discovery

Discovery of new triterpene glycosides from Dendrobium officinale with their α-glucosidase and α-amylase inhibitory activity

RSC Adv., 2024, 14,12147-12157
DOI: 10.1039/D4RA01483A, Paper
Open Access
Pham Hai Yen, Bui Huu Tai, Dan Thi Thuy Hang, Le Doan Tung Lam, Duong Thi Dung, Do Thi Trang, Duong Thi Hai Yen, Nguyen Huy Hoang, Phan Thi Thanh Huong, Nguyen Viet Dung, Ngo Anh Bang, Nguyen Duc Duy, Phan Van Kiem
Seven new oleanane saponins were discovered from Dendrobium officinale. These saponins containing 29-noroleana-12,20(30)-dien-28-oic acid framework, caffeoyl, and coumaroyl moieties potentially inhibited α-glucosidase and α-amylase activities.
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discovery

How discovery platforms are boosting women-run enterprises

Pandemic has hit women entrepreneurs badly — but help is at hand




discovery

Machine Learning Directed Discovery and Optimisation of a Platinum-Catalysed Amide Reduction

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC05273K, Communication
Open Access
Eleonora Casillo, Benon Maliszewski, Cesar Blanco, Thomas Scattolin, Catherine Cazin, Steven P Nolan
The discovery and optimisation of reaction conditions leading to the reduction of amides, a fundamental large-scale industrial reaction, is achieved using a machine learning (ML) platform and a platinum catalyst....
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discovery

Songs of the River Ganga: Shantanu Moitra’s lyrical journey to self-discovery

The six-episode series traces the emotional and spiritual calling of the 55-year-old Bollywood music composer, explores his creative dimension and puts his physical mettle to the test



  • Life & Style

discovery

Discovery of unregulated contaminants in drinking water [electronic resource] : evidence from PFAS and housing prices / Michelle M. Marcus, Rosie Mueller

Cambridge, MA. : National Bureau of Economic Research, 2023




discovery

Scientists make 1st discovery of electronic crystallites in solids




discovery

S. Korean scientists make 1st discovery of electronic crystallites in solids




discovery

Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00015C, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. Mendes
An effective workflow to discover selective saccharide receptors by combining dynamic combinatorial chemistry with isothermal titration calorimetry and NMR.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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discovery

Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00236A, Review Article
Goverdhan Mehta, Saumitra Sengupta, Srihari Pabbaraja
Often referred to as “second genome”, human microbiome is at the epicenter of a complex inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as significant determinant of...
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discovery

Empowering Pharma with AI, Analytics: Accelerating Drug Discovery, Optimizing Healthcare Outcomes By Rajesh Munirathnam

While AI is making significant strides in healthcare, it is also transforming other industries, such as insurance.




discovery

Discovery of excellent ultraviolet nonlinear optical materials in chlorates and bromates with highly stereochemically active lone pairs

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI00462K, Research Article
Chun-Li Hu, Qian-Qian Chen, Fang Kong, Jiang-Gao Mao
The long-neglected stereochemically active lone pair groups ClO3 and BrO3 are demonstrated to be important UV NLO functional motifs based on the fact that AClO3 and ABrO3 possess high SHG effects and short λPM and are promising UV NLO materials.
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discovery

‘India is a great discovery’

Acclaimed violinist Elmira Darvarova cherishes her visits to India and speaks of her encounters with Indian classical music.




discovery

A metabologenomics strategy for rapid discovery of polyketides derived from modular polyketide synthases

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC04174G, Edge Article
Open Access
Run-Zhou Liu, Zhihan Zhang, Min Li, Lihan Zhang
A metabologenomics workflow using mass defect filtering (MDF) and bioinformatics-based structural prediction was established for rapid screening of modular polyketide natural products, and led to the identification of 22 polyketides.
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discovery

Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer’s Disease

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05469E, Edge Article
Open Access
Jennifer Shyong, Jinliang Wang, Tran Quoc Dung Huynh, Marina Fayzullina, Bo Yuan, Ching-Kuo Lee, Thomas Minehan, Paul M. Seidler, Clay Wang
Alzheimer’s Disease (AD) is a neurodegenerative disorder proven to be caused by the aggregation of protein tau into fibrils, resulting in neuronal death. The irreparable neuronal damage leads to irreversible...
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discovery

2024 Land Rover Discovery Sport launched




discovery

Land Rover Discovery Sport: New Discoveries

As a do-it-all SUV, the Land Rover Discovery Sport offers more than its entry-level positioning might suggest




discovery

The role of silicon in drug discovery: a review

RSC Med. Chem., 2024, 15,3286-3344
DOI: 10.1039/D4MD00169A, Review Article
Open Access
Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van Otterlo
This review aims to highlight the role of silicon in drug discovery.
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discovery

Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists

RSC Med. Chem., 2024, 15,3477-3484
DOI: 10.1039/D4MD00266K, Research Article
Raitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps Jaudzems
The aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.
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discovery

Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
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discovery

Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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discovery

A journey of discovery

How you can make the best use of a management education.




discovery

Computational discovery of two-dimensional tetragonal group IV–V monolayers

RSC Adv., 2024, 14,36173-36180
DOI: 10.1039/D4RA06623E, Paper
Open Access
Qiubao Lin, Jungang Huang, Yimei Fang, Feng Zheng, Kaixuan Chen, Shunqing Wu, Zi-Zhong Zhu
Structural prediction of a stable tetragonal Td4 phase of 2D group IV–V monolayers.
The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

Data-driven discovery of electrode materials for protonic ceramic cells

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE03762F, Paper
Open Access
Xueyu Hu, Yucun Zhou, Zheyu Luo, Haoyu Li, Nai Shi, Zhijun Liu, Weilin Zhang, Weining Wang, Yong Ding, Meilin Liu
A schematic representation of a four-stage data-driven material screening methodology, progressing from uncovering unexplored chemical spaces through high-throughput calculations to validating findings in protonic ceramic cells.
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discovery

Water On The Moon: Surprising New Discovery Reveals The Moon Has More Water Than Expected!

New research reveals that the Moon contains far more water than previously thought, surprising scientists and reshaping future lunar exploration plans!




discovery

Celsius Therapeutics launches to tap single-cell genomics for drug discovery




discovery

Discovery of new poppy enzyme might help improve yeast-based opiate synthesis

Adding enzyme to engineered yeast boosts production of thebaine, a key morphine intermediate




discovery

Verge Genomics raises $32 million for machine learning-backed neuroscience drug discovery




discovery

GSK, 23andMe to apply personal genetics to drug discovery

New partnership is part of GSK’s R&D face-lift, which includes an increased focus on immune system targets




discovery

A journey of self discovery

R. Ramoo completes the the gruelling two-day biking challenge set by the Iron Butt Association




discovery

Data-based methods for materials design and discovery: basic ideas and general methods / Ghanshyam Pilania, Prasanna V. Balachandran, James E. Gubernatis, Turab Lookman

Online Resource




discovery

Worms farm germs: Discovery illuminates complex natural relationships

Princeton University researchers have found that the roundworms Caenorhabditis elegans have a sure-fire method of ensuring a steady supply of a bacteria they eat — they grow their own. The worms carry the bacteria Escherichia coli along with them, and drop bacteria along the way to create thriving new bacterial colonies that the worms later return to "harvest" and eat.




discovery

New discovery could end chronic rejection of transplanted organs

Chronic rejection of transplanted organs is the leading cause of transplant failure, and one that the field of organ transplantation has not overcome in almost six decades since the advent of immunosuppressive drugs enabled the field to flourish.




discovery

2019 Land Rover Discovery Sport Review: A powerful and efficient Ingenium diesel heart

As Land Rover gives the final update to the current generation of the Discovery Sport, before the brand new generation model arrives, we try to find out if these new changes allowed the SUV to hold on to its relevancy in the midst of its newer rivals




discovery

Land Rover's new plug-in hybrid Discovery Sport and Evoque

Its 4x4s have long been known for their thirstiness, but now Land Rover is launching two more frugal hybrids models.




discovery

Scientific discovery and the wireless telephone.

Archives, Room Use Only - TK6547.S354 1900




discovery

Chapman's principia, or, Nature's first principles: theory of universal electro-magnetism, simplified: explaining the elements of the important discovery of the laws of nature, which regulate the changes of the elements: exposing the numerous disc

Archives, Room Use Only - QC670.C43 1855




discovery

Immune system discovery paves way to lengthen organ transplant survival: Study




discovery

Breakthrough: The Dramatic Story of the Discovery of Insulin

Recalling the desperate fight for life that used to be waged by juvenile diabetes patients, and commemorating the events of 1921 that inaugurated a new era of hope for them and their families, the New-York Historical Society will present the exhibition Breakthrough: The Dramatic Story of the Discovery of Insulin from October 5, 2010 through January 31, 2011. Exploring the roles of science, government, higher education and industry in developing and distributing a life-saving drug, the exhibition will bring to life the personalities who discovered insulin and raced to bring it to the world and will tell the story of one extraordinary New York girl—Elizabeth Evans Hughes, daughter of the leading statesman and jurist Charles Evans Hughes—who was among the very first patients to be saved.

End Date: 
January 31st, 2011
Oct 5 2010 to Jan 31 2011
Teaser Image: 
Tuesday, October 5, 2010 to Monday, January 31, 2011
Start Date: 
Tuesday, October 5, 2010
Teaser Image Caption: 

Girl injecting herself with insulin (Lilly Girl), 1930. Photograph. Courtesy of Eli Lilly and Company Archives

Recalling the desperate fight for life that used to be waged by juvenile diabetes patients, and commemorating the events of 1921 that inaugurated a new era of hope for them and their families, the New-York Historical Society will present the exhibition Breakthrough: The Dramatic Story of the Discovery of Insulin from October 5, 2010 through January 31, 2011. Exploring the roles of science, government, higher education and industry in developing and distributing a life-saving drug, the exhibition will bring to life the personalities who discovered insulin and raced to bring it to the world and will tell the story of one extraordinary New York girl—Elizabeth Evans Hughes, daughter of the leading statesman and jurist Charles Evans Hughes—who was among the very first patients to be saved.

To lead visitors through this history, from the discovery of insulin in Toronto by Dr. Frederick Banting in 1921 and its first human trials in 1922 to its widespread use today, Breakthrough will feature digital interactives, film, artifacts and ephemera drawn from the Historical Society's own collections and from archives including those of the University of Toronto, Eli Lilly and Company, the Rockefeller Institute, the Joslin Clinic and the New York Academy of Medicine.

The first chapter will recount the excitement, and the clash of personalities, among the scientists whose research led to the discovery of insulin, beginning in May 1921. Also included in this chapter will be an account of the valiant but heartbreaking efforts of Dr. Frederick Allen in the years before the discovery to prolong the lives of diabetic children through the use of a starvation diet. The story of Elizabeth Evans Hughes, told in part through actual treatment charts and period letters, will bring to life the impact of insulin when it first became available. Because Elizabeth was the daughter of Charles Evans Hughes—Governor of New York (1907–1910), Associate Justice of the Supreme Court of the United States (1910–1916), United States Secretary of State (1921–1925) and Chief Justice of the United States (1930–1941)—her survival provided powerful testimony to the value of insulin, and helped bring the work of Dr. Allen and Dr. Banting to the world's stage.

The exhibition's second chapter will examine how insulin became available for widespread medical use through a partnership between the University of Toronto and Eli Lilly and Company—the first such collaboration between an academic institution and a drug company. Photographs from the Lilly archives will reveal the painstaking early method of manufacturing insulin in mass quantities—an innovative industrial process that ran from the slaughterhouse to the laboratory. Display cases of syringes, vials, testing kits for blood sugar and other equipment will take the story of insulin treatment from the 1920s up through today.

The exhibition's final chapter will tell about recent developments—notably the synthesis of insulin in the 1980s as the world's first biotechnology drug—and the current state of research, development, treatment and demography of diabetes. Included in this chapter will be information about the alarming increase in prevalence of Type 1 and Type 2 diabetes in the past decade, and the ways in which individuals, families and institutions can address this health crisis. The exhibition will conclude with a presentation of Life for a Child, a documentary film produced by the International Diabetes Federation and Eli Lilly and Company to raise awareness of the devastating impact of the disease.

Breakthrough will be installed in the Historical Society's 1,300-square-foot temporary gallery, located just off the 77th Street entrance, while the remainder of the landmark Central Park West building undergoes a $60 million architectural renovation.

Resources: 




discovery

Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1

Apoptosis is a crucial process by which multicellular organisms control tissue growth, removal and inflammation. Disruption of the normal apoptotic function is often observed in cancer, where cell death is avoided by the overexpression of anti-apoptotic proteins of the Bcl-2 (B-cell lymphoma 2) family, including Mcl-1 (myeloid cell leukaemia 1). This makes Mcl-1 a potential target for drug therapy, through which normal apoptosis may be restored by inhibiting the protective function of Mcl-1. Here, the discovery and biophysical properties of an anti-Mcl-1 antibody fragment are described and the utility of both the scFv and Fab are demonstrated in generating an Mcl-1 crystal system amenable to iterative structure-guided drug design.




discovery

Discovery triples number of stars in universe

The team discovered that there are about 20 times more red dwarfs in elliptical galaxies than in the Milky Way, said Charlie Conroy of the Harvard-Smithsonian Center for Astrophysics.

The post Discovery triples number of stars in universe appeared first on Smithsonian Insider.




discovery

Evidence of asteroid mining in our galaxy may lead to the discovery of extraterrestrial civilizations

If intelligent and more advanced civilizations exist on other planets then its a good bet that some of these civilizations turned to asteroid mining long ago. If so, the hallmarks of their mining activities, such as unusual dirty halos of cast-off dust and debris around large asteroids, might be detectable from earth.

The post Evidence of asteroid mining in our galaxy may lead to the discovery of extraterrestrial civilizations appeared first on Smithsonian Insider.




discovery

Space shuttle Discovery to be added to National Air and Space Museum collection

Discovery, the longest-serving orbiter in the space shuttle fleet, will be accepted into the Smithsonian’s National Air and Space Museum collection. The space shuttle has been the icon for American spaceflight for a generation, and Discovery has flown every type of mission during its 27-year career.

The post Space shuttle Discovery to be added to National Air and Space Museum collection appeared first on Smithsonian Insider.




discovery

Discovery of new prehistoric mosquitoes reveal these blood-suckers have changed little in 46 million years

Found in well preserved shale deposits the fossils are so detailed that scientists were able to determine they represent two previously unknown species.

The post Discovery of new prehistoric mosquitoes reveal these blood-suckers have changed little in 46 million years appeared first on Smithsonian Insider.



  • Dinosaurs & Fossils
  • Science & Nature
  • insects
  • National Museum of Natural History
  • new species

discovery

New method of finding planets scores first discovery

Detecting alien worlds presents a significant challenge since they are small, faint, and close to their stars. The two most prolific techniques for finding exoplanets […]

The post New method of finding planets scores first discovery appeared first on Smithsonian Insider.




discovery

Discovery: Turtle shells appeared 40 million years earlier than previously believed

Unique among Earth’s creatures, turtles are the only animals to form a shell on the outside of their bodies through a fusion of modified ribs, […]

The post Discovery: Turtle shells appeared 40 million years earlier than previously believed appeared first on Smithsonian Insider.




discovery

Nest discovery turns back the clock to days of Daniel Boone and Colonial America

Paddling the remote oxbow lakes and bayous of the White River National Wildlife Refuge in Arkansas, the team of scientists was seeking proof of a […]

The post Nest discovery turns back the clock to days of Daniel Boone and Colonial America appeared first on Smithsonian Insider.





discovery

The Submillimeter Array: Celebrating a decade of discovery

Ten years ago, eight antennas on the summit of Mauna Kea, Hawai’i, united to form a telescope unlike any other. Since then the Submillimeter Array […]

The post The Submillimeter Array: Celebrating a decade of discovery appeared first on Smithsonian Insider.




discovery

Volunteers needed to preserve astronomical history and promote discovery

Before iPhones and laptops there were human computers, some of whom worked at the Harvard College Observatory. Women like Henrietta Swan Leavitt, Williamina Fleming, and […]

The post Volunteers needed to preserve astronomical history and promote discovery appeared first on Smithsonian Insider.