Randy L. Buckner
Aug 24, 2005; 25:7709-7717
Neurobiology of Disease

A ring could explain a mysterious arrangement of impact craters near the equator and might even have caused an ice age, according to a new study

The notorious predators, nicknamed the “Man-Eaters of Tsavo,” terrorized railway workers in Kenya for roughly nine months

The deep penetrations suggest that the feline was pressing its claws into the clay, a behavior sometimes known as "making biscuits"

A new study has shattered historians' long-held assumptions about some of the people who died in Mount Vesuvius' eruption in 79 C.E.

Across Canada, there’s a growing number of political leaders proposing to force people into treatment for drug addiction, despite inconclusive evidence about its effectiveness.

Just before Christmas, federal lawmakers sent President Donald Trump the Foundations for Evidenced-Based Policymaking Act of 2017, which aims to improve how federal data is used, shared, and protected.

Teacher Antoinette Pippin engages her 5th grade students in a "Claims, Evidence, Reasoning" protocol. Using what she calls "the trifecta of argument," she helps her students make claims and support their claims with evidence and reasoning.

China’s Zhurong rover has discovered formations on Mars that could signal the remnants of a once vast ocean. Landing in the Utopia Planitia region, the rover identified formations commonly linked to past water presence, supporting the theory that Mars was once home to a massive body of water. While the findings do not offer definitive proof, they bring scientists closer to understanding Mars' history and its potential to support life.

West Nile Virus (WNV) has been detected in Delaware the first time for 2022 in a sentinel chicken, the Delaware Department of Natural Resources and Environmental Control announced today.

West Nile Virus (WNV) has been detected in Delaware the first time for 2023 in a sentinel chicken, DNREC announced today.

West Nile Virus (WNV) has been detected in Delaware for the first time for 2024 in sentinel chickens that help the Department of Natural Resources and Environmental Control monitor the state for mosquito-borne illnesses, DNREC announced today. The initial WNV occurrence was found in eight sentinel chickens sampled July 22 by the DNREC Mosquito Control Section which returned positive test results from the Delaware Division of Public Health Laboratory two days later.

Proceeding to the discovery phase means both parties must collect and exchange evidence.

Does competition enhance productivity growth of a developing economy? Is global competition conducive to economic development? Answers as evidenced from Korean microdata.

This study finds that investing in sanitation not only improved children’s health, but also created valuable time-savings for all household members.

This paper explores how oil price windfalls impact labor market regulation across 83 countries from 1970 to 2014.

This paper examines how booms and busts in peer-to-peer (P2P) lending in the People’s Republic of China (PRC) affect monetary policy transmission to inflation and output.

What anxiety actually is has puzzled scientists for decades. Now we are starting to figure out how it may arise from miscommunication between the body and the brain

Tiny pieces of stone found in a rock formation in Western Australia may be the oldest evidence of a meteorite impact on Earth, dating back nearly 3.5 billion years

Data collected by the Zhurong rover and orbiting satellites suggests the existence of an ancient shoreline in the Utopia Planitia region of Mars

Babies cannot tell us what they are experiencing, so it is hard to know what they are conscious of. But new research suggesting they perceive the world consciously could change how we care for them, says Claudia Passos-Ferreira

Title: More Evidence Virus Plays Role in Chronic Fatigue Syndrome
Category: Health News
Created: 8/23/2010 6:10:00 PM
Last Editorial Review: 8/24/2010 12:00:00 AM

Title: Little Evidence on Value of Treatments for Autism: Report
Category: Health News
Created: 8/28/2012 10:05:00 AM
Last Editorial Review: 8/28/2012 12:00:00 AM

Title: More Evidence Links the 'Mono' Virus to MS Risk
Category: Health News
Created: 8/30/2017 12:00:00 AM
Last Editorial Review: 8/31/2017 12:00:00 AM

Title: More Evidence Ties Stress to Heart Trouble
Category: Health News
Created: 8/28/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM

Title: More Evidence That Masks Help Shield You From Coronavirus
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/26/2020 12:00:00 AM

Title: More Evidence Ties Gum Disease With Heart Disease
Category: Health News
Created: 8/27/2021 12:00:00 AM
Last Editorial Review: 8/27/2021 12:00:00 AM

Title: More Evidence Fitness Trackers Can Boost Your Health
Category: Health News
Created: 7/26/2022 12:00:00 AM
Last Editorial Review: 7/27/2022 12:00:00 AM

Extract

Living with a respiratory illness requires patients to manage a wide range of symptoms, many of which will worsen as a disease progresses. Breathlessness is a hallmark feature of respiratory conditions, occurring in almost all individuals with COPD and interstitial lung disease (ILD) [1, 2]. Cough is present in 78% of people with ILD and is frequently distressing, with physical, social and emotional impacts [1, 3].

Bronchiectasis is a chronic lung condition which is characterised by recurrent chest infections, chronic sputum production and cough, and limited exercise tolerance. While bronchiectasis may be caused by various aetiologies, these features are shared by most patients with bronchiectasis regardless of the cause. This review consolidates the existing evidence on patient-managed interventions for adults with bronchiectasis, while also outlining areas for future research. Airway clearance techniques and hyperosmolar agents are key components of the bronchiectasis management and consistently recommended for clinical implementation. Questions around their prescription, such as optimal sequence of delivery, are still to be answered. Pulmonary rehabilitation and exercise are also recommended for patients with bronchiectasis. Relatively strong evidence underpins this recommendation during a clinically stable stage of the disease, although the role of pulmonary rehabilitation following an exacerbation is still unclear. Additionally, self-management programmes feature prominently in bronchiectasis treatment, yet the lack of consensus regarding their definition and outcomes presents hurdles to establishing a cohesive evidence base. Moreover, cough, a cardinal symptom of bronchiectasis, warrants closer examination. Although managing cough in bronchiectasis may initially appear risky, further research is necessary to ascertain whether strategies employed in other respiratory conditions can be safely and effectively adapted to bronchiectasis, particularly through identifying patient responder populations and criteria where cough may not enhance airway clearance efficacy and its control is needed. Overall, there is a growing recognition of the importance of patient-managed interventions in the bronchiectasis management. Efforts to improve research methodologies and increase research funding are needed to further advance our understanding of these interventions, and their role in optimising patient care and outcomes.

Pleiotropy, measured as expression breadth across tissues, is one of the best predictors for protein sequence and expression conservation. In this study, we investigated its effect on the evolution of cis-regulatory elements (CREs). To this end, we carefully reanalyzed the Epigenomics Roadmap data for nine fetal tissues, assigning a measure of pleiotropic degree to nearly half a million CREs. To assess the functional conservation of CREs, we generated ATAC-seq and RNA-seq data from humans and macaques. We found that more pleiotropic CREs exhibit greater conservation in accessibility, and the mRNA expression levels of the associated genes are more conserved. This trend of higher conservation for higher degrees of pleiotropy persists when analyzing the transcription factor binding repertoire. In contrast, simple DNA sequence conservation of orthologous sites between species tends to be even lower for pleiotropic CREs than for species-specific CREs. Combining various lines of evidence, we propose that the lack of sequence conservation in functionally conserved pleiotropic CREs is owing to within-element compensatory evolution. In summary, our findings suggest that pleiotropy is also a good predictor for the functional conservation of CREs, even though this is not reflected in the sequence conservation of pleiotropic CREs.

Introduction

Exacerbation of COPD complicated by respiratory acidaemia is the commonest indication for noninvasive ventilation (NIV). The NIV outcomes (NIVO) score offers the best estimate of survival for those ventilated. Unfortunately, two-thirds of cases of COPD are unrecognised, and patients may present without COPD having been confirmed by spirometry.

Inositol 1,4,5-triphosphate receptor type 1 (ITPR1) is an endoplasmic reticulum–bound intracellular inositol triphosphate receptor involved in the regulation of intracellular calcium. Pathogenic variants in ITPR1 are associated with spinocerebellar ataxia (SCA) types 15/16 and 29 and have recently been implicated in a facial microsomia syndrome. In this report, we present a family with three affected individuals found to have a heterozygous missense c.800C > T (predicted p.Thr267Met) who present clinically with a SCA29-like syndrome. All three individuals presented with varying degrees of ataxia, developmental delay, and apparent intellectual disability, as well as craniofacial involvement—an uncommon finding in patients with SCA29. The variant was identified using clinical exome sequencing and validated with Sanger sequencing. It is presumed to be inherited via parental germline mosaicism. We present our findings to provide additional evidence for germline mosaic inheritance of SCA29, as well as to expand the clinical phenotype of the syndrome.

Data collected by the Zhurong rover and orbiting satellites suggests the existence of an ancient shoreline in the Utopia Planitia region of Mars

An accurate description of low-density nuclear matter is crucial for explaining the physics of neutron star crusts, according to a team of theoretical physicists led by Argonne National Laboratory’s Dr. Alessandro Lovato.

The post Physicists Find Evidence for Superfluidity in Low-Density Neutron Matter appeared first on Sci.News: Breaking Science News.

Saline drops and sprays have already been linked to reduced cold symptoms in adults and now a study suggests they also work in children

A woman's brain was scanned throughout her pregnancy, adding to the growing body of evidence that dramatic remodelling takes place in preparation for motherhood

Genetic testing on samples collected during the earliest days of the covid-19 outbreak suggests it is likely that the virus spread from animals to humans at the Huanan seafood market

People who went from using social media for at least 2 hours a day to just 30 minutes a day reported no improvement to their sleep or emotional well-being

It didn't take long to see what makes 16-year-old Shola Jimoh a prospect for Canada's men's soccer team. In a frenzied training session on Wednesday, he was always on the attack, always on the balls of his feet, leaving coach Jesse Marsch impressed.

ACON last week released a short video to highlight new evidence in the fight to end HIV by 2020. As part of the ENDING HIV platform, the [TREAT EARLY] campaign was ...

The post Video highlights new evidence to support treating HIV early appeared first on Star Observer.

without evidence, and the responsibility to prove the same lies with the complainant.

Data collected by the Zhurong rover and orbiting satellites suggests the existence of an ancient shoreline in the Utopia Planitia region of Mars

The Intergovernmental Panel on Climate Change, or IPCC, convened for a four-day session on Tuesday to begin the next round of what is known as the assessment cycle.

The post Cause and Effect | ‘Scientist’s job isn’t to negotiate, but to give evidence to govts’: Aditi Mukherji, IWMI first appeared on International Water Management Institute (IWMI).

In the trial of Elizabeth Holmes, prosecutors have shown texts, emails and audio clips portraying her in her own words. WSJ’s Shelby Holliday asked Sara Randazzo about key pieces of evidence and what to expect. Photo: Nick Otto/AFP via Getty Images