A blend of pop, country, and electronic influences, 'Dear Diary' reflects the raw emotions and personal growth of navigating young adulthood. Dear Diary' explores the highs and lows of youth, with deeply personal lyrics that resonate with the hearth.

Experts joined KMWorld's webinar to explore how GenAI is rapidly changing the world of search and product experiences, from technological requirements to customer expectations

Advanced Litigation: Pre-Trial, Discovery and MSC - Part (1/2)…

Join us for this half-day event on trial techniques and skills, covering the entirety of a trial from discovery to decision. The expert panel of instructors will discuss the most…

The Arizona Court of Appeals ruled that a worker’s request for hearing was properly dismissed, given her failure to adhere to deadlines and failure to participate in discovery and a…

Editorial: Mass spectrometry-based proteomics in drug discovery and development  Frontiers

Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery  Frontiers

Discovery may propel advances in regenerative medicineTORONTO, ON – Consider the relationship between an air traffic controller and a pilot. The pilot gets the passengers to their destination, but the air traffic controller decides when the plane can take off and when it must wait. The same relationship plays out at the cellular level in […]

Toronto, ON –  Machine learning and artificial intelligence are poised to revolutionize the way companies do business in the fields of healthcare, transportation, and materials research. With the launch of the new Vector Institute, Toronto is quickly becoming a hub for machine learning development. Following this momentum is a three-part limited edition CIFAR seminar series, […]

Discovery that confirms theory of relativity makes headlines around the world “We see today that black holes exist in the universe and they do collide!” Associate Professor Harald Pfeiffer says (image courtesy NASA) For the first time, scientists have observed gravitational waves – ripples in the fabric of spacetime from a cataclysmic event in the […]

Massive deposit may be world’s most important animal fossil discovery in decadesKOOTENAY NATIONAL PARK, BRITISH COLUMBIA - Yoho National Park’s 505-million-year-old Burgess Shale – home to some of the planet’s earliest animals, including a very primitive human relative – is one of the world’s most important fossil sites. Now, more than a century after its […]

A New Discovery by James Coleman is a(n) Limited Edition. The Edition is Limited to Limited Edition of 95 pcs

Charles Anderson talks with James Phillips about service discovery and Consul, an open-source service discovery tool. The discussion begins by defining what service discovery is, what data is stored in a service discovery tool, and some scenarios in which it’s used. Then they dive into some details about the components of a service discovery tool and how reliability is achieved as a distributed system. Finally, James discusses Consul, the functions it provides, and how to integrate it with existing applications, even if they use configuration files instead of a service discovery tool.

In September, my wife and I did a half Ironman relay. While waiting for my wife to finish the swimming portion, I struck up a conversation with a cyclist who was with team Rockit™ Apple. Inevitably, the conversation eventually turned to packaging.

Stanford Medicine researchers on the hunt for an elusive cardiac fibrosis drug were surprised when a malaria drug with ancient origins emerged as their top candidate.

The post Old drug, new discovery: Scientists find novel use for ancient malaria remedy  appeared first on Scope.

Framework for service interworking with device discovery and management in heterogeneous Internet of things environments

Location: Electronic Resource- 

1840: Discovery of the Black Obelisk of King Shalmaneser of Assyria

A Q&A with Ria Madrid of Wurl - she discusses BrandDiscovery, their new tech that makes it possible for marketers to precisely match CTV ads with the emotion and context of what viewers are watching to create positive attention, using Plutchik's Wheel of Emotions. Partners like Media.Monks are already driving impressive results for their clients through Wurl's solution, which uses scene-level contextual targeting to help advertisers align the emotional sentiment of their campaign creatives with content closest to the ad break.

'Blade Runner 2049' production company Alcon Entertainment sued Tesla, Elon Musk and Warner Bros. Discovery for copyright infringement. Here's why.

Alexander Fleming’s 1928 discovery of a mold with antibacterial properties was only the first serendipitous event on the long road to penicillin as a life-saving drug.

The Nobel Prize-winning discovery of microRNA has reshaped our understanding of gene regulation. Learn what these tiny molecules mean for cancer research.

On Thursday, November 14, media and entertainment technology strategist Chris Pfaff will moderate the panel "Removing the Friction of Content Discovery on CTV." Incorporating viewership data into the content discoverability process can remove the pain points that have bubbled up in the new streaming landscape, lead to more engagement with the content, and open up more opportunities for advertisers to reach their target audiences. This panel of experts from NBCUniversal, Pluto TV, Revry TV, and Gatsby TV looks at the success of genre channels and provides attendees with insight into how they help their viewers find their content faster.

Warner Bros Discovery (WBD) has reported financial results for Q3, with highlights including 7.2m new Max subscriptions.

A Free 42-page PDF you can read on your phone, tablet, or laptop and enjoy!

My friend Jordanlafordan, organised and compiled a Fanzine to celebrate Star Trek: Discovery. Full of Fanfic, essays, photos, games, poems, and quotes from our beloved Star Trek: Discovery, this is the first annual Celebrate Disco fanzine! I (Faintdreams) submitted the crossword. Enjoy! If you like it please let the organiser know. They have a mastodon account here: ( https://tenforward.social/@jordanlafordan )

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Aidan Toner-Rodgers† MIT November 6, 2024 This paper studies the impact of artificial intelligence on innovation, exploiting the randomized introduction of a new materials discovery technology to 1,018 scientists in the R&D lab of a large U.S. firm. AI-assisted researchers discover 44% more materials, resulting in a 39% increase in patent filings and a 17% rise in downstream product in- novation. These compounds possess more novel chemical structures and lead to more radical inventions. However, the technology has strikingly disparate effects across the productivity distribution: while the bottom third of scientists see little benefit, the output of top researchers nearly doubles. Investigating the mechanisms behind these results, I show that AI automates 57% of “idea-generation” tasks, reallocating researchers to the new task of evaluating model-produced candidate materials. Top scientists leverage their domain knowledge to prioritize promising AI suggestions, while others waste significant resources testing false positives. Together, these findings demonstrate the potential of AI-augmented research and highlight the complemen- tarity between algorithms and expertise in the innovative process. Survey evidence reveals that these gains come at a cost, however, as 82% of scientists report reduced satisfaction with their work due to decreased creativity and skill underutilization.

Join our daily and weekly newsletters for the latest updates and exclusive content on industry-leading AI coverage. Learn More Google DeepMind has unexpectedly released the source code and model weights of AlphaFold 3 for academic use, marking a significant advance that could accelerate scientific…

Toma Keser
Dec 29, 2020; 0:RA120.002433v1-mcp.RA120.002433
Research

Alpha-1-acid glycoprotein (AGP) is an acute phase glycoprotein in blood, which is primarily synthetized in the liver and whose biological role is not completely understood. It consists of 45% carbohydrates that are present in the form of five N-linked complex glycans. AGP N-glycosylation was shown to be changed in many different diseases and some changes appear to be disease-specific, thus it has a great diagnostic and prognostic potential. However, AGP glycosylation was mainly analyzed in small cohorts and without detailed site-specific glycan information. Here, we developed a cost-effective method for a high-throughput and site-specific N-glycosylation LC-MS analysis of AGP which can be applied on large cohorts, aid in search for novel disease biomarkers and enable better understanding of AGP’s role and function in health and disease. The method does not require isolation of AGP with antibodies and affinity chromatography, but AGP is enriched by acid precipitation from 5 μl of bloodplasma in a 96 well format. After trypsinization, AGP glycopeptides are purified using a hydrophilic interaction chromatography based solid-phase extraction and analyzed by RP-LC-ESI-MS. We used our method to show for the first time that AGP N-glycan profile is stable in healthy individuals (14 individuals in 3 time points), which is a requirement for evaluation of its diagnostic potential. Furthermore, we tested our method on a population including individuals with registered hyperglycemia in critical illness (59 cases and 49 controls), which represents a significantly increased risk of developing type 2 diabetes. Individuals at higher risk of diabetes presented increased N-glycan branching on AGP’s second glycosylation site and lower sialylation of N-glycans on AGP’s third and AGP1’s fourth glycosylation site. Although this should be confirmed on a larger prospective cohort, it indicates that site-specific AGP N-glycan profile could help distinguish individuals who are at risk of type 2 diabetes.

Video by David VanZandt

At the site known as Oued Beht, archaeologists uncovered evidence of a large farming settlement where people used advanced techniques

Victor Ambros and Gary Ruvkun discovered microRNA, tiny molecules that play a crucial role in how cells develop, paving the way for new treatments for diseases

‘To design, I use my favorite tool, SOLIDWORKS’

Discovery Health Medical Scheme's (DHMS) 2023 cancer claims payouts were almost 19% higher than the previous year though the scheme says screening rates in South Africa have mostly returned to pre-pandemic levels.

Google DeepMind has silently open-sourced its frontier artificial intelligence (AI) model that can predict the interaction between proteins and other molecules. Dubbed AlphaFold 3, the large language model is the successor of AlphaFold 2, whose research led to the creators of the large language model (LLM) Demis Hassabis and John Jumper getting the Nobel Prize in Chemistry in 2024.

Sea-floor nodules raise oxygen levels in the deep ocean, suggesting they may have a valuable role in ecosystems and adding to concerns about the impact of deep-sea mining

Title: Discovery May Improve Diagnosis of Alzheimer's, Parkinson's
Category: Health News
Created: 8/29/2012 6:05:00 PM
Last Editorial Review: 8/30/2012 12:00:00 AM

The development of transforming growth factor βreceptor inhibitors (TGFβRi) as new medicines has been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species. PF-06952229 inhibited clinically translatable phospho-SMAD2 biomarker (≥60%) in human and cynomolgus monkey peripheral blood mononuclear cells, as well as in mouse and rat splenocytes. Using an optimized, intermittent dosing schedule (7-day on/7-day off/cycle; 5 cycles), PF-06952229 demonstrated efficacy in a 63-day syngeneic MC38 colon carcinoma mouse model. In the pivotal repeat-dose toxicity studies (rat and cynomolgus monkey), PF-06952229 on an intermittent dosing schedule (5-day on/5-day off cycle; 5 cycles, 28 doses) showed no cardiac-related adverse findings. However, new toxicity findings related to PF-06952229 included reversible hepatocellular (hepatocyte necrosis with corresponding clinically monitorable transaminase increases) and lung (hemorrhage with mixed cell inflammation) findings at ≥ targeted projected clinical efficacious exposures. Furthermore, partially reversible cartilage hypertrophy (trachea and femur in rat; femur in monkey) and partially to fully reversible, clinically monitorable decreases in serum phosphorus and urinary phosphate at ≥ projected clinically efficacious exposures were observed. Given the integral role of TGFβ in endochondral bone formation, cartilage findings in toxicity studies have been observed with other TGFβRi classes of compounds. The favorable cumulative profile of PF-06952229 in biochemical, pharmacodynamic, pharmacokinetic, and nonclinical studies allowed for its evaluation in cancer patients using the intermittent dosing schedule (7-day on/7-day off) and careful protocol-defined monitoring.

As radiopharmaceuticals enter a new phase, industry leaders must rethink external services and internal capabilities to master the complexities of delivering advanced therapies.

The post Unlocking the Future of Radioligand Therapy: From Discovery to Delivering at Scale appeared first on MedCity News.

Conoce a la familia Méndez, pionera en la transformación extrema de camiones. Texas Trocas, nueva serie de Discovery en Español. Estreno 15 de septiembre a las 10PM E/P.

Conoce al legendario restaurador y mecánico Martín Vaca quien construye autos fuera de serie desde hace más de 50 años. MEXICÁNICOS, estreno el 2 de marzo a las 10PM

Video james

Researchers from Cincinnati Children's Hospital and the University of Cincinnati College of Medicine have developed a novel approach to increase speed

Alzheimer's Drug Discovery Foundation Funds Amicus Therapeutics To Advance Pharmacological Chaperone Technology

Approximately one in five Americans experiences chronic pain, and existing medications aren't very promising. Feixiong Cheng, Ph.D, Director of the Genome