous ballot accounting procedures, and public compliance audits would increase election transparency and are urgently needed.

Helping California's Youth and Community Organizations Build Healthier Futures with Proven, Evidence-Based Programs

Continuing our election-eve counterprogramming, here’s another post with no political content. It comes from Constantine Frangakis, who writes: I think I have found something new and interesting. In studying the topic of “evidence” for my class, where the typical principles … Continue reading →

The Nebraska Court of Appeals upheld the denial of a worker’s claim because she failed to demonstrate a causal connection between her alleged injuries and her workplace accident. Case: Chavez v. Tyson…

The Hawaii Supreme Court ruled that the Department of Labor and Industrial Relations cannot reject an appeal as untimely based on its “sent” date for a decision without direct evidence that…

A trial court did not abuse its discretion when it reviewed new medical reports finding that a man was unable to return to work and in ordering San Francisco’s retirement system to…

West Virginia’s Intermediate Court of Appeals overturned the closure of a worker’s claim and ordered that additional evidence be developed as to his preexisting conditions and whether they contributed to his…

"Work Comp Matters" - the central location for all your workers' compensation, employment and labor law matters. Steve Appell hosts this weekly podcast from sunny southern California - presenting some…

Litigation Strategies for Developing the Issue of Accurate PD: Theory, Evidence, Negotiation and Trial. Understand how to Litigate a Workers’ Comp Case, when the primary issue is Permanent Disability. This…

This presentation aims to explain the concept and importance of evidence-based medicine (EBM) in managing workplace injuries. Troy Prevot, Director of Strategic Solutions from ODG by MCG, will cover how…

The Montana Workers’ Compensation Court granted summary judgment denying a worker’s request for additional temporary total disability benefits because he failed to offer objective medical findings of his alleged chronic headaches. Case:…

Could a metallic asteroid contain water and what can this teach us about the asteroid’s formation and evolution? This is what a recent study due for

How did a giant impact 4 billion years ago affect Jupiter’s moon, Ganymede? This is what a recent study published in Scientific Reports hopes to addr

How did a giant impact 4 billion years ago affect Jupiter’s moon, Ganymede? This is what a recent study published in Scientific Reports hopes to addr

Two new research studies have demonstrated that bacteria are able to retain and pass down 'memories' of temporary, short changes ...

Two new research studies have demonstrated that bacteria are able to retain and pass down 'memories' of temporary, short changes ...

ETSI releases standard for cyber digital evidence bag to confirm integrity of data in legal proceedings

Sophia Antipolis, 21 April 2020

The ETSI Technical Committee CYBER has recently released a key standard for digital evidence bag (DEB). ETSI TS 103 643 covers “techniques for assurance of digital material used in legal proceedings” and provides a set of extra tools for those wanting to demonstrate the integrity of digital evidence.

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Summary of the findings • We find that the PSNP did not significantly alter the risk of violent events. • However, it had a negative impact on demonstrations (protests and riots) as well as fatalities. • These effects are most pronounced during the period of 2014-18, coinciding with widespread protests in Amhara and Oromia, the […] Source: IFPRI Ethiopia: Ethiopia Strategy Support Program

PSNP is largest public works program in Africa • Started in 2005 in four main highland regions • Approximately 8 million participants • We examine the effect of PSNP on both high-intensity and low-intensity conflict • Using Govt. of Ethiopia administrative PSNP records and geocoded data on conflict events (Armed Conflict Location & Event Data […] Source: IFPRI Ethiopia: Ethiopia Strategy Support Program

Growing consensus in the scientific community indicates that higher temperatures and changing precipitation levels resulting from climate change will depress crop yields in many countries over the coming decades. This is particularly true in low-income countries, where adaptive capacity is low. Many African countries are particularly vulnerable to climate change because their economies largely depend on climate-sensitive agricultural production.

Agricultural production remains the main source of livelihood for rural communities in Sub-Saharan Africa, providing employment to more than 60 percent of the population and contributing about 30 percent of gross domestic product. With likely long-term changes in rainfall patterns and shifting temperature zones, climate change is expected to significantly affect agricultural production, which could be detrimental to the region’s food security and economic growth.

How much does take-up timing for agricultural inputs depend on price? Evidence from an experiment in Nigeria

Insights into buying behavior.

The post How much does take-up timing for agricultural inputs depend on price? Evidence from an experiment in Nigeria appeared first on IFPRI.

Does conflict-driven internal displacement influence demand for agricultural inputs? Evidence from Nigeria

Examining the effectiveness of vouchers and marketing information.

The post Does conflict-driven internal displacement influence demand for agricultural inputs? Evidence from Nigeria appeared first on IFPRI.

Supporting and shaping the global nutrition agenda with evidence: A three-decade journey of research and partnerships for impact

This year’s Forman Lecture will be delivered by Dr. Marie Ruel, Senior Research Fellow in the Nutrition, Diets, and Health Unit at IFPRI. She served as the Director of IFPRI’s Poverty, Health, and Nutrition Division from 2004 to 2023, after serving as Senior Research Fellow and Research Fellow in that division beginning in 1996. Dr. […]

The post Supporting and shaping the global nutrition agenda with evidence: A three-decade journey of research and partnerships for impact appeared first on IFPRI.

Scientists are keen to explore beneath Europa’s thick blanket of ice, and they can do so indirectly by hunting for evidence of activity emanating from below. A new study published in the AGU journal Geophysical Research Letters, did exactly this.

The post New evidence of watery plumes on Jupiter’s moon Europa appeared first on GeoSpace.

The Public Accounts Committee has agreed to invite Arlene Foster MLA to give evidence on its Inquiry into the Non-domestic Renewable Heat Incentive Scheme.

Deputy project scientist Ken Williford shares his hopes about what NASA's latest rover might discover on the Red Planet.

MERT is being marketed to families of children with autism. Providers suggest the treatment has been thoroughly studied, but there is little evidence to date of its efficacy.

Research suggests that the patients of female physicians' fare better on average. But old-fashioned sexism is still a barrier to their success in the profession.

In the wake of the Grenfell Tower fire in London, where 79 people died or are presumed dead and many more were injured, serious concerns and questions around flammability of exterior cladding, the lack of fire sprinklers and the notion of “shelter in place,” among other subjects, have been brought to the forefront by the news media and the public at large. Jim Pauley, president and CEO of the National Fire Protection Association (NFPA), addressed these troubling fire safety issues in the upcoming edition of NFPA Journal, the association’s membership publication, which will be officially released next month.

Report 69 published by the Social Care Institute for Excellence (SCIE) in November 2014. This research, commissioned by the Department of Health (DH), set out to identify what could be learned about current policy and practice in self-neglect, experienced as a highly challenging aspect of contemporary adult social care.

Footprints in New Mexico’s White Sands National Park challenge scientists’ timeline of when humans first came to North America.

UKHSA's Prof Susan Hopkins said respirator masks may have worked no better than thin surgical masks.

Over the past decade, parent advocacy groups led a grassroots movement resulting in most states adopting dyslexia-specific legislation, with many states mandating the use of the Orton-Gillingham (OG) approach to reading instruction. Orton-Gillingham is a direct, explicit, multisensory, structured, sequential, diagnostic, and prescriptive approach to reading for students with or at risk for word-level reading disabilities (WLRD). Evidence from a prior synthesis and What Works Clearinghouse reports yielded findings lacking support for the effectiveness of OG interventions.

Time's arrow may not be as unidirectional as we were led to believe. According to Scientific American, a group of quantum physical researchers at the University of Toronto had observed evidence of what they're calling "negative time"—specifically, of photons exiting a material before they ever entered it, to begin with. — Read the rest

The post Physicists find evidence of "negative time" in photons appeared first on Boing Boing.

Evidence Makgopa wore a sheepish smile when Bafana Bafana coach Hugo Broos showered him with praise before literally patting the forward on the back, making him blush at Dobsonville Stadium.

Cross-border conflict, evidence, policy and trends (XCEPT)

This five-year policy-focused research programme seeks to respond to the challenges of long-term cross-border conflicts by exploring the drivers behind them.

Protracted conflicts in the Middle East and North Africa, Horn of Africa and parts of Asia, although usually arising from intra-state disputes, rarely remain contained within national borders. Their effects reverberate outward and external actors are drawn in.

The longer these wars last, the more difficult they are to resolve as the interests of international actors collide and the web of economic and political interactions which sustain violence and connect conflict across borders expand and deepen.

The Cross-border conflict, evidence, policy and trends (XCEPT) research programme brings together world-leading experts to examine conflict-affected borderlands, how conflicts connect across borders, and the drivers of violent and peaceful behaviour.

Chatham House provides research leadership to the programme, as part of the wider consortium, and our research explores:

• the intersection of conflict supply chains which sustain and embed violence
• coping supply chains for survival-based economic activity which occurs in the context of violence

Three geographic case studies will be supported by cross-cutting workstreams on gender and social inclusion, livelihoods, and border security. Each will produce analysis and recommendations to inform international policy responses to conflict across borders.

These case studies will focus on:

• armed actors and financial flows through Iraq and the Levant
• human smuggling across Libya, East and West Africa
• gold mining and weapons flows across Sudanese borderlands

The consortium is made up of a range of other organizations, including the Asia Foundation, the Malcolm H. Kerr Carnegie Middle East Center, the Rift Valley Institute, Chemonics UK and King’s College London.

XCEPT is funded by UK Aid from the UK government.

CARM1 is a protein arginine methyltransferase (PRMT) that acts as a coactivator in a number of transcriptional programs. CARM1 orchestrates this coactivator activity in part by depositing the H3R17me2a histone mark in the vicinity of gene promoters that it regulates. However, the gross levels of H3R17me2a in CARM1 KO mice did not significantly decrease, indicating that other PRMT(s) may compensate for this loss. We thus performed a screen of type I PRMTs, which revealed that PRMT6 can also deposit the H3R17me2a mark in vitro. CARM1 knockout mice are perinatally lethal and display a reduced fetal size, whereas PRMT6 null mice are viable, which permits the generation of double knockouts. Embryos that are null for both CARM1 and PRMT6 are noticeably smaller than CARM1 null embryos, providing in vivo evidence of redundancy. Mouse embryonic fibroblasts (MEFs) from the double knockout embryos display an absence of the H3R17me2a mark during mitosis and increased signs of DNA damage. Moreover, using the combination of CARM1 and PRMT6 inhibitors suppresses the cell proliferation of WT MEFs, suggesting a synergistic effect between CARM1 and PRMT6 inhibitions. These studies provide direct evidence that PRMT6 also deposits the H3R17me2a mark and acts redundantly with CARM1.

Homologous recombination (HR) repairs DNA double-strand breaks using intact homologous sequences as template DNA. Broken DNA and intact homologous sequences form joint molecules (JMs), including Holliday junctions (HJs), as HR intermediates. HJs are resolved to form crossover and noncrossover products. A mismatch repair factor, MLH3 endonuclease, produces the majority of crossovers during meiotic HR, but it remains elusive whether mismatch repair factors promote HR in nonmeiotic cells. We disrupted genes encoding the MLH3 and PMS2 endonucleases in the human B cell line, TK6, generating null MLH3−/− and PMS2−/− mutant cells. We also inserted point mutations into the endonuclease motif of MLH3 and PMS2 genes, generating endonuclease death MLH3DN/DN and PMS2EK/EK cells. MLH3−/− and MLH3DN/DN cells showed a very similar phenotype, a 2.5-fold decrease in the frequency of heteroallelic HR-dependent repair of restriction enzyme–induced double-strand breaks. PMS2−/− and PMS2EK/EK cells showed a phenotype very similar to that of the MLH3 mutants. These data indicate that MLH3 and PMS2 promote HR as an endonuclease. The MLH3DN/DN and PMS2EK/EK mutations had an additive effect on the heteroallelic HR. MLH3DN/DN/PMS2EK/EK cells showed normal kinetics of γ-irradiation–induced Rad51 foci but a significant delay in the resolution of Rad51 foci and a 3-fold decrease in the number of cisplatin-induced sister chromatid exchanges. The ectopic expression of the Gen1 HJ re-solvase partially reversed the defective heteroallelic HR of MLH3DN/DN/PMS2EK/EK cells. Taken together, we propose that MLH3 and PMS2 promote HR as endonucleases, most likely by processing JMs in mammalian somatic cells.

Wen Grace Chen
Nov 9, 2022; 42:8498-8507
Symposium and Mini-Symposium