discovery

The Higgs boson discovery at the Large Hadron Collider / Roger Wolf

Wolf, Roger, author




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Allosterism in drug discovery / editor: Dario Doller

Online Resource




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Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development. / Ahmed F. Abdel-Magid, editor, Jaan A. Pesti, editor, Rajappa Vaidyanathan, editor ; sponsored by the ACS Division of Organic Chemistry

Online Resource




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Comprehensive accounts of pharmaceutical research and development: from discovery to late-stage process development / Ahmed F. Abdel-Magid, editor, Jaan A. Pesti, editor, Rajappa Vaidyanathan, editor ; sponsored by the ACS Division of Organic Chemistry

Online Resource




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Peptide-based drug discovery: challenges and new therapeutics / ediror: Ved Srivastava

Online Resource




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Enabling precision medicine: the role of genetics in clinical drug development: proceedings of a workshop / Morgan L. Boname [and four others], rapporteurs ; Forum on Drug Discovery, Development, and Translation ; Roundtable on Genomics and Precision Heal

Online Resource




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Biophysical techniques in drug discovery / edited by Angeles Canales

Online Resource




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Computational drug discovery and design / edited by Mohini Gore, Umesh B. Jagtap

Online Resource




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Bioinformatics techniques for drug discovery: applications for complex diseases / Aman Chandra Kaushik, Ajay Kumar, Shiv Bharadwaj, Ravi Chaudhary, Shakti Sahi

Online Resource




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Systems thinking in medicine and new drug discovery. by Robert E. Smith

Hayden Library - RM301.25.S65 2018




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Structural bioinformatics: applications in preclinical drug discovery process / C. Gopi Mohan, editor

Online Resource




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Drug discovery in Japan: investigating the sources of innovation / Sadao Nagaoka, editor

Online Resource




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Antibacterial drug discovery to combat MDR: natural compounds, nanotechnology and novel synthetic sources / Iqbal Ahmad, Shamim Ahmad, Kendra P. Rumbaugh, editors

Online Resource




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Conference on drug design and discovery technologies / editors: Manikanta Murahari [and 5 more]

Online Resource




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Computational discovery of promising new n-type dopable ABX Zintl thermoelectric materials

Mater. Horiz., 2020, Advance Article
DOI: 10.1039/D0MH00197J, Communication
Prashun Gorai, Alex Ganose, Alireza Faghaninia, Anubhav Jain, Vladan Stevanović
We develop a chemical replacements in structure prototype (CRISP) approach for novel materials discovery with functional applications.
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discovery

[ASAP] Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites

ACS Chemical Biology
DOI: 10.1021/acschembio.9b00890




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[ASAP] Discovery of the First Human Arylsulfatase A Reversible Inhibitor Impairing Mouse Oocyte Fertilization

ACS Chemical Biology
DOI: 10.1021/acschembio.9b00999




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[ASAP] Discovery of Cryptic Largimycins in <italic toggle="yes">Streptomyces</italic> Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family

ACS Chemical Biology
DOI: 10.1021/acschembio.0c00160




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[ASAP] mRNA Display Discovery of a Novel Programmed Death Ligand 1 (PD-L1) Binding Peptide (a Peptide Ligand for PD-L1)

ACS Chemical Biology
DOI: 10.1021/acschembio.0c00264




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[ASAP] Discovery and SAR of Natural-Product-Inspired RXR Agonists with Heterodimer Selectivity to PPARd-RXR

ACS Chemical Biology
DOI: 10.1021/acschembio.0c00146




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Exploring planetary climate: a history of scientific discovery on Earth, Mars, Venus, and Titan / Ralph D. Lorenz (John Hopkins Applied Physics Laboratory)

Hayden Library - QB603.A85 L67 2019




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Astrobiology, discovery, and societal impact / Steven J. Dick, former NASA Chief Historian, 2014 Baruch S. Blumberg NASA/Library of Congress Chair in Astrobiology

Hayden Library - QB54.D4695 2018




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Unveiling galaxies: the role of images in astronomical discovery / Jean-René Roy, formerly Gemini Observatory, La Serena, Chile

Hayden Library - QB121.R697 2018




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[ASAP] Evolution of Dip-Pen Nanolithography (DPN): From Molecular Patterning to Materials Discovery

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00725




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Information discovery and delivery [electronic journal].




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Fuzzy Systems and Knowledge Discovery, Fourth International Conference on [electronic journal].

IEEE Computer Society




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Current biochemical understanding regarding the metabolism of acinetobactin, the major siderophore of the human pathogen Acinetobacter baumannii, and outlook for discovery of novel anti-infectious agents based thereon

Nat. Prod. Rep., 2020, 37,477-487
DOI: 10.1039/C9NP00046A, Highlight
Woon Young Song, Hak Joong Kim
This Highlight covers recently unveiled biochemical aspects the acinetobactin metabolism, a central iron acquisition mechanism of Acinetobacter baumannii, in addition to various efforts for therapeutic application of these findings.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Protein allostery in drug discovery / Jian Zhang, Ruth Nussinov, editors

Online Resource




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Protein tyrosine phosphatases: structure, signaling and drug discovery / Lalima G. Ahuja

Hayden Library - QP609.P56 A38 2018




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Discovery beyond the standard model of elementary particle physics James D. Wells

Online Resource




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Evolutionary chemical space exploration for functional materials: computational organic semiconductor discovery

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC00554A, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Chi Y. Cheng, Josh E. Campbell, Graeme M. Day
Evolutionary optimisation and crystal structure prediction are used to explore chemical space for molecular organic semiconductors.
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The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

Geometric landscapes for material discovery within energy–structure–function maps

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC00049C, Edge Article
Open Access
Seyed Mohamad Moosavi, Henglu Xu, Linjiang Chen, Andrew I. Cooper, Berend Smit
We introduce a representation for the geometric features of the pores of porous molecular crystals. This representation provides a good basis for supervised (predict adsorption properties) and unsupervised (polymorph classification) tasks.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

Outdoor learning environments : spaces for exploration, discovery and risk-taking in the early years / edited by Helen Little, Sue Elliott and Shirley Wyver




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Machine learning and knowledge discovery in databases: International Workshops of ECML PKDD 2019, Würzburg, Germany, September 16-20, 2019, proceedings. / Peggy Cellier, Kurt Driessens (eds.)

Online Resource




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Machine learning and knowledge discovery in databases: International Workshops of ECML PKDD 2019, Würzburg, Germany, September 16-20, 2019, proceedings. / Peggy Cellier, Kurt Driessens (eds.)

Online Resource




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[ASAP] Mechanism-Based Rational Discovery and <italic toggle="yes">In Vitro</italic> Evaluation of Novel Microtubule Stabilizing Agents with Non-Taxol-Competitive Activity

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01133




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[ASAP] Discovery of Ubiquitin-Specific Protease 7 (USP7) Inhibitors with Novel Scaffold Structures by Virtual Screening, Molecular Dynamics Simulation, and Biological Evaluation

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00154




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[ASAP] Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00113




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[ASAP] Fragrant Venezuelaenes A and B with A 5–5–6–7 Tetracyclic Skeleton: Discovery, Biosynthesis, and Mechanisms of Central Catalysts

ACS Catalysis
DOI: 10.1021/acscatal.0c01575




discovery

Podcast: The archaeology of democracy, new additions to the uncanny valley, and the discovery of ant-ibiotics

This week, what bear-mounted cameras can tell us about their caribou-hunting habits, ants that mix up their own medicine, and feeling alienated by emotional robots with Online News Editor David Grimm. And Lizzie Wade joins Sarah Crespi to discuss new thinking on the origins of democracy outside of Europe, based on archeological sites in Mexico. Listen to previous podcasts. Download the show transcript. Transcripts courtesy of Scribie.com. [Image: rpbirdman/iStockphoto; Music: Jeffrey Cook]




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Advances in knowledge discovery and data mining : 22nd Pacific-Asia Conference, PAKDD 2018, Melbourne, VIC, Australia, June 3-6, 2018, Proceedings. Parts I-III / Dinh Phung, Vincent S. Tseng, Geoffrey I. Webb, Bao Ho, Mohadeseh Ganji, Lida Rashidi (eds.)

Pacific-Asia Conference on Knowledge Discovery and Data Mining (22nd : 2018 : Melbourne, Vic.)




discovery

Recent progress on phenotype-based discovery of dengue inhibitors

RSC Med. Chem., 2020, Advance Article
DOI: 10.1039/D0MD00052C, Review Article
Fumiaki Yokokawa
The review presents the discovery of new dengue inhibitors by a phenotype-based approach.
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The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1H-pyrazole-5-carboxylate as an HIV-1 replication inhibitor

RSC Med. Chem., 2020, Advance Article
DOI: 10.1039/D0MD00025F, Research Article
Jeanne Fichez, Cathia Soulie, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier-Pelletier, Anne-Geneviève Marcelin, Vincent Calvez, Patricia Busca
Identified as an HIV-1 inhibitor in cellulo, this pyrazole does not belong to the three main classes of anti HIV-drugs, a feature of prime interest in the context of viral resistance.
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The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

Computer-aided discovery of phenylpyrazole based amides as potent S6K1 inhibitors

RSC Med. Chem., 2020, Advance Article
DOI: 10.1039/C9MD00537D, Research Article
Yan Yin, Yuxing Sun, Lianhua Zhao, Jinpeng Pan, Yangbo Feng
Ribosomal protein S6 kinase beta-1 (S6K1) is an attractive therapeutic target.
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The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

Rediscovery of genetic and genomic resources for future food security Romesh Kumar Salgotra, Sajad Majeed Zargar, editors

Online Resource




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Discovery of new polycyclic polyprenylated acylphloroglucinols with diverse architectures as potent cyclooxygenase-2 inhibitors

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00259C, Research Article
Shuangshuang Xie, Changxing Qi, Yulin Duan, Qianqian Xu, Yaping Liu, Yingying Huang, Xu Yin, Weiguang Sun, Yuan Zhou, Yonghui Zhang
Cyclooxygenase-2 (COX-2) is a significant therapeutic target of chronic inflammatory diseases.
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The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

[ASAP] Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display

Journal of the American Chemical Society
DOI: 10.1021/jacs.0c03152




discovery

Biomarkers in Drug Discovery and Development: A Handbook of Practice, Application, and Strategy, 2nd Edition


 
This book continues the legacy of a well-established reference within the pharmaceutical industry – providing perspective, covering recent developments in technologies that have enabled the expanded use of biomarkers, and discussing biomarker characterization and validation and applications throughout drug discovery and development.

•    Explains where proper use of biomarkers can substantively impact drug development timelines and costs, enable selection

Read More...




discovery

[ASAP] Discovery of Potent and Novel Quinazolinone Sulfide Inhibitors with Anti-ToCV Activity

Journal of Agricultural and Food Chemistry
DOI: 10.1021/acs.jafc.0c00686




discovery

A chemist enters a popular TV baking competition, and a cat food discovery